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Aliases for PDRG1 Gene

Aliases for PDRG1 Gene

  • P53 And DNA Damage Regulated 1 2 3 5
  • C20orf126 3 4
  • PDRG 3 4
  • P53 And DNA Damage-Regulated Protein 1 3
  • Chromosome 20 Open Reading Frame 126 2
  • P53 And DNA-Damage Regulated 1 2

External Ids for PDRG1 Gene

Previous HGNC Symbols for PDRG1 Gene

  • C20orf126

Previous GeneCards Identifiers for PDRG1 Gene

  • GC20M029996
  • GC20M030532
  • GC20M027321

Summaries for PDRG1 Gene

GeneCards Summary for PDRG1 Gene

PDRG1 (P53 And DNA Damage Regulated 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot for PDRG1 Gene

  • May play a role in chaperone-mediated protein folding.

Additional gene information for PDRG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDRG1 Gene

Genomics for PDRG1 Gene

GeneHancer (GH) Regulatory Elements for PDRG1 Gene

Promoters and enhancers for PDRG1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I031950 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 550.4 +17.2 17205 2.4 PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 PDRG1 XKR7 DUSP15 TTLL9 PIR49802
GH20I031967 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.6 570 0.5 ATF1 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ZNF213 ELK1 ZNF143 ATF7 PDRG1 XKR7
GH20I031968 Enhancer 1.3 ENCODE dbSUPER 550.8 +0.2 157 0.2 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF213 E2F8 ZNF143 ENSG00000278012 PDRG1 XKR7 RSL24D1P6 FOXS1 TTLL9
GH20I031840 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 12.2 +124.7 124675 6.6 HDGF PKNOX1 SIN3A YBX1 ZNF48 TCF12 GLIS2 ZNF207 ZNF143 ATF7 FOXS1 GC20M031845 ASXL1 MYLK2 POFUT1 TSPY26P TTLL9 TM9SF4 BAK1P1 PLAGL2
GH20I032573 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.1 -606.3 -606331 2.3 HDGF ATF1 ARNT TCF12 GLIS2 FOS ATF7 NCOA1 ZNF623 ZNF592 RSL24D1P6 ASXL1 PDRG1 TM9SF4 CDK5RAP1 BAK1P1 NOL4L-DT TSPY26P ENSG00000228156 NOL4L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PDRG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDRG1 gene promoter:

Genomic Locations for PDRG1 Gene

Genomic Locations for PDRG1 Gene
24,369 bases
Minus strand

Genomic View for PDRG1 Gene

Genes around PDRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDRG1 Gene

Proteins for PDRG1 Gene

  • Protein details for PDRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    p53 and DNA damage-regulated protein 1
    Protein Accession:
    Secondary Accessions:
    • B2R511
    • Q96GP3
    • Q9BUW8

    Protein attributes for PDRG1 Gene

    133 amino acids
    Molecular mass:
    15511 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDRG1 Gene

Post-translational modifications for PDRG1 Gene

  • Ubiquitination at Lys27
  • Modification sites at PhosphoSitePlus

Other Protein References for PDRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDRG1 Gene

Domains & Families for PDRG1 Gene

Gene Families for PDRG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PDRG1 Gene

Suggested Antigen Peptide Sequences for PDRG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the prefoldin subunit beta family.
  • Belongs to the prefoldin subunit beta family.
genes like me logo Genes that share domains with PDRG1: view

Function for PDRG1 Gene

Molecular function for PDRG1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in chaperone-mediated protein folding.
UniProtKB/Swiss-Prot Induction:
By UV irradiation and repressed by p53/TP53.

Phenotypes From GWAS Catalog for PDRG1 Gene

Gene Ontology (GO) - Molecular Function for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with PDRG1: view

Phenotypes for PDRG1 Gene

GenomeRNAi human phenotypes for PDRG1:
genes like me logo Genes that share phenotypes with PDRG1: view

miRNA for PDRG1 Gene

miRTarBase miRNAs that target PDRG1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDRG1 Gene

Localization for PDRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDRG1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDRG1 gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016272 prefoldin complex IEA --
genes like me logo Genes that share ontologies with PDRG1: view

Pathways & Interactions for PDRG1 Gene

SuperPathways for PDRG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PDRG1: view

No data available for Pathways by source and SIGNOR curated interactions for PDRG1 Gene

Drugs & Compounds for PDRG1 Gene

No Compound Related Data Available

Transcripts for PDRG1 Gene

mRNA/cDNA for PDRG1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(244) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PDRG1 Gene

P53 and DNA-damage regulated 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDRG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - -

Relevant External Links for PDRG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDRG1 Gene

This gene is overexpressed in Bone marrow stromal cell (25.2) and Peripheral blood mononuclear cells (22.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDRG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PDRG1 Gene:


SOURCE GeneReport for Unigene cluster for PDRG1 Gene:


mRNA Expression by UniProt/SwissProt for PDRG1 Gene:

Tissue specificity: Predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs.

Evidence on tissue expression from TISSUES for PDRG1 Gene

  • Nervous system(4.5)
  • Muscle(4.2)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with PDRG1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDRG1 Gene

Orthologs for PDRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PDRG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PDRG1 33 34
  • 99.25 (n)
(Bos Taurus)
Mammalia PDRG1 33 34
  • 92.48 (n)
(Canis familiaris)
Mammalia PDRG1 33 34
  • 91.73 (n)
(Mus musculus)
Mammalia Pdrg1 33 16 34
  • 88.22 (n)
(Rattus norvegicus)
Mammalia Pdrg1 33
  • 86.47 (n)
(Monodelphis domestica)
Mammalia PDRG1 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia PDRG1 34
  • 63 (a)
(Gallus gallus)
Aves PDRG1 34
  • 51 (a)
(Anolis carolinensis)
Reptilia PDRG1 34
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pdrg1 33
  • 63.73 (n)
(Danio rerio)
Actinopterygii pdrg1 33 34
  • 59.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15863 34
  • 27 (a)
Species where no ortholog for PDRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDRG1 Gene

Gene Tree for PDRG1 (if available)
Gene Tree for PDRG1 (if available)

Paralogs for PDRG1 Gene Pseudogenes for PDRG1 Gene

genes like me logo Genes that share paralogs with PDRG1: view

No data available for Paralogs for PDRG1 Gene

Variants for PDRG1 Gene

Sequence variations from dbSNP and Humsavar for PDRG1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000030839 -- 31,952,053(-) G/A 5_prime_UTR_variant
rs1000175146 -- 31,947,896(-) A/G intron_variant
rs1000200999 -- 31,953,150(-) A/C upstream_transcript_variant
rs1000360235 -- 31,949,605(-) A/G intron_variant
rs1000458580 -- 31,947,640(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PDRG1 Gene

Variant ID Type Subtype PubMed ID
dgv4300n100 CNV gain 25217958
nsv833952 CNV gain 17160897

Variation tolerance for PDRG1 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDRG1 Gene

Disorders for PDRG1 Gene

Additional Disease Information for PDRG1

No disorders were found for PDRG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDRG1 Gene

Publications for PDRG1 Gene

  1. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation. (PMID: 14562055) Luo X … Sheikh MS (Oncogene 2003) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. (PMID: 28330616) Yadav L … Varjosalo M (Cell systems 2017) 3 58

Products for PDRG1 Gene

Sources for PDRG1 Gene

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