Aliases for PDGFD Gene
Aliases for PDGFD Gene
External Ids for PDGFD Gene
- HGNC: 30620
- Entrez Gene: 80310
- Ensembl: ENSG00000170962
- OMIM: 609673
- UniProtKB: Q9GZP0
Previous GeneCards Identifiers for PDGFD Gene
- GC11M103315
- GC11M103283
- GC11M103777
- GC11M099706
Summaries for PDGFD Gene
-
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PDGFD Gene
PDGFD (Platelet Derived Growth Factor D) is a Protein Coding gene. Diseases associated with PDGFD include Mesangial Proliferative Glomerulonephritis and Brain Cancer. Among its related pathways are ERK Signaling and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include growth factor activity and platelet-derived growth factor receptor binding. An important paralog of this gene is PDGFC.
UniProtKB/Swiss-Prot for PDGFD Gene
-
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).
-
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDGFD Gene
Genomics for PDGFD Gene
GeneHancer (GH) Regulatory Elements for PDGFD Gene
Promoters and enhancers for PDGFD Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J104163 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 655.2 | +0.4 | 379 | 2 | SIN3A FEZF1 ZNF2 GLIS2 ZNF213 ZNF143 KAT8 GLIS1 ZNF785 SP7 | PDGFD CASP12 DDI1 | |
| GH11J103958 | Enhancer | 0.7 | ENCODE | 11 | +205.2 | 205194 | 1.1 | PKNOX1 BACH1 EBF1 BMI1 BATF RELA NFATC1 ATF7 FOSL2 BCLAF1 | DDI1 PDGFD ENSG00000255548 | |
| GH11J104074 | Enhancer | 0.6 | Ensembl ENCODE | 11.1 | +90.2 | 90179 | 0.4 | POLR2A ZSCAN29 SPI1 | DDI1 PDGFD | |
| GH11J103987 | Enhancer | 0.5 | ENCODE | 10.7 | +176.1 | 176086 | 2 | CTCF FOXP2 FOS MAFK | ENSG00000255548 DDI1 PDGFD | |
| GH11J103960 | Enhancer | 0.4 | ENCODE | 11 | +203.1 | 203103 | 1.1 | SP1 FOSL2 FOS | DDI1 PDGFD ENSG00000255548 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PDGFD on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PDGFD gene promoter:
-
- Nkx2-5
- Msx-1
- NF-1/L
- NF-1
- AREB6
- MRF-2
- En-1
- TBP
- aMEF-2
- MEF-2A
Regulatory Element Products
Genomic Locations for PDGFD Gene
Genomic Locations for PDGFD Gene
- chr11:103,907,186-104,164,379
- (GRCh38/hg38)
- Size:
- 257,194 bases
- Orientation:
- Minus strand
- chr11:103,777,914-104,035,107
- (GRCh37/hg19)
- Size:
- 257,194 bases
- Orientation:
- Minus strand
Genomic View for PDGFD Gene
Genes around PDGFD on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q22.3 by Entrez Gene
- 11q22.3 by HGNC
- 11q22.3 by Ensembl
PDGFD Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDGFD Gene
Proteins for PDGFD Gene
-
Protein details for PDGFD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9GZP0-PDGFD_HUMAN
- Recommended name:
- Platelet-derived growth factor D
- Protein Accession:
- Q9GZP0
- A8K9T6
- Q9BWV5
Protein attributes for PDGFD Gene
- Size:
- 370 amino acids
- Molecular mass:
- 42848 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
Protein Expression for PDGFD Gene
Post-translational modifications for PDGFD Gene
- Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form.
