Aliases for PDYN Gene
Aliases for PDYN Gene
External Ids for PDYN Gene
- HGNC: 8820
- Entrez Gene: 5173
- Ensembl: ENSG00000101327
- OMIM: 131340
- UniProtKB: P01213
Previous HGNC Symbols for PDYN Gene
- SCA23
Previous GeneCards Identifiers for PDYN Gene
- GC20M001947
- GC20M001954
Summaries for PDYN Gene
-
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for PDYN Gene
PDYN (Prodynorphin) is a Protein Coding gene. Diseases associated with PDYN include Spinocerebellar Ataxia 23 and Drug Dependence. Among its related pathways are Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include opioid peptide activity. An important paralog of this gene is PENK.
UniProtKB/Swiss-Prot for PDYN Gene
-
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).
-
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).
-
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
Additional gene information for PDYN Gene
- Monarch Initiative
- Search for PDYN at DataMed
- Search for PDYN at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDYN Gene
Genomics for PDYN Gene
GeneHancer (GH) Regulatory Elements for PDYN Gene
Promoters and enhancers for PDYN Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH20J001994 | Promoter | 0.5 | EPDnew | 650.7 | +0.2 | 208 | 0.1 | PDYN GC20P001953 PDYN-AS1 | ||
| GH20J001839 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 11.7 | +153.6 | 153598 | 3 | MXI1 HLF CEBPB MNT ZNF623 FOXA1 ZNF664 JUND SCRT2 FOS | SIRPA PDYN ZNF343 ENSG00000230839 PIR58932 | |
| GH20J001827 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 4 | +164.7 | 164683 | 4.7 | FOXA2 ARID4B SIN3A DMAP1 ZNF48 YY1 FOS RXRA SP5 NFYC | SNRPB ZNF343 ACTG1P3 SIRPA SDCBP2-AS1 PDYN SDCBP2 ENSG00000230839 PIR58932 | |
| GH20J001808 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 1.8 | +182.8 | 182751 | 6.6 | FOXA2 ARID4B SIN3A DMAP1 IRF4 YY1 ATF7 FOS RXRA JUNB | SNRPB ENSG00000230839 SIRPA SDCBP2 ACTG1P3 PSMF1 PDYN SIRPB2 LOC100289473 | |
| GH20J001960 | Enhancer | 0.2 | FANTOM5 | 3.7 | +33.6 | 33612 | 0.2 | PDYN SIRPA GC20P001953 PDYN-AS1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PDYN on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PDYN gene promoter:
-
- Nkx2-5
- HOXA3
- c-Myb
- HOXA9
- HOXA9B
- Meis-1
- Meis-1b
Regulatory Element Products
Genomic Locations for PDYN Gene
Genomic Locations for PDYN Gene
- chr20:1,978,756-1,994,285
- (GRCh38/hg38)
- Size:
- 15,530 bases
- Orientation:
- Minus strand
- chr20:1,959,402-1,974,931
- (GRCh37/hg19)
- Size:
- 15,530 bases
- Orientation:
- Minus strand
Genomic View for PDYN Gene
Genes around PDYN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20p13 by Entrez Gene
- 20p13 by HGNC
- 20p13 by Ensembl
PDYN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDYN Gene
Proteins for PDYN Gene
-
Protein details for PDYN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01213-PDYN_HUMAN
- Recommended name:
- Proenkephalin-B
- Protein Accession:
- P01213
- A8K0Q3
Protein attributes for PDYN Gene
- Size:
- 254 amino acids
- Molecular mass:
- 28385 Da
- Quaternary structure:
- No Data Available
Protein Expression for PDYN Gene
Post-translational modifications for PDYN Gene
- The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PDYN Gene
Antibody Products
- Novus Biologicals Antibodies for PDYN
- Invitrogen Antibodies for PDYN
- GeneTex PDYN Antibody for PDYN
Protein Products
-
OriGene Purified Proteins for PDYN
- Search Origene for MassSpec and Protein Over-expression Lysates for PDYN
- Origene Custom Protein Services for PDYN
- antibodies-online: Search results for 3 available PDYN Proteins ranked by validation data
- Compare Top PDYN Proteins
-
Quality Products:
- Search GeneTex for Proteins for PDYN
Assay Products
No data available for DME Specific Peptides for PDYN Gene
Domains & Families for PDYN Gene
Gene Families for PDYN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Potential drug targets
- Predicted secreted proteins
- Transporters
Protein Domains for PDYN Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PDYN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P01213- Family:
-
- Belongs to the opioid neuropeptide precursor family.
Function for PDYN Gene
Molecular function for PDYN Gene
- UniProtKB/Swiss-Prot Function:
- Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).
- UniProtKB/Swiss-Prot Function:
- Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).
- UniProtKB/Swiss-Prot Function:
- Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
- GENATLAS Biochemistry:
- pro-dynorphin
Phenotypes From GWAS Catalog for PDYN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001515 | opioid peptide activity | IEA | -- |
| GO:0005184 | neuropeptide hormone activity | IBA | -- |
| GO:0031628 | opioid receptor binding | IBA | -- |
Phenotypes for PDYN Gene
- MGI mutant phenotypes for PDYN:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for PDYN:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PDYN
-
CRISPR Products
-
OriGene CRISPR knockouts for PDYN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDYN
- genomics-online: gRNA clones - Search results for 119 available PDYN gene related products
- Overview of 119 available PDYN gene related products
- Applied Biological Materials CRISPR for PDYN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDYN
- GenScript: Design CRISPR guide RNA sequences for PDYN
miRNA for PDYN Gene
- miRTarBase miRNAs that target PDYN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDYN
- Browse OriGene Inhibitory RNA Products For PDYN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDYN
- genomics-online: shRNA clones - Search results for 119 available PDYN gene related products
- Overview of 119 available PDYN gene related products
Clone Products
- Sino Biological Human cDNA Clone for PDYN
- VectorBuilder custom plasmid, inducible vectors for PDYN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDYN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDYN
- Applied Biological Materials Clones for PDYN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PDYN
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PDYN Gene
Localization for PDYN Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDYN Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005886 | plasma membrane | IDA | 9047294 |
| GO:0030425 | dendrite | IBA | -- |
| GO:0043025 | neuronal cell body | IBA | -- |
| GO:0043679 | axon terminus | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PDYN Gene
Pathways & Interactions for PDYN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Amphetamine addiction | ||
| 4 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.34
|
|
| 5 | BMP Pathway | ||
Pathways by source for PDYN Gene
1 BioSystems pathway for PDYN Gene
9 Reactome pathways for PDYN Gene
3 KEGG pathways for PDYN Gene
2 GeneGo (Thomson Reuters) pathways for PDYN Gene
2 Qiagen pathways for PDYN Gene
Interacting Proteins for PDYN Gene
GPS-Prot Interaction Network for PDYN
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
| GO:0007218 | neuropeptide signaling pathway | IBA | -- |
| GO:0007268 | chemical synaptic transmission | IBA | -- |
| GO:0007600 | sensory perception | IBA | -- |
| GO:0010469 | regulation of signaling receptor activity | IEA | -- |
No data available for SIGNOR curated interactions for PDYN Gene
Drugs & Compounds for PDYN Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| opioids | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for PDYN Gene
mRNA/cDNA for PDYN Gene
- (13) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000217305 2555 bps (uc002wfv.4)
- ENST00000539905 2725 bps (uc021vzu.2)
- ENST00000540134 2472 bps (uc021vzs.2)
CRISPR Products
-
OriGene CRISPR knockouts for PDYN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDYN
- genomics-online: gRNA clones - Search results for 119 available PDYN gene related products
- Overview of 119 available PDYN gene related products
- Applied Biological Materials CRISPR for PDYN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDYN
- GenScript: Design CRISPR guide RNA sequences for PDYN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDYN
- Browse OriGene Inhibitory RNA Products For PDYN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDYN
- genomics-online: shRNA clones - Search results for 119 available PDYN gene related products
- Overview of 119 available PDYN gene related products
Clone Products
- Sino Biological Human cDNA Clone for PDYN
- VectorBuilder custom plasmid, inducible vectors for PDYN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDYN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDYN
- Applied Biological Materials Clones for PDYN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP8: | - | - | - |
Expression for PDYN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Kidney (Urinary System)
- Juxtaglomerular Cells Afferent Arteriole
-
Smooth Muscle (Muscoskeletal System)
- Juxtaglomerular Cells Afferent Arteriole
-
Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for PDYN Gene
This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x21.4), Brain - Caudate (basal ganglia) (x11.3), and Brain - Putamen (basal ganglia) (x6.4).
