Aliases for PDE8A Gene
External Ids for PDE8A Gene
Previous GeneCards Identifiers for PDE8A Gene
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
GeneCards Summary for PDE8A Gene
PDE8A (Phosphodiesterase 8A) is a Protein Coding gene. Diseases associated with PDE8A include Granulomatous Amebic Encephalitis. Among its related pathways are Signaling by GPCR and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and 3',5'-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE8B.
UniProtKB/Swiss-Prot Summary for PDE8A Gene
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299).
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.