- Glycosylation at Asn276
- Ubiquitination at Lys160
- Modification sites at PhosphoSitePlus
Other Protein References for PDGFD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PDGFD (PDGF-D)
- Novus Biologicals Antibodies for PDGFD
-
Abcam antibodies for PDGFD
- Invitrogen Antibodies for PDGFD
- antibodies-online: Search results for 74 available PDGFD Antibodies ranked by validation data
- Compare Top PDGFD Antibodies
-
Recommended
- 23 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 8 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-mouse)
- 6 WB Antibodies (anti-mouse)
- Search GeneTex for Antibodies for PDGFD
-
Boster Bio Antibodies for PDGFD
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDGFD
- Sino Biological Antibodies for PDGFD
Protein Products
- R&D Systems Proteins and Enzymes for PDGFD (PDGF-DD)
-
OriGene Purified Proteins for PDGFD
- Search Origene for MassSpec and Protein Over-expression Lysates for PDGFD
- Origene Custom Protein Services for PDGFD
- ProSpec Recombinant Proteins for PDGFD
- Search GeneTex for Proteins for PDGFD
-
Abcam proteins for PDGFD
Assay Products
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for PDGFD (PDGF-DD)
-
Boster Bio ELISA Kits for PDGFD
No data available for DME Specific Peptides for PDGFD Gene
Domains & Families for PDGFD Gene
Gene Families for PDGFD Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for PDGFD Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PDGFD Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9GZP0- Family:
-
- Belongs to the PDGF/VEGF growth factor family.
Function for PDGFD Gene
Molecular function for PDGFD Gene
- UniProtKB/Swiss-Prot Function:
- Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).
Phenotypes From GWAS Catalog for PDGFD Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005161 | platelet-derived growth factor receptor binding | IEA,IBA | -- |
| GO:0008083 | growth factor activity | IEA | -- |
| GO:0070851 | growth factor receptor binding | IBA | -- |
Phenotypes for PDGFD Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for PDGFD
- Cyagen custom Knockout/knockin (KOKI) mouse models for PDGFD
-
CRISPR Products
-
OriGene CRISPR knockouts for PDGFD
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDGFD
- genomics-online: gRNA clones - Search results for 129 available PDGFD gene related products
- Overview of 129 available PDGFD gene related products
- Applied Biological Materials CRISPR for PDGFD
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDGFD
- GenScript: Design CRISPR guide RNA sequences for PDGFD
miRNA for PDGFD Gene
- miRTarBase miRNAs that target PDGFD
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDGFD
- Browse OriGene Inhibitory RNA Products For PDGFD
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDGFD
- genomics-online: shRNA clones - Search results for 129 available PDGFD gene related products
- Overview of 129 available PDGFD gene related products
Clone Products
- Sino Biological Human cDNA Clone for PDGFD
- VectorBuilder custom plasmid, inducible vectors for PDGFD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDGFD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDGFD
- Applied Biological Materials Clones for PDGFD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem 7SMOO32, NCr-fac & Meso Progenitor and PureStem Z11, Meso Progenitor for PDGFD
-
Horizon Cell Lines for PDGFD
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDGFD Gene
Localization for PDGFD Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDGFD Gene
- Secreted. Note=Released by platelets upon wounding.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 5 |
| golgi apparatus | 4 |
| plasma membrane | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| lysosome | 1 |
| endosome | 1 |
- Golgi apparatus (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA | -- |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for PDGFD Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 2 | GPCR Pathway |
.73
.62
|
.55
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
| 5 | CREB Pathway |
.68
.68
|
|
Pathways by source for PDGFD Gene
1 BioSystems pathway for PDGFD Gene
2 Reactome pathways for PDGFD Gene
1 PharmGKB pathway for PDGFD Gene
12 KEGG pathways for PDGFD Gene
2 GeneGo (Thomson Reuters) pathways for PDGFD Gene
Interacting Proteins for PDGFD Gene
GPS-Prot Interaction Network for PDGFD
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007596 | blood coagulation | IBA | -- |
| GO:0008284 | positive regulation of cell proliferation | IBA | -- |
| GO:0010469 | regulation of signaling receptor activity | IEA | -- |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | IBA | -- |
No data available for SIGNOR curated interactions for PDGFD Gene
Drugs & Compounds for PDGFD Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sunitinib | Approved, Investigational | Pharma | inhibitor | VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors, Potent VEGFR, PDGFRbeta and KIT inhibitor | 518 | |
| CR002 | Investigational | Pharma | Target | 0 | ||
| Tandutinib | Investigational | Pharma | Target | Kinase Inhibitors | 0 | |
| DMPQ dihydrochloride | Pharma | Potent, selective inhibitor of PDGFRbeta | 0 | |||
| Toceranib | Pharma | c-Kit/VEGFR/PDGFR inhibtor, Potent PDGFR and VEGFR inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| SU 6668 |
|
252916-29-3 |
|
|
(3) Tocris Compounds for PDGFD Gene
| Compound | Action | Cas Number |
|---|---|---|
| DMPQ dihydrochloride | Potent, selective inhibitor of PDGFRbeta | 1123491-15-5 |
| SU 6668 | PDGFR, VEGFR and FGFR inhibitor | 252916-29-3 |
| Toceranib | Potent PDGFR and VEGFR inhibitor | 356068-94-5 |
Drug Products
Transcripts for PDGFD Gene
mRNA/cDNA for PDGFD Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (94) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000393158 3801 bps (uc001phq.4)
- ENST00000302251 4052 bps (uc001php.4)
- ENST00000529268 620 bps (uc058gxc.1)
Unigene Clusters for PDGFD Gene
CRISPR Products
-
OriGene CRISPR knockouts for PDGFD
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDGFD
- genomics-online: gRNA clones - Search results for 129 available PDGFD gene related products
- Overview of 129 available PDGFD gene related products
- Applied Biological Materials CRISPR for PDGFD
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDGFD
- GenScript: Design CRISPR guide RNA sequences for PDGFD
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDGFD
- Browse OriGene Inhibitory RNA Products For PDGFD
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDGFD
- genomics-online: shRNA clones - Search results for 129 available PDGFD gene related products
- Overview of 129 available PDGFD gene related products
Clone Products
- Sino Biological Human cDNA Clone for PDGFD
- VectorBuilder custom plasmid, inducible vectors for PDGFD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDGFD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDGFD
- Applied Biological Materials Clones for PDGFD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | - |
Expression for PDGFD Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Liver Bud
- Natural Killer Cells Peripheral Blood
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
- Mesoderm (Gastrulation Derivatives)
- Neural Crest (Gastrulation Derivatives)
- Germ Cells (Reproductive System)
- Gonad
- Adipose (Muscoskeletal System)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Adrenal Gland (Endocrine System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for PDGFD Gene
This gene is overexpressed in Adrenal Gland (x7.4) and Artery - Aorta (x6.5).
This gene is overexpressed in Serum (42.0) and Peripheral blood mononuclear cells (16.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDGFD Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PDGFD Gene:
PDGFDSOURCE GeneReport for Unigene cluster for PDGFD Gene:
Hs.352298mRNA Expression by UniProt/SwissProt for PDGFD Gene:
Q9GZP0-PDGFD_HUMAN
Tissue specificity:
Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines.
Evidence on tissue expression from TISSUES for PDGFD Gene
- Eye(4.1)
- Muscle(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for PDGFD
-
OriGene qPCR primer pairs for PDGFD
- genomics-online: primer clones - Search results for 129 available PDGFD gene related products
- Overview of 129 available PDGFD gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PDGFD Gene
Orthologs for PDGFD Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PDGFD 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PDGFD 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PDGFD 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Pdgfd 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Pdgfd 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PDGFD 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PDGFD 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PDGFD 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PDGFD 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100492060 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100535718 33 |
|
||
| CABZ01114098.1 34 |
|
OneToOne |
- Species where no ortholog for PDGFD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PDGFD Gene
- ENSEMBL:
- Gene Tree for PDGFD (if available)
- TreeFam:
- Gene Tree for PDGFD (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PDGFD: view image
Paralogs for PDGFD Gene
Variants for PDGFD Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036418 | A colorectal cancer sample | p.Asp202Tyr | |||
| rs1000008990 | -- | 104,008,345(-) | C/G | intron_variant | |
| rs1000011354 | -- | 103,953,144(-) | A/G | intron_variant | |
| rs1000025581 | -- | 103,999,676(-) | C/T | intron_variant | |
| rs1000030728 | -- | 104,106,800(-) | G/A | intron_variant |
Residual Variation Intolerance Score:
70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.56;
