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This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function ... See more...
Aliases for PDGFRL Gene
Aliases for PDGFRL Gene
- Platelet Derived Growth Factor Receptor Like 2 3 5
- PRLTS 2 3 4
- Platelet-Derived Growth Factor Receptor-Like Protein 3 4
- PDGF Receptor Beta-Like Tumor Suppressor 3 4
- PDGFR-Like Protein 3 4
- Platelet-Derived Growth Factor-Beta-Like Tumor Suppressor 3
- Platelet-Derived Growth Factor Receptor-Like 2
- PDGFRL 5
- PDGRL 3
External Ids for PDGFRL Gene
- HGNC: 8805
- NCBI Entrez Gene: 5157
- Ensembl: ENSG00000104213
- OMIM®: 604584
- UniProtKB/Swiss-Prot: Q15198
Previous GeneCards Identifiers for PDGFRL Gene
- GC08P017327
- GC08P017514
- GC08P017444
- GC08P017478
- GC08P017435
- GC08P017436
- GC08P015978
Summaries for PDGFRL Gene
-
This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]
GeneCards Summary for PDGFRL Gene
PDGFRL (Platelet Derived Growth Factor Receptor Like) is a Protein Coding gene. Diseases associated with PDGFRL include Colorectal Cancer and Hepatocellular Carcinoma. Gene Ontology (GO) annotations related to this gene include platelet activating factor receptor activity and platelet-derived growth factor beta-receptor activity.
Additional gene information for PDGFRL Gene
- HGNC (8805)
- NCBI Entrez Gene (5157)
- Ensembl (ENSG00000104213)
- OMIM® (604584)
- UniProtKB/Swiss-Prot (Q15198)
- Open Targets Platform(ENSG00000104213)
- Monarch Initiative
- Search for PDGFRL at DataMed
- Search for PDGFRL at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDGFRL Gene
Genomics for PDGFRL Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PDGFRL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PDGFRL on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDGFRL
- Top Transcription factor binding sites by QIAGEN in the PDGFRL gene promoter:
-
- CUTL1
- E47
- E4BP4
- FOXD3
- FOXI1
- HFH-3
- Pax-2
- Pbx1a
- Tal-1
- TBP
Genomic Locations for PDGFRL Gene
Latest Assembly
- chr8:17,576,433-17,644,071
- (GRCh38/hg38)
- Size:
- 67,639 bases
- Orientation:
- Plus strand
Previous Assembly
- chr8:17,433,942-17,500,653
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 66,712 bases
- Orientation:
- Plus strand
- chr8:17,433,942-17,501,580
- (GRCh37/hg19 by Ensembl)
- Size:
- 67,639 bases
- Orientation:
- Plus strand
Genomic View for PDGFRL Gene
Genes around PDGFRL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p22 by HGNC
- 8p22 by Entrez Gene
- 8p22 by Ensembl
PDGFRL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDGFRL Gene
Proteins for PDGFRL Gene
-
Protein details for PDGFRL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15198-PGFRL_HUMAN
- Recommended name:
- Platelet-derived growth factor receptor-like protein
- Protein Accession:
- Q15198
- A8K085
- Q6FH04
Protein attributes for PDGFRL Gene
- Size:
- 375 amino acids
- Molecular mass:
- 41861 Da
- Quaternary structure:
-
- Forms a complex composed of PDGFRL, TNK2 and GRB2.
