The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an un... See more...

Aliases for PDGFC Gene

Aliases for PDGFC Gene

  • Platelet Derived Growth Factor C 2 3 5
  • SCDGF 2 3 4
  • Spinal Cord-Derived Growth Factor 3 4
  • Platelet-Derived Growth Factor C 3 4
  • Fallotein 2 4
  • PDGF-C 3 4
  • VEGF-E 3 4
  • Secretory Growth Factor-Like Protein 3
  • FALLOTEIN 3
  • PDGFC 5

External Ids for PDGFC Gene

Previous GeneCards Identifiers for PDGFC Gene

  • GC04M158562
  • GC04M158113
  • GC04M158260
  • GC04M158040
  • GC04M157902
  • GC04M157682
  • GC04M153433

Summaries for PDGFC Gene

Entrez Gene Summary for PDGFC Gene

  • The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for PDGFC Gene

PDGFC (Platelet Derived Growth Factor C) is a Protein Coding gene. Diseases associated with PDGFC include Milker's Nodule and Macular Degeneration, Age-Related, 1. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and platelet-derived growth factor receptor binding. An important paralog of this gene is PDGFD.

UniProtKB/Swiss-Prot Summary for PDGFC Gene

  • Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.

Tocris Summary for PDGFC Gene

  • Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.

Gene Wiki entry for PDGFC Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDGFC Gene

Genomics for PDGFC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PDGFC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDGFC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDGFC

Top Transcription factor binding sites by QIAGEN in the PDGFC gene promoter:
  • AhR
  • aMEF-2
  • Arnt
  • C/EBPalpha
  • C/EBPbeta
  • COMP1
  • E47
  • LCR-F1
  • MEF-2A
  • Tal-1beta

Genomic Locations for PDGFC Gene

Latest Assembly
chr4:156,760,454-156,971,799
(GRCh38/hg38)
Size:
211,346 bases
Orientation:
Minus strand

Previous Assembly
chr4:157,681,606-157,892,951
(GRCh37/hg19 by Entrez Gene)
Size:
211,346 bases
Orientation:
Minus strand

chr4:157,681,606-157,892,546
(GRCh37/hg19 by Ensembl)
Size:
210,941 bases
Orientation:
Minus strand

Genomic View for PDGFC Gene

Genes around PDGFC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDGFC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDGFC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDGFC Gene

Proteins for PDGFC Gene

  • Protein details for PDGFC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRA1-PDGFC_HUMAN
    Recommended name:
    Platelet-derived growth factor C
    Protein Accession:
    Q9NRA1
    Secondary Accessions:
    • B4DU34
    • B9EGR8
    • Q4W5M9
    • Q9UL22

    Protein attributes for PDGFC Gene

    Size:
    345 amino acids
    Molecular mass:
    39029 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts (via CUB domain) with PLAT (via kringle domain).
    Miscellaneous:
    • A lower molecular weight form (around 43 kDa) is present in patients with papillary thyroid carcinoma.

    Alternative splice isoforms for PDGFC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDGFC Gene

Post-translational modifications for PDGFC Gene

  • Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG.
  • Sumoylated with SUMO1.
  • N-glycosylated.
  • Glycosylation at Asn25 and Asn55
  • Modification sites at PhosphoSitePlus

Other Protein References for PDGFC Gene

No data available for DME Specific Peptides for PDGFC Gene

Domains & Families for PDGFC Gene

Gene Families for PDGFC Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PDGFC Gene

InterPro:
Blocks:
  • CUB domain
  • Platelet-derived growth factor (PDGF)

Suggested Antigen Peptide Sequences for PDGFC Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50219, highly similar to Homo sapiens platelet derived growth factor C (PDGFC), mRNA (B4DU34_HUMAN)
  • cDNA FLJ59151, highly similar to Homo sapiens platelet derived growth factor C (PDGFC), mRNA (B4E3A5_HUMAN)
  • VEGF-E (PDGFC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NRA1

UniProtKB/Swiss-Prot:

PDGFC_HUMAN :
  • Belongs to the PDGF/VEGF growth factor family.
Family:
  • Belongs to the PDGF/VEGF growth factor family.
genes like me logo Genes that share domains with PDGFC: view

Function for PDGFC Gene

Molecular function for PDGFC Gene

UniProtKB/Swiss-Prot Function:
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
UniProtKB/Swiss-Prot Induction:
Up-regulated by EWS-FLI1 chimeric transcription factor in tumor derived cells. Up-regulated in podocytes and interstitial cells after injury/activation of these cells. FGF2 activates PDGFC transcription via EGR1. Up-regulated by TGFB1 in concert with FGF2.

