Aliases for PDPN Gene
Aliases for PDPN Gene
External Ids for PDPN Gene
- HGNC: 29602
- Entrez Gene: 10630
- Ensembl: ENSG00000162493
- OMIM: 608863
- UniProtKB: Q86YL7
Previous GeneCards Identifiers for PDPN Gene
- GC01P013782
- GC01P013909
- GC01P012427
Summaries for PDPN Gene
-
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for PDPN Gene
PDPN (Podoplanin) is a Protein Coding gene. Diseases associated with PDPN include Lymphangioma and Subglottis Neoplasm. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and G beta-gamma signalling through PI3Kgamma. Gene Ontology (GO) annotations related to this gene include amino acid transmembrane transporter activity and folic acid transmembrane transporter activity.
UniProtKB/Swiss-Prot for PDPN Gene
-
Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation (PubMed:14522983, PubMed:15231832, PubMed:17616532, PubMed:18215137, PubMed:17222411). Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN (PubMed:18541721). Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness (PubMed:17046996, PubMed:21376833). Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (PubMed:20962267). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation (By similarity). Through binding with LGALS8 may participate to connection of the lymphatic endothelium to the surrounding extracellular matrix (PubMed:19268462). In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion (PubMed:15515019). Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1 (PubMed:25486435). Required for normal lung cell proliferation and alveolus formation at birth (By similarity). Does not function as a water channel or as a regulator of aquaporin-type water channels (PubMed:9651190). Does not have any effect on folic acid or amino acid transport (By similarity).
Additional gene information for PDPN Gene
- Monarch Initiative
- Search for PDPN at DataMed
- Search for PDPN at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDPN Gene
Genomics for PDPN Gene
GeneHancer (GH) Regulatory Elements for PDPN Gene
Promoters and enhancers for PDPN Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01I013583 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 556.8 | +1.8 | 1762 | 4.4 | ZSCAN4 KLF17 ZNF2 ZNF335 ZNF121 GLIS2 ZNF213 ZSCAN5C SCRT2 EGR2 | PDPN RNA5SP41 | |
| GH01I013592 | Promoter/Enhancer | 1.2 | EPDnew Ensembl ENCODE dbSUPER | 555.6 | +10.3 | 10337 | 1.8 | EZH2 | PDPN RNA5SP41 | |
| GH01I013604 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE dbSUPER | 14.1 | +21.8 | 21842 | 1 | ZNF217 CTBP1 GATA3 RFX1 FOS FOXA1 | PDPN LRRC38 PRDM2 RNA5SP41 | |
| GH01I013618 | Enhancer | 0.5 | ENCODE | 24.5 | +36.3 | 36347 | 2.2 | USF1 CREB1 ATF7 ATF2 | PDPN LRRC38 PRAMEF36P RNA5SP41 | |
| GH01I013617 | Enhancer | 0.4 | Ensembl ENCODE | 20.3 | +34.4 | 34439 | 0.7 | PDPN RNA5SP41 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PDPN on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PDPN gene promoter:
Regulatory Element Products
Genomic Locations for PDPN Gene
Genomic Locations for PDPN Gene
- chr1:13,583,465-13,617,957
- (GRCh38/hg38)
- Size:
- 34,493 bases
- Orientation:
- Plus strand
- chr1:13,909,960-13,944,452
- (GRCh37/hg19)
Genomic View for PDPN Gene
Genes around PDPN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.21 by Ensembl
- 1p36.21 by Entrez Gene
- 1p36.21 by HGNC
PDPN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDPN Gene
Proteins for PDPN Gene
-
Protein details for PDPN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86YL7-PDPN_HUMAN
- Recommended name:
- Podoplanin
- Protein Accession:
- Q86YL7
- A9Z1Y2
- B2R6J8
- E9PB68
- F6QWX5
- O60836
- O95128
- Q7L375
- Q8NBQ8
- Q8NBR3
Protein attributes for PDPN Gene
- Size:
- 162 amino acids
- Molecular mass:
- 16698 Da
- Quaternary structure:
-
- Homodimer (PubMed:21376833). Interacts with CLEC1B; the interaction is independent of CLEC1B glycosylation and activates CLEC1B; the interaction is dependent of sialic acid on O-glycans (PubMed:18215137, PubMed:17616532, PubMed:25458834). Interacts with CD9; this interaction is homophilic and attenuates platelet aggregation and pulmonary metastasis induced by PDPN (PubMed:18541721). Interacts with LGALS8; the interaction is glycosylation-dependent; may participate to connection of the lymphatic endothelium to the surrounding extracellular matrix (PubMed:19268462). Interacts with HSPA9 (PubMed:23541579). Interacts (via extracellular domain) with CD44; this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration (PubMed:20962267). Interacts (via cytoplasmic domain) with MSN and EZR; activates RHOA and promotes epithelial-mesenchymal transition (PubMed:17046996). Interacts with CCL21; relocalized PDPN to the basolateral membrane (PubMed:14978162).
