Aliases for PDE4A Gene
External Ids for PDE4A Gene
Previous HGNC Symbols for PDE4A Gene
Previous GeneCards Identifiers for PDE4A Gene
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
GeneCards Summary for PDE4A Gene
PDE4A (Phosphodiesterase 4A) is a Protein Coding gene. Diseases associated with PDE4A include Platelet Adenylate Cyclase Activity and Pulmonary Eosinophilia. Among its related pathways are Pyrimidine metabolism (KEGG) and G-protein signaling G-Protein alpha-i signaling cascades. Gene Ontology (GO) annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE4D.
UniProtKB/Swiss-Prot for PDE4A Gene
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.