Aliases for PDPK2P Gene

Aliases for PDPK2P Gene

  • 3-Phosphoinositide Dependent Protein Kinase 2, Pseudogene 2 3 5
  • EC 2.7.11.1 4 51
  • 3-Phosphoinositide Dependent Protein Kinase-1 Pseudogene 3
  • 3-Phosphoinositide-Dependent Protein Kinase 2 Pseudogene 4
  • Putative 3-Phosphoinositide-Dependent Protein Kinase 2 4
  • EC 2.7.11 51
  • PDPK2P 5
  • PDPK2 4

External Ids for PDPK2P Gene

Previous GeneCards Identifiers for PDPK2P Gene

  • GC16M002673
  • GC16M002617
  • GC16M002618
  • GC16M002637

Summaries for PDPK2P Gene

GeneCards Summary for PDPK2P Gene

PDPK2P (3-Phosphoinositide Dependent Protein Kinase 2, Pseudogene) is a Pseudogene. Among its related pathways are B cell receptor signaling pathway (KEGG).

UniProtKB/Swiss-Prot Summary for PDPK2P Gene

  • Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity).

Additional gene information for PDPK2P Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDPK2P Gene

Genomics for PDPK2P Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PDPK2P Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDPK2P on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for PDPK2P Gene

Genomic Locations for PDPK2P Gene
chr16:2,616,121-2,643,296
(GRCh38/hg38)
Size:
27,176 bases
Orientation:
Minus strand
chr16:2,666,121-2,693,297
(GRCh37/hg19)
Size:
27,177 bases
Orientation:
Minus strand

Genomic View for PDPK2P Gene

Genes around PDPK2P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDPK2P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDPK2P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDPK2P Gene

Proteins for PDPK2P Gene

  • Protein details for PDPK2P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6A1A2-PDPK2_HUMAN
    Recommended name:
    Putative 3-phosphoinositide-dependent protein kinase 2
    Protein Accession:
    Q6A1A2

    Protein attributes for PDPK2P Gene

    Size:
    396 amino acids
    Molecular mass:
    44765 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDPK2P Gene

Selected DME Specific Peptides for PDPK2P Gene

Q6A1A2:
  • PELLTEKSA
  • ALEYLHGKGI
  • AEIVSAL
  • VGTAQYVSPE
  • RDLKPEN
  • KSSDLWA
  • DLVEKLLV
  • LEYDFPE

Post-translational modifications for PDPK2P Gene

Domains & Families for PDPK2P Gene

Protein Domains for PDPK2P Gene

Graphical View of Domain Structure for InterPro Entry

Q6A1A2

UniProtKB/Swiss-Prot:

PDPK2_HUMAN :
  • The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.
Domain:
  • The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.
genes like me logo Genes that share domains with PDPK2P: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for PDPK2P Gene

Function for PDPK2P Gene

Molecular function for PDPK2P Gene

UniProtKB/Swiss-Prot Function:
Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for PDPK2P Gene

Phenotypes From GWAS Catalog for PDPK2P Gene

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PDPK2P Gene

Localization for PDPK2P Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDPK2P Gene

Cytoplasm. Membrane. Peripheral membrane protein.

No data available for Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PDPK2P Gene

Pathways & Interactions for PDPK2P Gene

PathCards logo

SuperPathways for PDPK2P Gene

genes like me logo Genes that share pathways with PDPK2P: view

Pathways by source for PDPK2P Gene

1 BioSystems pathway for PDPK2P Gene

Interacting Proteins for PDPK2P Gene

Selected Interacting proteins: Q6A1A2-PDPK2_HUMAN for PDPK2P Gene via IID

SIGNOR curated interactions for PDPK2P Gene

Activates:

Gene Ontology (GO) - Biological Process for PDPK2P Gene

None

Drugs & Compounds for PDPK2P Gene

No Compound Related Data Available

Transcripts for PDPK2P Gene

mRNA/cDNA for PDPK2P Gene

3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PDPK2P Gene

No ASD Table

Relevant External Links for PDPK2P Gene

GeneLoc Exon Structure for
PDPK2P

Expression for PDPK2P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PDPK2P Gene

Protein differential expression in normal tissues from HIPED for PDPK2P Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDPK2P Gene



Protein tissue co-expression partners for PDPK2P Gene

- Elite partner
genes like me logo Genes that share expression patterns with PDPK2P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDPK2P Gene

Orthologs for PDPK2P Gene

Evolution for PDPK2P Gene

ENSEMBL:
Gene Tree for PDPK2P (if available)
TreeFam:
Gene Tree for PDPK2P (if available)

No data available for Orthologs for PDPK2P Gene

Paralogs for PDPK2P Gene

No data available for Paralogs for PDPK2P Gene

Variants for PDPK2P Gene

Additional Variant Information for PDPK2P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDPK2P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for PDPK2P Gene

Disorders for PDPK2P Gene

No disorders were found for PDPK2P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for PDPK2P Gene

Publications for PDPK2P Gene

  1. lncRNA-PDPK2P promotes hepatocellular carcinoma progression through the PDK1/AKT/Caspase 3 pathway. (PMID: 31368655) Pan W … Zheng SG (Molecular oncology 2019) 2 3

Products for PDPK2P Gene

Sources for PDPK2P Gene