Aliases for PDGFA Gene
Aliases for PDGFA Gene
External Ids for PDGFA Gene
- HGNC: 8799
- Entrez Gene: 5154
- Ensembl: ENSG00000197461
- OMIM: 173430
- UniProtKB: P04085
Previous GeneCards Identifiers for PDGFA Gene
- GC07U990063
- GC07Mh00634
- GC07M000503
- GC07M000536
- GC07M000455
Summaries for PDGFA Gene
-
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
GeneCards Summary for PDGFA Gene
PDGFA (Platelet Derived Growth Factor Subunit A) is a Protein Coding gene. Diseases associated with PDGFA include Denys-Drash Syndrome and Pulmonary Fibrosis. Among its related pathways are RET signaling and Development EGFR signaling via small GTPases. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is PDGFB.
UniProtKB/Swiss-Prot for PDGFA Gene
-
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).
-
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.
Additional gene information for PDGFA Gene
- Monarch Initiative
- Search for PDGFA at DataMed
- Search for PDGFA at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDGFA Gene
Genomics for PDGFA Gene
GeneHancer (GH) Regulatory Elements for PDGFA Gene
Promoters and enhancers for PDGFA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PDGFA on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PDGFA Gene
Genomic Locations for PDGFA Gene
- chr7:497,258-520,668
- (GRCh38/hg38)
- Size:
- 23,411 bases
- Orientation:
- Minus strand
- chr7:536,895-559,933
- (GRCh37/hg19)
Genomic View for PDGFA Gene
Genes around PDGFA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p22.3 by Ensembl
- 7p22.3 by Entrez Gene
- 7p22.3 by HGNC
PDGFA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDGFA Gene
Proteins for PDGFA Gene
-
Protein details for PDGFA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04085-PDGFA_HUMAN
- Recommended name:
- Platelet-derived growth factor subunit A
- Protein Accession:
- P04085
- B5BU73
Protein attributes for PDGFA Gene
- Size:
- 211 amino acids
- Molecular mass:
- 24043 Da
- Quaternary structure:
-
- Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.
Protein Expression for PDGFA Gene
Post-translational modifications for PDGFA Gene
Other Protein References for PDGFA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PDGFA (PDGF)
- R&D Systems Antibodies for PDGFA (PDGF-A)
- R&D Systems Antibodies for PDGFA (PDGF-AA)
- Novus Biologicals Antibodies for PDGFA
-
Abcam antibodies for PDGFA
-
Cloud-Clone Corp. Antibodies for PDGFA
- Invitrogen Antibodies for PDGFA
- Search GeneTex for Antibodies for PDGFA
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDGFA
Protein Products
- R&D Systems Proteins and Enzymes for PDGFA (PDGF)
- R&D Systems Proteins and Enzymes for PDGFA (PDGF-AA)
- Search Origene for MassSpec and Protein Over-expression Lysates for PDGFA
- Origene Custom Protein Services for PDGFA
- Sino Biological Recombinant Proteins for PDGFA
- Sino Biological Cell Lysates for PDGFA
- ProSpec Recombinant Proteins for PDGFA
-
Cloud-Clone Corp. Proteins for PDGFA
- Search GeneTex for Proteins for PDGFA
-
Abcam proteins for PDGFA
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for PDGFA (PDGF-AA)
- Novus Biologicals ELISA Kits for PDGFA
No data available for DME Specific Peptides for PDGFA Gene
Domains & Families for PDGFA Gene
Gene Families for PDGFA Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for PDGFA Gene
Suggested Antigen Peptide Sequences for PDGFA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P04085UniProtKB/Swiss-Prot:
PDGFA_HUMAN :- The long form contains a basic insert which acts as a cell retention signal.
- Belongs to the PDGF/VEGF growth factor family.
- Domain:
-
- The long form contains a basic insert which acts as a cell retention signal.
- Family:
-
- Belongs to the PDGF/VEGF growth factor family.
Function for PDGFA Gene
Molecular function for PDGFA Gene
- GENATLAS Biochemistry:
- platelet-derived growth factor,alpha polypeptide,24kDa,potent mitogen for cells of mesenchymal origin,also involved in transformation process
- UniProtKB/Swiss-Prot Function:
- Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).
