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This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
PDGFA (Platelet Derived Growth Factor Subunit A) is a Protein Coding gene. Diseases associated with PDGFA include Denys-Drash Syndrome and Ureteral Obstruction. Among its related pathways are Transcriptional misregulation in cancer and RET signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is PDGFB.
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005161 | platelet-derived growth factor receptor binding | IBA,IPI | 2536956 |
GO:0005515 | protein binding | IPI | 7679113 |
GO:0005518 | collagen binding | IDA | 8900172 |
GO:0008083 | growth factor activity | IEA,IDA | 12070119 |
GO:0042803 | protein homodimerization activity | IDA | 2836953 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA,IDA | 3754619 |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0005796 | Golgi lumen | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
3 | GAB1 signalosome |
.89
|
|
4 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
5 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0001525 | angiogenesis | ISS | -- |
GO:0001775 | cell activation | TAS | 10508235 |
GO:0001942 | hair follicle development | ISS | -- |
GO:0002053 | positive regulation of mesenchymal cell proliferation | ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Sunitinib | Approved, Investigational | Pharma | inhibitor | VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 552 | |
Nintedanib (BIBF 1120) | Pharma | VEGFR/PDGFR/FGFR inhibitor | 0 | |||
DMPQ dihydrochloride | Pharma | Potent, selective inhibitor of PDGFRbeta | 0 | |||
Toceranib | Pharma | c-Kit/VEGFR/PDGFR inhibtor, Potent PDGFR and VEGFR inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
SU 6668 |
|
252916-29-3 |
|
|
Compound | Action | Cas Number |
---|---|---|
DMPQ dihydrochloride | Potent, selective inhibitor of PDGFRbeta | 1123491-15-5 |
SU 6668 | PDGFR, VEGFR and FGFR inhibitor | 252916-29-3 |
Toceranib | Potent PDGFR and VEGFR inhibitor | 356068-94-5 |
Compound | Action | Cas Number |
---|---|---|
Nintedanib (BIBF 1120) | VEGFR/PDGFR/FGFR inhibitor | 928326-83-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PDGFA 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PDGFA 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pdgfa 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pdgfa 30 |
|
||
Cow (Bos Taurus) |
Mammalia | PDGFA 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PDGFA 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PDGFA 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PDGFA 30 |
|
||
PDGF-A 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | PDGFA 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pdgfa 30 |
|
||
Str.20307 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | PDGFA 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | pdgfaa 30 31 |
|
OneToMany | |
pdgfab 31 |
|
OneToMany | |||
pdgfa 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2733620 | CNV | deletion | 23290073 |
nsv1074989 | CNV | deletion | 25765185 |
nsv1119098 | CNV | deletion | 24896259 |
nsv1137182 | CNV | deletion | 24896259 |
nsv1137568 | CNV | deletion | 24896259 |
nsv1144158 | CNV | deletion | 24896259 |
nsv950782 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
denys-drash syndrome |
|
|
ureteral obstruction |
|
|
middle cerebral artery infarction |
|
|
retinal detachment |
|
|
familiar ovarian carcinoma |
|
|