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This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. T... See more...
Aliases for PDGFA Gene
Aliases for PDGFA Gene
External Ids for PDGFA Gene
- HGNC: 8799
- NCBI Entrez Gene: 5154
- Ensembl: ENSG00000197461
- OMIM®: 173430
- UniProtKB/Swiss-Prot: P04085
Previous GeneCards Identifiers for PDGFA Gene
- GC07U990063
- GC07Mh00634
- GC07M000503
- GC07M000536
- GC07M000455
Summaries for PDGFA Gene
-
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
GeneCards Summary for PDGFA Gene
PDGFA (Platelet Derived Growth Factor Subunit A) is a Protein Coding gene. Diseases associated with PDGFA include Denys-Drash Syndrome and Ureteral Obstruction. Among its related pathways are RET signaling and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is PDGFB.
UniProtKB/Swiss-Prot Summary for PDGFA Gene
-
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).
-
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.
Additional gene information for PDGFA Gene
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDGFA Gene
Genomics for PDGFA Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PDGFA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PDGFA on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDGFA
- Top Transcription factor binding sites by QIAGEN in the PDGFA gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- Sp1
- STAT5A
Genomic Locations for PDGFA Gene
Latest Assembly
- chr7:497,245-520,668
- (GRCh38/hg38)
- Size:
- 23,424 bases
- Orientation:
- Minus strand
Previous Assembly
- chr7:536,895-559,483
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 22,589 bases
- Orientation:
- Minus strand
Genomic View for PDGFA Gene
Genes around PDGFA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p22.3 by HGNC
- 7p22.3 by Entrez Gene
- 7p22.3 by Ensembl
PDGFA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDGFA Gene
Proteins for PDGFA Gene
-
Protein details for PDGFA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04085-PDGFA_HUMAN
- Recommended name:
- Platelet-derived growth factor subunit A
- Protein Accession:
- P04085
- B5BU73
Protein attributes for PDGFA Gene
- Size:
- 211 amino acids
- Molecular mass:
- 24043 Da
- Quaternary structure:
-
- Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.
Protein Expression for PDGFA Gene
Post-translational modifications for PDGFA Gene
Other Protein References for PDGFA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PDGF-AA Antibody and PDGF-AA Monoclonal Antibody
- G Biosciences Immunotag™ PDGFA Antibody
- Novus Biologicals Antibodies for PDGFA
-
Abcam antibodies for PDGFA
- Invitrogen Antibodies for PDGFA (AFLGC-PDGFA)
- antibodies-online: Show 82 available PDGFA Antibodies ranked by validation data
- Compare Top PDGFA Antibodies
-
Recommended
- 116 WB Antibodies (anti-human)
- 15 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 26 WB Antibodies (anti-mouse)
- 15 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 24 WB Antibodies (anti-rat)
- 15 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
-
Boster Bio Antibodies for PDGFA
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDGFA
- Sino Biological Antibodies for PDGFA
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PDGFA
- Origene Custom Protein Services for PDGFA
- Sino Biological Recombinant Proteins for PDGFA
- Sino Biological Cell Lysates for PDGFA
- ProSpec Recombinant Proteins for PDGFA
-
ProSci Proteins for PDGFA
- platelet-derived growth factor alpha polypeptide [40-157]
- platelet derived growth factor, alpha [40-457]
- platelet-derived growth factor alpha polypeptide [40-512]
- platelet-derived growth factor alpha polypeptide [40-712]
- platelet derived growth factor subunit A [92-262]
- platelet derived growth factor subunit A [92-294]
-
Abcam proteins for PDGFA
Assay products for research
- RayBiotech Human PDGF-AA ELISA
-
Custom Assay ServicesOriGene ELISA Kits for PDGFA
- Novus Biologicals ELISA Kits for PDGFA
- antibodies-online: Show 193 available PDGFA Elisa Kits ranked by validation data
- Compare Top PDGFA Elisa Kits
-
Quality Products:
- ABIN1116563
- ABIN625072
- ABIN625344
- ABIN1116545
- ABIN411345
- ABIN415178
- ABIN414664
- ABIN417366
- ABIN3032977
- ABIN491898
- ABIN1672747
- ABIN858062
- ABIN424234
- ABIN1116559
- ABIN1116579
- ABIN1116583
- ABIN5522382
- ABIN2708588
- ABIN6720205
- ABIN2685163
- ABIN1116558
- ABIN1116580
- ABIN578384
- ABIN411346
- ABIN625450
- ABIN5563542
- ABIN5522384
- ABIN5522383
- ABIN5525476
- ABIN2708674
- ABIN847530
- ABIN1057326
- ABIN994760
- ABIN1148352
-
Boster Bio ELISA Kits for PDGFA
No data available for DME Specific Peptides for PDGFA Gene
Domains & Families for PDGFA Gene
Gene Families for PDGFA Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for PDGFA Gene
- InterPro:
- Blocks:
-
- Platelet-derived growth factor (PDGF)
- Growth factor cystine knot superfamily signature
- Platelet-derived growth factor, N-terminal
Suggested Antigen Peptide Sequences for PDGFA Gene
- GenScript: Design optimal peptide antigens:
-
- Platelet-derived growth factor alpha polypeptide (PDGFA_HUMAN)
- Platelet-derived growth factor alpha polypeptide (Q32M96_HUMAN)
- Platelet-derived growth factor A chain (Q9UGN0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P04085UniProtKB/Swiss-Prot:
PDGFA_HUMAN :- The long form contains a basic insert which acts as a cell retention signal.
