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Aliases for PDIA6 Gene

Aliases for PDIA6 Gene

  • Protein Disulfide Isomerase Family A Member 6 2 3 5
  • Thioredoxin Domain Containing 7 (Protein Disulfide Isomerase) 2 3
  • Protein Disulfide Isomerase-Related Protein 2 3
  • Protein Disulfide Isomerase-Associated 6 2 3
  • Thioredoxin Domain-Containing Protein 7 3 4
  • Endoplasmic Reticulum Protein 5 3 4
  • Protein Disulfide Isomerase P5 3 4
  • ER Protein 5 3 4
  • EC 4 56
  • TXNDC7 3 4
  • ERP5 3 4
  • P5 3 4
  • Protein Disulfide Isomerase Family A, Member 6 2
  • Protein Disulfide-Isomerase A6 3

External Ids for PDIA6 Gene

Previous HGNC Symbols for PDIA6 Gene

  • TXNDC7

Previous GeneCards Identifiers for PDIA6 Gene

  • GC02M010875
  • GC02M010923

Summaries for PDIA6 Gene

Entrez Gene Summary for PDIA6 Gene

  • This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

GeneCards Summary for PDIA6 Gene

PDIA6 (Protein Disulfide Isomerase Family A Member 6) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Unfolded Protein Response (UPR). Gene Ontology (GO) annotations related to this gene include isomerase activity and protein disulfide isomerase activity. An important paralog of this gene is DNAJC10.

UniProtKB/Swiss-Prot for PDIA6 Gene

  • May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936).

Additional gene information for PDIA6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDIA6 Gene

Genomics for PDIA6 Gene

GeneHancer (GH) Regulatory Elements for PDIA6 Gene

Promoters and enhancers for PDIA6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I010809 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 556.6 +26.3 26270 3.8 HDGF PKNOX1 SMAD1 ARNT ZFP64 SIN3A DMAP1 IRF4 ZNF143 FOS PDIA6 NOL10 ATP6V1C2 LOC101929882 LOC105373428 RNU7-176P
GH02I010838 Promoter 0.5 EPDnew 550.8 -0.1 -78 0.1 PDIA6 LINC01954 ENSG00000232056
GH02I010772 Enhancer 0.8 Ensembl ENCODE 17.6 +63.5 63469 3.5 ZNF263 ZNF687 CEBPB NFXL1 ZNF592 GATA3 POLR2A ZBTB33 ZNF444 PRDM1 LOC105373428 PDIA6 RNU7-176P ATP6V1C2
GH02I010901 Enhancer 0.7 Ensembl ENCODE 11.7 -63.4 -63356 0.3 SMARCE1 JUND CEBPB FOSL2 DPF2 ELF1 FOS PDIA6 RNU7-176P KCNF1 LINC01954
GH02I010900 Enhancer 0.6 ENCODE 11.9 -62.4 -62423 0.2 ELF3 CTCF ZNF10 TRIM22 ELF1 RAD21 ATF2 GABPA GATA3 CREB1 ENSG00000232056 PDIA6 KCNF1 LINC01954
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PDIA6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDIA6 gene promoter:

Genomic Locations for PDIA6 Gene

Genomic Locations for PDIA6 Gene
54,587 bases
Minus strand

Genomic View for PDIA6 Gene

Genes around PDIA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDIA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDIA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDIA6 Gene

Proteins for PDIA6 Gene

  • Protein details for PDIA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein disulfide-isomerase A6
    Protein Accession:
    Secondary Accessions:
    • B3KY95
    • B5MCQ5
    • B7Z254
    • B7Z4M8
    • F8WA83
    • Q53RC7
    • Q6ZSH5
    • Q99778

    Protein attributes for PDIA6 Gene

    440 amino acids
    Molecular mass:
    48121 Da
    Quaternary structure:
    • Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (PubMed:12475965). Interacts with MICA on the surface of tumor cells, leading to MICA disulfide bond reduction which is required for its release from tumor cells (PubMed:17495932). Interacts with ITGB3 following platelet stimulation (PubMed:15466936). Interacts with ERN1; the interaction is direct (PubMed:24508390). Interacts with EIF2AK3 (PubMed:24508390).

    Three dimensional structures from OCA and Proteopedia for PDIA6 Gene

    Alternative splice isoforms for PDIA6 Gene


neXtProt entry for PDIA6 Gene

Selected DME Specific Peptides for PDIA6 Gene


Post-translational modifications for PDIA6 Gene

  • Ubiquitination at Lys108, isoforms=2, 3, 4, 5216, isoforms=2, 3, 4, 5241, isoforms=2, 3, 4, 5245, and isoforms=2, 3, 4, 5368

Domains & Families for PDIA6 Gene

Gene Families for PDIA6 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PDIA6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein disulfide isomerase family.
  • Belongs to the protein disulfide isomerase family.
genes like me logo Genes that share domains with PDIA6: view

Function for PDIA6 Gene

Molecular function for PDIA6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Catalyzes the rearrangement of -S-S- bonds in proteins.
UniProtKB/Swiss-Prot Function:
May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936).

Enzyme Numbers (IUBMB) for PDIA6 Gene

Phenotypes From GWAS Catalog for PDIA6 Gene

Gene Ontology (GO) - Molecular Function for PDIA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IBA --
GO:0005515 protein binding IPI 15466936
GO:0015037 peptide disulfide oxidoreductase activity IDA 16677074
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PDIA6: view
genes like me logo Genes that share phenotypes with PDIA6: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDIA6 Gene

Localization for PDIA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDIA6 Gene

Endoplasmic reticulum lumen. Cell membrane. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269 PubMed:12643545}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDIA6 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
cytosol 5
plasma membrane 4
mitochondrion 1
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDIA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 19995400
GO:0005783 endoplasmic reticulum TAS 16130169
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
genes like me logo Genes that share ontologies with PDIA6: view

Pathways & Interactions for PDIA6 Gene

genes like me logo Genes that share pathways with PDIA6: view

Pathways by source for PDIA6 Gene

Gene Ontology (GO) - Biological Process for PDIA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 7590364
GO:0034976 response to endoplasmic reticulum stress IBA --
GO:0036498 IRE1-mediated unfolded protein response TAS --
GO:0043277 apoptotic cell clearance IBA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with PDIA6: view

No data available for SIGNOR curated interactions for PDIA6 Gene

Drugs & Compounds for PDIA6 Gene

No Compound Related Data Available

Transcripts for PDIA6 Gene

Unigene Clusters for PDIA6 Gene

Protein disulfide isomerase family A, member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDIA6 Gene

No ASD Table

Relevant External Links for PDIA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDIA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDIA6 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDIA6 Gene

Protein tissue co-expression partners for PDIA6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PDIA6 Gene:


SOURCE GeneReport for Unigene cluster for PDIA6 Gene:


mRNA Expression by UniProt/SwissProt for PDIA6 Gene:

Tissue specificity: Expressed in platelets (at protein level).

Evidence on tissue expression from TISSUES for PDIA6 Gene

  • Liver(4.9)
  • Nervous system(4.9)
  • Intestine(3.8)
  • Lung(3.8)
  • Pancreas(3.6)
  • Skin(3.4)
  • Kidney(2.9)
  • Eye(2.8)
  • Thyroid gland(2.3)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with PDIA6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDIA6 Gene

Orthologs for PDIA6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDIA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PDIA6 33 34
  • 99.62 (n)
(Canis familiaris)
Mammalia -- 34
  • 95 (a)
PDIA6 33
  • 88.33 (n)
-- 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia PDIA6 34
  • 90 (a)
(Bos Taurus)
Mammalia PDIA6 33 34
  • 88.79 (n)
(Monodelphis domestica)
Mammalia PDIA6 34
  • 88 (a)
(Mus musculus)
Mammalia Pdia6 33 16 34
  • 87.05 (n)
(Rattus norvegicus)
Mammalia Pdia6 33
  • 86.89 (n)
(Gallus gallus)
Aves PDIA6 33 34
  • 77.5 (n)
(Anolis carolinensis)
Reptilia PDIA6 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pdia6 33
  • 73.64 (n)
(Danio rerio)
Actinopterygii pdip5 33 34
  • 72.48 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10220 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001919 33
  • 60 (n)
fruit fly
(Drosophila melanogaster)
Insecta CaBP1 33 34
  • 59.74 (n)
(Caenorhabditis elegans)
Secernentea tag-320 33
  • 59.66 (n)
pdi-6 34
  • 55 (a)
Y49E10.4 34
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPD1 34 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PDIL2-2 33
  • 52.9 (n)
(Oryza sativa)
Liliopsida Os09g0451500 33
  • 51.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
-- 34
  • 44 (a)
Species where no ortholog for PDIA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDIA6 Gene

Gene Tree for PDIA6 (if available)
Gene Tree for PDIA6 (if available)

Paralogs for PDIA6 Gene

Paralogs for PDIA6 Gene

(6) SIMAP similar genes for PDIA6 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PDIA6: view

Variants for PDIA6 Gene

Sequence variations from dbSNP and Humsavar for PDIA6 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000017519 -- 10,793,501(-) G/A intron_variant
rs1000055335 -- 10,808,054(-) C/A intron_variant
rs1000073764 -- 10,832,578(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000083670 -- 10,787,920(-) G/A intron_variant
rs1000282763 -- 10,816,446(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PDIA6 Gene

Variant ID Type Subtype PubMed ID
nsv580968 CNV loss 21841781
nsv524969 CNV loss 19592680
nsv508074 OTHER sequence alteration 20534489
nsv478379 CNV novel sequence insertion 20440878
nsv1000731 CNV gain 25217958
esv2719659 CNV deletion 23290073

Variation tolerance for PDIA6 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.69; 86.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDIA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDIA6 Gene

Disorders for PDIA6 Gene

Additional Disease Information for PDIA6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PDIA6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDIA6 Gene

Publications for PDIA6 Gene

  1. Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands. (PMID: 17495932) Kaiser BK … Spies T (Nature 2007) 3 4 22 58
  2. A role for the thiol isomerase protein ERP5 in platelet function. (PMID: 15466936) Jordan PA … Gibbins JM (Blood 2005) 3 4 22 58
  3. Functional analysis of human P5, a protein disulfide isomerase homologue. (PMID: 12204115) Kikuchi M … Tsujimoto Y (Journal of biochemistry 2002) 2 3 4 58
  4. Cloning and sequencing of the cDNA encoding human P5. (PMID: 7590364) Hayano T … Kikuchi M (Gene 1995) 2 3 4 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for PDIA6 Gene

Sources for PDIA6 Gene

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