Aliases for PDGFRA Gene
Aliases for PDGFRA Gene
- Platelet Derived Growth Factor Receptor Alpha 2 3 5
- Platelet-Derived Growth Factor Receptor, Alpha Polypeptide 2 3
- Alpha-Type Platelet-Derived Growth Factor Receptor 3 4
- Platelet-Derived Growth Factor Receptor 2 3 4
- CD140 Antigen-Like Family Member A 3 4
- CD140a Antigen 3 4
- PDGF-R-Alpha 3 4
- EC 2.7.10.1 4 56
- PDGFR-2 3 4
External Ids for PDGFRA Gene
- HGNC: 8803
- Entrez Gene: 5156
- Ensembl: ENSG00000134853
- OMIM: 173490
- UniProtKB: P16234
Previous GeneCards Identifiers for PDGFRA Gene
- GC04P054806
- GC04P055065
- GC04P054945
- GC04P055010
- GC04P054936
- GC04P055095
- GC04P051043
Summaries for PDGFRA Gene
-
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
-
Commonly mutated in GI tract tumors, PDGFR family genes (mutually exclusive to KIT mutations) are a hallmark of gastrointestinal stromal tumors. Gene fusions involving the PDGFRA kinase domain are highly correlated with eosinophilia, and the WHO classifies myeloid and lymphoid neoplasms with these characteristics as a distinct disorder. Mutations in the 842 region of PDGFRA have been often found to confer resistance to the tyrosine kinase inhibitor, imatinib.
GeneCards Summary for PDGFRA Gene
PDGFRA (Platelet Derived Growth Factor Receptor Alpha) is a Protein Coding gene. Diseases associated with PDGFRA include Gastrointestinal Stromal Tumor and Hypereosinophilic Syndrome, Idiopathic. Among its related pathways are RET signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is ENSG00000282278.
UniProtKB/Swiss-Prot for PDGFRA Gene
-
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
-
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.
Additional gene information for PDGFRA Gene
- Monarch Initiative
- Search for PDGFRA at DataMed
- Search for PDGFRA at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDGFRA Gene
Genomics for PDGFRA Gene
GeneHancer (GH) Regulatory Elements for PDGFRA Gene
Promoters and enhancers for PDGFRA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PDGFRA on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PDGFRA Gene
Genomic Locations for PDGFRA Gene
- chr4:54,229,097-54,298,247
- (GRCh38/hg38)
- Size:
- 69,151 bases
- Orientation:
- Plus strand
- chr4:55,095,264-55,164,414
- (GRCh37/hg19)
Genomic View for PDGFRA Gene
Genes around PDGFRA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q12 by Ensembl
- 4q12 by Entrez Gene
- 4q12 by HGNC
PDGFRA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDGFRA Gene
Proteins for PDGFRA Gene
-
Protein details for PDGFRA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P16234-PGFRA_HUMAN
- Recommended name:
- Platelet-derived growth factor receptor alpha
- Protein Accession:
- P16234
- B2RE69
- E9PBH0
- Q6P4H5
- Q96KZ7
- Q9UD28
Protein attributes for PDGFRA Gene
- Size:
- 1089 amino acids
- Molecular mass:
- 122670 Da
- Quaternary structure:
-
- Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand. Interaction with dimeric PDGFA, PDGFB and/or PDGFC leads to receptor dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts (tyrosine phosphorylated) with SHB (via SH2 domain) (By similarity). Interacts (tyrosine phosphorylated) with SHF (via SH2 domain). Interacts (tyrosine phosphorylated) with SRC (via SH2 domain). Interacts (tyrosine phosphorylated) with PIK3R1. Interacts (tyrosine phosphorylated) with PLCG1 (via SH2 domain). Interacts (tyrosine phosphorylated) with CRK, GRB2 and GRB7. Interacts with human cytomegalovirus/HHV-5 envelop glycoprotein B/gB.