- Belongs to the PDGF/VEGF growth factor family.
- Domain:
-
- The long form contains a basic insert which acts as a cell retention signal.
- Family:
-
- Belongs to the PDGF/VEGF growth factor family.
Function for PDGFA Gene
Molecular function for PDGFA Gene
- UniProtKB/Swiss-Prot Function:
- Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).
- GENATLAS Biochemistry:
- platelet-derived growth factor,alpha polypeptide,24kDa,potent mitogen for cells of mesenchymal origin,also involved in transformation process
LifeMap Function Summary for PDGFA Gene
During embryonic development, PDGFA as signaling molecule is secreted from the following cells
- Epiblast
- Somite
It affects the following cells:
- Primitive Streak
-
Neural Tube
- Oligodendrocyte Precursor Cells (Lateral Ganglionic Eminence)
- Oligodendrocyte Precursor Cells (Caudal Ganglionic Eminence)
- Oligodendrocyte Precursor Cells (Anterior Entopeduncular Area)
- Oligodendrocyte Precursor Cells (Motor Neural Progenitor Domain)
- Oligodendrocyte Precursor Cells (Medial Ganglionic Eminence)
- Somite
Phenotypes From GWAS Catalog for PDGFA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005161 | platelet-derived growth factor receptor binding | IBA,IPI | 2536956 |
| GO:0005515 | protein binding | IPI | 7679113 |
| GO:0005518 | collagen binding | IDA | 8900172 |
| GO:0008083 | growth factor activity | IEA,IDA | 12070119 |
| GO:0042802 | identical protein binding | IPI | -- |
Phenotypes for PDGFA Gene
- MGI mutant phenotypes for PDGFA:
-
inferred from 2 alleles
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- mortality/aging
- renal/urinary system phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- skeleton phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for PDGFA:
Animal Models for PDGFA Gene
- MGI Knock Outs for PDGFA:
-
- Pdgfa Pdgfa<tm1Cbet>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PDGFA - Starting at $85 >
- * PDGFA CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PDGFA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDGFA
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDGFA
miRNA for PDGFA Gene
- miRTarBase miRNAs that target PDGFA
-
- hsa-let-7d-5p (MIRT005549)
- hsa-miR-221-3p (MIRT053724)
- hsa-miR-29b-3p (MIRT438915)
- hsa-miR-514b-3p (MIRT622846)
- hsa-miR-514a-3p (MIRT622847)
- hsa-miR-6809-3p (MIRT622848)
- hsa-miR-6833-3p (MIRT622849)
- hsa-miR-4768-5p (MIRT622850)
- hsa-miR-4753-3p (MIRT622851)
- hsa-miR-6873-3p (MIRT622852)
- hsa-miR-130b-5p (MIRT622853)
- hsa-miR-6817-3p (MIRT622854)
- hsa-miR-7110-3p (MIRT622855)
- hsa-miR-1273g-5p (MIRT655310)
- hsa-miR-203a-5p (MIRT655311)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDGFA
- Browse OriGene Inhibitory RNA Products For PDGFA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDGFA
Clone products for research
- Applied Biological Materials (abm): Clones for PDGFA - Starting at $45 >
- * PDGFA as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG201931
- MR201931
- MR201931L3
- MR201931L4
- RC214164
- RC214164L1
- RC214164L2
- RC214164L3
- RC214164L4
- RC223058
- RC223058L1
- RC223058L2
- RC223058L3
- RC223058L4
- RG214164
- RG223058
- RR207740
- RR207740L3
- RR207740L4
- MR201931L3V
- MR201931L4V
- RC214164L1V
- RC214164L2V
- RC214164L3V
- RC214164L4V
- RC223058L1V
- RC223058L2V
- RC223058L3V
- RC223058L4V
- RR207740L3V
- RR207740L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PDGFA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDGFA
Cell Lines for research
-
Horizon Cell Lines for PDGFA
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDGFA Gene
Localization for PDGFA Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDGFA Gene
- Secreted. Note=Released by platelets upon wounding.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| plasma membrane | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005615 | extracellular space | IBA,IDA | 3754619 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
Pathways & Interactions for PDGFA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 3 | PI3K/AKT activation |
.89
|
|
| 4 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
| 5 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
Pathways by source for PDGFA Gene
7 BioSystems pathways for PDGFA Gene
65 Reactome pathways for PDGFA Gene
1 PharmGKB pathway for PDGFA Gene
3 GeneGo (Thomson Reuters) pathways for PDGFA Gene
- Cytoskeleton remodeling_Role of PDGFs in cell migration
