Aliases for PDGFC Gene
External Ids for PDGFC Gene
Previous GeneCards Identifiers for PDGFC Gene
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
GeneCards Summary for PDGFC Gene
PDGFC (Platelet Derived Growth Factor C) is a Protein Coding gene. Diseases associated with PDGFC include Milker's Nodule and Macular Degeneration, Age-Related, 1. Among its related pathways are Phospholipase D signaling pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and platelet-derived growth factor receptor binding. An important paralog of this gene is PDGFD.
UniProtKB/Swiss-Prot Summary for PDGFC Gene
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.