- SequenceCaution:
-
- Sequence=AAM73655.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO22143.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11550.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11557.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG35495.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for PDPN Gene
Post-translational modifications for PDPN Gene
- Cleaved by a metalloprotease within its extracellular (EC) domain, generating a membrane-bound C-terminal fragment (PCTF33) and an extracellular fragment. The resulting membrane-bound C-terminal fragment (PCTF33) is further processed between Val-150 and Val-151 by PSEN1/gamma-secretase generating the intracellular domain of podoplanin (PICD).
- Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity. Disialylated at Thr-52; sialic acid is critical for platelet-aggregating activity and for CLEC1B interaction (PubMed:17222411, PubMed:25458834).
- The N-terminus is blocked.
- Glycosylation at Thr25, isoforms=3, 432, Thr34, Thr35, Thr52, Thr55, isoforms=3, 4, 5, 665, isoforms=3, 4, 5, 666, Thr76, Thr85, Ser86, isoforms=3, 4, 5, 688, isoforms=3, 4, 5, 689, Ser96, Ser98, isoforms=3, 4, 5, 6100, isoforms=3, 4, 5, 6102, isoforms=3, 4, 5, 6106, Ser107, isoforms=3, 4, 5, 6109, isoforms=3, 4, 5, 6110, isoforms=3, 4, 5, 6117, isoforms=3, 4, 5, 6119, and isoforms=3, 4, 5, 6120
- Modification sites at PhosphoSitePlus
Other Protein References for PDPN Gene
Antibody Products
- R&D Systems Antibodies for PDPN (Podoplanin)
- Novus Biologicals Antibodies for PDPN
-
Abcam antibodies for PDPN
-
Cloud-Clone Corp. Antibodies for PDPN
- Invitrogen Antibodies for PDPN
- antibodies-online: Search results for 434 available Podoplanin Antibodies ranked by validation data
- Compare Top Podoplanin Antibodies
-
Recommended
- 2 IF Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 28 WB Antibodies (anti-rat)
- 2 ELISPOT (Detection) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 18 FACS Antibodies (anti-mouse)
- 120 WB Antibodies (anti-mouse)
- 1 IHC (fro) Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 3 ICFC Antibodies (anti-human)
- 11 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 15 IHC (p) Antibodies (anti-human)
- 24 FACS Antibodies (anti-human)
- 202 WB Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 28 WB Antibodies (anti-rat)
- 2 IF Antibodies (anti-mouse)
- 2 ELISPOT (Detection) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 18 FACS Antibodies (anti-mouse)
- 120 WB Antibodies (anti-mouse)
- 1 IHC (fro) Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 3 ICFC Antibodies (anti-human)
- 11 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 15 IHC (p) Antibodies (anti-human)
- 24 FACS Antibodies (anti-human)
- 202 WB Antibodies (anti-human)
- GeneTex PDPN antibody for PDPN
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDPN
- Sino Biological Antibodies for PDPN
Protein Products
- R&D Systems Proteins and Enzymes for PDPN (Podoplanin)
-
OriGene Purified Proteins for PDPN
- Search Origene for MassSpec and Protein Over-expression Lysates for PDPN
