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The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological pr... See more...
Aliases for PDE4A Gene
Aliases for PDE4A Gene
External Ids for PDE4A Gene
- HGNC: 8780
- Entrez Gene: 5141
- Ensembl: ENSG00000065989
- OMIM: 600126
- UniProtKB: P27815
Previous HGNC Symbols for PDE4A Gene
- DPDE2
Previous GeneCards Identifiers for PDE4A Gene
- GC19P010663
- GC19P010376
- GC19P010392
- GC19P010527
- GC19P010111
Summaries for PDE4A Gene
-
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
GeneCards Summary for PDE4A Gene
PDE4A (Phosphodiesterase 4A) is a Protein Coding gene. Diseases associated with PDE4A include Asthma and Pulmonary Eosinophilia. Among its related pathways are ADP signalling through P2Y purinoceptor 12 and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include 3',5'-cyclic-nucleotide phosphodiesterase activity and 3',5'-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE4D.
UniProtKB/Swiss-Prot Summary for PDE4A Gene
-
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
-
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.
Additional gene information for PDE4A Gene
- HGNC(8780)
- Entrez Gene(5141)
- Ensembl(ENSG00000065989)
- OMIM(600126)
- UniProtKB(P27815)
- Open Targets Platform(ENSG00000065989)
- Monarch Initiative
- Search for PDE4A at DataMed
- Search for PDE4A at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDE4A Gene
Genomics for PDE4A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PDE4A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PDE4A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDE4A
- Top Transcription factor binding sites by QIAGEN in the PDE4A gene promoter:
-
- AP-1
- C/EBPalpha
- CREB
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for PDE4A Gene
Genomic Locations for PDE4A Gene
- chr19:10,416,773-10,469,631
- (GRCh38/hg38)
- Size:
- 52,859 bases
- Orientation:
- Plus strand
- chr19:10,527,449-10,580,307
- (GRCh37/hg19)
- Size:
- 52,859 bases
- Orientation:
- Plus strand
Genomic View for PDE4A Gene
Genes around PDE4A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
PDE4A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDE4A Gene
Proteins for PDE4A Gene
-
Protein details for PDE4A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P27815-PDE4A_HUMAN
- Recommended name:
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A
- Protein Accession:
- P27815
- O75522
- O76092
- Q16255
- Q16691
- Q5DM53
- Q6PMT2
- Q8IVA7
- Q8WUQ3
- Q9H3H2
Protein attributes for PDE4A Gene
- Size:
- 886 amino acids
- Molecular mass:
- 98143 Da
- Cofactor:
- Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Quaternary structure:
-
- Isoform 1 interacts with LYN. Isoform 2 and isoform 6 interact weakly with LYN. Isoform 1, isoform 2 and isoform 6 interact with ARRB2.
- Miscellaneous:
-
- [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Probably represents a non-functional splice isoform.
Protein Expression for PDE4A Gene
Selected DME Specific Peptides for PDE4A Gene
- P27815:
-
- SVLENHH
- VLATDMS
- IVTPFAQVLASLR
- HLWRQPR
- AVFTDLEILAA
- LDTLEDNR
- PIRIQQR
- ETLEELDWCL
- LNRELTHLSE
- DLIVTPFAQ
- LLADLKTMVE
- FELTLEE
- CDIFQNL
- VHCADLSNP
- SVLENHHLAVGFKLLQ
- IDMVLAT
- QSTHVLL
- RRESFLYR
- EKSQVGFIDYI
- HDVDHPG
- HNSLHAADV
- VEIPSPT
- SVSEMAS
- MYNDESVLE
- TDMSKHM
- ETWADLV
- RQWTDRI
- RMSWPSSF
- GVLLLDNY
Post-translational modifications for PDE4A Gene
- Phosphorylation by MAPKAPK2 its activation through PKA phosphorylation (By similarity). Phosphorylated at Ser-686 and Ser-688 when expressed in S.frugiperda cells. Isoform 2 and isoform 7 are activated by phosphorylation at Ser-119 and Ser-123 respectively by PKA.
- Proteolytically cleaved by caspase-3.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PDE4A Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PDE4A
- AP00655SU-N
- CF501152
- CF501153
- CF501192
- CF501198
- CF501199
- CF501200
- CF501201
- CF501202
- CF501203
- CF501206
- CF501207
- TA351506
- TA501152
- TA501152S
- TA501153
- TA501153S
- TA501192
- TA501192S
- TA501198
- TA501198S
- TA501199
- TA501199S
- TA501200
- TA501200S
- TA501201
- TA501201S
- TA501202
- TA501202S
- TA501203
- TA501203S
- TA501206
- TA501206S
- TA501207
- TA501207S
- Novus Biologicals Antibodies for PDE4A
- Invitrogen Antibodies for PDE4A (AFLGC-Pde4a)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDE4A
Protein Products
-
OriGene Purified Proteins for PDE4A
- Search Origene for MassSpec and Protein Over-expression Lysates for PDE4A
- Origene Custom Protein Services for PDE4A
-
Abcam proteins for PDE4A
Domains & Families for PDE4A Gene
Gene Families for PDE4A Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for PDE4A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PDE4A Gene
- GenScript: Design optimal peptide antigens:
-
- PDE46 (PDE4A_HUMAN)
- Phosphodiesterase isozyme 4 (Q86V67_HUMAN)
- CAMP specific phosphodiesterase variant PDE4A-10 (Q9HC30_HUMAN)
- CAMP specific phosphodiesterase variant TM3 (Q9HC31_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P27815UniProtKB/Swiss-Prot:
PDE4A_HUMAN :- Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
- Family:
-
- Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Function for PDE4A Gene
Molecular function for PDE4A Gene
- UniProtKB/Swiss-Prot Function:
- Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53;.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=4.0 uM for cAMP (isoform 2) {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}; KM=3 uM for cAMP (isoform 6) {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Isoform 1, isoform 2, isoform 6 and isoform 7 are inhibited by rolipram and cilomilast. Isoform 1, isoform 2 and isoform 6 are inhibited by 4-[(3-butoxy-4-methoxyphenyl)-methyl]-2-imidazolidinone (Ro 20-1724), roflumilast and denbufylline.
- GENATLAS Biochemistry:
- cAMP specific nucleotide phosphodiesterase class IV,A,with homology to Drosophila dunce gene,involved in signal transduction
Enzyme Numbers (IUBMB) for PDE4A Gene
Phenotypes From GWAS Catalog for PDE4A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | IEA | -- |
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | TAS,IGI | 8413254 |
| GO:0005515 | protein binding | IPI | 11306681 |
| GO:0008081 | phosphoric diester hydrolase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PDE4A Gene
- MGI mutant phenotypes for PDE4A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PDE4A:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PDE4A - Select products 50% OFF >
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OriGene CRISPR knockouts for PDE4A
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-
Santa Cruz Biotechnology (SCBT) CRISPR for PDE4A
miRNA for PDE4A Gene
- miRTarBase miRNAs that target PDE4A
-
- hsa-miR-335-5p (MIRT016809)
- hsa-miR-744-5p (MIRT037515)
- hsa-miR-18a-3p (MIRT040823)
- hsa-miR-19a-3p (MIRT149309)
- hsa-miR-19b-3p (MIRT149310)
- hsa-miR-6731-5p (MIRT149366)
- hsa-miR-6846-5p (MIRT149369)
- hsa-miR-6848-5p (MIRT149370)
- hsa-miR-8085 (MIRT149377)
- hsa-miR-6825-5p (MIRT492787)
- hsa-miR-6729-5p (MIRT492788)
- hsa-miR-4649-5p (MIRT492789)
- hsa-miR-7106-5p (MIRT492790)
- hsa-miR-6797-5p (MIRT492791)
- hsa-miR-1249-5p (MIRT492792)
- hsa-miR-765 (MIRT492793)
- hsa-miR-4644 (MIRT492794)
- hsa-miR-4306 (MIRT492795)
- hsa-miR-185-5p (MIRT492796)
- hsa-miR-6133 (MIRT492797)
- hsa-miR-6130 (MIRT492798)
- hsa-miR-6129 (MIRT492799)
- hsa-miR-6127 (MIRT492800)
- hsa-miR-4510 (MIRT492801)
- hsa-miR-4419a (MIRT492802)
- hsa-miR-6760-5p (MIRT492803)
- hsa-miR-4779 (MIRT492804)
- hsa-miR-6856-5p (MIRT492805)
- hsa-miR-6758-5p (MIRT492806)
- hsa-miR-1911-3p (MIRT492807)
- hsa-miR-6805-5p (MIRT569132)
- hsa-miR-4313 (MIRT709569)
- hsa-miR-874-5p (MIRT709570)
- hsa-miR-3620-3p (MIRT709571)
- hsa-miR-504-5p (MIRT709572)
- hsa-miR-26b-5p (MIRT732934)
- hsa-miR-6717-5p (MIRT753732)
- hsa-miR-6721-5p (MIRT753819)
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for PDE4A - Select products 50% OFF >
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-
- MG216607
- MG218106
- MR216607
- MR216607L3
- MR216607L4
- MR218106
- MR218106L3
- MR218106L4
- RC207765
- RC207765L1
- RC207765L2
- RC207765L3
- RC207765L4
- RC226195
- RC226195L3
- RC226195L4
- RC226216
- RC226216L3
- RC226216L4
- RC226235
- RC226235L1
- RC226235L2
- RC226235L3
- RC226235L4
- RC234973
- RG207765
- RG226195
- RG226216
- RG226235
- RG234973
- RR207991
- RR207991L3
- RR207991L4
- MR216607L3V
- MR216607L4V
- MR218106L3V
- MR218106L4V
- RC207765L1V
- RC207765L2V
- RC207765L3V
- RC207765L4V
- RC226195L3V
- RC226195L4V
- RC226216L3V
- RC226216L4V
- RC226235L1V
- RC226235L2V
- RC226235L3V
- RC226235L4V
- RR207991L3V
- RR207991L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PDE4A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDE4A
Cell Line Products
-
Horizon Cell Lines for PDE4A
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDE4A Gene
Localization for PDE4A Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDE4A Gene
- [Isoform 1]: Cytoplasm, perinuclear region.
- [Isoform 2]: Cytoplasm, perinuclear region. Cell projection, ruffle membrane.
- [Isoform 4]: Membrane. Peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes.
- [Isoform 6]: Cytoplasm, perinuclear region.
- [Isoform 7]: Cytoplasm. Membrane. Note=Predominantly cytoplasmic.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA,IDA | -- |
| GO:0016020 | membrane | TAS | 9677330 |
Pathways & Interactions for PDE4A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Sweet Taste Signaling |
Cellular Effects of Sildenafil
.46
|
Sperm Motility
.37
|
| 3 | DAG and IP3 signaling | ||
| 4 | cAMP signaling pathway | ||
| 5 | Metabolism | ||
Pathways by source for PDE4A Gene
1 BioSystems pathway for PDE4A Gene
6 Reactome pathways for PDE4A Gene
1 PharmGKB pathway for PDE4A Gene
5 KEGG pathways for PDE4A Gene
2 GeneGo (Thomson Reuters) pathways for PDE4A Gene
- G-protein signaling G-Protein alpha-s signaling cascades
- Signal transduction_PKA signaling
2 Qiagen pathways for PDE4A Gene
- Cellular Effects of Sildenafil
- Sperm Motility
UniProtKB/Swiss-Prot P27815-PDE4A_HUMAN
- Pathway: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Interacting Proteins for PDE4A Gene
Selected Interacting proteins:
P27815-PDE4A_HUMAN
ENSP00000370078
for PDE4A Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PDE4A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006198 | cAMP catabolic process | IEA | -- |
| GO:0007165 | signal transduction | TAS | 8940140 |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0007608 | sensory perception of smell | IEA | -- |
| GO:0010738 | regulation of protein kinase A signaling | IEA | -- |
No data available for SIGNOR curated interactions for PDE4A Gene
Drugs & Compounds for PDE4A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dipyridamole | Approved | Pharma | Inhibitor, Inhibition, Target, inhibitor | Adenosine transport inhibitor | 93 | |
| Dyphylline | Approved | Pharma | Target, inhibitor | 0 | ||
| Roflumilast | Approved | Pharma | Target, inhibitor | PDE-4 inhibitor | 0 | |
| Theophylline | Approved | Pharma | Antagonist, Target, inhibitor, antagonist | 75 | ||
| Enprofylline | Approved, Experimental | Pharma | Target, inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| IBMX |
|
Antagonist | 28822-58-4 |
|
||
| Ro201724 |
|
Inhibitor, Inhibition |
|
|||
| Eggmanone |
|
505068-32-6 |
|
|
||
| Etazolate hydrochloride |
|
35838-58-5 |
|
|
||
| MY-5445 |
|
78351-75-4 |
|
|
(5) Tocris Compounds for PDE4A Gene
| Compound | Action | Cas Number |
|---|---|---|
| Eggmanone | Potent and selective PDE4 inhibitor; suppresses hedgehog signaling | 505068-32-6 |
| Etazolate hydrochloride | PDE4 inhibitor | 35838-58-5 |
| IBMX | PDE inhibitor (non-selective) | 28822-58-4 |
| MY-5445 | PDE5 inhibitor | 78351-75-4 |
| Ro 20-1724 | PDE4 inhibitor | 29925-17-5 |
(18) ApexBio Compounds for PDE4A Gene
| Compound | Action | Cas Number |
|---|---|---|
| Aminophylline | 317-34-0 | |
| AN-2728 | PDE4 inhibitor,anti-inflammatory compound | 906673-24-3 |
| Anagrelide HCl | Thrombocytopenic agent | 58579-51-4 |
| Apremilast (CC-10004) | PDE4 inhibitor | 608141-41-9 |
| CDP 840 hydrochloride | PDE4 inhibitor,potent and selective | 162542-90-7 |
| Cilomilast | Potent PDE4 inhibitor | 153259-65-5 |
| Deltarasin | KRAS-PDEδ interaction inhibitor | 1440898-61-2 |
| Dipyridamole | 58-32-2 | |
| Doxofylline | 69975-86-6 | |
| Dyphylline | 479-18-5 | |
| GSK256066 | PDE4-inhibitor,selective and highly potent | 801312-28-7 |
| Irsogladine | PDE4 inhibitor | 57381-26-7 |
| Pimobendan hydrochloride | 77469-98-8 | |
| Roflumilast | PDE-4 inhibitor | 162401-32-3 |
| Rolipram | PDE4-inhibitor and an anti-inflammatory agent | 61413-54-5 |
| S- (+)-Rolipram | CAMP-specific PDE4 inhibitor | 85416-73-5 |
| Vinpocetine | PDE inhibitor | 42971-09-5 |
| Zardaverine | PDE III and IV inhibitor | 101975-10-4 |
Transcripts for PDE4A Gene
mRNA/cDNA for PDE4A Gene
- 5 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000293683 2583 nts (view in UCSC)
- ENST00000344979 2579 nts (view in UCSC)
- ENST00000380702 4897 nts (view in UCSC)
- ENST00000440014 2478 nts (view in UCSC)
- ENST00000586275 695 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PDE4A - Select products 50% OFF >
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-
Santa Cruz Biotechnology (SCBT) CRISPR for PDE4A
miRNA Products
Inhibitory RNA Products
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Clone Products
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-
- MG216607
- MG218106
- MR216607
- MR216607L3
- MR216607L4
- MR218106
- MR218106L3
- MR218106L4
- RC207765
- RC207765L1
- RC207765L2
- RC207765L3
- RC207765L4
- RC226195
- RC226195L3
- RC226195L4
- RC226216
- RC226216L3
- RC226216L4
- RC226235
- RC226235L1
- RC226235L2
- RC226235L3
- RC226235L4
- RC234973
- RG207765
- RG226195
- RG226216
- RG226235
- RG234973
- RR207991
- RR207991L3
- RR207991L4
- MR216607L3V
- MR216607L4V
- MR218106L3V
- MR218106L4V
- RC207765L1V
- RC207765L2V
- RC207765L3V
- RC207765L4V
- RC226195L3V
- RC226195L4V
- RC226216L3V
- RC226216L4V
- RC226235L1V
- RC226235L2V
- RC226235L3V
- RC226235L4V
- RR207991L3V
- RR207991L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PDE4A
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| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | ^ | 19a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - |
| ExUns: | 19b | · | 19c | · | 19d |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: |
Relevant External Links for PDE4A Gene
- GeneLoc Exon Structure for
- PDE4A
Expression for PDE4A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Kidney (Urinary System)
- Eye (Sensory Organs)
This gene is overexpressed in Pancreatic juice (54.0) and Frontal cortex (15.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDE4A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDE4A
SOURCE GeneReport for Unigene cluster for PDE4A Gene:
Hs.89901mRNA Expression by UniProt/SwissProt for PDE4A Gene:
P27815-PDE4A_HUMAN
Tissue specificity:
Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level).
Evidence on tissue expression from TISSUES for PDE4A Gene
- Nervous system(4.6)
- Blood(4.6)
- Muscle(3.4)
- Heart(2.8)
- Lung(2.7)
- Kidney(2.3)
- Intestine(2.3)
- Skin(2.2)
- Adrenal gland(2.1)
- Liver(2.1)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs for PDE4A
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDE4A Gene
Orthologs for PDE4A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | PDE4A 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PDE4A 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pde4a 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Pde4a 30 17 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | PDE4A 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PDE4A 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PDE4A 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100488846 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | pde4a 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | dnc 32 |
|
|
|
| Worm (Caenorhabditis elegans) |
Secernentea | R153.1a 32 |
|
|
- Species where no ortholog for PDE4A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PDE4A Gene
- ENSEMBL:
- Gene Tree for PDE4A (if available)
- TreeFam:
- Gene Tree for PDE4A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PDE4A: view image
Paralogs for PDE4A Gene
Paralogs for PDE4A Gene
(6) SIMAP similar genes for PDE4A Gene using alignment to 5 proteins:
- PDE4A_HUMAN
- K7EKV1_HUMAN
- K7ENX7_HUMAN
- Q9HC30_HUMAN
- Q9HC31_HUMAN
Variants for PDE4A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDE4A Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710380 | Benign: not provided | 10,420,815(+) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 713585 | Likely Benign: not provided | 10,459,411(+) | C/T | SYNONYMOUS_VARIANT | |
| 723426 | Likely Benign: not provided | 10,467,240(+) | G/C | SYNONYMOUS_VARIANT | |
| 735287 | Likely Benign: not provided | 10,459,474(+) | C/T | SYNONYMOUS_VARIANT | |
| 735288 | Likely Benign: not provided | 10,467,011(+) | G/A | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.03;
75.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PDE4A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE4A Gene
Disorders for PDE4A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| asthma |
|
|
| pulmonary eosinophilia |
|
|
| pulmonary disease, chronic obstructive |
|
|
| platelet adenylate cyclase activity |
|
|
| respiratory failure |
|
Search PDE4A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PDE4A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PDE4A Gene
Publications for PDE4A Gene
- Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. (PMID: 20196770) Li X … Baillie GS (The Biochemical journal 2010) 3 4 23
- Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change. (PMID: 18095939) Mackenzie KF … Bolger GB (The Biochemical journal 2008) 3 4 23
- Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. (PMID: 8009369) Milatovich A … Francke U (Somatic cell and molecular genetics 1994) 2 3 23
- Ibudilast inhibits cerebral aneurysms by down-regulating inflammation-related molecules in the vascular wall of rats. (PMID: 20124930) Yagi K … Nagahiro S (Neurosurgery 2010) 23 26
- Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex. (PMID: 20086095) Bjørgo E … Taskén K (Molecular and cellular biology 2010) 3 23
ExternalLinks
Products for PDE4A Gene
- View all 2 R&D Systems PDE4A (Phosphodiesterase 4A/PDE4A) Products
- View all R&D Systems PDE4A (Phosphodiesterase 4A/PDE4A) Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for PDE4A
- AP00655SU-N
- CF501152
- CF501153
- CF501192
- CF501198
- CF501199
- CF501200
- CF501201
- CF501202
- CF501203
- CF501206
- CF501207
- TA351506
- TA501152
- TA501152S
- TA501153
- TA501153S
- TA501192
- TA501192S
- TA501198
- TA501198S
- TA501199
- TA501199S
- TA501200
- TA501200S
- TA501201
- TA501201S
- TA501202
- TA501202S
- TA501203
- TA501203S
- TA501206
- TA501206S
- TA501207
- TA501207S
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- MG216607
- MG218106
- MR216607
- MR216607L3
- MR216607L4
- MR218106
- MR218106L3
- MR218106L4
- RC207765
- RC207765L1
- RC207765L2
- RC207765L3
- RC207765L4
- RC226195
- RC226195L3
- RC226195L4
- RC226216
- RC226216L3
- RC226216L4
- RC226235
- RC226235L1
- RC226235L2
- RC226235L3
- RC226235L4
- RC234973
- RG207765
- RG226195
- RG226216
- RG226235
- RG234973
- RR207991
- RR207991L3
- RR207991L4
- MR216607L3V
- MR216607L4V
- MR218106L3V
- MR218106L4V
- RC207765L1V
- RC207765L2V
- RC207765L3V
- RC207765L4V
- RC226195L3V
- RC226195L4V
- RC226216L3V
- RC226216L4V
- RC226235L1V
- RC226235L2V
- RC226235L3V
- RC226235L4V
- RR207991L3V
- RR207991L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PDE4A
- Sino Biological Human cDNA Clone for PDE4A
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
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- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PDE4A
- Novus Biologicals proteins and lysates for PDE4A
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for PDE4A
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
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- Invitrogen Antibodies for PDE4A (AFLGC-Pde4a)
- ApexBio compounds for PDE4A
- VectorBuilder Custom and pre-made DNA vectors for PDE4A (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PDE4A (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PDE4A (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PDE4A CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PDE4A
- antibodies-online: Show 22 available PDE4A Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for PDE4A
- Search Santa Cruz Biotechnology (SCBT) for PDE4A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PDE4A
- Horizon Cell Lines for PDE4A
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDE4A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDE4A
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PDE4A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDE4A
Sources for PDE4A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78)