- SequenceCaution:
-
- Sequence=AAP69563.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for PDGFRA Gene
Selected DME Specific Peptides for PDGFRA Gene
- P16234:
-
- LIRAKEEDSG
- QVARGME
- RDLAARN
- YIGVTYKNE
- FLKSDHPAV
- VAVKMLK
- TLIENLTEI
- QYVPMLE
- IYIYVPDP
- LPVKWMA
- DLLSFTYQVA
- EPEKRPSFYHLSEIVE
- NIVNLLGACT
- SDVWSYGI
- ALMSELK
- WEIFSLG
- SKYSDIQRS
- KICDFGLARD
- FLASKNCVHRDLAARNVL
- AARNVLL
- PLPDIDPV
- KWMAPESIF
- LYTTLSDVWS
- LGGTPYP
- ENLTEITT
- RSYVILS
- DEQRLSADSGYI
- GILLWEIF
- DGHEYIYVDP
- GPIYIITEYC
- KPRYEIRW
- PVKWMAPE
- CYYNHTQ
- GETIVVTC
- KRNRHSSQTSEESAI
- FYNKIKSGYRM
- PIYIITE
- DFGLARDI
- ELTVAAAVLVLLVIVIISLIVLV
Post-translational modifications for PDGFRA Gene
- Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-731 and Tyr-742 is important for interaction with PIK3R1. Phosphorylation at Tyr-720 and Tyr-754 is important for interaction with PTPN11. Phosphorylation at Tyr-762 is important for interaction with CRK. Phosphorylation at Tyr-572 and Tyr-574 is important for interaction with SRC and SRC family members. Phosphorylation at Tyr-988 and Tyr-1018 is important for interaction with PLCG1.
- N-glycosylated.
- Ubiquitinated, leading to its degradation.
- Glycosylation at Asn42, Asn76, isoforms=2, 3103, isoforms=2, 3179, isoforms=3353, isoforms=3359, Asn458, and isoforms=3468
- Modification sites at PhosphoSitePlus
Other Protein References for PDGFRA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PDGFRA (PDGF R alpha)
-
Custom Antibody ServicesOriGene Antibodies for PDGFRA
- AM12068AC-N
- CF807658
- TA807658
- CF807657
- TA807657
- CF807656
- TA807656
- CF807645
- TA807645
- CF807644
- TA807644
- CF807642
- TA807642
- CF807641
- TA807641
- CF804990
- TA804990
- CF804957
- TA804957
- TA804956
- TA354019
- TA353378
- TA348040
- TA347459
- TA327910
- TA325767
- TA320442
- TA312820
- BM028
- AP55868PU-S
- AP55868PU-N
- AP31623PU-N
- AP21128PU-N
- AP20262PU-N
- AP14398PU-N
- AP14396PU-N
- AP14394PU-N
- AP14392PU-N
- AP14390PU-N
- AP08919PU-N
- AP08514PU-N
- AP07928PU-N
- AM12068PU-N
- AM12068PE-N
- AM12068BT-N
- Novus Biologicals Antibodies for PDGFRA
-
Abcam antibodies for PDGFRA
-
Cloud-Clone Corp. Antibodies for PDGFRA
- Invitrogen Antibodies for PDGFRA
- antibodies-online: Search results for 560 available PDGFRA Antibodies ranked by validation data
- Compare Top PDGFRA Antibodies
-
Recommended
- 1 in vitro Antibody (anti-human)
- 3 IP Antibodies (anti-human)
- 5 IF/ICC Antibodies (anti-human)
- 10 IHC Antibodies (anti-human)
- 10 ICC Antibodies (anti-human)
- 13 IF Antibodies (anti-human)
- 17 IHC (p) Antibodies (anti-human)
- 43 FACS Antibodies (anti-human)
- 60 IF (p) Antibodies (anti-human)
- 270 WB Antibodies (anti-human)
- 6 IHC Antibodies (anti-rat)
- 8 IHC (p) Antibodies (anti-rat)
- 60 IF (p) Antibodies (anti-rat)
- 75 WB Antibodies (anti-rat)
- 9 IHC (p) Antibodies (anti-mouse)
- 9 IHC Antibodies (anti-mouse)
- 15 FACS Antibodies (anti-mouse)
- 60 IF (p) Antibodies (anti-mouse)
- 150 WB Antibodies (anti-mouse)
- GeneTex PDGFRA antibody for PDGFRA
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDGFRA
- Sino Biological Antibodies for PDGFRA
Protein Products
- R&D Systems Proteins and Enzymes for PDGFRA (PDGF R alpha)
-
OriGene Purified Proteins for PDGFRA
- Search Origene for MassSpec and Protein Over-expression Lysates for PDGFRA
- Origene Custom Protein Services for PDGFRA
- Sino Biological Cell Lysates for PDGFRA
- Sino Biological Recombinant Proteins for PDGFRA
- ProSpec Recombinant Proteins for PDGFRA
-
Cloud-Clone Corp. Proteins for PDGFRA
- Search GeneTex for Proteins for PDGFRA
-
Abcam proteins for PDGFRA
Assay Products
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for PDGFRA (PDGF R alpha)
-
Cloud-Clone Corp. Assay Kits for PDGFRA
- Sino Biological Assays for PDGFRA
Domains & Families for PDGFRA Gene
Gene Families for PDGFRA Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Disease related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for PDGFRA Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PDGFRA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P16234UniProtKB/Swiss-Prot:
PGFRA_HUMAN :- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Function for PDGFRA Gene
Molecular function for PDGFRA Gene
- GENATLAS Biochemistry:
- platelet-derived growth factor receptor,alpha,growth arrest specific gene (gas),subunit,homodimerizing and heterodimerizing with PDGFRB,immunoglobulin superfamily
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib, nilotinib and sorafenib.
