Aliases for PDXP Gene
External Ids for PDXP Gene
Previous GeneCards Identifiers for PDXP Gene
Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PDXP Gene
PDXP (Pyridoxal Phosphatase) is a Protein Coding gene. Diseases associated with PDXP include Dysbaric Osteonecrosis and Epilepsy, Familial Temporal Lobe, 6. Among its related pathways are Vitamin B6 metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and phosphoprotein phosphatase activity. An important paralog of this gene is PGP.
UniProtKB/Swiss-Prot Summary for PDXP Gene
Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine (PubMed:15580268). Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP (PubMed:14522954).