55.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PDGFD Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDGFD Gene
Disorders for PDGFD Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mesangial proliferative glomerulonephritis |
|
|
| brain cancer |
|
|
| prostate cancer |
|
|
Search PDGFD in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PDGFD
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PDGFD Gene
Publications for PDGFD Gene
- Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein. (PMID: 11162582) Hamada T … Miyata Y (Biochemical and biophysical research communications 2001) 2 3 4 22 58
- Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer. (PMID: 11980634) LaRochelle WJ … Lichenstein HS (Cancer research 2002) 2 3 4 58
- Platelet-derived growth factor-D expression in developing and mature human kidneys. (PMID: 12427128) Changsirikulchai S … Alpers CE (Kidney international 2002) 3 4 22 58
- Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFD genes. (PMID: 11342471) Uutela M … Alitalo K (Circulation 2001) 3 4 22 58
- Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G … Boerwinkle E (PLoS genetics 2011) 3 44 58
Products for PDGFD Gene
- R&D Systems Antibodies for PDGFD (PDGF-D)
- R&D Systems Proteins and Enzymes for PDGFD (PDGF-DD)
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for PDGFD (PDGF-DD)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PDGFD
- Search Origene for MassSpec and Protein Over-expression Lysates for PDGFD
- Origene Custom Protein Services for PDGFD
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDGFD
- Browse OriGene Inhibitory RNA Products For PDGFD
- OriGene qPCR primer pairs and template standards for PDGFD
- OriGene qPCR primer pairs for PDGFD
- OriGene CRISPR knockouts for PDGFD
- OriGene ORF clones in human for PDGFD
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PDGFD
- GenScript: Next-day shipping of latest version cDNA ORF clones for PDGFD in any vector
- GenScript Purified and Recombinant Proteins for PDGFD
- GenScript Custom Purified and Recombinant Proteins Services for PDGFD
- GenScript Custom Assay Services for PDGFD
- GenScript Custom overexpressing Cell Line Services for PDGFD
- GenScript: Design CRISPR guide RNA sequences for PDGFD
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PDGFD
- Sino Biological Human cDNA Clone for PDGFD
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for PDGFD
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PDGFD
- Novus Biologicals proteins and lysates for PDGFD
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PDGFD
- Abcam proteins for PDGFD
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for PDGFD
- ESI BIO PureStem 7SMOO32, NCr-fac & Meso Progenitor and PureStem Z11, Meso Progenitor for PDGFD
- Taconic Biosciences Mouse Models for PDGFD
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PDGFD
- Cyagen custom Knockout/knockin (KOKI) mouse models for PDGFD
- VectorBuilder custom plasmid, inducible vectors for PDGFD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDGFD
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 74 available PDGFD Antibodies ranked by validation data
- Compare Top PDGFD Antibodies
- Recommended
- 23 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 8 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-mouse)
- 6 WB Antibodies (anti-mouse)
- antibodies-online: Search results for 48 available PDGFD Elisa Kits ranked by validation data
- Compare Top PDGFD Elisa Kits
- antibodies-online: Search results for 12 available PDGFD Proteins ranked by validation data
- Compare Top PDGFD Proteins
- Search GeneTex for Antibodies for PDGFD
- Search GeneTex for Proteins for PDGFD
- Santa Cruz Biotechnology (SCBT) Antibodies for PDGFD
- Search Santa Cruz Biotechnology (SCBT) for PDGFD siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PDGFD
- Horizon Cell Lines for PDGFD
- genomics-online: cdna clones - Search results for 129 available PDGFD gene related products
- Overview of 129 available PDGFD gene related products
- orf clones - Search results for 129 available PDGFD gene related products
- Overview of 129 available PDGFD gene related products
- genomics-online: gRNA clones - Search results for 129 available PDGFD gene related products
- Overview of 129 available PDGFD gene related products
- genomics-online: primer clones - Search results for 129 available PDGFD gene related products
- Overview of 129 available PDGFD gene related products
- genomics-online: shRNA clones - Search results for 129 available PDGFD gene related products
- Overview of 129 available PDGFD gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDGFD
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDGFD
- GeneCopoeia miRNA 3'UTR Target clone products for PDGFD
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDGFD
Sources for PDGFD Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt