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Aliases for PDE4C Gene

Aliases for PDE4C Gene

  • Phosphodiesterase 4C 2 3 5
  • DPDE1 3 4
  • PDE21 3 4
  • Phosphodiesterase 4C, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E1) 2
  • Phosphodiesterase 4C, CAMP-Specific (Phosphodiesterase E1 Dunce Homolog, Drosophila) 3
  • Phosphodiesterase E1 Dunce Homolog (Drosophila) 2
  • CAMP-Specific 3,5-Cyclic Phosphodiesterase 4C 3
  • Phosphodiesterase 4C, CAMP-Specific 2
  • Dunce-Like Phosphodiesterase E1 3
  • EC 3.1.4.53 4

External Ids for PDE4C Gene

Previous HGNC Symbols for PDE4C Gene

  • DPDE1

Previous GeneCards Identifiers for PDE4C Gene

  • GC19M018814
  • GC19M018678
  • GC19M018165
  • GC19M018318
  • GC19M017882

Summaries for PDE4C Gene

Entrez Gene Summary for PDE4C Gene

  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for PDE4C Gene

PDE4C (Phosphodiesterase 4C) is a Protein Coding gene. Diseases associated with PDE4C include Ocular Hypotension. Among its related pathways are Pyrimidine metabolism (KEGG) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is ENSG00000285188.

UniProtKB/Swiss-Prot for PDE4C Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Tocris Summary for PDE4C Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE4C Gene

Additional gene information for PDE4C Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE4C Gene

Genomics for PDE4C Gene

GeneHancer (GH) Regulatory Elements for PDE4C Gene

Promoters and enhancers for PDE4C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J018223 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 686.5 +23.3 23333 2.8 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 POLR2B ZNF213 E2F8 PDE4C IQCN MPV17L2 ENSG00000268938 ENSG00000269191 ENSG00000268030 UPF1 NR2C2AP PLVAP LSM4
GH19J018231 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 650.4 +15.4 15380 2.2 CLOCK ZFP64 ARID4B SIN3A SLC30A9 ZNF766 ZNF143 MXD4 REST SMARCB1 PDE4C IQCN JUND ENSG00000285188 LOC102725254
GH19J018222 Promoter 1 EPDnew 662.9 +26.0 25955 0.1 NCOA3 ELF3 IRF2 SAP130 ZNF644 ZNF48 ZNF614 NCOR1 NR2F6 SP5 PDE4C IQCN MPV17L2 LSM4 LOC102725254 ENSG00000285188
GH19J018226 Promoter 0.7 EPDnew 663.5 +21.7 21742 0.1 VEZF1 ZNF48 PDE4C MPV17L2 IQCN LOC102725254 ENSG00000285188
GH19J018211 Promoter 0.6 EPDnew 663.4 +36.3 36345 0.1 ZBTB33 PDE4C IQCN LSM4 LOC102725254 ENSG00000285188
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDE4C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDE4C gene promoter:
  • NRSF form 1
  • NRSF form 2

Genomic Locations for PDE4C Gene

Genomic Locations for PDE4C Gene
chr19:18,207,961-18,248,200
(GRCh38/hg38)
Size:
40,240 bases
Orientation:
Minus strand
chr19:18,318,771-18,366,229
(GRCh37/hg19)
Size:
47,459 bases
Orientation:
Minus strand

Genomic View for PDE4C Gene

Genes around PDE4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE4C Gene

Proteins for PDE4C Gene

  • Protein details for PDE4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08493-PDE4C_HUMAN
    Recommended name:
    cAMP-specific 3,5-cyclic phosphodiesterase 4C
    Protein Accession:
    Q08493
    Secondary Accessions:
    • B3KTC4
    • Q9UN44
    • Q9UN45
    • Q9UN46
    • Q9UPJ6
    • B3KTC4
    • Q9UN44
    • Q9UN45
    • Q9UN46
    • Q9UPJ6

    Protein attributes for PDE4C Gene

    Size:
    712 amino acids
    Molecular mass:
    79902 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.
    • Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.

    Three dimensional structures from OCA and Proteopedia for PDE4C Gene

    Alternative splice isoforms for PDE4C Gene

neXtProt entry for PDE4C Gene

Post-translational modifications for PDE4C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PDE4C Gene

Domains & Families for PDE4C Gene

Gene Families for PDE4C Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for PDE4C Gene

Graphical View of Domain Structure for InterPro Entry

Q08493

UniProtKB/Swiss-Prot:

PDE4C_HUMAN :
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
genes like me logo Genes that share domains with PDE4C: view

Function for PDE4C Gene

Molecular function for PDE4C Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
UniProtKB/Swiss-Prot CatalyticActivity:
Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by rolipram.
GENATLAS Biochemistry:
cAMP specific nucleotide phosphodiesterase class IV,C,with homology to Drosophila dunce gene,involved in signal transduction

Enzyme Numbers (IUBMB) for PDE4C Gene

Phenotypes From GWAS Catalog for PDE4C Gene

Gene Ontology (GO) - Molecular Function for PDE4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity TAS --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE4C: view
genes like me logo Genes that share phenotypes with PDE4C: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PDE4C

CRISPR Products

miRNA for PDE4C Gene

miRTarBase miRNAs that target PDE4C

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDE4C

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDE4C Gene

Localization for PDE4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE4C Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDE4C gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PDE4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005829 cytosol TAS --
GO:0005929 cilium ISS --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with PDE4C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PDE4C Gene

Pathways & Interactions for PDE4C Gene

genes like me logo Genes that share pathways with PDE4C: view

UniProtKB/Swiss-Prot Q08493-PDE4C_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1.
  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1.