Protein Expression for PDGFRL Gene
Post-translational modifications for PDGFRL Gene
Other Protein References for PDGFRL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ PDGFRL Antibody
-
Custom Antibody ServicesOriGene Antibodies for PDGFRL
- Novus Biologicals Antibodies for PDGFRL
-
Abcam antibodies for PDGFRL
- Invitrogen Antibodies for PDGFRL (AFLGC-PDGFRL)
- antibodies-online: Show 20 available PDGFRL Antibodies ranked by validation data
- Compare Top PDGFRL Antibodies
-
Recommended
- 58 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 7 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 22 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
-
Boster Bio Antibodies for PDGFRL
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDGFRL
Protein products for research
-
OriGene Purified Proteins for PDGFRL
- Search Origene for MassSpec and Protein Over-expression Lysates for PDGFRL
- Origene Custom Protein Services for PDGFRL
-
Abcam proteins for PDGFRL
Assay products for research
- antibodies-online: Show 55 available PDGFRL Elisa Kits ranked by validation data
- Compare Top PDGFRL Elisa Kits
-
Quality Products:
- ABIN1116555
- ABIN418607
- ABIN1571785
- ABIN5669173
- ABIN1081818
- ABIN511019
- ABIN5657909
- ABIN5657908
- ABIN2537977
- ABIN2944545
- ABIN1116554
- ABIN426117
- ABIN1571786
- ABIN5523563
- ABIN5670109
- ABIN1081819
- ABIN512008
- ABIN5657910
- ABIN5657911
- ABIN2537978
- ABIN1116556
- ABIN433253
- ABIN5523564
- ABIN5670781
- ABIN510128
- ABIN5657912
- ABIN2950456
- ABIN6220425
- ABIN6220428
- ABIN5073091
- ABIN775422
- ABIN1565515
- ABIN6220421
No data available for DME Specific Peptides for PDGFRL Gene
Domains & Families for PDGFRL Gene
Gene Families for PDGFRL Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted secreted proteins
Protein Domains for PDGFRL Gene
- InterPro:
- Blocks:
-
- Immunoglobulin subtype
- ProtoNet:
Suggested Antigen Peptide Sequences for PDGFRL Gene
- GenScript: Design optimal peptide antigens:
-
- PDGF receptor beta-like tumor suppressor (PGFRL_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PDGFRL Gene
Function for PDGFRL Gene
Molecular function for PDGFRL Gene
- GENATLAS Biochemistry:
- platelet-derived growth factor receptor-like
Phenotypes From GWAS Catalog for PDGFRL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004992 | platelet activating factor receptor activity | TAS | 7898930 |
| GO:0005019 | platelet-derived growth factor beta-receptor activity | TAS | 7898930 |
Phenotypes for PDGFRL Gene
- MGI mutant phenotypes for PDGFRL:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PDGFRL:
Animal Models for research
-
Taconic Biosciences Mouse Models for PDGFRL
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PDGFRL - Starting at $85 >
- * PDGFRL CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PDGFRL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDGFRL
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDGFRL
miRNA for PDGFRL Gene
- miRTarBase miRNAs that target PDGFRL
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDGFRL
- Browse OriGene Inhibitory RNA Products For PDGFRL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDGFRL
Clone products for research
- Applied Biological Materials (abm): Clones for PDGFRL - Starting at $45 >
- * PDGFRL as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PDGFRL
- Addgene plasmids for PDGFRL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDGFRL
Cell Lines for research
-
Horizon Cell Lines for PDGFRL
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PDGFRL Gene
Localization for PDGFRL Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDGFRL Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 3 |
| nucleus | 3 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
| endoplasmic reticulum | 0 |
| cytosol | 0 |
- Golgi apparatus (2)
- Nucleoli (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005576 | extracellular region | IEA | -- |
Pathways & Interactions for PDGFRL Gene
Interacting Proteins for PDGFRL Gene
GPS-Prot Interaction Network for PDGFRL
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PDGFRL Gene
Drugs & Compounds for PDGFRL Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Crenolanib (CP-868596) | Pharma | PDGFR-β inhibitor,potent and selective | 0 |
(1) ApexBio Compounds for PDGFRL Gene
| Compound | Action | Cas Number |
|---|---|---|
| Crenolanib (CP-868596) | PDGFR-β inhibitor,potent and selective | 670220-88-9 |
Transcripts for PDGFRL Gene
mRNA/cDNA for PDGFRL Gene
- 2 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000251630 1508 nts (view in UCSC)
- ENST00000523248 644 nts (view in UCSC)
- ENST00000541323 1905 nts (view in UCSC)
- ENST00000673645 577 nts
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PDGFRL - Starting at $85 >
- * PDGFRL CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PDGFRL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDGFRL
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDGFRL
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDGFRL
- Browse OriGene Inhibitory RNA Products For PDGFRL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDGFRL
Clone products for research
- Applied Biological Materials (abm): Clones for PDGFRL - Starting at $45 >
- * PDGFRL as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PDGFRL
- Addgene plasmids for PDGFRL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDGFRL
Relevant External Links for PDGFRL Gene
- GeneLoc Exon Structure for
- PDGFRL
Expression for PDGFRL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Crest (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
- Mesenchymal Stem Cells (Uncategorized)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
- Umbilical Cord (Extraembryonic Tissues)
- Eye (Sensory Organs)
-
Thyroid (Endocrine System)
-
Limb (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for PDGFRL Gene
This gene is overexpressed in Nerve - Tibial (x6.4).
This gene is overexpressed in Synovial fluid (47.9) and Placenta (21.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDGFRL Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDGFRL
SOURCE GeneReport for Unigene cluster for PDGFRL Gene:
Hs.458573mRNA Expression by UniProt/SwissProt for PDGFRL Gene:
Q15198-PGFRL_HUMAN
Tissue specificity:
Expressed in colon, lung and liver.
Evidence on tissue expression from TISSUES for PDGFRL Gene
- Nervous system(4.2)
- Lung(4.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PDGFRL Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- reproductive
- skeletal muscle
- urinary
Regions:
Head and neck:
- brain
- head
- mouth
- salivary gland
Thorax:
- breast
- esophagus
Abdomen:
- intestine
- kidney
- large intestine
- liver
- spleen
- stomach
Pelvis:
- anus
- rectum
- testicle
- ureter
- urethra
- urinary bladder
- uterus
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood vessel
- coagulation system
- skin
Primer products for research
-
OriGene qPCR primer pairs for PDGFRL
-
OriGene qPCR primer pairs and template standards for PDGFRL
Gene Expression Assays for research
Orthologs for PDGFRL Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PDGFRL 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PDGFRL 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PDGFRL 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pdgfrl 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pdgfrl 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PDGFRL 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PDGFRL 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PDGFRL 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PDGFRL 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pdgfrl 30 |
|
||
| Str.8504 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23703 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | pdgfrl 30 31 |
|
OneToOne | |
| zgc56104 30 |
|
- Species where no ortholog for PDGFRL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PDGFRL Gene
- ENSEMBL:
- Gene Tree for PDGFRL (if available)
- TreeFam:
- Gene Tree for PDGFRL (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PDGFRL: view image
Paralogs for PDGFRL Gene
No data available for Paralogs for PDGFRL Gene
Variants for PDGFRL Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDGFRL Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs115588653 | Likely Benign: not provided | 17,577,264(+) |
G/T NM_001372073.1(PDGFRL):c.12G>T (p.Trp4Cys) |
MISSENSE | |
| rs137853148 | Pathogenic: Carcinoma of colon. Colorectal cancer (CRC) [MIM:114500] | 17,589,479(+) |
C/Tp.His23Tyr NM_006207.2(PDGFRL):c.67C>T (p.His23Tyr) |
MISSENSE | |
| rs35704589 | Benign: not provided | 17,589,618(+) |
T/C NM_001372073.1(PDGFRL):c.206T>C (p.Met69Thr) |
MISSENSE | |
| rs61733860 | Benign: not provided | 17,589,661(+) |
C/A NM_001372073.1(PDGFRL):c.249C>A (p.Thr83=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2670212 | CNV | deletion | 23128226 |
| esv2676506 | CNV | deletion | 23128226 |
| esv2759600 | CNV | loss | 17122850 |
| esv2761191 | CNV | loss | 21179565 |
| esv2764066 | CNV | gain+loss | 21179565 |
| esv34867 | CNV | loss | 17911159 |
| esv3616489 | CNV | loss | 21293372 |
| esv3616490 | CNV | loss | 21293372 |
| esv3616491 | CNV | loss | 21293372 |
| esv3616492 | CNV | loss | 21293372 |
| esv3616493 | CNV | loss | 21293372 |
| esv3891363 | CNV | loss | 25118596 |
| esv3891364 | CNV | gain | 25118596 |
| esv989082 | CNV | deletion | 20482838 |
| nsv516779 | CNV | gain+loss | 19592680 |
| nsv516988 | CNV | loss | 19592680 |
| nsv818612 | CNV | loss | 17921354 |
| nsv824559 | CNV | loss | 20364138 |
| nsv8306 | CNV | loss | 18304495 |
| nsv831246 | CNV | gain | 17160897 |
| nsv831247 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.34;
53.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PDGFRL Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDGFRL Gene
Disorders for PDGFRL Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colorectal cancer |
|
|
| hepatocellular carcinoma |
|
|
| adult hepatocellular carcinoma |
|
|
| deafness, autosomal recessive 71 |
|
|
| progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 3 |
|
|
Search PDGFRL in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PGFRL_HUMAN- Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269 PubMed:7898930}. Note=The gene represented in this entry is involved in disease pathogenesis.
- Note=A polymorphism in PDGFRL has been reported to be associated with susceptibility to Behcet disease (PubMed:22926996). Behcet disease is a complex multiple-system disorder characterized by recurrent oral ulcerations, recurrent genital ulcerations, typical skin lesions, and uveitis. Behcet disease also involves joints, blood vessels, musculoskeletal, neurological systems, and the gastrointestinal tract. {ECO:0000269 PubMed:22926996}.
Additional Disease Information for PDGFRL
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for PDGFRL Gene
Publications for PDGFRL Gene
- Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene. (PMID: 7898930) Fujiwara Y … Nakamura Y (Oncogene 1995) 3 4 23 74
- Genetic variant on PDGFRL associated with Behçet disease in Chinese Han populations. (PMID: 22926996) Hou S … Yang P (Human mutation 2013) 3 4
- Expression and functional characterization of platelet-derived growth factor receptor-like gene. (PMID: 20333786) Guo FJ … Li GC (World journal of gastroenterology 2010) 3 23
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T … Xu R (Neurobiology of aging 2014) 3
ExternalLinks
Products for PDGFRL Gene
- View all 12 R&D Systems PDGFRL (PDGFRL) Products
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- Learn more about R&D Systems custom PDGFRL antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for PDGFRL
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDGFRL
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for PDGFRL
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PDGFRL (AFLGC-PDGFRL)
- ApexBio compounds for PDGFRL
- VectorBuilder Custom and pre-made DNA vectors for PDGFRL (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PDGFRL (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PDGFRL (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PDGFRL CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PDGFRL
- Addgene plasmids for PDGFRL
- antibodies-online: Show 20 available PDGFRL Antibodies ranked by validation data
- Compare Top PDGFRL Antibodies
- Recommended
- 58 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 7 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 22 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Show 55 available PDGFRL Elisa Kits ranked by validation data
- Compare Top PDGFRL Elisa Kits
- Quality Products:
- ABIN1116555
- ABIN418607
- ABIN1571785
- ABIN5669173
- ABIN1081818
- ABIN511019
- ABIN5657909
- ABIN5657908
- ABIN2537977
- ABIN2944545
- ABIN1116554
- ABIN426117
- ABIN1571786
- ABIN5523563
- ABIN5670109
- ABIN1081819
- ABIN512008
- ABIN5657910
- ABIN5657911
- ABIN2537978
- ABIN1116556
- ABIN433253
- ABIN5523564
- ABIN5670781
- ABIN510128
- ABIN5657912
- ABIN2950456
- ABIN6220425
- ABIN6220428
- ABIN5073091
- ABIN775422
- ABIN1565515
- ABIN6220421
- antibodies-online: Show 9 available PDGFRL Proteins ranked by validation data
- Compare Top PDGFRL Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PDGFRL
- Search Santa Cruz Biotechnology (SCBT) for PDGFRL siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PDGFRL
- Horizon Cell Lines for PDGFRL
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDGFRL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDGFRL
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PDGFRL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDGFRL
- Boster Bio Antibodies for PDGFRL
- Browse Boster Bio ELISA Kits
Sources for PDGFRL Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB