Aliases for PDIA5 Gene
External Ids for PDIA5 Gene
Previous GeneCards Identifiers for PDIA5 Gene
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]
GeneCards Summary for PDIA5 Gene
PDIA5 (Protein Disulfide Isomerase Family A Member 5) is a Protein Coding gene. Among its related pathways are Unfolded Protein Response (UPR) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and protein disulfide isomerase activity. An important paralog of this gene is TXNDC5.