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Aliases for PDE7A Gene

Aliases for PDE7A Gene

  • Phosphodiesterase 7A 2 3 5
  • HCP1 3 4
  • TM22 3 4
  • High Affinity CAMP-Specific 3,5-Cyclic Phosphodiesterase 7A 3
  • Phosphodiesterase Isozyme 7 3
  • EC 3.1.4.53 4
  • PDE7 3

External Ids for PDE7A Gene

Previous GeneCards Identifiers for PDE7A Gene

  • GC08P065764
  • GC08M066569
  • GC08M066354
  • GC08M066681
  • GC08M066793
  • GC08M062120
  • GC08M066629

Summaries for PDE7A Gene

Entrez Gene Summary for PDE7A Gene

  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for PDE7A Gene

PDE7A (Phosphodiesterase 7A) is a Protein Coding gene. Diseases associated with PDE7A include Leukemia, Chronic Lymphocytic. Among its related pathways are Pyrimidine metabolism (KEGG) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE7B.

UniProtKB/Swiss-Prot for PDE7A Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Tocris Summary for PDE7A Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE7A Gene

Additional gene information for PDE7A Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE7A Gene

Genomics for PDE7A Gene

GeneHancer (GH) Regulatory Elements for PDE7A Gene

Promoters and enhancers for PDE7A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J065836 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 654.4 +2.2 2212 7 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 PDE7A MTFR1 C8orf44 DNAJC5B LINC01299 ENSG00000272192 GC08M065824
GH08J065980 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.5 -139.8 -139783 4.1 PKNOX1 SMAD1 STAT5A BMI1 BATF KLF5 IRF4 ZNF207 ZNF143 ATF7 DNAJC5B GC08M065983 PDE7A MTFR1 LINC01299 GC08P065965 LOC105375883
GH08J065944 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.9 -108.5 -108451 12.7 PKNOX1 NEUROD1 SIN3A FEZF1 ZNF2 IRF4 ZNF143 FOS DEK SP3 PDE7A MTFR1 DNAJC5B LINC01299 ENSG00000272010 RRS1 GC08P065965 GC08M065874
GH08J066021 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 16 -180.0 -179960 2.3 PKNOX1 FOXA2 NEUROD1 ZNF766 GLIS2 FOS SP5 REST SMARCB1 GLIS1 LOC105375883 DNAJC5B PDE7A MTFR1 ADHFE1 RRS1 RRS1-AS1 GC08P066013 GC08M066012
GH08J065877 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 17.4 -36.8 -36845 3.3 HDGF SMAD1 IRF4 RELA POLR2A NFATC1 ATF7 ETV6 BCLAF1 IKZF2 PDE7A MTFR1 LINC01299 GC08M065874 GC08P065965
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PDE7A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDE7A gene promoter:
  • Nkx6-1
  • GATA-2
  • AREB6
  • HNF-1A
  • HNF-1
  • c-Jun
  • RORalpha1
  • AP-1
  • c-Fos
  • FosB

Genomic Locations for PDE7A Gene

Genomic Locations for PDE7A Gene
chr8:65,714,334-65,842,322
(GRCh38/hg38)
Size:
127,989 bases
Orientation:
Minus strand
chr8:66,629,745-66,754,557
(GRCh37/hg19)
Size:
124,813 bases
Orientation:
Minus strand

Genomic View for PDE7A Gene

Genes around PDE7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE7A Gene

Proteins for PDE7A Gene

  • Protein details for PDE7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13946-PDE7A_HUMAN
    Recommended name:
    High affinity cAMP-specific 3,5-cyclic phosphodiesterase 7A
    Protein Accession:
    Q13946
    Secondary Accessions:
    • A0AVH6
    • A8K436
    • A8K9G5
    • O15380
    • Q96T72

    Protein attributes for PDE7A Gene

    Size:
    482 amino acids
    Molecular mass:
    55505 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Interacts with CBFA2T3.

    Three dimensional structures from OCA and Proteopedia for PDE7A Gene

    Alternative splice isoforms for PDE7A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE7A Gene

Post-translational modifications for PDE7A Gene

  • Ubiquitination at Lys448
  • Modification sites at PhosphoSitePlus

Other Protein References for PDE7A Gene

No data available for DME Specific Peptides for PDE7A Gene

Domains & Families for PDE7A Gene

Gene Families for PDE7A Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PDE7A Gene

Suggested Antigen Peptide Sequences for PDE7A Gene

Graphical View of Domain Structure for InterPro Entry

Q13946

UniProtKB/Swiss-Prot:

PDE7A_HUMAN :
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.
Domain:
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.
genes like me logo Genes that share domains with PDE7A: view

Function for PDE7A Gene

Molecular function for PDE7A Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
UniProtKB/Swiss-Prot CatalyticActivity:
Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Insensitive to all selective PDE inhibitors.
GENATLAS Biochemistry:
cAMP specific nucleotide phosphodiesterase class VII,A,high affinity with two alternatively spliced forms PDE7A1 and PDE7A2 expressed in skeletal muscle,involved in signal transduction

Enzyme Numbers (IUBMB) for PDE7A Gene

Phenotypes From GWAS Catalog for PDE7A Gene

Gene Ontology (GO) - Molecular Function for PDE7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity TAS,IDA 8389765
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE7A: view
genes like me logo Genes that share phenotypes with PDE7A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PDE7A

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDE7A Gene

Localization for PDE7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE7A Gene

Isoform PDE7A1: Cytoplasm, cytosol. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.
Isoform PDE7A2: Cytoplasm. Note=PDE7A2 (50 kDa) is located to particulate cellular fractions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDE7A gene
Compartment Confidence
cytosol 5
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PDE7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PDE7A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PDE7A Gene

Pathways & Interactions for PDE7A Gene

genes like me logo Genes that share pathways with PDE7A: view

Pathways by source for PDE7A Gene

UniProtKB/Swiss-Prot Q13946-PDE7A_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1.

Gene Ontology (GO) - Biological Process for PDE7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006198 cAMP catabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PDE7A: view

No data available for SIGNOR curated interactions for PDE7A Gene

Drugs & Compounds for PDE7A Gene

(19) Drugs for PDE7A Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dyphylline Approved Pharma inhibitor, Target 0
Trapidil Approved Pharma Target, inhibitor 1
Caffeine Approved Nutra Antagonist, Activator, Target, inhibitor 434
Cafcit Injection Approved September 1999 Pharma 0
Ketotifen Approved Pharma 22

(6) Additional Compounds for PDE7A Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IBMX
Antagonist 28822-58-4
Eggmanone
505068-32-6
Etazolate hydrochloride
35838-58-5
MY-5445
78351-75-4
Ro 20-1724
29925-17-5

(5) Tocris Compounds for PDE7A Gene

Compound Action Cas Number
Eggmanone Potent and selective PDE4 inhibitor; suppresses hedgehog signaling 505068-32-6
Etazolate hydrochloride PDE4 inhibitor 35838-58-5
IBMX PDE inhibitor (non-selective) 28822-58-4
MY-5445 PDE5 inhibitor 78351-75-4
Ro 20-1724 PDE4 inhibitor 29925-17-5

(1) ApexBio Compounds for PDE7A Gene

Compound Action Cas Number
BRL 50481 PDE7 inhibitor,potent and selective
genes like me logo Genes that share compounds with PDE7A: view

Drug Products

Transcripts for PDE7A Gene

Unigene Clusters for PDE7A Gene

Phosphodiesterase 7A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE7A Gene

No ASD Table

Relevant External Links for PDE7A Gene

GeneLoc Exon Structure for
PDE7A
ECgene alternative splicing isoforms for
PDE7A

Expression for PDE7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDE7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE7A Gene

This gene is overexpressed in Muscle - Skeletal (x5.8) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for PDE7A Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDE7A Gene



Protein tissue co-expression partners for PDE7A Gene

NURSA nuclear receptor signaling pathways regulating expression of PDE7A Gene:

PDE7A

SOURCE GeneReport for Unigene cluster for PDE7A Gene:

Hs.527119

mRNA Expression by UniProt/SwissProt for PDE7A Gene:

Q13946-PDE7A_HUMAN
Tissue specificity: PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.

Evidence on tissue expression from TISSUES for PDE7A Gene

  • Muscle(4.4)
  • Kidney(4.2)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with PDE7A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PDE7A Gene

Orthologs for PDE7A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE7A 34 33
  • 99.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PDE7A 34 33
  • 94.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PDE7A 34 33
  • 92.45 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde7a 33
  • 90.8 (n)
mouse
(Mus musculus)
Mammalia Pde7a 16 34 33
  • 90.66 (n)
oppossum
(Monodelphis domestica)
Mammalia PDE7A 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE7A 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDE7A 34 33
  • 83.49 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE7A 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde7a 33
  • 78.64 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32174 33
zebrafish
(Danio rerio)
Actinopterygii pde7a 34 33 33
  • 70.89 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005536 33
  • 51.56 (n)
Species where no ortholog for PDE7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDE7A Gene

ENSEMBL:
Gene Tree for PDE7A (if available)
TreeFam:
Gene Tree for PDE7A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PDE7A: view image

Paralogs for PDE7A Gene

(6) SIMAP similar genes for PDE7A Gene using alignment to 3 proteins:

  • PDE7A_HUMAN
  • E5RG23_HUMAN
  • Q7Z7I0_HUMAN

Pseudogenes.org Pseudogenes for PDE7A Gene

genes like me logo Genes that share paralogs with PDE7A: view

Variants for PDE7A Gene

Sequence variations from dbSNP and Humsavar for PDE7A Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000038038 -- 65,826,072(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000050014 -- 65,831,328(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000070490 -- 65,747,028(-) A/G intron_variant
rs1000087034 -- 65,825,779(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000128510 -- 65,798,044(-) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PDE7A Gene

Variant ID Type Subtype PubMed ID
nsv6233 CNV insertion 18451855
nsv395893 CNV deletion 16902084
nsv395879 CNV deletion 16902084
nsv395873 CNV deletion 16902084
nsv395795 CNV deletion 16902084
esv3617471 CNV gain 21293372
dgv248n6 CNV deletion 16902084
dgv247n6 CNV deletion 16902084

Variation tolerance for PDE7A Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDE7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDE7A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE7A Gene

Disorders for PDE7A Gene

MalaCards: The human disease database

(1) MalaCards diseases for PDE7A Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
leukemia, chronic lymphocytic
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search PDE7A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PDE7A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PDE7A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE7A Gene

Publications for PDE7A Gene

  1. Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. (PMID: 8389765) Michaeli T … Wigler M (The Journal of biological chemistry 1993) 2 3 4 22 58
  2. Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7. (PMID: 15994308) Wang H … Ke H (The Journal of biological chemistry 2005) 3 4 22 58
  3. Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart. (PMID: 9195912) Han P … Michaeli T (The Journal of biological chemistry 1997) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for PDE7A Gene

Sources for PDE7A Gene

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