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Aliases for PDGFRL Gene

Aliases for PDGFRL Gene

  • Platelet Derived Growth Factor Receptor Like 2 3 5
  • PDGF Receptor Beta-Like Tumor Suppressor 3 4
  • PDGFR-Like Protein 3 4
  • PRLTS 3 4
  • Platelet-Derived Growth Factor-Beta-Like Tumor Suppressor 3
  • Platelet-Derived Growth Factor Receptor-Like Protein 3
  • Platelet-Derived Growth Factor Receptor-Like 2
  • PDGRL 3

External Ids for PDGFRL Gene

Previous GeneCards Identifiers for PDGFRL Gene

  • GC08P017327
  • GC08P017514
  • GC08P017444
  • GC08P017478
  • GC08P017435
  • GC08P017436
  • GC08P015978

Summaries for PDGFRL Gene

Entrez Gene Summary for PDGFRL Gene

  • This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDGFRL Gene

PDGFRL (Platelet Derived Growth Factor Receptor Like) is a Protein Coding gene. Diseases associated with PDGFRL include Colorectal Cancer and Hepatocellular Carcinoma. Gene Ontology (GO) annotations related to this gene include platelet activating factor receptor activity and platelet-derived growth factor beta-receptor activity.

Additional gene information for PDGFRL Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDGFRL Gene

Genomics for PDGFRL Gene

GeneHancer (GH) Regulatory Elements for PDGFRL Gene

Promoters and enhancers for PDGFRL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I017575 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 562.6 +0.9 853 2.9 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF48 GLIS2 ZNF143 SP3 SP5 PDGFRL ENSG00000277466
GH08I017693 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 16.7 +119.4 119378 4.8 ATF1 JUN MAX ZIC2 ATF2 POLR2A ETV6 RUNX3 MAFK MTUS1 GC08M017697 PDGFRL MIR548V
GH08I017538 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 17.1 -36.3 -36285 2.8 PKNOX1 FOXA2 CLOCK NEUROD1 FEZF1 ZNF2 YY1 ZNF213 FOS SP3 SLC7A2 PDGFRL GC08P017569 ENSG00000279932
GH08I017613 Enhancer 1.4 Ensembl ENCODE dbSUPER 17.2 +40.4 40372 7.6 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 SLC30A9 ZNF213 SP3 SP5 MICU3 PCM1 PDGFRL ENSG00000249258 MTUS1 FGF20 ENSG00000277466 MIR548V
GH08I017602 Enhancer 1.2 Ensembl ENCODE dbSUPER 18.7 +26.4 26384 1.3 ELF3 FOXA2 ARID4B ZNF2 RAD21 RARA ZNF335 ZNF213 ZNF143 RCOR1 PDGFRL MTUS1 ENSG00000277466 MIR548V
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PDGFRL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDGFRL gene promoter:

Genomic Locations for PDGFRL Gene

Genomic Locations for PDGFRL Gene
67,639 bases
Plus strand

Genomic View for PDGFRL Gene

Genes around PDGFRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDGFRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDGFRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDGFRL Gene

Proteins for PDGFRL Gene

  • Protein details for PDGFRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Platelet-derived growth factor receptor-like protein
    Protein Accession:
    Secondary Accessions:
    • A8K085
    • Q6FH04

    Protein attributes for PDGFRL Gene

    375 amino acids
    Molecular mass:
    41861 Da
    Quaternary structure:
    • Forms a complex composed of PDGFRL, TNK2 and GRB2.

neXtProt entry for PDGFRL Gene

Post-translational modifications for PDGFRL Gene

  • Glycosylation at Asn132 and isoforms=219

Other Protein References for PDGFRL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDGFRL Gene

Domains & Families for PDGFRL Gene

Gene Families for PDGFRL Gene

Protein Domains for PDGFRL Gene

Suggested Antigen Peptide Sequences for PDGFRL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PDGFRL: view

No data available for UniProtKB/Swiss-Prot for PDGFRL Gene

Function for PDGFRL Gene

Molecular function for PDGFRL Gene

GENATLAS Biochemistry:
platelet-derived growth factor receptor-like

Phenotypes From GWAS Catalog for PDGFRL Gene

Gene Ontology (GO) - Molecular Function for PDGFRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004992 platelet activating factor receptor activity TAS 7898930
GO:0005019 platelet-derived growth factor beta-receptor activity TAS 7898930
genes like me logo Genes that share ontologies with PDGFRL: view
genes like me logo Genes that share phenotypes with PDGFRL: view

Human Phenotype Ontology for PDGFRL Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for PDGFRL Gene

miRTarBase miRNAs that target PDGFRL

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PDGFRL Gene

Localization for PDGFRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDGFRL Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDGFRL gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDGFRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PDGFRL: view

Pathways & Interactions for PDGFRL Gene

SuperPathways for PDGFRL Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDGFRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008150 biological_process ND --
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway IEA --
genes like me logo Genes that share ontologies with PDGFRL: view

No data available for Pathways by source and SIGNOR curated interactions for PDGFRL Gene

Drugs & Compounds for PDGFRL Gene

(2) Drugs for PDGFRL Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Crenolanib (CP-868596) Pharma PDGFR-β inhibitor,potent and selective 0

(1) ApexBio Compounds for PDGFRL Gene

Compound Action Cas Number
Crenolanib (CP-868596) PDGFR-β inhibitor,potent and selective 670220-88-9
genes like me logo Genes that share compounds with PDGFRL: view

Drug Products

Transcripts for PDGFRL Gene


Unigene Clusters for PDGFRL Gene

Platelet-derived growth factor receptor-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDGFRL Gene

No ASD Table

Relevant External Links for PDGFRL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDGFRL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDGFRL Gene

mRNA differential expression in normal tissues according to GTEx for PDGFRL Gene

This gene is overexpressed in Nerve - Tibial (x6.4).

Protein differential expression in normal tissues from HIPED for PDGFRL Gene

This gene is overexpressed in Synovial fluid (47.9) and Placenta (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PDGFRL Gene

Protein tissue co-expression partners for PDGFRL Gene

NURSA nuclear receptor signaling pathways regulating expression of PDGFRL Gene:


SOURCE GeneReport for Unigene cluster for PDGFRL Gene:


mRNA Expression by UniProt/SwissProt for PDGFRL Gene:

Tissue specificity: Expressed in colon, lung and liver.

Evidence on tissue expression from TISSUES for PDGFRL Gene

  • Lung(4.1)
  • Nervous system(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PDGFRL Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • reproductive
  • skeletal muscle
  • urinary
Head and neck:
  • brain
  • head
  • mouth
  • salivary gland
  • breast
  • esophagus
  • intestine
  • kidney
  • large intestine
  • liver
  • spleen
  • stomach
  • anus
  • rectum
  • testicle
  • ureter
  • urethra
  • urinary bladder
  • uterus
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
  • blood vessel
  • coagulation system
  • skin
genes like me logo Genes that share expression patterns with PDGFRL: view

Orthologs for PDGFRL Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDGFRL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PDGFRL 33 34
  • 98.93 (n)
(Canis familiaris)
Mammalia PDGFRL 33 34
  • 87.56 (n)
(Bos Taurus)
Mammalia PDGFRL 33 34
  • 86.04 (n)
(Mus musculus)
Mammalia Pdgfrl 33 16 34
  • 84.09 (n)
(Rattus norvegicus)
Mammalia Pdgfrl 33
  • 84.09 (n)
(Monodelphis domestica)
Mammalia PDGFRL 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia PDGFRL 34
  • 63 (a)
(Gallus gallus)
Aves PDGFRL 33 34
  • 69.7 (n)
(Anolis carolinensis)
Reptilia PDGFRL 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pdgfrl 33
  • 70.8 (n)
Str.8504 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23703 33
(Danio rerio)
Actinopterygii pdgfrl 33 34
  • 61.75 (n)
zgc56104 33
Species where no ortholog for PDGFRL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDGFRL Gene

Gene Tree for PDGFRL (if available)
Gene Tree for PDGFRL (if available)

Paralogs for PDGFRL Gene

No data available for Paralogs for PDGFRL Gene

Variants for PDGFRL Gene

Sequence variations from dbSNP and Humsavar for PDGFRL Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs137853148 pathogenic, Carcinoma of colon, Colorectal cancer (CRC) [MIM:114500] 17,589,479(+) C/T coding_sequence_variant, missense_variant
rs1000002260 -- 17,594,664(+) C/T intron_variant
rs1000028112 -- 17,619,583(+) C/T intron_variant
rs1000110290 -- 17,618,456(+) T/C intron_variant
rs1000255244 -- 17,603,466(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PDGFRL Gene

Variant ID Type Subtype PubMed ID
nsv831247 CNV gain 17160897
nsv831246 CNV gain 17160897
nsv8306 CNV loss 18304495
nsv824559 CNV loss 20364138
nsv818612 CNV loss 17921354
nsv516988 CNV loss 19592680
nsv516779 CNV gain+loss 19592680
esv989082 CNV deletion 20482838
esv3891364 CNV gain 25118596
esv3891363 CNV loss 25118596
esv3616493 CNV loss 21293372
esv3616492 CNV loss 21293372
esv3616491 CNV loss 21293372
esv3616490 CNV loss 21293372
esv3616489 CNV loss 21293372
esv34867 CNV loss 17911159
esv2764066 CNV gain+loss 21179565
esv2761191 CNV loss 21179565
esv2759600 CNV loss 17122850
esv2676506 CNV deletion 23128226
esv2670212 CNV deletion 23128226

Variation tolerance for PDGFRL Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDGFRL Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDGFRL Gene

Disorders for PDGFRL Gene

MalaCards: The human disease database

(5) MalaCards diseases for PDGFRL Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • crc
hepatocellular carcinoma
  • hcc
colonic benign neoplasm
  • colon neoplasm
adult hepatocellular carcinoma
  • adult primary hepatocellular carcinoma
perrault syndrome
  • gonadal dysgenesis, xx type
- elite association - COSMIC cancer census association via MalaCards


  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269 PubMed:7898930}. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Note=A polymorphism in PDGFRL has been reported to be associated with susceptibility to Behcet disease (PubMed:22926996). Behcet disease is a complex multiple-system disorder characterized by recurrent oral ulcerations, recurrent genital ulcerations, typical skin lesions, and uveitis. Behcet disease also involves joints, blood vessels, musculoskeletal, neurological systems, and the gastrointestinal tract. {ECO:0000269 PubMed:22926996}.

Additional Disease Information for PDGFRL

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PDGFRL: view

No data available for Genatlas for PDGFRL Gene

Publications for PDGFRL Gene

  1. Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene. (PMID: 7898930) Fujiwara Y … Nakamura Y (Oncogene 1995) 3 4 22 58
  2. Genetic variant on PDGFRL associated with Behçet disease in Chinese Han populations. (PMID: 22926996) Hou S … Yang P (Human mutation 2013) 3 4 58
  3. Expression and functional characterization of platelet-derived growth factor receptor-like gene. (PMID: 20333786) Guo FJ … Li GC (World journal of gastroenterology 2010) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T … Xu R (Neurobiology of aging 2014) 3 58

Products for PDGFRL Gene

Sources for PDGFRL Gene

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