Interacting Proteins for PDE4C Gene

SIGNOR curated interactions for PDE4C Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PDE4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006198 cAMP catabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PDE4C: view

Drugs & Compounds for PDE4C Gene

(33) Drugs for PDE4C Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dyphylline Approved Pharma inhibitor, Target 0
Ibudilast Approved, Investigational Pharma inhibitor, Target 11
Iloprost Approved, Investigational Pharma Full agonist, Agonist, Target, inducer Others, Prostacyclin (PGI2) analog 83
Roflumilast Approved Pharma Target, inhibitor PDE-4 inhibitor 0
Crisaborole Approved, Investigational Pharma Target, inhibitor 0

(6) Additional Compounds for PDE4C Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ro201724
Inhibition, Inhibitor
Eggmanone
505068-32-6
Etazolate hydrochloride
35838-58-5
IBMX
Antagonist 28822-58-4
MY-5445
78351-75-4

(5) Tocris Compounds for PDE4C Gene

Compound Action Cas Number
Eggmanone Potent and selective PDE4 inhibitor; suppresses hedgehog signaling 505068-32-6
Etazolate hydrochloride PDE4 inhibitor 35838-58-5
IBMX PDE inhibitor (non-selective) 28822-58-4
MY-5445 PDE5 inhibitor 78351-75-4
Ro 20-1724 PDE4 inhibitor 29925-17-5
genes like me logo Genes that share compounds with PDE4C: view

Transcripts for PDE4C Gene

mRNA/cDNA for PDE4C Gene

Unigene Clusters for PDE4C Gene

Phosphodiesterase 4C, cAMP-specific:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDE4C

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE4C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - -
SP7:
SP8: -
SP9:
SP10: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PDE4C Gene

GeneLoc Exon Structure for
PDE4C
ECgene alternative splicing isoforms for
PDE4C

Expression for PDE4C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDE4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDE4C Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDE4C Gene



Protein tissue co-expression partners for PDE4C Gene

NURSA nuclear receptor signaling pathways regulating expression of PDE4C Gene:

PDE4C

SOURCE GeneReport for Unigene cluster for PDE4C Gene:

Hs.132584

mRNA Expression by UniProt/SwissProt for PDE4C Gene:

Q08493-PDE4C_HUMAN
Tissue specificity: Expressed in various tissues but not in cells of the immune system.

Evidence on tissue expression from TISSUES for PDE4C Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PDE4C: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDE4C Gene

Orthologs for PDE4C Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE4C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PDE4C 34 33
  • 87.21 (n)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDE4C 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDE4C 34 33
  • 86.04 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde4c 33
  • 81.29 (n)
mouse
(Mus musculus)
Mammalia Pde4c 16 34 33
  • 80.66 (n)
oppossum
(Monodelphis domestica)
Mammalia PDE4C 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii pde4cb 34
  • 66 (a)
OneToMany
pde4ca 34
  • 62 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3555 33
fruit fly
(Drosophila melanogaster)
Insecta dnc 35
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea R153.1a 35
  • 55 (a)
R153.1b 35
  • 53 (a)
Species where no ortholog for PDE4C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PDE4C Gene

ENSEMBL:
Gene Tree for PDE4C (if available)
TreeFam:
Gene Tree for PDE4C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PDE4C: view image

Paralogs for PDE4C Gene

(16) SIMAP similar genes for PDE4C Gene using alignment to 16 proteins:

  • PDE4C_HUMAN
  • B7Z6T1_HUMAN
  • M0R1P5_HUMAN
  • O43849_HUMAN
  • O43850_HUMAN
  • O43851_HUMAN
  • O76104_HUMAN
  • O76105_HUMAN
  • Q2VPB9_HUMAN
  • Q32MM7_HUMAN
  • Q9P1U3_HUMAN
  • Q9UPJ5_HUMAN
  • U3KPR3_HUMAN
  • U3KPR4_HUMAN
  • V9GYN0_HUMAN
  • V9GYP2_HUMAN
genes like me logo Genes that share paralogs with PDE4C: view

Variants for PDE4C Gene

Sequence variations from dbSNP and Humsavar for PDE4C Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000039674 -- 18,227,063(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000088975 -- 18,220,633(-) C/T intron_variant
rs1000101105 -- 18,234,786(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000127365 -- 18,240,133(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000231320 -- 18,249,768(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PDE4C Gene

Variant ID Type Subtype PubMed ID
nsv1071516 CNV deletion 25765185
nsv1131407 CNV deletion 24896259
nsv1131408 CNV deletion 24896259
nsv470131 CNV loss 18288195
nsv833775 CNV loss 17160897
nsv952420 CNV deletion 24416366

Variation tolerance for PDE4C Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.27; 85.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDE4C Gene

Human Gene Mutation Database (HGMD)
PDE4C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDE4C

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE4C Gene

Disorders for PDE4C Gene

MalaCards: The human disease database

(1) MalaCards diseases for PDE4C Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
ocular hypotension
  • hypotony of eye
- elite association - COSMIC cancer census association via MalaCards
Search PDE4C in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PDE4C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PDE4C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE4C Gene

Publications for PDE4C Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. (PMID: 17727341) Wang H … Ke H (The Biochemical journal 2007) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  5. Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain. (PMID: 11207431) Pérez-Torres S … Mengod G (Journal of chemical neuroanatomy 2000) 3 22 58

Products for PDE4C Gene

Sources for PDE4C Gene

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