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Aliases for PDIA5 Gene

Aliases for PDIA5 Gene

  • Protein Disulfide Isomerase Family A Member 5 2 3 5
  • Protein Disulfide Isomerase-Related Protein 3 4
  • Protein Disulfide Isomerase-Associated 5 2 3
  • EC 4 56
  • PDIR 3 4
  • Protein Disulfide Isomerase Family A, Member 5 2
  • Protein Disulfide-Isomerase A5 3

External Ids for PDIA5 Gene

Previous GeneCards Identifiers for PDIA5 Gene

  • GC03P124269
  • GC03P122785
  • GC03P120158

Summaries for PDIA5 Gene

Entrez Gene Summary for PDIA5 Gene

  • This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]

GeneCards Summary for PDIA5 Gene

PDIA5 (Protein Disulfide Isomerase Family A Member 5) is a Protein Coding gene. Among its related pathways are Unfolded Protein Response (UPR) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and protein disulfide isomerase activity. An important paralog of this gene is TXNDC5.

Additional gene information for PDIA5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDIA5 Gene

Genomics for PDIA5 Gene

GeneHancer (GH) Regulatory Elements for PDIA5 Gene

Promoters and enhancers for PDIA5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I123066 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.3 +0.9 890 3 CLOCK FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B PDIA5 ADCY5 SEMA5B GC03P123071
GH03I123096 Enhancer 0.8 ENCODE dbSUPER 12.4 +31.2 31235 4.1 CTCF SP1 USF1 HLF MAX REST RAD21 NR2F2 PDIA5 SEMA5B KALRN GC03P123071 MIR7110
GH03I123079 Enhancer 1.4 Ensembl ENCODE dbSUPER 4.9 +14.1 14078 4.8 ATF1 FEZF1 NCOA2 TCF12 ZNF766 GATA2 FOS RUNX3 NCOA1 ZNF592 SEMA5B PDIA5 GC03P123071 MIR7110
GH03I123084 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.8 +18.3 18332 2.7 PKNOX1 FOXA2 ZFP64 ARID4B THRB RAD21 RARA THAP11 RXRA SP5 SEMA5B PDIA5 GC03P123071 MIR7110
GH03I123076 Enhancer 1.1 Ensembl ENCODE dbSUPER 4.7 +9.8 9809 1.9 BCOR ZFP64 MAX ZMYM3 RAD21 ADNP PRDM10 RCOR1 ZBTB20 ZNF10 SEMA5B PDIA5 GC03P123071 MIR7110
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PDIA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDIA5 gene promoter:

Genomic Locations for PDIA5 Gene

Genomic Locations for PDIA5 Gene
158,219 bases
Plus strand

Genomic View for PDIA5 Gene

Genes around PDIA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDIA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDIA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDIA5 Gene

Proteins for PDIA5 Gene

  • Protein details for PDIA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein disulfide-isomerase A5
    Protein Accession:
    Secondary Accessions:
    • D3DN95
    • Q9BV43

    Protein attributes for PDIA5 Gene

    519 amino acids
    Molecular mass:
    59594 Da
    Quaternary structure:
    • Interacts with CALR (via P-domain).

    Three dimensional structures from OCA and Proteopedia for PDIA5 Gene

    Alternative splice isoforms for PDIA5 Gene


neXtProt entry for PDIA5 Gene

Selected DME Specific Peptides for PDIA5 Gene


Post-translational modifications for PDIA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDIA5 Gene

Antibody Products

  • Abcam antibodies for PDIA5

Domains & Families for PDIA5 Gene

Gene Families for PDIA5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PDIA5 Gene

Suggested Antigen Peptide Sequences for PDIA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein disulfide isomerase family.
  • Belongs to the protein disulfide isomerase family.
genes like me logo Genes that share domains with PDIA5: view

Function for PDIA5 Gene

Molecular function for PDIA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Catalyzes the rearrangement of -S-S- bonds in proteins.

