Aliases for PDLIM2 Gene
External Ids for PDLIM2 Gene
Previous GeneCards Identifiers for PDLIM2 Gene
This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for PDLIM2 Gene
PDLIM2 (PDZ And LIM Domain 2) is a Protein Coding gene. Diseases associated with PDLIM2 include Cogan-Reese Syndrome. Among its related pathways are Cytoskeletal Signaling and Immune response_IL-12 signaling pathway. Gene Ontology (GO) annotations related to this gene include alpha-actinin binding and filamin binding. An important paralog of this gene is PDLIM4.
UniProtKB/Swiss-Prot Summary for PDLIM2 Gene
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.