- UniProtKB/Swiss-Prot Function:
- Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
Enzyme Numbers (IUBMB) for PDGFRA Gene
Phenotypes From GWAS Catalog for PDGFRA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IDA | 24190966 |
| GO:0004713 | protein tyrosine kinase activity | IEA | -- |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IDA | 1646396 |
| GO:0005018 | platelet-derived growth factor alpha-receptor activity | IMP | 2554309 |
Phenotypes for PDGFRA Gene
- MGI mutant phenotypes for PDGFRA:
-
inferred from 17 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- pigmentation phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- no phenotypic analysis
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for PDGFRA:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Condensed cis-Golgi
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
Animal Models for PDGFRA Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PDGFRA
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PDGFRA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDGFRA gene
- Search ViGene Biosciences for PDGFRA
CRISPR Products
-
OriGene CRISPR knockouts for PDGFRA
- genomics-online: gRNA clones - Search results for 125 available PDGFRA gene related products
- Overview of 125 available PDGFRA gene related products
- Applied Biological Materials CRISPR for PDGFRA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDGFRA
- GenScript: Design CRISPR guide RNA sequences for PDGFRA
miRNA for PDGFRA Gene
- miRTarBase miRNAs that target PDGFRA
-
- hsa-let-7b-5p (MIRT004955)
- hsa-mir-34a-5p (MIRT006212)
- hsa-mir-140-5p (MIRT006218)
- hsa-mir-26b-5p (MIRT030342)
- hsa-mir-34c-5p (MIRT053382)
- hsa-mir-130a-3p (MIRT053637)
- hsa-mir-143-3p (MIRT053643)
- hsa-mir-181a-5p (MIRT053679)
- hsa-mir-630 (MIRT053734)
- hsa-mir-130b-3p (MIRT054126)
- hsa-mir-218-5p (MIRT054127)
- hsa-mir-146b-5p (MIRT054833)
- hsa-mir-1910-3p (MIRT310359)
- hsa-mir-6511a-5p (MIRT310365)
- hsa-mir-29b-3p (MIRT438912)
- hsa-mir-6780a-5p (MIRT510133)
- hsa-mir-6779-5p (MIRT510134)
- hsa-mir-3689c (MIRT510135)
- hsa-mir-3689b-3p (MIRT510136)
- hsa-mir-3689a-3p (MIRT510137)
- hsa-mir-30b-3p (MIRT510138)
- hsa-mir-1273h-5p (MIRT510139)
- hsa-mir-6799-5p (MIRT510140)
- hsa-mir-6883-5p (MIRT510141)
- hsa-mir-6785-5p (MIRT510142)
- hsa-mir-4728-5p (MIRT510143)
- hsa-mir-149-3p (MIRT510144)
- hsa-mir-7106-5p (MIRT510145)
- hsa-mir-6739-5p (MIRT510146)
- hsa-mir-6733-5p (MIRT510147)
- hsa-mir-3153 (MIRT510148)
- hsa-mir-650 (MIRT510149)
- hsa-mir-3612 (MIRT510150)
- hsa-mir-139-3p (MIRT510151)
- hsa-mir-298 (MIRT510152)
- hsa-mir-1827 (MIRT510153)
- hsa-mir-6746-5p (MIRT510154)
- hsa-mir-483-5p (MIRT510155)
- hsa-mir-4668-5p (MIRT612057)
- hsa-mir-544a (MIRT612058)
- hsa-mir-2276-3p (MIRT612059)
- hsa-mir-4772-3p (MIRT612060)
- hsa-mir-5582-3p (MIRT612061)
- hsa-mir-548x-3p (MIRT612062)
- hsa-mir-548j-3p (MIRT612063)
- hsa-mir-548aq-3p (MIRT612064)
- hsa-mir-548am-3p (MIRT612065)
- hsa-mir-548aj-3p (MIRT612066)
- hsa-mir-548ah-3p (MIRT612067)
- hsa-mir-548ae-3p (MIRT612068)
- hsa-mir-455-3p (MIRT622841)
- hsa-mir-4719 (MIRT622842)
- hsa-mir-7853-5p (MIRT622843)
- hsa-mir-105-5p (MIRT622844)
- hsa-mir-8485 (MIRT622845)
- hsa-mir-129-5p (MIRT626867)
- hsa-mir-6885-3p (MIRT626868)
- hsa-mir-628-5p (MIRT626869)
- hsa-mir-8075 (MIRT626870)
- hsa-mir-6778-5p (MIRT700976)
- hsa-mir-1233-5p (MIRT700977)
miRNA Products
- Search ViGene Biosciences for PDGFRA
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PDGFRA
- Browse OriGene Inhibitory RNA Products For PDGFRA
- genomics-online: shRNA clones - Search results for 125 available PDGFRA gene related products
- Overview of 125 available PDGFRA gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PDGFRA gene
Clone Products