LifeMap Function Summary for PDGFA Gene
During embryonic development, PDGFA as signaling molecule is secreted from the following cells
- Epiblast
- Somite
It affects the following cells:
- Primitive Streak
-
Neural Tube
- Oligodendrocyte Precursor Cells (Lateral Ganglionic Eminence)
- Oligodendrocyte Precursor Cells (Caudal Ganglionic Eminence)
- Oligodendrocyte Precursor Cells (Anterior Entopeduncular Area)
- Oligodendrocyte Precursor Cells (Motor Neural Progenitor Domain)
- Oligodendrocyte Precursor Cells (Medial Ganglionic Eminence)
- Somite
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005161 | platelet-derived growth factor receptor binding | IPI | 2536956 |
| GO:0005515 | protein binding | IPI | 7679113 |
| GO:0005518 | collagen binding | IDA | 8900172 |
| GO:0008083 | growth factor activity | IEA,IDA | 12070119 |
Phenotypes for PDGFA Gene
- MGI mutant phenotypes for PDGFA:
-
inferred from 2 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- growth/size/body region phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- integument phenotype
- embryo phenotype
- skeleton phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for PDGFA:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Mildly decreased CFP-tsO45G cell surface transport
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased IL-8 secretion
- Decreased shRNA abundance
- Increased cell number in S
- Negative genetic interaction between BLM-/- and BLM+/+
Animal Models for PDGFA Gene
- MGI Knock Outs for PDGFA:
-
- Pdgfa tm1Cbet
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PDGFA
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PDGFA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDGFA gene
- Search ViGene Biosciences for PDGFA
CRISPR Products
-
OriGene CRISPR knockouts for PDGFA
- genomics-online: gRNA clones - Search results for 142 available PDGFA gene related products
- Overview of 142 available PDGFA gene related products
- Applied Biological Materials CRISPR for PDGFA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDGFA
- GenScript: Design CRISPR guide RNA sequences for PDGFA
miRNA for PDGFA Gene
- miRTarBase miRNAs that target PDGFA
-
- hsa-let-7d-5p (MIRT005549)
- hsa-mir-221-3p (MIRT053724)
- hsa-mir-29b-3p (MIRT438915)
- hsa-mir-514b-3p (MIRT622846)
- hsa-mir-514a-3p (MIRT622847)
- hsa-mir-6809-3p (MIRT622848)
- hsa-mir-6833-3p (MIRT622849)
- hsa-mir-4768-5p (MIRT622850)
- hsa-mir-4753-3p (MIRT622851)
- hsa-mir-6873-3p (MIRT622852)
- hsa-mir-130b-5p (MIRT622853)
- hsa-mir-6817-3p (MIRT622854)
- hsa-mir-7110-3p (MIRT622855)
- hsa-mir-1273g-5p (MIRT655310)
- hsa-mir-203a-5p (MIRT655311)
miRNA Products
- Search ViGene Biosciences for PDGFA
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDGFA
- Browse OriGene Inhibitory RNA Products For PDGFA
- genomics-online: shRNA clones - Search results for 142 available PDGFA gene related products
- Overview of 142 available PDGFA gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PDGFA gene
Clone Products
- Sino Biological Human cDNA Clone for PDGFA
- VectorBuilder custom plasmid, inducible vectors for PDGFA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDGFA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PDGFA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PDGFA
-
ViGene Biosciences adenoviral particle packaged cDNA for PDGFA gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PDGFA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDGFA gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDGFA Gene
Localization for PDGFA Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDGFA Gene
- Secreted. Note=Released by platelets upon wounding.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| nucleus | 2 |
| plasma membrane | 1 |
- Microtubule organizing center (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 3754619 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
Pathways & Interactions for PDGFA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 3 | PI3K/AKT activation |
.89
|
|
| 4 | GPCR Pathway |
.73
.62
|
.55
|
| 5 | ERK Signaling |
.61
.58
|
.49
|
Pathways by source for PDGFA Gene
7 BioSystems pathways for PDGFA Gene
65 Reactome pathways for PDGFA Gene
1 PharmGKB pathway for PDGFA Gene
3 GeneGo (Thomson Reuters) pathways for PDGFA Gene
1 R&D Systems pathway for PDGFA Gene
Interacting Proteins for PDGFA Gene
Selected Interacting proteins:
P04085-PDGFA_HUMAN
ENSP00000346508
for PDGFA Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0001525 | angiogenesis | ISS | -- |
| GO:0001775 | cell activation | TAS | 10508235 |
| GO:0001942 | hair follicle development | ISS | -- |
| GO:0002053 | positive regulation of mesenchymal cell proliferation | ISS | -- |
Drugs & Compounds for PDGFA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sunitinib | Approved, Investigational | Pharma | inhibitor | VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 518 | |
| Nintedanib (BIBF 1120) | Pharma | VEGFR/PDGFR/FGFR inhibitor | 0 | |||
| DMPQ dihydrochloride | Pharma | Potent, selective inhibitor of PDGFRbeta | 0 | |||
| Toceranib | Pharma | c-Kit/VEGFR/PDGFR inhibtor, Potent PDGFR and VEGFR inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| SU 6668 |
