Aliases for PDGFB Gene
- Platelet Derived Growth Factor Subunit B 2 3 5
- Becaplermin 2 3 4
- Platelet-Derived Growth Factor Beta Polypeptide (Simian Sarcoma Viral (V-Sis) Oncogene Homolog) 2 3
- Platelet-Derived Growth Factor Beta Polypeptide 2 4
- Platelet-Derived Growth Factor B Chain 3 4
- Proto-Oncogene C-Sis 3 4
- PDGF Subunit B 3 4
- PDGF-2 3 4
- PDGF2 3 4
- SIS 3 4
External Ids for PDGFB Gene
Previous HGNC Symbols for PDGFB Gene
Previous GeneCards Identifiers for PDGFB Gene
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
GeneCards Summary for PDGFB Gene
PDGFB (Platelet Derived Growth Factor Subunit B) is a Protein Coding gene. Diseases associated with PDGFB include Dermatofibrosarcoma Protuberans and Basal Ganglia Calcification, Idiopathic, 5. Among its related pathways are RET signaling and Development EGFR signaling via small GTPases. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is PDGFA.
UniProtKB/Swiss-Prot for PDGFB Gene
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.