- Sino Biological Human cDNA Clone for PDGFRA
- VectorBuilder custom plasmid, inducible vectors for PDGFRA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDGFRA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PDGFRA
- Applied Biological Materials Clones for PDGFRA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for PDGFRA (PDGF R alpha)
Cell Line Products
- ESI BIO PureStem 4D20.8, NCr-fac Progenitor for PDGFRA
-
Horizon Cell Lines for PDGFRA
-
ViGene Biosciences adenoviral particle packaged cDNA for PDGFRA gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PDGFRA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDGFRA gene
No data available for Transcription Factor Targets and HOMER Transcription for PDGFRA Gene
Localization for PDGFRA Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDGFRA Gene
- Cell membrane; Single-pass type I membrane protein. Note=The activated receptor is rapidly internalized and degraded.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
- Cell Junctions (3)
- Plasma membrane (3)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,ISS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005886 | plasma membrane | IDA,TAS | -- |
| GO:0005887 | integral component of plasma membrane | IDA | 2536956 |
| GO:0016020 | membrane | IEA,HDA | 19946888 |
Pathways & Interactions for PDGFRA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 3 | GPCR Pathway |
.73
.62
|
.55
|
| 4 | PI3K/AKT activation |
.89
|
|
| 5 | Endometrial cancer |
.52
.47
|
.32
|
Pathways by source for PDGFRA Gene
10 BioSystems pathways for PDGFRA Gene
59 Reactome pathways for PDGFRA Gene
2 PharmGKB pathways for PDGFRA Gene
21 KEGG pathways for PDGFRA Gene
5 GeneGo (Thomson Reuters) pathways for PDGFRA Gene
4 R&D Systems pathways for PDGFRA Gene
2 Tocris pathways for PDGFRA Gene
58 Qiagen pathways for PDGFRA Gene
2 Cell Signaling Technology pathways for PDGFRA Gene
Interacting Proteins for PDGFRA Gene
Selected Interacting proteins:
ENSP00000257290
P16234-PGFRA_HUMAN
for PDGFRA Gene via
STRING
MINT
UniProtKB
IID
SIGNOR curated interactions for PDGFRA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0001553 | luteinization | ISS | -- |
| GO:0001775 | cell activation | TAS | 10508235 |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006935 | chemotaxis | IEA | -- |
Drugs & Compounds for PDGFRA Gene
(81) Drugs for PDGFRA Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sunitinib | Approved, Investigational | Pharma | Target, inhibitor | VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 518 | |
| imatinib | Approved | Pharma | Target, antagonist, inhibitor | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 0 | |
| Pazopanib | Approved | Pharma | Target, inhibitor | VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| regorafenib | Approved | Pharma | Target, inhibitor | Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| Becaplermin | Approved, Investigational | Pharma | Target, inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| N-desmethylimatinib |
|
|
||||
| SU 6668 |
|
252916-29-3 |
|
|
(3) Tocris Compounds for PDGFRA Gene
| Compound | Action | Cas Number |
|---|---|---|
| DMPQ dihydrochloride | Potent, selective inhibitor of PDGFRbeta | 1123491-15-5 |
| SU 6668 | PDGFR, VEGFR and FGFR inhibitor | 252916-29-3 |
| Toceranib | Potent PDGFR and VEGFR inhibitor | 356068-94-5 |
(34) ApexBio Compounds for PDGFRA Gene
| Compound | Action | Cas Number |
|---|---|---|
| AG-18 | EGFR/PDGFR inhibitor | 118409-57-7 |
| Amuvatinib (MP-470, HPK 56) | Tyrosine kinase inhibitor | 850879-09-3 |
| Apatinib | VEGFR2 inhibitor, orally bioavailable, selective | 811803-05-1 |
| BIBF 1120 | VEGFR/PDGF/FGFR inhibitor | 656247-17-5 |
| CP-673451 | PDGFRα/β inhibitor,potent and selective | 343787-29-1 |
| Crenolanib (CP-868596) | PDGFR-β inhibitor,potent and selective | 670220-88-9 |
| DCC-2618 | C-Kit/PDGFR inhibtor | 1225278-16-9 |
| DMPQ dihydrochloride | 1123491-15-5 | |
| Dovitinib (TKI258) Lactate | Oral tyrosine kinase inhibitor (TKI) against FGFR1–3, VEGFR1–3, and platelet-derived growth factor receptor (PDGFR) | 915769-50-5 |
| Flumatinib mesylate | 895519-91-2 | |
| Imatinib (STI571) | Protein-tyrosine kinase inhibitor | 152459-95-5 |
| Imatinib hydrochloride | V-Abl/c-Kit/PDGFR inhibitor | 862366-25-4 |
| Imatinib Mesylate (STI571) | Abl/c-kit/PDGFR inhibitor | 220127-57-1 |
| Linifanib (ABT-869) | VEGFR/PDGFR inhibitor | 796967-16-3 |
| Masitinib (AB1010) | Tyrosine kinase inhibitor, potent and selective | 790299-79-5 |
| Masitinib mesylate | Tyrosine kinase inhibitor | 1048007-93-7 |
| MK-2461 | C-Met (WT/mutants) inhibitor | 917879-39-1 |
| Motesanib Diphosphate (AMG-706) | VEGFR/ PDGFR/c-Kit/Ret inhibitor | 857876-30-3 |
| N-Desethyl Sunitinib | VEGFR/PDGFRβ/KIT inhibitor | 356068-97-8 |
| Nintedanib (BIBF 1120) | VEGFR/PDGFR/FGFR inhibitor | 928326-83-4 |
| Pazopanib (GW-786034) | VEGFR/PDGFR/FGFR inhibitor | 635702-64-6 |
| Pazopanib Hydrochloride | VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor | 635702-64-6 |
| PP121 | Dual inhibitor of tyrosine and phosphoinositide kinases | 1092788-83-4 |
| Regorafenib | Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1 | 755037-03-7 |
| Sennoside B | 128-57-4 | |
| SU 16f | 251356-45-3 | |
| SU 4312 | 5812-07-7 | |
| SU 5402 | VEGFR2/FGFR/PDGFR/EGFR inhibitor | 215543-92-3 |
| Sunitinib | RTK inhibitor | 557795-19-4 |
| Toceranib | c-Kit/VEGFR/PDGFR inhibtor | 356068-94-5 |
| Toceranib phosphate | c-Kit/VEGFR/PDGFR inhibtor | 874819-74-6 |
| TSU-68 (SU6668,Orantinib) | PDGFR/Flk-1/FGFR1 inhibitor,potent and competitive | 252916-29-3 |
| Tyrphostin 9 | Selective EGFR/PDGFR inhibitor | 10537-47-0 |
| Tyrphostin AG 1296 | PDGFR inhibitor,selective and ATP-competitive | 146535-11-7 |
Transcripts for PDGFRA Gene
mRNA/cDNA for PDGFRA Gene
- (12) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (240) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PDGFRA Gene
CRISPR Products
-
OriGene CRISPR knockouts for PDGFRA
- genomics-online: gRNA clones - Search results for 125 available PDGFRA gene related products
- Overview of 125 available PDGFRA gene related products
- Applied Biological Materials CRISPR for PDGFRA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDGFRA
- GenScript: Design CRISPR guide RNA sequences for PDGFRA
miRNA Products
- Search ViGene Biosciences for PDGFRA
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PDGFRA
- Browse OriGene Inhibitory RNA Products For PDGFRA
- genomics-online: shRNA clones - Search results for 125 available PDGFRA gene related products
- Overview of 125 available PDGFRA gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PDGFRA gene
Clone Products
- Sino Biological Human cDNA Clone for PDGFRA
- VectorBuilder custom plasmid, inducible vectors for PDGFRA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDGFRA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PDGFRA
- Applied Biological Materials Clones for PDGFRA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for PDGFRA (PDGF R alpha)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | |||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | |||||||||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | |||||||||||||||||||||
| SP9: |
Expression for PDGFRA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Oligodendrocyte Precursor Cells Lateral Ganglionic Eminence
- Oligodendrocyte Precursor Cells dP3 Neural Domain
- Oligodendrocyte Precursor Cells Caudal Ganglionic Eminence
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Oligodendrocyte Precursor Cells dP5 Neural Domain