|
252916-29-3 |
|
|
(3) Tocris Compounds for PDGFA Gene
| Compound | Action | Cas Number |
|---|---|---|
| DMPQ dihydrochloride | Potent, selective inhibitor of PDGFRbeta | 1123491-15-5 |
| SU 6668 | PDGFR, VEGFR and FGFR inhibitor | 252916-29-3 |
| Toceranib | Potent PDGFR and VEGFR inhibitor | 356068-94-5 |
(1) ApexBio Compounds for PDGFA Gene
| Compound | Action | Cas Number |
|---|---|---|
| Nintedanib (BIBF 1120) | VEGFR/PDGFR/FGFR inhibitor | 928326-83-4 |
Transcripts for PDGFA Gene
mRNA/cDNA for PDGFA Gene
- (8) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (25) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PDGFA Gene
CRISPR Products
-
OriGene CRISPR knockouts for PDGFA
- genomics-online: gRNA clones - Search results for 142 available PDGFA gene related products
- Overview of 142 available PDGFA gene related products
- Applied Biological Materials CRISPR for PDGFA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDGFA
- GenScript: Design CRISPR guide RNA sequences for PDGFA
miRNA Products
- Search ViGene Biosciences for PDGFA
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDGFA
- Browse OriGene Inhibitory RNA Products For PDGFA
- genomics-online: shRNA clones - Search results for 142 available PDGFA gene related products
- Overview of 142 available PDGFA gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PDGFA gene
Clone Products
- Sino Biological Human cDNA Clone for PDGFA
- VectorBuilder custom plasmid, inducible vectors for PDGFA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDGFA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PDGFA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PDGFA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
- Mature Endothelial Cells Corneal Endothelium
- Conjunctival Epithelium
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- Mural Trophectoderm Cells Mural Trophectoderm
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Inner Cell Mass (Early Embryo)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- Kidney (Urinary System)
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Corneal Endothelium
- Angioblasts Embryonic Blood Islands
- Fibroblasts (Uncategorized)
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Hypoblast (Extraembryonic Tissues)
- Parietal Endoderm Cells Hypoblast
-
Ovary (Reproductive System)
- Primary Oocyte Primordial Follicle
-
Gonad
- Primary Oocyte Primordial Follicle
-
Blood (Hematopoietic System)
- Megakaryocytes Hematopoietic Bone Marrow
-
Heart (Cardiovascular System)
- Epicardial Progenitors Cells Epicardium
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Angioblasts Embryonic Blood Islands
- Brain (Nervous System)
- Intermediate Mesoderm (Gastrulation Derivatives)
- Gut Tube (Gastrointestinal Tract)
- NULL (Integumentary System)
- Uncategorized
- Dermis (Integumentary System)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for PDGFA Gene
This gene is overexpressed in Artery - Aorta (x4.4).
This gene is overexpressed in Peripheral blood mononuclear cells (57.2) and Islet of Langerhans (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PDGFA Gene
NURSA nuclear receptor signaling pathways regulating expression of PDGFA Gene:
PDGFASOURCE GeneReport for Unigene cluster for PDGFA Gene:
Hs.535898Evidence on tissue expression from TISSUES for PDGFA Gene
- Muscle(2.7)
- Lung(2.6)
- Heart(2.5)
- Kidney(2.3)
- Nervous system(2.3)
- Skin(2.2)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for PDGFA
-
OriGene qPCR primer pairs for PDGFA
- genomics-online: primer clones - Search results for 142 available PDGFA gene related products
- Overview of 142 available PDGFA gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDGFA Gene
Orthologs for PDGFA Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PDGFA 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PDGFA 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Pdgfa 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pdgfa 33 |
|
||
| cow (Bos Taurus) |
Mammalia | PDGFA 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PDGFA 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PDGFA 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PDGFA 33 |
|
||
| PDGF-A 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | PDGFA 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pdgfa 33 |
|
||
| Str.20307 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | PDGFA 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pdgfaa 33 34 |
|
||
| pdgfab 34 |
|
OneToMany | |||
| pdgfa 33 |
|
- Species where no ortholog for PDGFA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PDGFA Gene
(1) SIMAP similar genes for PDGFA Gene using alignment to 4 proteins:
Variants for PDGFA Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000045852 | -- | 497,632(-) | C/T | 3_prime_UTR_variant | |
| rs1000155153 | -- | 505,880(-) | C/A | intron_variant | |
| rs1000175026 | -- | 519,292(-) | C/T | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000288632 | -- | 520,568(-) | A/G | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000320874 | -- | 520,737(-) | G/C | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2733620 | CNV | deletion | 23290073 |