- Development PDGF signaling via MAPK cascades
- Development PDGF signaling via STATs and NF-kB
1 R&D Systems pathway for PDGFA Gene
59 Qiagen pathways for PDGFA Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
Interacting Proteins for PDGFA Gene
Selected Interacting proteins:
P04085-PDGFA_HUMAN
ENSP00000346508
for PDGFA Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PDGFA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0001525 | angiogenesis | ISS | -- |
| GO:0001775 | cell activation | TAS | 10508235 |
| GO:0001942 | hair follicle development | ISS | -- |
| GO:0002053 | positive regulation of mesenchymal cell proliferation | ISS | -- |
Drugs & Compounds for PDGFA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sunitinib | Approved, Investigational | Pharma | inhibitor | VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 556 | |
| Nintedanib (BIBF 1120) | Pharma | VEGFR/PDGFR/FGFR inhibitor | 0 | |||
| DMPQ dihydrochloride | Pharma | Potent, selective inhibitor of PDGFRbeta | 0 | |||
| Toceranib | Pharma | c-Kit/VEGFR/PDGFR inhibtor, Potent PDGFR and VEGFR inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| SU 6668 |
|
252916-29-3 |
|
|
(3) Tocris Compounds for PDGFA Gene
| Compound | Action | Cas Number |
|---|---|---|
| DMPQ dihydrochloride | Potent, selective inhibitor of PDGFRbeta | 1123491-15-5 |
| SU 6668 | PDGFR, VEGFR and FGFR inhibitor | 252916-29-3 |
| Toceranib | Potent PDGFR and VEGFR inhibitor | 356068-94-5 |
(1) ApexBio Compounds for PDGFA Gene
| Compound | Action | Cas Number |
|---|---|---|
| Nintedanib (BIBF 1120) | VEGFR/PDGFR/FGFR inhibitor | 928326-83-4 |
Transcripts for PDGFA Gene
mRNA/cDNA for PDGFA Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000354513 1308 nts (view in UCSC)
- ENST00000400761 689 nts (view in UCSC)
- ENST00000402802 2305 nts (view in UCSC)
- ENST00000405692 663 nts (view in UCSC)
- ENST00000426681 357 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PDGFA - Starting at $85 >
- * PDGFA CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PDGFA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDGFA
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDGFA
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDGFA
- Browse OriGene Inhibitory RNA Products For PDGFA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDGFA
Clone products for research
- Applied Biological Materials (abm): Clones for PDGFA - Starting at $45 >
- * PDGFA as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG201931
- MR201931
- MR201931L3
- MR201931L4
- RC214164
- RC214164L1
- RC214164L2
- RC214164L3
- RC214164L4
- RC223058
- RC223058L1
- RC223058L2
- RC223058L3
- RC223058L4
- RG214164
- RG223058
- RR207740
- RR207740L3
- RR207740L4
- MR201931L3V
- MR201931L4V
- RC214164L1V
- RC214164L2V
- RC214164L3V
- RC214164L4V
- RC223058L1V
- RC223058L2V
- RC223058L3V
- RC223058L4V
- RR207740L3V
- RR207740L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PDGFA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDGFA
Relevant External Links for PDGFA Gene
- GeneLoc Exon Structure for
- PDGFA
Expression for PDGFA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
- Mature Endothelial Cells Corneal Endothelium
- Conjunctival Epithelium
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- Mural Trophectoderm Cells Mural Trophectoderm
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Inner Cell Mass (Early Embryo)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- Kidney (Urinary System)
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Corneal Endothelium
- Angioblasts Embryonic Blood Islands
- Fibroblasts (Uncategorized)
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Hypoblast (Extraembryonic Tissues)
- Parietal Endoderm Cells Hypoblast
-
Ovary (Reproductive System)
- Primary Oocyte Primordial Follicle
-
Gonad
- Primary Oocyte Primordial Follicle
-
Blood (Hematopoietic System)
- Megakaryocytes Hematopoietic Bone Marrow
-
Heart (Cardiovascular System)
- Epicardial Progenitors Cells Epicardium
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Angioblasts Embryonic Blood Islands
- Brain (Nervous System)
- Intermediate Mesoderm (Gastrulation Derivatives)
- Gut Tube (Gastrointestinal Tract)
- NULL (Integumentary System)
- Uncategorized
- Dermis (Integumentary System)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for PDGFA Gene
This gene is overexpressed in Artery - Aorta (x4.4).