-
Neural Tube (Nervous System)
- Oligodendrocyte Precursor Cells Lateral Ganglionic Eminence
- Oligodendrocyte Precursor Cells dP3 Neural Domain
- Oligodendrocyte Precursor Cells Caudal Ganglionic Eminence
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Oligodendrocyte Precursor Cells dP5 Neural Domain
- Spinal Cord (Nervous System)
- Oligodendrocytes (Nervous System)
-
Heart (Cardiovascular System)
- Mesenchymal Cells Epicardium
- Cushion Mesenchymal Cells Endocardium
- Cardiac Fibroblasts Myocardium
- Hypoblast (Extraembryonic Tissues)
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
- Glial Cells (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for PDGFRA Gene
This gene is overexpressed in Ovary (x5.4).
This gene is overexpressed in Bone marrow stromal cell (27.9) and Cervix (13.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PDGFRA Gene
NURSA nuclear receptor signaling pathways regulating expression of PDGFRA Gene:
PDGFRASOURCE GeneReport for Unigene cluster for PDGFRA Gene:
Hs.74615mRNA Expression by UniProt/SwissProt for PDGFRA Gene:
P16234-PGFRA_HUMAN
Tissue specificity:
Detected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts, smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue.
Evidence on tissue expression from TISSUES for PDGFRA Gene
- Nervous system(4.8)
- Lung(4.5)
- Blood(4.4)
- Intestine(2.9)
- Stomach(2.9)
- Muscle(2.6)
- Heart(2.5)
- Gall bladder(2.2)
- Liver(2.2)
- Spleen(2.1)
- Bone marrow(2)
- Skin(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PDGFRA Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- ear
- head
- mouth
- pharynx
Thorax:
- esophagus
- heart
- heart valve
- lung
Abdomen:
- intestine
- large intestine
- liver
- small intestine
- spleen
- stomach
Pelvis:
- rectum
Limb:
- digit
- finger
- hand
- upper limb
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for PDGFRA
- genomics-online: primer clones - Search results for 125 available PDGFRA gene related products
- Overview of 125 available PDGFRA gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners for PDGFRA Gene
Orthologs for PDGFRA Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PDGFRA 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PDGFRA 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PDGFRA 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Pdgfra 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pdgfra 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PDGFRA 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | PDGFRA 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PDGFRA 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100124862 33 |
|
||
| Str.9869 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | pdgfra-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pdgfra 33 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG3277 35 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | C24G6.2 33 |
|
||
| R09D1.12 35 |
|
|
|||
| ver-2 35 |
|
|
- Species where no ortholog for PDGFRA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PDGFRA Gene
Paralogs for PDGFRA Gene
(5) SIMAP similar genes for PDGFRA Gene using alignment to 5 proteins:
Variants for PDGFRA Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001537658 | likely-benign, Gastrointestinal stromal tumor | 54,273,660(+) | C/G | coding_sequence_variant, synonymous_variant | |
| rs10028020 | benign, not specified, Gastrointestinal stromal tumor, Idiopathic hypereosinophilic syndrome | 54,277,410(+) | G/A/C | coding_sequence_variant, synonymous_variant | |