This gene is overexpressed in Testis (25.8), Lymph node (10.6), and Ovary (9.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDYN Gene
NURSA nuclear receptor signaling pathways regulating expression of PDYN Gene:
PDYNSOURCE GeneReport for Unigene cluster for PDYN Gene:
Hs.22584Evidence on tissue expression from TISSUES for PDYN Gene
- Nervous system(4.9)
- Adrenal gland(2.1)
- Intestine(2.1)
- Muscle(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PDYN Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- eye
- head
Limb:
- foot
- lower limb
- upper limb
General:
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs and template standards for PDYN
-
OriGene qPCR primer pairs for PDYN
- genomics-online: primer clones - Search results for 119 available PDYN gene related products
- Overview of 119 available PDYN gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PDYN Gene
Orthologs for PDYN Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PDYN 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PDYN 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PDYN 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Pdyn 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Pdyn 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PDYN 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PDYN 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PDYN 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | LOC100536328 33 |
|
||
| pdyn 34 34 |
|
OneToMany |
- Species where no ortholog for PDYN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PDYN Gene
- ENSEMBL:
- Gene Tree for PDYN (if available)
- TreeFam:
- Gene Tree for PDYN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PDYN: view image
Paralogs for PDYN Gene
Variants for PDYN Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1004881058 | ataxia 23 (SCA23) [MIM:610245] | 1,980,471(-) | C/T | coding_sequence_variant, missense_variant | |
| rs1031150313 | uncertain-significance, Spinocerebellar Ataxia, Dominant | 1,978,791(-) | G/A | 3_prime_UTR_variant | |
| rs10485703 | likely-benign, Spinocerebellar Ataxia, Dominant | 1,979,667(-) | A/G | 3_prime_UTR_variant | |
| rs111525766 | likely-benign, Spinocerebellar Ataxia, Dominant | 1,980,185(-) | T/C | 3_prime_UTR_variant | |
| rs112661575 | likely-benign, Spinocerebellar Ataxia, Dominant | 1,978,929(-) | G/A/T | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.68;
32.13% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PDYN Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDYN Gene
Disorders for PDYN Gene
(33) MalaCards diseases for PDYN Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinocerebellar ataxia 23 |
|
|
| drug dependence |
|
|
| cocaine dependence |
|
|
| temporal lobe epilepsy |
|
|
| cutaneous solitary mastocytoma |
|
|
Search PDYN in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PDYN_HUMAN- Spinocerebellar ataxia 23 (SCA23) [MIM:610245]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. {ECO:0000269 PubMed:21035104, ECO:0000269 PubMed:21712028, ECO:0000269 PubMed:23108490, ECO:0000269 PubMed:23471613}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for PDYN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PDYN Gene
Publications for PDYN Gene
- Prodynorphin mutations cause the neurodegenerative disorder spinocerebellar ataxia type 23. (PMID: 21035104) Bakalkin G … Verbeek DS (American journal of human genetics 2010) 2 3 4 58
- A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain. (PMID: 18923396) Yuferov V … Kreek MJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009) 3 22 44 58
- Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. (PMID: 19219857) Bousman CA … Tsuang MT (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 22 44 58
- Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly. (PMID: 19468819) Kölsch H … Dichgans M (Journal of neural transmission (Vienna, Austria : 1996) 2009) 3 22 44 58
- Analysis of the prodynorphin promoter polymorphism in atopic dermatitis and disease-related pruritus. (PMID: 19486061) Greisenegger EK … Kopp T (Clinical and experimental dermatology 2009) 3 22 44 58
Products for PDYN Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PDYN
- Search Origene for MassSpec and Protein Over-expression Lysates for PDYN
- Origene Custom Protein Services for PDYN
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDYN
- Browse OriGene Inhibitory RNA Products For PDYN
- OriGene qPCR primer pairs and template standards for PDYN
- OriGene qPCR primer pairs for PDYN
- OriGene CRISPR knockouts for PDYN
- OriGene ORF clones in human for PDYN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PDYN
- GenScript: Next-day shipping of latest version cDNA ORF clones for PDYN in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PDYN
- GenScript Custom Assay Services for PDYN
- GenScript Custom overexpressing Cell Line Services for PDYN
- GenScript: Design CRISPR guide RNA sequences for PDYN
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PDYN
- Sino Biological Human cDNA Clone for PDYN
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PDYN
- Novus Biologicals proteins and lysates for PDYN
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for PDYN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDYN
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 96 available PDYN Antibodies ranked by validation data
- Compare Top PDYN Antibodies
- antibodies-online: Search results for 26 available PDYN Elisa Kits ranked by validation data
- Compare Top PDYN Elisa Kits
- antibodies-online: Search results for 3 available PDYN Proteins ranked by validation data
- Compare Top PDYN Proteins
- Quality Products:
- GeneTex PDYN Antibody for PDYN
- Search GeneTex for Proteins for PDYN
- Horizon Cell Lines for PDYN
- genomics-online: cdna clones - Search results for 119 available PDYN gene related products
- Overview of 119 available PDYN gene related products
- orf clones - Search results for 119 available PDYN gene related products
- Overview of 119 available PDYN gene related products
- genomics-online: gRNA clones - Search results for 119 available PDYN gene related products
- Overview of 119 available PDYN gene related products
- genomics-online: primer clones - Search results for 119 available PDYN gene related products
- Overview of 119 available PDYN gene related products
- genomics-online: shRNA clones - Search results for 119 available PDYN gene related products
- Overview of 119 available PDYN gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDYN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDYN
- GeneCopoeia miRNA 3'UTR Target clone products for PDYN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDYN
Sources for PDYN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt