Aliases for PDE4B Gene
- Phosphodiesterase 4B 2 3 5
- CAMP-Specific 3',5'-Cyclic Phosphodiesterase 4B 2 3 4
- Phosphodiesterase 4B, CAMP-Specific (Phosphodiesterase E4 Dunce Homolog, Drosophila) 2 3
- DPDE4 3 4
- Phosphodiesterase 4B, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E4) 2
- Phosphodiesterase E4 Dunce Homolog (Drosophila) 2
External Ids for PDE4B Gene
Previous HGNC Symbols for PDE4B Gene
Previous GeneCards Identifiers for PDE4B Gene
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
GeneCards Summary for PDE4B Gene
PDE4B (Phosphodiesterase 4B) is a Protein Coding gene. Diseases associated with PDE4B include Ocular Hypotension and Schizophrenia 1. Among its related pathways are DAG and IP3 signaling and Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling. Gene Ontology (GO) annotations related to this gene include ion channel binding and cAMP binding. An important paralog of this gene is PDE4D.
UniProtKB/Swiss-Prot Summary for PDE4B Gene
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.