| rs10034498 | benign, Idiopathic hypereosinophilic syndrome, Gastrointestinal stromal tumor | 54,297,659(+) | T/G | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1007954435 | uncertain-significance, Gastrointestinal stromal tumor | 54,290,358(+) | G/A/C | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs1018795199 | uncertain-significance, Gastrointestinal stromal tumor | 54,263,893(+) | C/G/T | coding_sequence_variant, missense_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5209n100 | CNV | gain | 25217958 |
| esv2763361 | CNV | loss | 21179565 |
| esv3569425 | CNV | loss | 25503493 |
| esv3569426 | CNV | loss | 25503493 |
| nsv1002905 | CNV | loss | 25217958 |
| nsv1008497 | CNV | gain | 25217958 |
| nsv1123794 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.96;
68.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PDGFRA Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDGFRA Gene
Disorders for PDGFRA Gene
(68) MalaCards diseases for PDGFRA Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastrointestinal stromal tumor |
|
|
| hypereosinophilic syndrome, idiopathic |
|
|
| myeloid/lymphoid neoplasm associated with pdgfra rearrangement |
|
|
| chronic eosinophilic leukemia |
|
|
| primary hypereosinophilic syndrome |
|
|
Search PDGFRA in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PGFRA_HUMAN- Gastrointestinal stromal tumor (GIST) [MIM:606764]: Common mesenchymal neoplasms arising in the gastrointestinal tract, most often in the stomach. They are histologically, immunohistochemically, and genetically different from typical leiomyomas, leiomyosarcomas, and schwannomas. Most GISTs are composed of a fairly uniform population of spindle-shaped cells. Some tumors are dominated by epithelioid cells or contain a mixture of spindle and epithelioid morphologies. Primary GISTs in the gastrointestinal tract commonly metastasize in the omentum and mesenteries, often as multiple nodules. However, primary tumors may also occur outside of the gastrointestinal tract, in other intra-abdominal locations, especially in the omentum and mesentery. {ECO:0000269 PubMed:12522257, ECO:0000269 PubMed:15928335}. Note=The gene represented in this entry may be involved in disease pathogenesis. Mutations causing PDGFRA constitutive activation have been found in gastrointestinal stromal tumors lacking KIT mutations (PubMed:12522257). {ECO:0000269 PubMed:12522257}.
- Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA). Mutations that cause overexpression and/or constitutive activation of PDGFRA may be a cause of hypereosinophilic syndrome. {ECO:0000269 PubMed:12808148}.
Additional Disease Information for PDGFRA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PDGFRA Gene
Publications for PDGFRA Gene
- PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. (PMID: 15928335) Corless CL … Heinrich MC (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005) 3 4 22 25 58
- Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma. (PMID: 19563658) Longatto-Filho A … Reis RM (BMC cancer 2009) 3 22 44 58
- A prospective, multicenter, phase 2 study of imatinib mesylate in korean patients with metastatic or unresectable gastrointestinal stromal tumor. (PMID: 19307738) Ryu MH … Kang YK (Oncology 2009) 3 22 44 58
- Interaction of PDGFRA promoter haplotypes and maternal environmental exposures in the risk of spina bifida. (PMID: 19215021) Toepoel M … van Zoelen EJ (Birth defects research. Part A, Clinical and molecular teratology 2009) 3 22 44 58
- Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor. (PMID: 18955458) Heinrich MC … Demetri GD (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008) 3 22 44 58
Products for PDGFRA Gene
- R&D Systems Antibodies for PDGFRA (PDGF R alpha)
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- AM12068AC-N
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- TA807656
- CF807656
- TA807657
- CF807657
- TA807658
- CF807658
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