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The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
PDYN (Prodynorphin) is a Protein Coding gene. Diseases associated with PDYN include Spinocerebellar Ataxia 23 and Drug Dependence. Among its related pathways are Signaling by GPCR and Spinocerebellar ataxia. Gene Ontology (GO) annotations related to this gene include opioid peptide activity. An important paralog of this gene is PENK.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001515 | opioid peptide activity | IEA | -- |
GO:0031628 | opioid receptor binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005886 | plasma membrane | IBA,IDA | 9047294 |
GO:0030425 | dendrite | IBA | 21873635 |
GO:0043025 | neuronal cell body | IBA | 21873635 |
GO:0043679 | axon terminus | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | Amphetamine addiction | ||
4 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.35
|
|
5 | Spinocerebellar ataxia |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007218 | neuropeptide signaling pathway | IBA | 21873635 |
GO:0007268 | chemical synaptic transmission | IEA,IBA | 21873635 |
GO:0007600 | sensory perception | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
opioids | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP8: | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PDYN 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PDYN 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PDYN 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pdyn 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Pdyn 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PDYN 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PDYN 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PDYN 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | pdyn 30 31 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
727810 | Likely Benign: not provided | 1,980,788(-) | C/A | SYNONYMOUS_VARIANT | |
728105 | Conflicting Interpretations: Spinocerebellar ataxia type 23; not provided | 1,980,506(-) | G/A | SYNONYMOUS_VARIANT | |
734141 | Likely Benign: not provided | 1,980,950(-) | G/A | SYNONYMOUS_VARIANT | |
739703 | Likely Benign: not provided | 1,980,644(-) | A/G | SYNONYMOUS_VARIANT | |
746654 | Likely Benign: not provided | 1,980,527(-) | T/G | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
spinocerebellar ataxia 23 |
|
|
drug dependence |
|
|
cocaine dependence |
|
|
temporal lobe epilepsy |
|
|
opiate dependence |
|