| nsv1074989 | CNV | deletion | 25765185 |
| nsv1119098 | CNV | deletion | 24896259 |
| nsv1137182 | CNV | deletion | 24896259 |
| nsv1137568 | CNV | deletion | 24896259 |
| nsv1144158 | CNV | deletion | 24896259 |
| nsv950782 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.69;
14.65% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PDGFA Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PDGFA
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDGFA Gene
Disorders for PDGFA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| denys-drash syndrome |
|
|
| pulmonary fibrosis |
|
|
| pulmonary fibrosis, idiopathic |
|
|
| glioblastoma |
|
|
| wrinkles |
|
|
Search PDGFA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PDGFA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PDGFA Gene
Publications for PDGFA Gene
- DNA sequence variants of the platelet-derived growth factor A-chain gene. (PMID: 11678848) Baron R … Drazen JM (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2001) 3 22 44 58
- The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22. (PMID: 1505216) Stenman G … Betsholtz C (Cytogenetics and cell genetics 1992) 2 3 22 58
- Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite. (PMID: 1612586) Bonthron D … Speleman F (Genomics 1992) 3 4 22 58
- Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y … Huang W (Journal of human genetics 2010) 3 44 58
- Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. (PMID: 20534510) Shim AH … He X (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 58
Products for PDGFA Gene
- R&D Systems Antibodies for PDGFA (PDGF)
- R&D Systems Antibodies for PDGFA (PDGF-A)
- R&D Systems Antibodies for PDGFA (PDGF-AA)
- R&D Systems Proteins and Enzymes for PDGFA (PDGF)
- R&D Systems Proteins and Enzymes for PDGFA (PDGF-AA)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for PDGFA (PDGF-AA)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PDGFA
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PDGFA
- Origene Custom Protein Services for PDGFA
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDGFA
- Browse OriGene Inhibitory RNA Products For PDGFA
- OriGene qPCR primer pairs and template standards for PDGFA
- OriGene qPCR primer pairs for PDGFA
- OriGene CRISPR knockouts for PDGFA
- OriGene ORF clones in human for PDGFA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PDGFA
- GenScript: Next-day shipping of latest version cDNA ORF clones for PDGFA in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PDGFA
- GenScript Custom Assay Services for PDGFA
- GenScript Custom overexpressing Cell Line Services for PDGFA
- GenScript: Design CRISPR guide RNA sequences for PDGFA
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PDGFA
- Sino Biological Human cDNA Clone for PDGFA
- Sino Biological Recombinant Proteins for PDGFA
- Sino Biological Cell Lysates for PDGFA
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for PDGFA
- Novus Biologicals lysates and proteins for PDGFA
- Novus Biologicals ELISA Kits for PDGFA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PDGFA
- Abcam proteins for PDGFA
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for PDGFA
- Cloud-Clone Corp. Antibodies for PDGFA
- Cloud-Clone Corp. Proteins for PDGFA
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- ApexBio compounds for PDGFA
- Cyagen custom Knockout/knockin (KOKI) mouse models for PDGFA
- VectorBuilder custom plasmid, inducible vectors for PDGFA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDGFA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 93 available PDGFA Antibodies ranked by validation data
- Compare Top PDGFA Antibodies
- antibodies-online: Search results for 53 available PDGFA Elisa Kits ranked by validation data
- Compare Top PDGFA Elisa Kits
- antibodies-online: Search results for 42 available PDGFA Proteins ranked by validation data
- Compare Top PDGFA Proteins
- Search GeneTex for Antibodies for PDGFA
- Search GeneTex for Proteins for PDGFA
- ViGene Biosciences adenoviral particle packaged cDNA for PDGFA gene
- ViGene Biosciences lentiviral particle packaged cDNA for PDGFA gene
- ViGene Biosciences ready-to-package AAV shRNAs for PDGFA gene
- Search ViGene Biosciences for PDGFA
- Santa Cruz Biotechnology (SCBT) Antibodies for PDGFA
- Search Santa Cruz Biotechnology (SCBT) for PDGFA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PDGFA
- Horizon Cell Lines for PDGFA
- genomics-online: cdna clones - Search results for 142 available PDGFA gene related products
- Overview of 142 available PDGFA gene related products
- orf clones - Search results for 142 available PDGFA gene related products
- Overview of 142 available PDGFA gene related products
- genomics-online: gRNA clones - Search results for 142 available PDGFA gene related products
- Overview of 142 available PDGFA gene related products
- genomics-online: primer clones - Search results for 142 available PDGFA gene related products
- Overview of 142 available PDGFA gene related products
- genomics-online: shRNA clones - Search results for 142 available PDGFA gene related products
- Overview of 142 available PDGFA gene related products
Sources for PDGFA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82)