The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological pr... See more...

Aliases for PDE4A Gene

Aliases for PDE4A Gene

  • Phosphodiesterase 4A 2 3 5
  • CAMP-Specific 3',5'-Cyclic Phosphodiesterase 4A 3 4
  • DPDE2 3 4
  • PDE46 3 4
  • Phosphodiesterase 4A, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E2) 2
  • Phosphodiesterase E2 Dunce Homolog (Drosophila) 2
  • Phosphodiesterase E2 Dunce Homolog, Drosophila 3
  • Phosphodiesterase 4A, CAMP-Specific (Dunce 3
  • Phosphodiesterase 4A, CAMP-Specific 2
  • Phosphodiesterase Isozyme 4 3
  • EC 50
  • EC 4
  • EC 3.1.4 50
  • PDE4A 5
  • PDE4 3

External Ids for PDE4A Gene

Previous HGNC Symbols for PDE4A Gene

  • DPDE2

Previous GeneCards Identifiers for PDE4A Gene

  • GC19P010663
  • GC19P010376
  • GC19P010392
  • GC19P010527
  • GC19P010111

Summaries for PDE4A Gene

Entrez Gene Summary for PDE4A Gene

  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for PDE4A Gene

PDE4A (Phosphodiesterase 4A) is a Protein Coding gene. Diseases associated with PDE4A include Asthma and Pulmonary Eosinophilia. Among its related pathways are Signaling by GPCR and Signal transduction_PKA signaling. Gene Ontology (GO) annotations related to this gene include 3',5'-cyclic-nucleotide phosphodiesterase activity and 3',5'-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE4D.

UniProtKB/Swiss-Prot Summary for PDE4A Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Tocris Summary for PDE4A Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE4A Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDE4A Gene

Genomics for PDE4A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PDE4A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010400 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 260.8 -12.6 -12556 6.5 BCLAF1 SP1 ZNF207 MYC IKZF1 ZNF654 ZNF600 JUND ZNF580 ATF2 PDE4A MIR1181 lnc-PDE4A-4-001 lnc-PDE4A-4-002 CDC37 ICAM1 KANK2 MRPL4 ICAM5 ICAM4
GH19J010415 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 258.4 +1.9 1856 5.9 EZH2 BCLAF1 SP1 ZNF207 MYC IKZF1 NCOR1 ZNF600 SSRP1 JUND CDC37 PDE4A ILF3 ZNF266 KRI1 LOC100419831 DNMT1 RAVER1 FBXL12 PPAN
GH19J010427 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 265.7 +13.8 13792 6.5 EZH2 BCLAF1 NCOR1 IKZF1 MYC ZNF592 ZMYM3 NFIC CHD4 NONO PDE4A piR-56480-029 ZNF266 TYK2 ILF3 FBXL12 RAVER1 EIF3G KRI1 ZNF561
GH19J010452 Promoter/Enhancer 1.4 EPDnew Ensembl CraniofacialAtlas 250.3 +36.2 36190 0.7 ZNF600 ZIC2 GLIS1 ZFP69B EGR2 ZNF692 GLIS2 ZNF579 POLR2A ZFHX2 PDE4A NONHSAG024793.2 piR-56480-029 CDC37 KEAP1 lnc-TIMM29-1
GH19J010423 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 19.6 +7.9 7943 3 EZH2 SP1 ZNF207 MYC NCOR1 ZNF600 IKZF1 ZNF580 ZNF592 ZMYM3 PDE4A C19orf38 KRI1 ICAM1 SMARCA4 ZNF266 DNMT1 RAVER1 PPAN ZNF121
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDE4A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDE4A

Top Transcription factor binding sites by QIAGEN in the PDE4A gene promoter:
  • AP-1
  • C/EBPalpha
  • CREB
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for PDE4A Gene

Latest Assembly
52,859 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
52,859 bases
Plus strand

(GRCh37/hg19 by Ensembl)
52,857 bases
Plus strand

Genomic View for PDE4A Gene

Genes around PDE4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE4A Gene

Proteins for PDE4A Gene

  • Protein details for PDE4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    cAMP-specific 3',5'-cyclic phosphodiesterase 4A
    Protein Accession:
    Secondary Accessions:
    • O75522
    • O76092
    • Q16255
    • Q16691
    • Q5DM53
    • Q6PMT2
    • Q8IVA7
    • Q8WUQ3
    • Q9H3H2

    Protein attributes for PDE4A Gene

    886 amino acids
    Molecular mass:
    98143 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Isoform 1 interacts with LYN. Isoform 2 and isoform 6 interact weakly with LYN. Isoform 1, isoform 2 and isoform 6 interact with ARRB2.
    • [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Probably represents a non-functional splice isoform.

    Three dimensional structures from OCA and Proteopedia for PDE4A Gene

    Alternative splice isoforms for PDE4A Gene

neXtProt entry for PDE4A Gene

Selected DME Specific Peptides for PDE4A Gene


Post-translational modifications for PDE4A Gene

  • Phosphorylation by MAPKAPK2 its activation through PKA phosphorylation (By similarity). Phosphorylated at Ser-686 and Ser-688 when expressed in S.frugiperda cells. Isoform 2 and isoform 7 are activated by phosphorylation at Ser-119 and Ser-123 respectively by PKA.
  • Proteolytically cleaved by caspase-3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PDE4A Gene

Gene Families for PDE4A Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PDE4A Gene

GenScript: Design optimal peptide antigens:
  • Phosphodiesterase isozyme 4 (Q86V67_HUMAN)
  • CAMP specific phosphodiesterase variant PDE4A-10 (Q9HC30_HUMAN)
  • CAMP specific phosphodiesterase variant TM3 (Q9HC31_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
genes like me logo Genes that share domains with PDE4A: view

Function for PDE4A Gene

Molecular function for PDE4A Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4.0 uM for cAMP (isoform 2) {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}; KM=3 uM for cAMP (isoform 6) {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310};
UniProtKB/Swiss-Prot EnzymeRegulation:
Isoform 1, isoform 2, isoform 6 and isoform 7 are inhibited by rolipram and cilomilast. Isoform 1, isoform 2 and isoform 6 are inhibited by 4-[(3-butoxy-4-methoxyphenyl)-methyl]-2-imidazolidinone (Ro 20-1724), roflumilast and denbufylline.
GENATLAS Biochemistry:
cAMP specific nucleotide phosphodiesterase class IV,A,with homology to Drosophila dunce gene,involved in signal transduction

Enzyme Numbers (IUBMB) for PDE4A Gene

Phenotypes From GWAS Catalog for PDE4A Gene

Gene Ontology (GO) - Molecular Function for PDE4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity IBA 21873635
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity IEA,IGI 8413254
GO:0005515 protein binding IPI 11306681
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PDE4A: view
genes like me logo Genes that share phenotypes with PDE4A: view

Animal Models for PDE4A Gene

MGI Knock Outs for PDE4A:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDE4A

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDE4A Gene

Localization for PDE4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE4A Gene

[Isoform 1]: Cytoplasm, perinuclear region.
[Isoform 2]: Cytoplasm, perinuclear region. Cell projection, ruffle membrane.
[Isoform 4]: Membrane. Peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes.
[Isoform 6]: Cytoplasm, perinuclear region.
[Isoform 7]: Cytoplasm. Membrane. Note=Predominantly cytoplasmic.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDE4A gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDE4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with PDE4A: view

Pathways & Interactions for PDE4A Gene

PathCards logo

SuperPathways for PDE4A Gene

genes like me logo Genes that share pathways with PDE4A: view

Pathways by source for PDE4A Gene

2 GeneGo (Thomson Reuters) pathways for PDE4A Gene
  • G-protein signaling G-Protein alpha-s signaling cascades
  • Signal transduction_PKA signaling
2 Qiagen pathways for PDE4A Gene
  • Cellular Effects of Sildenafil
  • Sperm Motility

UniProtKB/Swiss-Prot P27815-PDE4A_HUMAN

  • Pathway: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

SIGNOR curated interactions for PDE4A Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PDE4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006198 cAMP catabolic process IEA --
GO:0007165 signal transduction TAS,IBA 21873635
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0010738 regulation of protein kinase A signaling IEA --
genes like me logo Genes that share ontologies with PDE4A: view

Drugs & Compounds for PDE4A Gene

(119) Drugs for PDE4A Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dipyridamole Approved Pharma Target, inhibitor Adenosine transport inhibitor 97
Dyphylline Approved Pharma Target, inhibitor 2
Roflumilast Approved Pharma Target, inhibitor PDE-4 inhibitor 0
Theophylline Approved Pharma Target, inhibitor, antagonist 78
Enprofylline Approved, Experimental Pharma Target, inhibitor 0

(51) Additional Compounds for PDE4A Gene - From: Novoseek, Tocris, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Inhibitor, Inhibition
Etazolate hydrochloride

(5) Tocris Compounds for PDE4A Gene

Compound Action Cas Number
Eggmanone Potent and selective PDE4 inhibitor; suppresses hedgehog signaling 505068-32-6
Etazolate hydrochloride PDE4 inhibitor 35838-58-5
IBMX PDE inhibitor (non-selective) 28822-58-4
MY-5445 PDE5 inhibitor 78351-75-4
Ro 20-1724 PDE4 inhibitor 29925-17-5

(18) ApexBio Compounds for PDE4A Gene

Compound Action Cas Number
Aminophylline 317-34-0
AN-2728 PDE4 inhibitor,anti-inflammatory compound 906673-24-3
Anagrelide HCl Thrombocytopenic agent 58579-51-4
Apremilast (CC-10004) PDE4 inhibitor 608141-41-9
CDP 840 hydrochloride PDE4 inhibitor,potent and selective 162542-90-7
Cilomilast Potent PDE4 inhibitor 153259-65-5
Deltarasin KRAS-PDEδ interaction inhibitor 1440898-61-2
Dipyridamole 58-32-2
Doxofylline 69975-86-6
Dyphylline 479-18-5
GSK256066 PDE4-inhibitor,selective and highly potent 801312-28-7
Irsogladine PDE4 inhibitor 57381-26-7
Pimobendan hydrochloride 77469-98-8
Roflumilast PDE-4 inhibitor 162401-32-3
Rolipram PDE4-inhibitor and an anti-inflammatory agent 61413-54-5
S- (+)-Rolipram CAMP-specific PDE4 inhibitor 85416-73-5
Vinpocetine PDE inhibitor 42971-09-5
Zardaverine PDE III and IV inhibitor 101975-10-4
genes like me logo Genes that share compounds with PDE4A: view

Drug products for research

Transcripts for PDE4A Gene

mRNA/cDNA for PDE4A Gene

16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDE4A

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for PDE4A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b ^ 19a ·
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - -
SP6: -
SP7: - - - - -
SP8: - - - - -
SP9: -
SP10: -

ExUns: 19b · 19c · 19d

Relevant External Links for PDE4A Gene

GeneLoc Exon Structure for

Expression for PDE4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PDE4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDE4A Gene

This gene is overexpressed in Pancreatic juice (54.0) and Frontal cortex (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDE4A Gene

Protein tissue co-expression partners for PDE4A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDE4A

SOURCE GeneReport for Unigene cluster for PDE4A Gene:


mRNA Expression by UniProt/SwissProt for PDE4A Gene:

Tissue specificity: Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level).

Evidence on tissue expression from TISSUES for PDE4A Gene

  • Nervous system(4.6)
  • Blood(4.5)
  • Muscle(3.2)
  • Heart(2.5)
  • Lung(2.5)
  • Kidney(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with PDE4A: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDE4A Gene

Orthologs for PDE4A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE4A Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PDE4A 29 30
  • 87.05 (n)
(Bos Taurus)
Mammalia PDE4A 30
  • 87 (a)
(Rattus norvegicus)
Mammalia Pde4a 29
  • 82.92 (n)
(Mus musculus)
Mammalia Pde4a 29 16 30
  • 82.05 (n)
(Pan troglodytes)
Mammalia PDE4A 30
  • 82 (a)
(Monodelphis domestica)
Mammalia PDE4A 30
  • 72 (a)
(Anolis carolinensis)
Reptilia PDE4A 30
  • 75 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100488846 29
  • 75.72 (n)
(Danio rerio)
Actinopterygii pde4a 29 30
  • 75.56 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta dnc 31
  • 60 (a)
(Caenorhabditis elegans)
Secernentea R153.1a 31
  • 54 (a)
Species where no ortholog for PDE4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PDE4A Gene

Gene Tree for PDE4A (if available)
Gene Tree for PDE4A (if available)
Evolutionary constrained regions (ECRs) for PDE4A: view image
Alliance of Genome Resources:
Additional Orthologs for PDE4A

Paralogs for PDE4A Gene

(6) SIMAP similar genes for PDE4A Gene using alignment to 5 proteins:

  • Q9HC30_HUMAN
  • Q9HC31_HUMAN
genes like me logo Genes that share paralogs with PDE4A: view

Variants for PDE4A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDE4A Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs117495488 Benign: not provided 10,420,815(+) C/T
NM_001111307.2(PDE4A):c.51C>T (p.Pro17=)
rs143260301 Likely Benign: not provided 10,459,411(+) C/T
NM_001111307.2(PDE4A):c.1113C>T (p.Asn371=)
rs146370645 Likely Benign: not provided 10,467,011(+) G/A
NM_001111307.2(PDE4A):c.2051G>A (p.Arg684Gln)
rs150660796 Benign/Likely Benign: not provided 10,457,992(+) C/T
NM_001111307.2(PDE4A):c.991C>T (p.Pro331Ser)
rs186353937 Benign: not provided 10,450,945(+) T/G

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PDE4A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PDE4A Gene

Variant ID Type Subtype PubMed ID
nsv1127650 CNV deletion 24896259
nsv518008 CNV gain 19592680
nsv521918 CNV gain 19592680
nsv833744 CNV loss 17160897

Variation tolerance for PDE4A Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDE4A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE4A Gene

Disorders for PDE4A Gene

MalaCards: The human disease database

(25) MalaCards diseases for PDE4A Gene - From: COP and GCD

Disorder Aliases PubMed IDs
  • asthma, susceptibility to
pulmonary eosinophilia
  • asthmatic pulmonary eosinophilia
pulmonary disease, chronic obstructive
  • copd
platelet adenylate cyclase activity
ocular hypotension
  • hypotony of eye
- elite association - COSMIC cancer census association via MalaCards
Search PDE4A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PDE4A

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PDE4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE4A Gene

Publications for PDE4A Gene

  1. Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. (PMID: 20196770) Li X … Baillie GS (The Biochemical journal 2010) 3 4 22
  2. Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change. (PMID: 18095939) Mackenzie KF … Bolger GB (The Biochemical journal 2008) 3 4 22
  3. Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. (PMID: 8009369) Milatovich A … Francke U (Somatic cell and molecular genetics 1994) 2 3 22
  4. Ibudilast inhibits cerebral aneurysms by down-regulating inflammation-related molecules in the vascular wall of rats. (PMID: 20124930) Yagi K … Nagahiro S (Neurosurgery 2010) 22 25
  5. Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex. (PMID: 20086095) Bjørgo E … Taskén K (Molecular and cellular biology 2010) 3 22

Products for PDE4A Gene

Sources for PDE4A Gene