Enzyme Numbers (IUBMB) for PDIA5 Gene

Phenotypes From GWAS Catalog for PDIA5 Gene

Gene Ontology (GO) - Molecular Function for PDIA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity TAS 7556671
GO:0005515 protein binding IPI 25416956
GO:0015037 peptide disulfide oxidoreductase activity IDA 16677074
GO:0016491 oxidoreductase activity TAS 7556671
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PDIA5: view
genes like me logo Genes that share phenotypes with PDIA5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PDIA5

Clone Products

  • Addgene plasmids for PDIA5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDIA5 Gene

Localization for PDIA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDIA5 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDIA5 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
plasma membrane 2
nucleus 2
cytosol 2
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoli fibrillar center (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDIA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen TAS 7556671
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with PDIA5: view

Pathways & Interactions for PDIA5 Gene

genes like me logo Genes that share pathways with PDIA5: view

Gene Ontology (GO) - Biological Process for PDIA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 7556671
GO:0034976 response to endoplasmic reticulum stress IBA --
GO:0036498 IRE1-mediated unfolded protein response TAS --
GO:0045454 cell redox homeostasis IEA --
GO:0055114 oxidation-reduction process TAS 7556671
genes like me logo Genes that share ontologies with PDIA5: view

No data available for SIGNOR curated interactions for PDIA5 Gene

Drugs & Compounds for PDIA5 Gene

No Compound Related Data Available

Transcripts for PDIA5 Gene

Unigene Clusters for PDIA5 Gene

Protein disulfide isomerase family A, member 5:
Representative Sequences:

Clone Products

  • Addgene plasmids for PDIA5

Alternative Splicing Database (ASD) splice patterns (SP) for PDIA5 Gene

No ASD Table

Relevant External Links for PDIA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDIA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDIA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDIA5 Gene

This gene is overexpressed in Liver (x6.0).

Protein differential expression in normal tissues from HIPED for PDIA5 Gene

This gene is overexpressed in Testis (14.4), Peripheral blood mononuclear cells (7.7), and Liver (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDIA5 Gene

Protein tissue co-expression partners for PDIA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PDIA5 Gene:


SOURCE GeneReport for Unigene cluster for PDIA5 Gene:


Evidence on tissue expression from TISSUES for PDIA5 Gene

  • Liver(4.5)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with PDIA5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDIA5 Gene

Orthologs for PDIA5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDIA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PDIA5 33 34
  • 99.49 (n)
(Canis familiaris)
Mammalia PDIA5 33 34
  • 92.04 (n)
(Bos Taurus)
Mammalia PDIA5 33 34
  • 90.88 (n)
(Rattus norvegicus)
Mammalia Pdia5 33
  • 89.02 (n)
(Mus musculus)
Mammalia Pdia5 33 16 34
  • 88.05 (n)
(Monodelphis domestica)
Mammalia PDIA5 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia PDIA5 34
  • 17 (a)
(Gallus gallus)
Aves PDIA5 33 34
  • 75.28 (n)
(Anolis carolinensis)
Reptilia PDIA5 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1407 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10921 33
(Danio rerio)
Actinopterygii pdia5 33 34
  • 66.86 (n)
sbcb441 33
fruit fly
(Drosophila melanogaster)
Insecta CG9302 33 34
  • 53.4 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010217 33
  • 52 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPD1 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
Species where no ortholog for PDIA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDIA5 Gene

Gene Tree for PDIA5 (if available)
Gene Tree for PDIA5 (if available)

Paralogs for PDIA5 Gene

Paralogs for PDIA5 Gene

(4) SIMAP similar genes for PDIA5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PDIA5: view

Variants for PDIA5 Gene

Sequence variations from dbSNP and Humsavar for PDIA5 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000014097 -- 123,154,316(+) C/T intron_variant
rs1000070658 -- 123,160,282(+) C/T intron_variant
rs1000093544 -- 123,119,737(+) G/A intron_variant
rs1000110187 -- 123,149,258(+) G/A intron_variant
rs1000147126 -- 123,098,580(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PDIA5 Gene

Variant ID Type Subtype PubMed ID
esv1278477 CNV insertion 17803354
esv3304686 CNV mobile element insertion 20981092
esv3442112 CNV insertion 20981092
esv3597621 CNV loss 21293372
nsv1117023 CNV deletion 24896259
nsv1119510 CNV insertion 24896259
nsv1125398 OTHER inversion 24896259
nsv478500 CNV novel sequence insertion 20440878
nsv521590 CNV loss 19592680

Variation tolerance for PDIA5 Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDIA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDIA5 Gene

Disorders for PDIA5 Gene

Additional Disease Information for PDIA5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PDIA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDIA5 Gene

Publications for PDIA5 Gene

  1. Molecular cloning of the cDNA encoding a novel protein disulfide isomerase-related protein (PDIR). (PMID: 7556671) Hayano T … Kikuchi M (FEBS letters 1995) 2 3 4 22 58
  2. Structure of the non-catalytic domain of the protein disulfide isomerase-related protein (PDIR) reveals function in protein binding. (PMID: 23614004) Vinaik R … Gehring K (PloS one 2013) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for PDIA5 Gene

  • Addgene plasmids for PDIA5

Sources for PDIA5 Gene

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