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Aliases for PDGFRB Gene

Aliases for PDGFRB Gene

  • Platelet Derived Growth Factor Receptor Beta 2 3 5
  • Platelet-Derived Growth Factor Receptor, Beta Polypeptide 2 3
  • Beta-Type Platelet-Derived Growth Factor Receptor 3 4
  • Platelet-Derived Growth Factor Receptor 1 3 4
  • CD140 Antigen-Like Family Member B 3 4
  • PDGF-R-Beta 3 4
  • EC 2.7.10.1 4 56
  • PDGFR-Beta 3 4
  • PDGFR-1 3 4
  • PDGFR1 3 4
  • PDGFR 3 4
  • Platelet-Derived Growth Factor Receptor Beta 3
  • Beta Platelet-Derived Growth Factor Receptor 4
  • Activated Tyrosine Kinase PDGFRB 3
  • CD140b Antigen 4
  • NDEL1-PDGFRB 3
  • EC 2.7.10 56
  • CD140B 3
  • IBGC4 3
  • JTK12 3
  • PENTT 3
  • IMF1 3
  • KOGS 3

External Ids for PDGFRB Gene

Previous HGNC Symbols for PDGFRB Gene

  • PDGFR

Previous GeneCards Identifiers for PDGFRB Gene

  • GC05M149563
  • GC05M150021
  • GC05M149476
  • GC05M149521
  • GC05M149473
  • GC05M144641
  • GC05M149494

Summaries for PDGFRB Gene

Entrez Gene Summary for PDGFRB Gene

  • The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]

CIViC summary for PDGFRB Gene

GeneCards Summary for PDGFRB Gene

PDGFRB (Platelet Derived Growth Factor Receptor Beta) is a Protein Coding gene. Diseases associated with PDGFRB include Kosaki Overgrowth Syndrome and Basal Ganglia Calcification, Idiopathic, 4. Among its related pathways are RET signaling and Development EGFR signaling via small GTPases. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PDGFRA.

UniProtKB/Swiss-Prot for PDGFRB Gene

  • Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

Tocris Summary for PDGFRB Gene

  • Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.

Gene Wiki entry for PDGFRB Gene

Additional gene information for PDGFRB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDGFRB Gene

Genomics for PDGFRB Gene

GeneHancer (GH) Regulatory Elements for PDGFRB Gene

Promoters and enhancers for PDGFRB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I150152 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.8 -5.2 -5155 17.7 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZNF48 ARID2 ZNF143 REST PPARG CDX1 PDGFRB HMGXB3 TCOF1 RPL7P1 ZNF300P1 ZNF300 SLC6A7 SYNPO
GH05I149956 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.2 +196.2 196235 6.7 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 SLC26A2 PDE6A HMGXB3 TCOF1 ZNF300 ZNF300P1 TIGD6 RPL7P1 CSNK1A1 RPS20P4
GH05I149449 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.4 +702.4 702417 8.5 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B YBX1 DMAP1 HMGXB3 TCOF1 TIGD6 RPL7P1 RPS20P4 CARMN CSNK1A1 PDGFRB RPS14 ARHGEF37
GH05I151074 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 -925.4 -925388 13.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 TNIP1 ZNF300P1 TCOF1 G3BP1 ANXA6 RPL7P1 ZNF300 RPS14 SMIM3 PDGFRB
GH05I150129 Enhancer 1.3 Ensembl ENCODE dbSUPER 17.9 +24.8 24800 3 FOXA2 ATF1 ARID4B DMAP1 ZNF2 ZNF48 E2F8 ARID2 ZNF207 ZNF143 CDX1 PDGFRB SLC6A7 TCOF1 ZNF300P1 CSF1R
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PDGFRB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDGFRB gene promoter:

Genomic Locations for PDGFRB Gene

Genomic Locations for PDGFRB Gene
chr5:150,113,837-150,155,884
(GRCh38/hg38)
Size:
42,048 bases
Orientation:
Minus strand
chr5:149,493,400-149,535,435
(GRCh37/hg19)