LifeMap Function Summary for PDGFC Gene

Phenotypes From GWAS Catalog for PDGFC Gene

Gene Ontology (GO) - Molecular Function for PDGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005161 platelet-derived growth factor receptor binding IBA,IPI 10806482
GO:0005515 protein binding IPI 10806482
GO:0008083 growth factor activity IEA --
GO:0042803 protein homodimerization activity IPI 10806482
GO:0070851 growth factor receptor binding IBA 21873635
genes like me logo Genes that share ontologies with PDGFC: view
genes like me logo Genes that share phenotypes with PDGFC: view

Animal Models for PDGFC Gene

MGI Knock Outs for PDGFC:
  • Pdgfc Pdgfc<tm1Nagy>
  • Pdgfc Pdgfc<tm1.1Hdin>
  • Pdgfc Pdgfc<tm1b(EUCOMM)Hmgu>

Animal Models for research

  • Taconic Biosciences Mouse Models for PDGFC

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDGFC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDGFC Gene

Localization for PDGFC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDGFC Gene

Cytoplasm, cytosol. Secreted. Nucleus. Cytoplasmic granule. Cell membrane. Note=Sumoylated form is predominant in the nucleus (PubMed:15247255). Stored in alpha granules in platelets (PubMed:15061151). {ECO:0000269 PubMed:16443219}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDGFC gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 4
endoplasmic reticulum 4
cytosol 4
golgi apparatus 4
cytoskeleton 2
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,IDA 10806482
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PDGFC: view

Pathways & Interactions for PDGFC Gene

PathCards logo

SuperPathways for PDGFC Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
3 ERK Signaling
.61
.61
.58
.51
.49
4 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
5 CREB Pathway
.68
.68
.63
.50
genes like me logo Genes that share pathways with PDGFC: view

Pathways by source for PDGFC Gene

1 BioSystems pathway for PDGFC Gene
2 Reactome pathways for PDGFC Gene
1 PharmGKB pathway for PDGFC Gene
2 GeneGo (Thomson Reuters) pathways for PDGFC Gene
  • Cytoskeleton remodeling_Role of PDGFs in cell migration
  • Development PDGF signaling via MAPK cascades
59 Qiagen pathways for PDGFC Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

SIGNOR curated interactions for PDGFC Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PDGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA --
GO:0007275 multicellular organism development IEA --
GO:0007417 central nervous system development TAS 10858496
GO:0008284 positive regulation of cell proliferation IBA,IDA 10806482
GO:0009887 animal organ morphogenesis IEA --
genes like me logo Genes that share ontologies with PDGFC: view

Drugs & Compounds for PDGFC Gene

(3) Drugs for PDGFC Gene - From: DGIdb and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sunitinib Approved, Investigational Pharma inhibitor VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 556
DMPQ dihydrochloride Pharma Potent, selective inhibitor of PDGFRbeta 0
Toceranib Pharma c-Kit/VEGFR/PDGFR inhibtor, Potent PDGFR and VEGFR inhibitor 0

(2) Additional Compounds for PDGFC Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SU 6668
252916-29-3

(3) Tocris Compounds for PDGFC Gene

Compound Action Cas Number
DMPQ dihydrochloride Potent, selective inhibitor of PDGFRbeta 1123491-15-5
SU 6668 PDGFR, VEGFR and FGFR inhibitor 252916-29-3
Toceranib Potent PDGFR and VEGFR inhibitor 356068-94-5
genes like me logo Genes that share compounds with PDGFC: view

Transcripts for PDGFC Gene

mRNA/cDNA for PDGFC Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDGFC

Alternative Splicing Database (ASD) splice patterns (SP) for PDGFC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for PDGFC Gene

GeneLoc Exon Structure for
PDGFC

Expression for PDGFC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PDGFC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDGFC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.9) and Amniocyte (32.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDGFC Gene



