Aliases for PDE8B Gene
External Ids for PDE8B Gene
Previous GeneCards Identifiers for PDE8B Gene
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
GeneCards Summary for PDE8B Gene
PDE8B (Phosphodiesterase 8B) is a Protein Coding gene. Diseases associated with PDE8B include Striatal Degeneration, Autosomal Dominant 1 and Pigmented Nodular Adrenocortical Disease, Primary, 3. Among its related pathways are Pyrimidine metabolism (KEGG) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is ENSG00000284762.
UniProtKB/Swiss-Prot for PDE8B Gene
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.