Genomic View for PDGFRB Gene

Genes around PDGFRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDGFRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDGFRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDGFRB Gene

Proteins for PDGFRB Gene

  • Protein details for PDGFRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09619-PGFRB_HUMAN
    Recommended name:
    Platelet-derived growth factor receptor beta
    Protein Accession:
    P09619
    Secondary Accessions:
    • B5A957
    • Q8N5L4

    Protein attributes for PDGFRB Gene

    Size:
    1106 amino acids
    Molecular mass:
    123968 Da
    Quaternary structure:
    • Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB. May also interact with homodimeric PDGFC. Monomer in the absence of bound ligand. Interaction with homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD, leads to receptor dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts with SH2B2/APS. Interacts directly (tyrosine phosphorylated) with SHB. Interacts (tyrosine phosphorylated) with PIK3R1 and RASA1. Interacts (tyrosine phosphorylated) with CBL. Interacts (tyrosine phosphorylated) with SRC and SRC family kinases. Interacts (tyrosine phosphorylated) with PIK3C2B, maybe indirectly. Interacts (tyrosine phosphorylated) with SHC1, GRB7, GRB10 and NCK1. Interaction with GRB2 is mediated by SHC1. Interacts (via C-terminus) with SLC9A3R1.

    Three dimensional structures from OCA and Proteopedia for PDGFRB Gene

    Alternative splice isoforms for PDGFRB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDGFRB Gene

Selected DME Specific Peptides for PDGFRB Gene

P09619:
  • ESDGGYMDMSKDE
  • RDLAARN
  • VAVKMLK
  • NVPVRVLELSESHP
  • HLNVVNLLGACTK
  • VVEATAHGLSHSQ
  • ALMSELK
  • KICDFGLARD
  • FLASKNCVHRDLAARNVL
  • LVLGRTLGSGAFG
  • KWMAPESIF
  • TEYCRYGDLVDYLHRNKHTFLQ
  • LYTTLSDVWS
  • LGGTPYP
  • PAHASDE
  • GILLWEIF
  • DGHEYIYVDP
  • GPIYIITEYC
  • KPRYEIRW
  • DFGLARDI
  • PIYIITE

Post-translational modifications for PDGFRB Gene

  • Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-579, and to a lesser degree, at Tyr-581, is important for interaction with SRC family kinases. Phosphorylation at Tyr-740 and Tyr-751 is important for interaction with PIK3R1. Phosphorylation at Tyr-751 is important for interaction with NCK1. Phosphorylation at Tyr-771 and Tyr-857 is important for interaction with RASA1/GAP. Phosphorylation at Tyr-857 is important for efficient phosphorylation of PLCG1 and PTPN11, resulting in increased phosphorylation of AKT1, MAPK1/ERK2 and/or MAPK3/ERK1, PDCD6IP/ALIX and STAM, and in increased cell proliferation. Phosphorylation at Tyr-1009 is important for interaction with PTPN11. Phosphorylation at Tyr-1009 and Tyr-1021 is important for interaction with PLCG1. Phosphorylation at Tyr-1021 is important for interaction with CBL; PLCG1 and CBL compete for the same binding site. Dephosphorylated by PTPRJ at Tyr-751, Tyr-857, Tyr-1009 and Tyr-1021. Dephosphorylated by PTPN2 at Tyr-579 and Tyr-1021.
  • N-glycosylated.
  • Ubiquitinated. After autophosphorylation, the receptor is polyubiquitinated, leading to its degradation.
  • Ubiquitination at isoforms=707
  • Glycosylation at Asn45, Asn89, Asn103, Asn215, Asn230, Asn292, isoforms=2307, Asn354, isoforms=371, isoforms=468, and Asn479
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for PDGFRB Gene

Gene Families for PDGFRB Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PDGFRB Gene