Protein tissue co-expression partners for PDGFC Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDGFC

SOURCE GeneReport for Unigene cluster for PDGFC Gene:

Hs.570855

mRNA Expression by UniProt/SwissProt for PDGFC Gene:

Q9NRA1-PDGFC_HUMAN
Tissue specificity: Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for PDGFC Gene

  • Nervous system(4.6)
  • Lung(4.4)
  • Heart(2.8)
  • Muscle(2.5)
  • Kidney(2.5)
  • Liver(2.4)
  • Blood(2.3)
  • Skin(2.2)
  • Eye(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with PDGFC: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDGFC Gene

Orthologs for PDGFC Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDGFC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PDGFC 29 30
  • 99.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PDGFC 29 30
  • 94.14 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PDGFC 30
  • 88 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PDGFC 30
  • 88 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia PDGFC 29 30
  • 86.57 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pdgfc 29 16 30
  • 84.35 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pdgfc 29
  • 84.06 (n)
Chicken
(Gallus gallus)
Aves PDGFC 29 30
  • 79.9 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PDGFC 30
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pdgfc 29
  • 73.53 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC560564 29
  • 63.44 (n)
PDGFC 30
  • 62 (a)
OneToOne
Species where no ortholog for PDGFC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PDGFC Gene

ENSEMBL:
Gene Tree for PDGFC (if available)
TreeFam:
Gene Tree for PDGFC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PDGFC: view image
Alliance of Genome Resources:
Additional Orthologs for PDGFC

Paralogs for PDGFC Gene

(1) SIMAP similar genes for PDGFC Gene using alignment to 4 proteins:

  • PDGFC_HUMAN
  • B4E3A5_HUMAN
  • H0Y9N2_HUMAN
  • J3KN71_HUMAN
genes like me logo Genes that share paralogs with PDGFC: view

Variants for PDGFC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDGFC Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs139145392 Benign: not provided 156,970,791(-) T/C
NM_016205.3(PDGFC):c.113A>G (p.Gln38Arg)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs142817291 Benign: not provided 156,767,839(-) G/C
NM_016205.3(PDGFC):c.855C>G (p.Ala285=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PDGFC Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PDGFC Gene

Variant ID Type Subtype PubMed ID
dgv1037e214 CNV loss 21293372
esv2591391 CNV deletion 19546169
esv2657401 CNV deletion 23128226
esv2669335 CNV deletion 23128226
esv2677099 CNV deletion 23128226
esv3602793 CNV loss 21293372
esv3602794 CNV loss 21293372
esv3602795 CNV loss 21293372
esv3602799 CNV gain 21293372
esv3602800 CNV loss 21293372
esv3602801 CNV gain 21293372
nsv1023220 CNV loss 25217958
nsv830122 CNV gain 17160897

Variation tolerance for PDGFC Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDGFC Gene

Human Gene Mutation Database (HGMD)
PDGFC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDGFC
Leiden Open Variation Database (LOVD)
PDGFC

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDGFC Gene

Disorders for PDGFC Gene

MalaCards: The human disease database

(7) MalaCards diseases for PDGFC Gene - From: COP and GCD

Disorder Aliases PubMed IDs
milker's nodule
  • milker nodule
macular degeneration, age-related, 1
  • armd1
medulloblastoma
  • mdb
contagious pustular dermatitis
  • ecthyma contagiosum
cleft palate, isolated
  • cpi
- elite association - COSMIC cancer census association via MalaCards
Search PDGFC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PDGFC

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PDGFC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDGFC Gene

Publications for PDGFC Gene

  1. A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family. (PMID: 10858496) Hamada T … Miyata Y (FEBS letters 2000) 2 3 4 22
  2. The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with CL/P. (PMID: 19092777) Choi SJ … Hart TC (European journal of human genetics : EJHG 2009) 3 22 40
  3. Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata. (PMID: 17482170) Hwu YM … Lin SY (Fertility and sterility 2008) 3 4 22
  4. Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines. (PMID: 16443219) Reigstad LJ … Lillehaug JR (Experimental cell research 2006) 3 4 22
  5. Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. (PMID: 15728360) Campbell JS … Fausto N (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22

Products for PDGFC Gene

Sources for PDGFC Gene