- Origene Custom Protein Services for PDPN
- Sino Biological Cell Lysates for PDPN
- Sino Biological Recombinant Proteins for PDPN
- Sino Biological Recombinant Proteins for PDPN
- ProSpec Recombinant Proteins for PDPN
-
Cloud-Clone Corp. Proteins for PDPN
- Search GeneTex for Proteins for PDPN
-
ProSci Proteins for PDPN
-
Abcam proteins for PDPN
Assay Products
-
Cloud-Clone Corp. Assay Kits for PDPN
- antibodies-online: Search results for 44 available Podoplanin Elisa Kits ranked by validation data
- Compare Top Podoplanin Elisa Kits
-
Recommended
- 1 Sheep (Ovine) ELISA Kit
- 10 Rat (Rattus) ELISA Kits
- 2 Rabbit ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 8 Mouse (Murine) ELISA Kits
- 2 Monkey ELISA Kits
- 13 Human ELISA Kits
- 1 Guinea Pig ELISA Kit
- 2 Dog (Canine) ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 1 Chicken ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 10 Rat (Rattus) ELISA Kits
- 2 Rabbit ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 8 Mouse (Murine) ELISA Kits
- 2 Monkey ELISA Kits
- 13 Human ELISA Kits
- 1 Guinea Pig ELISA Kit
- 2 Dog (Canine) ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 1 Chicken ELISA Kit
No data available for DME Specific Peptides for PDPN Gene
Domains & Families for PDPN Gene
Gene Families for PDPN Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for PDPN Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PDPN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86YL7UniProtKB/Swiss-Prot:
PDPN_HUMAN :- The cytoplasmic domain controls FRC elongation but is dispensable for contraction (By similarity). The cytoplasmic domain is essential for recruitment to invadopodia and ECM degradation (PubMed:25486435).
- Belongs to the podoplanin family.
- Domain:
-
- The cytoplasmic domain controls FRC elongation but is dispensable for contraction (By similarity). The cytoplasmic domain is essential for recruitment to invadopodia and ECM degradation (PubMed:25486435).
- Family:
-
- Belongs to the podoplanin family.
Function for PDPN Gene
Molecular function for PDPN Gene
- UniProtKB/Swiss-Prot Function:
- Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation (PubMed:14522983, PubMed:15231832, PubMed:17616532, PubMed:18215137, PubMed:17222411). Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN (PubMed:18541721). Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness (PubMed:17046996, PubMed:21376833). Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (PubMed:20962267). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation (By similarity). Through binding with LGALS8 may participate to connection of the lymphatic endothelium to the surrounding extracellular matrix (PubMed:19268462). In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion (PubMed:15515019). Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1 (PubMed:25486435). Required for normal lung cell proliferation and alveolus formation at birth (By similarity). Does not function as a water channel or as a regulator of aquaporin-type water channels (PubMed:9651190). Does not have any effect on folic acid or amino acid transport (By similarity).