Graphical View of Domain Structure for InterPro Entry

P09619

UniProtKB/Swiss-Prot:

PGFRB_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
genes like me logo Genes that share domains with PDGFRB: view

Function for PDGFRB Gene

Molecular function for PDGFRB Gene

GENATLAS Biochemistry:
platelet-derived growth factor receptor,beta,subunit,homodimerizing and heterodimerizing with PDGFRA,immunoglobulin superfamily type III RTK subfamily,constitutively activated through amino-acid(s) substitution in a WW-like domain (phosphoserine- or phosphothreonine binding)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Present in an inactive conformation in the absence of bound ligand. Binding of PDGFB and/or PDGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib.
UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

Enzyme Numbers (IUBMB) for PDGFRB Gene

Phenotypes From GWAS Catalog for PDGFRB Gene

Gene Ontology (GO) - Molecular Function for PDGFRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IDA 1653029
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA --
GO:0004992 platelet activating factor receptor activity TAS 2536956
genes like me logo Genes that share ontologies with PDGFRB: view
genes like me logo Genes that share phenotypes with PDGFRB: view

Human Phenotype Ontology for PDGFRB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PDGFRB Gene

MGI Knock Outs for PDGFRB:

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for PDGFRB Gene

Localization for PDGFRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDGFRB Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDGFRB gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
lysosome 5
cytosol 3
cytoskeleton 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDGFRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IEA --
GO:0005737 cytoplasm IEA,ISS --
GO:0005764 lysosome IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with PDGFRB: view

Pathways & Interactions for PDGFRB Gene

SuperPathways for PDGFRB Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 GPCR Pathway
4 PI3K/AKT activation
5 Endometrial cancer
.52
.47
genes like me logo Genes that share pathways with PDGFRB: view

Pathways by source for PDGFRB Gene

SIGNOR curated interactions for PDGFRB Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PDGFRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006024 glycosaminoglycan biosynthetic process IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006935 chemotaxis IEA --
GO:0007165 signal transduction IDA 10821867
genes like me logo Genes that share ontologies with PDGFRB: view

Drugs & Compounds for PDGFRB Gene

(130) Drugs for PDGFRB Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sunitinib Approved, Investigational Pharma Target, inhibitor VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 518
Sorafenib Approved, Investigational Pharma Target, antagonist, inhibitors, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 717
imatinib Approved Pharma Target, antagonist, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
Dasatinib Approved, Investigational Pharma Target, antagonist, Inhibition, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 295
regorafenib Approved Pharma Target, inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0

(35) Additional Compounds for PDGFRB Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
N-desmethylimatinib
  • CGP74588
SU 6668
252916-29-3

(3) Tocris Compounds for PDGFRB Gene

Compound Action Cas Number
DMPQ dihydrochloride Potent, selective inhibitor of PDGFRbeta 1123491-15-5
SU 6668 PDGFR, VEGFR and FGFR inhibitor 252916-29-3
Toceranib Potent PDGFR and VEGFR inhibitor 356068-94-5

(47) ApexBio Compounds for PDGFRB Gene

Compound Action Cas Number
AG-18 EGFR/PDGFR inhibitor 118409-57-7
Amuvatinib (MP-470, HPK 56) Tyrosine kinase inhibitor 850879-09-3
AZD2932 inhibitor of VEGFR-2, PDGFRβ, Flt-3, and c-Kit 883986-34-3
BIBF 1120 VEGFR/PDGF/FGFR inhibitor 656247-17-5
BIBF 1202 VEGFR/PDGFR/FGFR inhibitor 894783-71-2
CHIR-124 Chk1 inhibitor,novel and potent 405168-58-3
CP-673451 PDGFRα/β inhibitor,potent and selective 343787-29-1
Crenolanib (CP-868596) PDGFR-β inhibitor,potent and selective 670220-88-9
DCC-2618 C-Kit/PDGFR inhibtor 1225278-16-9
DMPQ dihydrochloride 1123491-15-5
Dovitinib (TKI258) Lactate Oral tyrosine kinase inhibitor (TKI) against FGFR1–3, VEGFR1–3, and platelet-derived growth factor receptor (PDGFR) 915769-50-5
Dovitinib Dilactic acid 852433-84-2
Flumatinib mesylate 895519-91-2
Imatinib (STI571) Protein-tyrosine kinase inhibitor 152459-95-5
Imatinib hydrochloride V-Abl/c-Kit/PDGFR inhibitor 862366-25-4
Imatinib Mesylate (STI571) Abl/c-kit/PDGFR inhibitor 220127-57-1
Linifanib (ABT-869) VEGFR/PDGFR inhibitor 796967-16-3
Masitinib (AB1010) Tyrosine kinase inhibitor, potent and selective 790299-79-5
Masitinib mesylate Tyrosine kinase inhibitor 1048007-93-7
MK-2461 C-Met (WT/mutants) inhibitor 917879-39-1
Motesanib Diphosphate (AMG-706) VEGFR/ PDGFR/c-Kit/Ret inhibitor 857876-30-3
N-Desethyl Sunitinib VEGFR/PDGFRβ/KIT inhibitor 356068-97-8
Nintedanib (BIBF 1120) VEGFR/PDGFR/FGFR inhibitor 928326-83-4
Pazopanib (GW-786034) VEGFR/PDGFR/FGFR inhibitor 635702-64-6
Pazopanib Hydrochloride VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor 635702-64-6
PP121 Dual inhibitor of tyrosine and phosphoinositide kinases 1092788-83-4
Regorafenib Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1 755037-03-7
Sennoside B 128-57-4
Sorafenib Raf kinases and tyrosine kinases inhibitor 284461-73-0
Sorafenib Tosylate Raf kinases and tyrosine kinases inhibitor 475207-59-1
SU 16f 251356-45-3
SU 4312 5812-07-7
SU 5402 VEGFR2/FGFR/PDGFR/EGFR inhibitor 215543-92-3
SU14813 Tyrosine kinase inhibitor 627908-92-3
SU14813 double bond Z Tyrosine kinase inhibitor 452105-23-6
SU14813 maleate VEGFR/PDGFR/Kit/FLT-3 inhibitor 849643-15-8
Sunitinib RTK inhibitor 557795-19-4
Sunitinib malate VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor 341031-54-7
Telatinib (BAY 57-9352) VEGFR-2/-3,PDGFR-β and c-Kit inhibitor 332012-40-5
TG 100801 Multi-kinase inhibitor 867331-82-6
TG 100801 Hydrochloride VEGFr2 inhibitor 1018069-81-2
Toceranib c-Kit/VEGFR/PDGFR inhibtor 356068-94-5
Toceranib phosphate c-Kit/VEGFR/PDGFR inhibtor 874819-74-6
TSU-68 (SU6668,Orantinib) PDGFR/Flk-1/FGFR1 inhibitor,potent and competitive 252916-29-3
Tyrphostin 9 Selective EGFR/PDGFR inhibitor 10537-47-0
Tyrphostin AG 1296 PDGFR inhibitor,selective and ATP-competitive 146535-11-7
Vatalanib (PTK787) 2HCl Tyrosine kinase receptor inhibitor 212141-51-0
genes like me logo Genes that share compounds with PDGFRB: view

Drug Products

Transcripts for PDGFRB Gene

Unigene Clusters for PDGFRB Gene

Platelet-derived growth factor receptor, beta polypeptide:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDGFRB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^
SP1: - - - - - -
SP2: - - - - - - -
SP3:
SP4: -
SP5: - - - - -
SP6:
SP7:
SP8: -
SP9:

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for PDGFRB Gene

GeneLoc Exon Structure for
PDGFRB
ECgene alternative splicing isoforms for
PDGFRB

Expression for PDGFRB Gene