This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by gl... See more...

Aliases for PDK4 Gene

Aliases for PDK4 Gene

  • Pyruvate Dehydrogenase Kinase 4 2 3 5
  • [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 4, Mitochondrial 3 4
  • Pyruvate Dehydrogenase Kinase, Isoenzyme 4 2 3
  • Pyruvate Dehydrogenase Kinase, Isozyme 4 2 3
  • EC 2.7.11.2 4 50
  • [Pyruvate Dehydrogenase [Lipoamide]] Kinase Isozyme 4, Mitochondrial 3
  • Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 4, Mitochondrial 3
  • Pyruvate Dehydrogenase Kinase Isoform 4 4
  • EC 2.7.11 50
  • PDHK4 4
  • PDK4 5

External Ids for PDK4 Gene

Previous GeneCards Identifiers for PDK4 Gene

  • GC07M093748
  • GC07M094811
  • GC07M094826
  • GC07M094824
  • GC07M094857
  • GC07M095050
  • GC07M095212
  • GC07M089819

Summaries for PDK4 Gene

Entrez Gene Summary for PDK4 Gene

  • This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDK4 Gene

PDK4 (Pyruvate Dehydrogenase Kinase 4) is a Protein Coding gene. Diseases associated with PDK4 include Type 2 Diabetes Mellitus and Rhabdomyosarcoma. Among its related pathways are Signaling by Retinoic Acid and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. An important paralog of this gene is PDK1.

UniProtKB/Swiss-Prot Summary for PDK4 Gene

  • Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.

Gene Wiki entry for PDK4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDK4 Gene

Genomics for PDK4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PDK4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J095590 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +2.8 2816 9 ZNF600 KLF9 CEBPA ATF3 NFIC YY1 CEBPB FOXA1 CHD2 ZNF341 PDK4 DYNC1I1 ENSG00000231170 LOC107986824 lnc-PON2-3 ASB4
GH07J095627 Enhancer 1.2 VISTA Ensembl ENCODE 11 -33.5 -33454 4.9 CEBPB FEZF1 ZNF639 EP300 PRDM1 TBP ZNF843 TCF7L2 INSM2 ZNF24 PDK4 ENSG00000231170 HSALNG0059697 HSALNG0059696 DYNC1I1
GH07J096302 Enhancer 1.2 Ensembl ENCODE 5.1 -713.5 -713543 14.9 NCOR1 ZNF600 IKZF1 SIX5 SSRP1 ZNF580 ATF2 KLF9 CEBPA ZNF10 lnc-SEM1-4 MIR591 SLC25A13 PDK4 ENSG00000275834 HSALNG0059714-001 DYNC1I1
GH07J095511 Enhancer 1 Ensembl ENCODE 4.2 +84.6 84646 1.7 BCLAF1 ZNF654 REST CEBPB TRIM22 BHLHE40 CTCF RAD21 IRF4 SMC3 PON3 PON1 PDK4 RF00017-5912 HSALNG0059691 ASB4
GH07J096250 Enhancer 0.5 Ensembl 4.7 -654.7 -654685 0.8 MAFF ZNF316 RBM22 MAFK SPI1 MAFG GABPB1 TRIM24 EMSY MIR591 SLC25A13 PDK4 lnc-DYNC1I1-6 RPL21P74 DYNC1I1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDK4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDK4

Top Transcription factor binding sites by QIAGEN in the PDK4 gene promoter:
  • HNF-1
  • HNF-1A
  • MEF-2A
  • MyoD
  • PPAR-alpha
  • RFX1
  • STAT5A

Genomic Locations for PDK4 Gene

Latest Assembly
chr7:95,583,499-95,596,516
(GRCh38/hg38)
Size:
13,018 bases
Orientation:
Minus strand

Previous Assembly
chr7:95,212,811-95,225,828
(GRCh37/hg19 by Entrez Gene)
Size:
13,018 bases
Orientation:
Minus strand

chr7:95,212,811-95,225,803
(GRCh37/hg19 by Ensembl)
Size:
12,993 bases
Orientation:
Minus strand

Genomic View for PDK4 Gene

Genes around PDK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDK4 Gene

Proteins for PDK4 Gene

  • Protein details for PDK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16654-PDK4_HUMAN
    Recommended name:
    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
    Protein Accession:
    Q16654

    Protein attributes for PDK4 Gene

    Size:
    411 amino acids
    Molecular mass:
    46469 Da
    Quaternary structure:
    • Homodimer. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3).