Phenotypes From GWAS Catalog for PDPN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | IDA | 18215137 |
| GO:0005372 | NOT water transmembrane transporter activity | ISS | -- |
| GO:0005515 | protein binding | IPI | 17046996 |
| GO:0008517 | NOT folic acid transmembrane transporter activity | ISS | -- |
| GO:0015171 | NOT amino acid transmembrane transporter activity | ISS | -- |
Phenotypes for PDPN Gene
- MGI mutant phenotypes for PDPN:
-
inferred from 6 alleles
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- GenomeRNAi human phenotypes for PDPN:
Animal Models for PDPN Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PDPN
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PDPN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDPN gene
- Search ViGene Biosciences for PDPN
CRISPR Products
-
OriGene CRISPR knockouts for PDPN
- genomics-online: gRNA clones - Search results for 144 available Podoplanin gene related products
- Overview of 144 available Podoplanin gene related products
- Applied Biological Materials CRISPR for PDPN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDPN
- GenScript: Design CRISPR guide RNA sequences for PDPN
miRNA for PDPN Gene
- miRTarBase miRNAs that target PDPN
-
- hsa-mir-363-3p (MIRT007320)
- hsa-mir-665 (MIRT666985)
- hsa-mir-514b-3p (MIRT666986)
- hsa-mir-514a-3p (MIRT666987)
- hsa-mir-489-3p (MIRT666988)
- hsa-mir-3140-3p (MIRT666989)
- hsa-mir-7160-5p (MIRT666990)
- hsa-mir-4722-5p (MIRT666991)
- hsa-mir-6884-5p (MIRT666992)
- hsa-mir-485-5p (MIRT666993)
- hsa-mir-1827 (MIRT666994)
- hsa-mir-3913-3p (MIRT666995)
- hsa-mir-219b-3p (MIRT666996)
- hsa-mir-4649-3p (MIRT666997)
- hsa-mir-3664-3p (MIRT666998)
- hsa-mir-4433a-3p (MIRT666999)
- hsa-mir-4459 (MIRT667000)
- hsa-mir-4768-3p (MIRT667001)
- hsa-mir-5690 (MIRT667002)
- hsa-mir-4478 (MIRT667003)
- hsa-mir-4419b (MIRT667004)
- hsa-mir-3929 (MIRT667005)
- hsa-mir-940 (MIRT667006)
- hsa-mir-6893-5p (MIRT667007)
- hsa-mir-6808-5p (MIRT667008)
- hsa-mir-4695-5p (MIRT667009)
- hsa-mir-510-5p (MIRT667010)
- hsa-mir-512-5p (MIRT667011)
- hsa-mir-302f (MIRT667012)
miRNA Products
- Search ViGene Biosciences for PDPN
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PDPN
- Browse OriGene Inhibitory RNA Products For PDPN
- genomics-online: shRNA clones - Search results for 144 available Podoplanin gene related products
- Overview of 144 available Podoplanin gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PDPN gene
Clone Products
- Sino Biological Human cDNA Clone for PDPN
- VectorBuilder custom plasmid, inducible vectors for PDPN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDPN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PDPN
- Applied Biological Materials Clones for PDPN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PDPN
-
ViGene Biosciences adenoviral particle packaged cDNA for PDPN gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PDPN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDPN gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDPN Gene
Localization for PDPN Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDPN Gene
- Podoplanin: Membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Membrane raft. Apical cell membrane. Basolateral cell membrane. Cell projection, invadopodium. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles (By similarity). Association to the lipid rafts is required for PDPN-induced epithelial to mesenchymal transition (EMT) (PubMed:21376833). Colocalizes with CD9 in tetraspanin microdomains (PubMed:18541721). Localized at invadopodium adhesion rings in tumor cell. Association to the lipid rafts is essential for PDPN recruitment to invadopodia and ECM degradation (PubMed:25486435). {ECO:0000250 UniProtKB:Q62011, ECO:0000269 PubMed:18541721, ECO:0000269 PubMed:21376833, ECO:0000269 PubMed:25486435}.
- 29kDa cytosolic podoplanin intracellular domain: Cytoplasm, cytosol.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | ISS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IEA,IDA | 24275092 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 10393083 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PDPN Gene
Pathways & Interactions for PDPN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 2 | Angiogenesis (CST) | ||
| 3 | Cytoskeletal Signaling | ||
| 4 | G beta-gamma signalling through PI3Kgamma | ||
Pathways by source for PDPN Gene
3 Reactome pathways for PDPN Gene
2 Cell Signaling Technology pathways for PDPN Gene
Interacting Proteins for PDPN Gene
Selected Interacting proteins:
Q86YL7-PDPN_HUMAN
ENSP00000294489
for PDPN Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000902 | cell morphogenesis | ISS | -- |
| GO:0001946 | lymphangiogenesis | ISS | -- |
| GO:0006833 | NOT water transport | ISS | -- |
| GO:0006865 | NOT amino acid transport | ISS | -- |
| GO:0007266 | Rho protein signal transduction | IMP | 25486435 |
No data available for SIGNOR curated interactions for PDPN Gene
Drugs & Compounds for PDPN Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Analgesics | Pharma | 12601 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for PDPN Gene
mRNA/cDNA for PDPN Gene
- (5) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (180) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PDPN
- genomics-online: gRNA clones - Search results for 144 available Podoplanin gene related products
- Overview of 144 available Podoplanin gene related products
- Applied Biological Materials CRISPR for PDPN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDPN
- GenScript: Design CRISPR guide RNA sequences for PDPN
miRNA Products
- Search ViGene Biosciences for PDPN
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PDPN
- Browse OriGene Inhibitory RNA Products For PDPN
- genomics-online: shRNA clones - Search results for 144 available Podoplanin gene related products
- Overview of 144 available Podoplanin gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PDPN gene
Clone Products
- Sino Biological Human cDNA Clone for PDPN
- VectorBuilder custom plasmid, inducible vectors for PDPN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDPN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PDPN
- Applied Biological Materials Clones for PDPN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||
| SP8: | - |
Expression for PDPN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Epithelial Cells
- Podocytes Podocyte Layer
- Alveolar Epithelial Type 1 Cells Alveoli
- Duct Cells Pancreatic Ducts
- Placenta (Extraembryonic Tissues)
- Mesenchymal Stem Cells (Uncategorized)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Mesoderm (Gastrulation Derivatives)
- Mesothelial Cells Hepatic Mesenchyme
-
Liver (Hepatobiliary System)
- Mesothelial Cells Hepatic Mesenchyme
-
Adipose (Muscoskeletal System)
- Visceral White Adipocytes Visceral White Adipose
-
Lymph (Hematopoietic System)
- Lymphatic Endothelial Cells Lymphatic Vessels
-
Endothelium (Cardiovascular System)
- Lymphatic Endothelial Cells Lymphatic Vessels
-
Kidney (Urinary System)
- Podocytes Podocyte Layer
-
Lung (Respiratory System)
- Alveolar Epithelial Type 1 Cells Alveoli
- Brain (Nervous System)
- NULL (Uncategorized)
- Ovary (Reproductive System)
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Gonad
- Primordial Germ Cells Allantois
This gene is overexpressed in Fetal Brain (21.6), Prostate (17.6), Testis (15.9), and Oral epithelium (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PDPN Gene
NURSA nuclear receptor signaling pathways regulating expression of PDPN Gene:
PDPNSOURCE GeneReport for Unigene cluster for PDPN Gene:
Hs.468675mRNA Expression by UniProt/SwissProt for PDPN Gene:
Q86YL7-PDPN_HUMAN
Tissue specificity:
Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
Evidence on tissue expression from TISSUES for PDPN Gene
- Nervous system(4.8)
- Intestine(3.2)
- Lymph node(3.2)
- Lung(2.9)
- Heart(2.8)
- Gall bladder(2.7)
- Muscle(2.6)
- Kidney(2.2)
- Skin(2.2)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for PDPN
-
OriGene qPCR primer pairs and template standards for PDPN
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDPN Gene
Orthologs for PDPN Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PDPN 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PDPN 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pdpn 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Pdpn 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | BOVAGGRUS 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PDPN 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PDPN 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PDPN 34 |
|
OneToOne |
- Species where no ortholog for PDPN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for PDPN Gene
No data available for Paralogs for PDPN Gene
Variants for PDPN Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000053183 | -- | 13,587,118(+) | C/T | intron_variant | |
| rs1000109461 | -- | 13,586,071(+) | G/A | intron_variant | |
| rs1000166979 | -- | 13,590,038(+) | G/A | intron_variant | |
| rs1000247617 | -- | 13,598,072(+) | G/A | intron_variant | |
| rs1000279498 | -- | 13,582,284(+) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2744064 | CNV | deletion | 23290073 |
| esv3306243 | CNV | mobile element insertion | 20981092 |
| esv3372731 | CNV | insertion | 20981092 |
| esv3892081 | CNV | loss | 25118596 |
| nsv1113080 | CNV | deletion | 24896259 |
| nsv1144354 | CNV | deletion | 24896259 |
| nsv460483 | CNV | loss | 19166990 |
| nsv545567 | CNV | gain | 21841781 |
| nsv545568 | CNV | loss | 21841781 |
| nsv833092 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.84;
17.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PDPN Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PDPN
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDPN Gene
Disorders for PDPN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphangioma |
|
|
| subglottis neoplasm |
|
|
| mucinous cystadenocarcinoma of the pancreas |
|
|
| seminoma |
|
|
| hemangioma |
|
Search PDPN in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PDPN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PDPN Gene
Publications for PDPN Gene
- Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. (PMID: 10393083) Zimmer G … Herrler G (The Biochemical journal 1999) 2 3 4 22 58
- Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels. (PMID: 9651190) Ma T … Verkman AS (American journal of respiratory cell and molecular biology 1998) 2 3 4 22 58
- Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions. (PMID: 19268462) Cueni LN … Detmar M (Experimental cell research 2009) 3 4 22 58
- Renal cells activate the platelet receptor CLEC-2 through podoplanin. (PMID: 18215137) Christou CM … O'Callaghan CA (The Biochemical journal 2008) 3 4 22 58
- Functional glycosylation of human podoplanin: glycan structure of platelet aggregation-inducing factor. (PMID: 17222411) Kaneko MK … Narimatsu H (FEBS letters 2007) 3 4 22 58
Products for PDPN Gene
- R&D Systems Antibodies for PDPN (Podoplanin)
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- Novus Biologicals Tissue Microarrays
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- ProSpec Recombinant Proteins for PDPN
- Cloud-Clone Corp. Antibodies for PDPN
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- Browse Knockouts at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for PDPN
- VectorBuilder custom plasmid, inducible vectors for PDPN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDPN
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PDPN
- antibodies-online: Search results for 434 available PDPN Antibodies ranked by validation data
- Compare Top PDPN Antibodies
- Recommended
- 202 WB Antibodies (anti-human)
- 24 FACS Antibodies (anti-human)
- 15 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 11 IHC Antibodies (anti-human)
- 3 ICFC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 120 WB Antibodies (anti-mouse)
- 18 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 ELISPOT (Detection) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 28 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 202 WB Antibodies (anti-human)
- 24 FACS Antibodies (anti-human)
- 15 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 11 IHC Antibodies (anti-human)
- 3 ICFC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 120 WB Antibodies (anti-mouse)
- 18 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 ELISPOT (Detection) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 28 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 44 available PDPN Elisa Kits ranked by validation data
- Compare Top PDPN Elisa Kits
- Recommended
- 1 Chicken ELISA Kit
- 2 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 1 Guinea Pig ELISA Kit
- 13 Human ELISA Kits
- 2 Monkey ELISA Kits
- 8 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 2 Rabbit ELISA Kits
- 10 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 1 Chicken ELISA Kit
- 2 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 1 Guinea Pig ELISA Kit
- 13 Human ELISA Kits
- 2 Monkey ELISA Kits
- 8 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 2 Rabbit ELISA Kits
- 10 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- antibodies-online: Search results for 31 available PDPN Proteins ranked by validation data
- Compare Top PDPN Proteins
- GeneTex PDPN antibody for PDPN
- Search GeneTex for Proteins for PDPN
- ViGene Biosciences adenoviral particle packaged cDNA for PDPN gene
- ViGene Biosciences lentiviral particle packaged cDNA for PDPN gene
- ViGene Biosciences ready-to-package AAV shRNAs for PDPN gene
- Search ViGene Biosciences for PDPN
- Santa Cruz Biotechnology (SCBT) Antibodies for PDPN
- Search Santa Cruz Biotechnology (SCBT) for PDPN siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PDPN
- Search for PDPN Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for PDPN
- Horizon Cell Lines for PDPN
- genomics-online: cdna clones - Search results for 144 available PDPN gene related products
- Overview of 144 available PDPN gene related products
- orf clones - Search results for 144 available PDPN gene related products
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- Overview of 144 available PDPN gene related products
- genomics-online: primer clones - Search results for 144 available PDPN gene related products
- Overview of 144 available PDPN gene related products
- genomics-online: shRNA clones - Search results for 144 available PDPN gene related products
- Overview of 144 available PDPN gene related products
Sources for PDPN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
