PDE4B Gene (Protein Coding)

Phosphodiesterase 4B

GC01P065792
GIFtS:
44
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use... See more...

Aliases for PDE4B Gene

Aliases for PDE4B Gene

  • Phosphodiesterase 4B 2 3 5
  • CAMP-Specific 3',5'-Cyclic Phosphodiesterase 4B 2 3 4
  • Phosphodiesterase 4B, CAMP-Specific (Phosphodiesterase E4 Dunce Homolog, Drosophila) 2 3
  • DPDE4 3 4
  • Phosphodiesterase 4B, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E4) 2
  • Phosphodiesterase E4 Dunce Homolog (Drosophila) 2
  • Phosphodiesterase 4B, CAMP-Specific 2
  • Dunce-Like Phosphodiesterase E4 3
  • EC 3.1.4.17 51
  • EC 3.1.4.53 4
  • EC 3.1.4 51
  • PDEIVB 3
  • PDE4B 5
  • PDE32 4

External Ids for PDE4B Gene

Previous HGNC Symbols for PDE4B Gene

  • DPDE4

Previous GeneCards Identifiers for PDE4B Gene

  • GC01P066339
  • GC01P065729
  • GC01P065615
  • GC01P065628
  • GC01P065970
  • GC01P064366

Summaries for PDE4B Gene

Entrez Gene Summary for PDE4B Gene

  • This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for PDE4B Gene

PDE4B (Phosphodiesterase 4B) is a Protein Coding gene. Diseases associated with PDE4B include Schizophrenia and Brugada Syndrome 3. Among its related pathways are Neuroscience and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include ion channel binding and cAMP binding. An important paralog of this gene is PDE4D.

UniProtKB/Swiss-Prot Summary for PDE4B Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Tocris Summary for PDE4B Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE4B Gene

Additional gene information for PDE4B Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDE4B Gene

Genomics for PDE4B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PDE4B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J066329 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 613 +541.6 541627 9.3 SP1 PRDM10 ZNF629 POLR2A BACH1 FOXA1 LARP7 STAT3 PRDM1 ZNF143 PDE4B MIER1 SLC35D1 HSALNG0004217 piR-61289-003 SGIP1
GH01J066339 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 607.9 +555.1 555065 17 SP1 PRDM10 RFX1 POLR2A BACH1 ZNF143 RELA TCF12 IKZF2 TRIM22 PDE4B HSALNG0004217 piR-61289-003 SGIP1
GH01J065791 Promoter 1.5 EPDnew Ensembl CraniofacialAtlas 600.7 +0.5 490 2.4 PRDM10 PRDM1 ZSCAN4 EZH2 ZNF561 SCRT2 ZBTB20 ZBTB48 ZBTB26 SCRT1 PDE4B PDE4B-AS1 SGIP1
GH01J065992 Promoter/Enhancer 1.1 EPDnew Ensembl dbSUPER 600.1 +201.9 201890 4.4 CTCF POLR2A RAD21 SIN3A EZH2 PDE4B PDE4B-AS1 SGIP1
GH01J066315 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 32.3 +524.2 524191 2.6 REST FOXA1 GABPA SP1 FOXA2 ATF3 YY1 ZBTB33 JUND NR2F2 PDE4B HSALNG0004217 piR-61289-003 SGIP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDE4B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDE4B

Top Transcription factor binding sites by QIAGEN in the PDE4B gene promoter:
  • AREB6
  • C/EBPbeta
  • FOXL1
  • FOXO4
  • Lmo2
  • Sox5
  • Sox9
  • SRY

Genomic Locations for PDE4B Gene

Genomic Locations for PDE4B Gene
chr1:65,792,510-66,374,579
(GRCh38/hg38)
Size:
582,070 bases
Orientation:
Plus strand
chr1:66,258,193-66,840,262
(GRCh37/hg19)
Size:
582,070 bases
Orientation:
Plus strand

Genomic View for PDE4B Gene

Genes around PDE4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE4B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PDE4B Gene

Proteins for PDE4B Gene

Products:

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  • Protein details for PDE4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07343-PDE4B_HUMAN
    Recommended name:
    cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    Protein Accession:
    Q07343
    Secondary Accessions:
    • A5YW33
    • O15443
    • Q13945
    • Q5TEK4
    • Q5TEK5
    • Q5TEK6

    Protein attributes for PDE4B Gene

    Size:
    736 amino acids
    Molecular mass:
    83343 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA35643.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform PDE4B5]: Brain-specific isoform.

    Three dimensional structures from OCA and Proteopedia for PDE4B Gene

    Alternative splice isoforms for PDE4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE4B Gene

Protein Expression for PDE4B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PDE4B Gene

Q07343:
  • SVLENHH
  • EELDWCLDQLET
  • VLATDMS
  • IVTPFAQVLASLR
  • AVFTDLEILAA
  • LDTLEDNR
  • QERDLLKTF
  • QISGVKKLMHSSSL
  • EMASNKFKR
  • ETLEELDWCL
  • LNRELTHLSE
  • IPQSPSP
  • DLIVTPFAQ
  • LTKKQRQ
  • LLADLKTMVE
  • VHCADLSNP
  • SVLENHHLAVGFKLLQ
  • PDAQDILDTLE
  • IDMVLAT
  • QSTHVLL
  • RRESFLYR
  • EKSQVGFIDYI
  • HDVDHPG
  • HNSLHAADV
  • VEIPSPT
  • SVSEMAS
  • MYNDESVLE
  • TDMSKHM
  • ETWADLV
  • KKQRQTLRKMVID
  • RQWTDRI
  • GVLLLDNY

Post-translational modifications for PDE4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDE4B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PDE4B Gene

Gene Families for PDE4B Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PDE4B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PDE4B Gene

GenScript: Design optimal peptide antigens:
  • Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila) (B1AN65_HUMAN)
  • PDE32 (PDE4B_HUMAN)
  • cDNA FLJ75521, highly similar to Homo sapiens cyclic AMP specific phosphodiesterase mRNA (Q5TEK4_HUMAN)
  • cDNA FLJ75596, highly similar to Homo sapiens phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) (PDE4B), mRNA (Q5TEK6_HUMAN)
  • Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila) (Q5TEK7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q07343

UniProtKB/Swiss-Prot:

PDE4B_HUMAN :
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
genes like me logo Genes that share domains with PDE4B: view

Function for PDE4B Gene

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  2. CRISPR
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  6. Cell Line

Molecular function for PDE4B Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by rolipram.
GENATLAS Biochemistry:
cAMP specific nucleotide phosphodiesterase class IV,B,with homology to Drosophila dunce gene,involved in signal transduction

Enzyme Numbers (IUBMB) for PDE4B Gene

Phenotypes From GWAS Catalog for PDE4B Gene

Gene Ontology (GO) - Molecular Function for PDE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity IEA --
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity TAS,ISS --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0030552 cAMP binding IGI 8413254
genes like me logo Genes that share ontologies with PDE4B: view
genes like me logo Genes that share phenotypes with PDE4B: view

Animal Models for PDE4B Gene

MGI Knock Outs for PDE4B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDE4B

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDE4B Gene

Localization for PDE4B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDE4B gene
Compartment Confidence
plasma membrane 4
cytosol 4
cytoskeleton 3
extracellular 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000930 gamma-tubulin complex IEA --
GO:0005813 centrosome IEA --
GO:0005829 cytosol TAS --
GO:0005891 voltage-gated calcium channel complex ISS --
GO:0008021 synaptic vesicle IEA --
genes like me logo Genes that share ontologies with PDE4B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE4B Gene

Pathways & Interactions for PDE4B Gene

genes like me logo Genes that share pathways with PDE4B: view

Pathways by source for PDE4B Gene

1 PharmGKB pathway for PDE4B Gene
2 Qiagen pathways for PDE4B Gene
  • Cellular Effects of Sildenafil
  • Sperm Motility
2 Cell Signaling Technology pathways for PDE4B Gene

UniProtKB/Swiss-Prot Q07343-PDE4B_HUMAN

  • Pathway: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

SIGNOR curated interactions for PDE4B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PDE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001780 neutrophil homeostasis ISS --
GO:0006198 cAMP catabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0030593 neutrophil chemotaxis ISS --
genes like me logo Genes that share ontologies with PDE4B: view

Drugs & Compounds for PDE4B Gene

Products:

  1. Drug

(55) Drugs for PDE4B Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amrinone Approved Pharma Target, inhibitor 0
Caffeine Approved Pharma Antagonist, Activator, Target, Target, inhibitor, antagonist 603
Dyphylline Approved Pharma Target, inhibitor 0
Enprofylline Approved, Experimental Pharma Target, inhibitor 0
Papaverine Approved, Investigational Pharma Target, inhibitor 18

(6) Additional Compounds for PDE4B Gene - From: Tocris and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ro201724
Inhibitor, Inhibition
Eggmanone
505068-32-6
Etazolate hydrochloride
35838-58-5
IBMX
Antagonist 28822-58-4
MY-5445
78351-75-4

(5) Tocris Compounds for PDE4B Gene

Compound Action Cas Number
Eggmanone Potent and selective PDE4 inhibitor; suppresses hedgehog signaling 505068-32-6
Etazolate hydrochloride PDE4 inhibitor 35838-58-5
IBMX PDE inhibitor (non-selective) 28822-58-4
MY-5445 PDE5 inhibitor 78351-75-4
Ro 20-1724 PDE4 inhibitor 29925-17-5

(10) ApexBio Compounds for PDE4B Gene

Compound Action Cas Number
AN-2728 PDE4 inhibitor,anti-inflammatory compound 906673-24-3
Apremilast (CC-10004) PDE4 inhibitor 608141-41-9
CDP 840 hydrochloride PDE4 inhibitor,potent and selective 162542-90-7
Cilomilast Potent PDE4 inhibitor 153259-65-5
Doxofylline 69975-86-6
GSK256066 PDE4-inhibitor,selective and highly potent 801312-28-7
Irsogladine PDE4 inhibitor 57381-26-7
Roflumilast PDE-4 inhibitor 162401-32-3
Rolipram PDE4-inhibitor and an anti-inflammatory agent 61413-54-5
S- (+)-Rolipram CAMP-specific PDE4 inhibitor 85416-73-5
genes like me logo Genes that share compounds with PDE4B: view

Drug Products

Transcripts for PDE4B Gene

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mRNA/cDNA for PDE4B Gene

7 REFSEQ mRNAs :
32 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDE4B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE4B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10: - - - - - - - - - -

ExUns: 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PDE4B Gene

GeneLoc Exon Structure for
PDE4B

Expression for PDE4B Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PDE4B Gene

mRNA expression in normal human tissues for PDE4B Gene
mRNA expression by BioGPS for PDE4B GenemRNA expression by GTEx for PDE4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDE4B Gene

This gene is overexpressed in Fetal Brain (50.8) and Heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDE4B Gene



Protein tissue co-expression partners for PDE4B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDE4B

SOURCE GeneReport for Unigene cluster for PDE4B Gene:

Hs.198072

mRNA Expression by UniProt/SwissProt for PDE4B Gene:

Q07343-PDE4B_HUMAN
Tissue specificity: Expressed in brain, heart, lung and skeletal muscle.

Evidence on tissue expression from TISSUES for PDE4B Gene

  • Nervous system(5)
  • Muscle(2.9)
  • Heart(2.6)
  • Spleen(2.5)
  • Blood(2.4)
  • Lung(2.4)
  • Intestine(2.4)
  • Bone marrow(2.1)
  • Skin(2.1)
  • Lymph node(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with PDE4B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDE4B Gene

Orthologs for PDE4B Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE4B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PDE4B 30 31
  • 99.49 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia PDE4B 31
  • 93 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia PDE4B 30 31
  • 92.33 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia PDE4B 30 31
  • 92.14 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia PDE4B 31
  • 90 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Pde4b 30 17 31
  • 89.74 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Pde4b 30
  • 89 (n)
Chicken
(Gallus gallus)
 Aves PDE4B 30 31
  • 79.12 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia PDE4B 31
  • 91 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia pde4c 30
  • 71.23 (n)
Str.13756 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.1853 30
Zebrafish
(Danio rerio)
 Actinopterygii pde4bb 31
  • 79 (a)
 OneToMany
PDE4B (3 of 3) 31
  • 78 (a)
 OneToMany
pde4ba 30 31
  • 73.74 (n)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta dnc 32
  • 61 (a)
Worm
(Caenorhabditis elegans)
 Secernentea R153.1a 32
  • 58 (a)
R153.1b 32
  • 58 (a)
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.3388 30
Species where no ortholog for PDE4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PDE4B Gene

ENSEMBL:
Gene Tree for PDE4B (if available)
TreeFam:
Gene Tree for PDE4B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PDE4B: view image

Paralogs for PDE4B Gene

Paralogs for PDE4B Gene

(8) SIMAP similar genes for PDE4B Gene using alignment to 6 proteins:

  • PDE4B_HUMAN
  • E9PJ03_HUMAN
  • E9PMG3_HUMAN
  • E9PNB0_HUMAN
  • E9PR34_HUMAN
  • H0YCV7_HUMAN
genes like me logo Genes that share paralogs with PDE4B: view

Variants for PDE4B Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDE4B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
708064 Benign: not provided 66,372,393(+) C/T SYNONYMOUS_VARIANT
718969 Benign: not provided 66,365,723(+) C/T SYNONYMOUS_VARIANT
728986 Benign: not provided 66,372,574(+) A/T MISSENSE_VARIANT
773110 Benign: not provided 66,368,912(+) G/A SYNONYMOUS_VARIANT
798852 Likely Benign: not provided 66,363,203(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PDE4B Gene

Structural Variations from Database of Genomic Variants (DGV) for PDE4B Gene

Variant ID Type Subtype PubMed ID
dgv3n17 CNV loss 16327808
dgv97n106 CNV deletion 24896259
esv1957663 CNV deletion 18987734
esv2449251 CNV deletion 19546169
esv25256 CNV loss 19812545
esv2584680 CNV deletion 19546169
esv2668868 CNV deletion 23128226
esv2671160 CNV deletion 23128226
esv2672085 CNV deletion 23128226
esv2673068 CNV deletion 23128226
esv2676257 CNV deletion 23128226
esv2749318 CNV deletion 23290073
esv2749329 CNV deletion 23290073
esv2749340 CNV deletion 23290073
esv2749351 CNV deletion 23290073
esv2762148 CNV gain 21179565
esv2764244 CNV loss 21179565
esv3306072 CNV mobile element insertion 20981092
esv3365990 CNV insertion 20981092
esv3402340 CNV insertion 20981092
esv3563349 CNV deletion 23714750
esv3563371 CNV deletion 23714750
esv3586289 CNV loss 21293372
esv3586291 CNV loss 21293372
esv3586292 CNV loss 21293372
esv3586293 CNV loss 21293372
esv3586294 CNV loss 21293372
esv4724 CNV loss 18987735
nsv1014111 CNV loss 25217958
nsv1122357 CNV deletion 24896259
nsv1127004 CNV deletion 24896259
nsv1133862 CNV deletion 24896259
nsv1145349 CNV deletion 24896259
nsv1199 CNV insertion 18451855
nsv159040 CNV deletion 16902084
nsv159464 CNV deletion 16902084
nsv160460 CNV deletion 16902084
nsv437216 CNV loss 16327808
nsv461716 CNV gain 19166990
nsv475416 CNV novel sequence insertion 20440878
nsv506931 OTHER sequence alteration 20534489
nsv546440 CNV gain 21841781
nsv998127 CNV loss 25217958

Variation tolerance for PDE4B Gene

Residual Variation Intolerance Score: 7.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDE4B Gene

Human Gene Mutation Database (HGMD)
PDE4B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDE4B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE4B Gene

Disorders for PDE4B Gene

MalaCards: The human disease database

(8) MalaCards diseases for PDE4B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • sczd
brugada syndrome 3
  • brgda3
schizophrenia 1
  • sczd1
bipolar disorder
  • major affective disorder 1
ocular hypotension
  • hypotony of eye
- elite association - COSMIC cancer census association via MalaCards
Search PDE4B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PDE4B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PDE4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE4B Gene

Publications for PDE4B Gene

  1. Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples. (PMID: 19350560) Kähler AK … Djurovic S (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 23 41
  2. Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia. (PMID: 19632097) Rastogi A … Wong AH (Schizophrenia research 2009) 3 23 41
  3. Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. (PMID: 18785206) Numata S … Ohmori T (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 23 41
  4. Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population. (PMID: 18329668) Numata S … Ohmori T (Journal of psychiatric research 2008) 3 23 41
  5. PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. (PMID: 18394866) Fatemi SH … Menniti FS (Schizophrenia research 2008) 3 23 41

ExternalLinks

View latest publications for PDE4B gene in Mastermind

Products for PDE4B Gene

  • Signalway Proteins for PDE4B

Sources for PDE4B Gene