    Three dimensional structures from OCA and Proteopedia for PDK4 Gene

neXtProt entry for PDK4 Gene

Selected DME Specific Peptides for PDK4 Gene

Q16654:
  • HIGSIDP
  • SPSPLSMKQ
  • VYVPSHL
  • GGGVPLR
  • ELPVRLAN
  • SDRGGGV
  • VRNRHHNVVPTMAQGI
  • IYLKALS
  • QYFLDRFY
  • CTVDPVTNQ
  • GYGLPISRLYA
  • KNAMRAT

Post-translational modifications for PDK4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDK4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for PDK4

Domains & Families for PDK4 Gene

Gene Families for PDK4 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PDK4 Gene

InterPro:
Blocks:
  • ATP-binding region, ATPase-like

Suggested Antigen Peptide Sequences for PDK4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92766, Homo sapiens pyruvate dehydrogenase kinase, isoenzyme 4 (PDK4), mRNA (A4D1H4_HUMAN)
  • cDNA FLJ39109 fis, clone NTONG2005137, highly similar to dehydrogenase (B3KU25_HUMAN)
  • Pyruvate dehydrogenase kinase isoform 4 (PDK4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16654

UniProtKB/Swiss-Prot:

PDK4_HUMAN :
  • Belongs to the PDK/BCKDK protein kinase family.
Family:
  • Belongs to the PDK/BCKDK protein kinase family.
genes like me logo Genes that share domains with PDK4: view

Function for PDK4 Gene

Molecular function for PDK4 Gene

UniProtKB/Swiss-Prot Function:
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]; Xref=Rhea:RHEA:23052, Rhea:RHEA-COMP:13689, Rhea:RHEA-COMP:13690, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.2; Evidence={ECO:0000269|PubMed:21904029};.
UniProtKB/Swiss-Prot Induction:
Up-regulated by prolonged fasting, in glucose-deprived cells and in response to a high-fat diet. Down-regulated by insulin. Up-regulated by PPARD.
GENATLAS Biochemistry:
pyruvate dehydrogenase kinase 4,highly expressed in heart and skeletal muscle,regulating mitochondrial PDH activity

Enzyme Numbers (IUBMB) for PDK4 Gene

Phenotypes From GWAS Catalog for PDK4 Gene

Gene Ontology (GO) - Molecular Function for PDK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity TAS,IDA 18658136
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity TAS,ISS --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with PDK4: view
genes like me logo Genes that share phenotypes with PDK4: view

Animal Models for PDK4 Gene

MGI Knock Outs for PDK4:

Animal Models for research

  • Taconic Biosciences Mouse Models for PDK4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDK4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDK4 Gene

Localization for PDK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDK4 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDK4 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PDK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS,IBA 21873635
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with PDK4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PDK4 Gene

Pathways & Interactions for PDK4 Gene

genes like me logo Genes that share pathways with PDK4: view

Pathways by source for PDK4 Gene

1 KEGG pathway for PDK4 Gene
1 Qiagen pathway for PDK4 Gene
  • eNOS Signaling

SIGNOR curated interactions for PDK4 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for PDK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006006 glucose metabolic process IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006885 regulation of pH ISS --
GO:0008286 insulin receptor signaling pathway IMP 21852536
genes like me logo Genes that share ontologies with PDK4: view

Drugs & Compounds for PDK4 Gene

(10) Drugs for PDK4 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra Target 288
4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol Experimental Pharma Target 0
Phosphate Experimental Pharma 0
CPI-613 Investigational Pharma PDH/α-KGDH inhibitor 0
ATP Investigational Nutra 0

(8) Additional Compounds for PDK4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0

(1) ApexBio Compounds for PDK4 Gene

Compound Action Cas Number
AZD7545 PDHK inhibitor,potent and selective 252017-04-2
genes like me logo Genes that share compounds with PDK4: view

Drug products for research

Transcripts for PDK4 Gene

mRNA/cDNA for PDK4 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDK4

Alternative Splicing Database (ASD) splice patterns (SP) for PDK4 Gene

No ASD Table

Relevant External Links for PDK4 Gene

GeneLoc Exon Structure for
PDK4

Expression for PDK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PDK4 Gene

mRNA differential expression in normal tissues according to GTEx for PDK4 Gene

This gene is overexpressed in Muscle - Skeletal (x15.8).

Protein differential expression in normal tissues from HIPED for PDK4 Gene

This gene is overexpressed in Heart (35.4), Pancreas (9.1), and Adrenal (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDK4 Gene



Protein tissue co-expression partners for PDK4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDK4

SOURCE GeneReport for Unigene cluster for PDK4 Gene:

Hs.8364

mRNA Expression by UniProt/SwissProt for PDK4 Gene:

Q16654-PDK4_HUMAN
Tissue specificity: Ubiquitous; highest levels of expression in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for PDK4 Gene

  • Nervous system(4.6)
  • Muscle(4)
  • Heart(3.8)
  • Pancreas(3.7)
  • Liver(3.6)
  • Kidney(3.1)
  • Adrenal gland(2.8)
  • Spleen(2.7)
  • Lung(2.6)
  • Thyroid gland(2.6)
  • Intestine(2.6)
  • Blood(2.3)
  • Stomach(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with PDK4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDK4 Gene

Orthologs for PDK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDK4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PDK4 29 30
  • 99.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PDK4 29 30
  • 91.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PDK4 29 30
  • 90.82 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pdk4 29 16 30
  • 86.44 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PDK4 30
  • 86 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pdk4 29
  • 85.87 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia PDK4 30
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PDK4 29 30
  • 76.44 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PDK4 30
  • 63 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii pdk4 29 30
  • 68.07 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Pdk 30 31
  • 49 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ZK370.5 31
  • 50 (a)
pdhk-2 30
  • 48 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKP1 30
  • 22 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3938 30
  • 43 (a)
OneToMany
Species where no ortholog for PDK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for PDK4 Gene

ENSEMBL:
Gene Tree for PDK4 (if available)
TreeFam:
Gene Tree for PDK4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PDK4: view image
Alliance of Genome Resources:
Additional Orthologs for PDK4

Paralogs for PDK4 Gene

Paralogs for PDK4 Gene

(3) SIMAP similar genes for PDK4 Gene using alignment to 3 proteins:

  • PDK4_HUMAN
  • A4D1H4_HUMAN
  • B3KU25_HUMAN
genes like me logo Genes that share paralogs with PDK4: view

Variants for PDK4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDK4 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs139435831 Uncertain Significance: not provided 95,595,123(-) G/A
NM_002612.4(PDK4):c.172C>T (p.Arg58Ter)
NONSENSE
rs144262262 Benign: not provided 95,592,889(-) T/C
NM_002612.4(PDK4):c.400A>G (p.Met134Val)
MISSENSE
rs368570522 Likely Benign: not provided 95,587,717(-) G/C
NM_002612.4(PDK4):c.870+10C>G
INTRON
rs864622014 Uncertain Significance: Malignant tumor of prostate 95,596,235(-) A/C
NM_002612.4(PDK4):c.59T>G (p.Val20Gly)
MISSENSE
rs34898343 -- p.Asp109Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PDK4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PDK4 Gene

Variant ID Type Subtype PubMed ID
nsv1023193 CNV gain 25217958

Variation tolerance for PDK4 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 43.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDK4 Gene

Human Gene Mutation Database (HGMD)
PDK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDK4
Leiden Open Variation Database (LOVD)
PDK4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDK4 Gene

Disorders for PDK4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PDK4 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
type 2 diabetes mellitus
  • t2d
rhabdomyosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search PDK4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PDK4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PDK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDK4 Gene

Publications for PDK4 Gene

  1. Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity. (PMID: 18658136) Wynn RM … Chuang DT (The Journal of biological chemistry 2008) 3 4 22
  2. Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta. (PMID: 17669420) Degenhardt T … Carlberg C (Journal of molecular biology 2007) 3 4 22
  3. Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells. (PMID: 15955060) Abbot EL … Yeaman SJ (The FEBS journal 2005) 3 4 22
  4. Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting. (PMID: 14966024) Spriet LL … Cameron-Smith D (Journal of applied physiology (Bethesda, Md. : 1985) 2004) 3 4 22
  5. [Genetic polymorphism of pyruvate dehydrogenase kinase 4 (PDK4), paraoxonase 2 (PON2), and fatty acid binding protein 2 (FABP2) in the NIDDM population of Senegal]. (PMID: 15776585) Che D … Trivin F (Dakar medical 2002) 3 22 40

Products for PDK4 Gene

  • Addgene plasmids for PDK4

Sources for PDK4 Gene