This gene is overexpressed in Peripheral blood mononuclear cells (57.2) and Islet of Langerhans (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDGFA Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDGFA
SOURCE GeneReport for Unigene cluster for PDGFA Gene:
Hs.535898Evidence on tissue expression from TISSUES for PDGFA Gene
- Muscle(2.7)
- Heart(2.7)
- Nervous system(2.7)
- Skin(2.6)
- Lung(2.5)
- Blood(2.4)
- Kidney(2.4)
- Pancreas(2.3)
- Liver(2.1)
- Intestine(2)
Primer products for research
-
OriGene qPCR primer pairs for PDGFA
-
OriGene qPCR primer pairs and template standards for PDGFA
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDGFA Gene
Orthologs for PDGFA Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PDGFA 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PDGFA 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pdgfa 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pdgfa 29 |
|
||
| Cow (Bos Taurus) |
Mammalia | PDGFA 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PDGFA 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PDGFA 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PDGFA 29 |
|
||
| PDGF-A 30 |
|
OneToOne | |||
| Lizard (Anolis carolinensis) |
Reptilia | PDGFA 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pdgfa 29 |
|
||
| Str.20307 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | PDGFA 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | pdgfaa 29 30 |
|
OneToMany | |
| pdgfab 30 |
|
OneToMany | |||
| pdgfa 29 |
|
- Species where no ortholog for PDGFA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PDGFA Gene
- ENSEMBL:
- Gene Tree for PDGFA (if available)
- TreeFam:
- Gene Tree for PDGFA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PDGFA: view image
- Alliance of Genome Resources:
- Additional Orthologs for PDGFA
Paralogs for PDGFA Gene
Variants for PDGFA Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDGFA Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs138786227 | Likely Benign: not provided | 517,429(-) |
C/T NM_002607.5(PDGFA):c.125G>A (p.Arg42Gln) |
MISSENSE | |
| rs61733314 | Benign: not provided | 501,186(-) |
C/T NM_002607.5(PDGFA):c.510G>A (p.Arg170=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2733620 | CNV | deletion | 23290073 |
| nsv1074989 | CNV | deletion | 25765185 |
| nsv1119098 | CNV | deletion | 24896259 |
| nsv1137182 | CNV | deletion | 24896259 |
| nsv1137568 | CNV | deletion | 24896259 |
| nsv1144158 | CNV | deletion | 24896259 |
| nsv950782 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.69;
14.65% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PDGFA Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDGFA Gene
Disorders for PDGFA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| denys-drash syndrome |
|
|
| ureteral obstruction |
|
|
| middle cerebral artery infarction |
|
|
| retinal detachment |
|
|
| tendinitis |
|
|
Search PDGFA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PDGFA
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PDGFA Gene
Publications for PDGFA Gene
- DNA sequence variants of the platelet-derived growth factor A-chain gene. (PMID: 11678848) Baron R … Drazen JM (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2001) 3 22 40
- Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite. (PMID: 1612586) Bonthron D … Speleman F (Genomics 1992) 3 4 22
- The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22. (PMID: 1505216) Stenman G … Betsholtz C (Cytogenetics and cell genetics 1992) 2 3 22
- Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y … Huang W (Journal of human genetics 2010) 3 40
- Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. (PMID: 20534510) Shim AH … He X (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4
ExternalLinks
Products for PDGFA Gene
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- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ApexBio compounds for PDGFA
- VectorBuilder Custom and pre-made DNA vectors for PDGFA (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PDGFA (ie. lentivirus, AAV, adenovirus)
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- antibodies-online: Show 82 available PDGFA Antibodies ranked by validation data
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- 24 WB Antibodies (anti-rat)
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- antibodies-online: Show 115 available PDGFA Proteins ranked by validation data
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- Search Santa Cruz Biotechnology (SCBT) for PDGFA siRNA/shRNA
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- ProSci Proteins for PDGFA