Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PDE3A Gene

Aliases for PDE3A Gene

  • Phosphodiesterase 3A 2 3 5
  • Cyclic GMP-Inhibited Phosphodiesterase A 3 4
  • Phosphodiesterase 3A, CGMP-Inhibited 2 3
  • CGI-PDE A 3 4
  • CAMP Phosphodiesterase, Myocardial CGMP-Inhibited 3
  • CGMP-Inhibited 3,5-Cyclic Phosphodiesterase A 3
  • EC 4
  • CGI-PDE-A 3
  • CGI-PDE 3
  • HTNB 3

External Ids for PDE3A Gene

Previous GeneCards Identifiers for PDE3A Gene

  • GC12P020791
  • GC12P020523
  • GC12P020422
  • GC12P020413

Summaries for PDE3A Gene

Entrez Gene Summary for PDE3A Gene

  • This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for PDE3A Gene

PDE3A (Phosphodiesterase 3A) is a Protein Coding gene. Diseases associated with PDE3A include Hypertension And Brachydactyly Syndrome and Brachydactyly. Among its related pathways are G-Beta Gamma Signaling and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE3B.

UniProtKB/Swiss-Prot for PDE3A Gene

  • Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.

Tocris Summary for PDE3A Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Additional gene information for PDE3A Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE3A Gene

Genomics for PDE3A Gene

GeneHancer (GH) Regulatory Elements for PDE3A Gene

Promoters and enhancers for PDE3A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J020367 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 650.7 +3.6 3553 8.9 SIN3A KLF14 RFX5 ZNF335 GLIS2 ELK1 ZNF366 RCOR1 ELK4 SP3 PDE3A ENSG00000256879 GC12M020385
GH12J020320 Promoter 0.5 EPDnew 673 -47.7 -47714 0.1 PDE3A LOC105369688 GC12P020273
GH12J020300 Promoter 0.5 EPDnew 650.2 -67.8 -67818 0.1 PDE3A LOC105369688 GC12P020273
GH12J020272 Promoter 0.5 EPDnew 650.2 -96.2 -96150 0.1 GC12P020273 PDE3A LOC105369687
GH12J020366 Enhancer 0.4 dbSUPER 658.1 -1.5 -1517 0.5 POLR2A RCOR1 CHD2 PDE3A ENSG00000256879 LOC105369688
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDE3A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDE3A gene promoter:
  • CUTL1
  • RSRFC4
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • STAT5B
  • Pax-5
  • Evi-1
  • AP-2alpha

Genomic Locations for PDE3A Gene

Genomic Locations for PDE3A Gene
319,132 bases
Plus strand
315,137 bases
Plus strand

Genomic View for PDE3A Gene

Genes around PDE3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE3A Gene

Proteins for PDE3A Gene

  • Protein details for PDE3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    cGMP-inhibited 3,5-cyclic phosphodiesterase A
    Protein Accession:
    Secondary Accessions:
    • O60865
    • Q13348
    • Q17RD1

    Protein attributes for PDE3A Gene

    1141 amino acids
    Molecular mass:
    124979 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PDE3A Gene

neXtProt entry for PDE3A Gene

Post-translational modifications for PDE3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDE3A Gene

No data available for DME Specific Peptides for PDE3A Gene

Domains & Families for PDE3A Gene

Gene Families for PDE3A Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for PDE3A Gene

Suggested Antigen Peptide Sequences for PDE3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
genes like me logo Genes that share domains with PDE3A: view

Function for PDE3A Gene

Molecular function for PDE3A Gene

UniProtKB/Swiss-Prot Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside 3,5-cyclic phosphate + H(2)O = nucleoside 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by cGMP.
GENATLAS Biochemistry:
cAMP,cGMP inhibited nucleotide phosphodiesterase 3A homolog,involved in fat metabolism

Enzyme Numbers (IUBMB) for PDE3A Gene

Phenotypes From GWAS Catalog for PDE3A Gene

Gene Ontology (GO) - Molecular Function for PDE3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity IEA --
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity IEA,TAS --
GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity IEA --
GO:0005515 protein binding IPI 19332778
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PDE3A: view
genes like me logo Genes that share phenotypes with PDE3A: view

Human Phenotype Ontology for PDE3A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PDE3A Gene

MGI Knock Outs for PDE3A:

Animal Model Products

  • Taconic Biosciences Mouse Models for PDE3A

miRNA for PDE3A Gene

miRTarBase miRNAs that target PDE3A

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for PDE3A Gene

Localization for PDE3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE3A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDE3A gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PDE3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PDE3A: view

Pathways & Interactions for PDE3A Gene

genes like me logo Genes that share pathways with PDE3A: view

SIGNOR curated interactions for PDE3A Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PDE3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001556 oocyte maturation IEA --
GO:0006198 cAMP catabolic process IMP,IEA 19252089
GO:0006629 lipid metabolic process TAS 8921398
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PDE3A: view

Drugs & Compounds for PDE3A Gene

(35) Drugs for PDE3A Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Milrinone Approved Pharma Inhibition, Inhibitor, inhibitor, Target PDE-3 inhibitor 37
Cilostazol Approved, Investigational Pharma inhibitor, Target PDE3 inhibitor 112
Amrinone Approved Pharma inhibitor, Target 0
Anagrelide Approved Pharma inhibitor, Target 24
Enoximone Approved, Investigational Pharma inhibitor, Target 5

(7) Additional Compounds for PDE3A Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Etazolate hydrochloride
Antagonist 28822-58-4
Ro 20-1724

(5) Tocris Compounds for PDE3A Gene

Compound Action Cas Number
Eggmanone Potent and selective PDE4 inhibitor; suppresses hedgehog signaling 505068-32-6
Etazolate hydrochloride PDE4 inhibitor 35838-58-5
IBMX PDE inhibitor (non-selective) 28822-58-4
MY-5445 PDE5 inhibitor 78351-75-4
Ro 20-1724 PDE4 inhibitor 29925-17-5

(8) ApexBio Compounds for PDE3A Gene

Compound Action Cas Number
Cilostazol PDE3 inhibitor 73963-72-1
Dipyridamole 58-32-2
Milrinone PDE-3 inhibitor 78415-72-2
Olprinone PDE3 inhibitor 106730-54-5
Olprinone Hydrochloride Phosphodiesterase 3 (PDE3) inhibitor, selective 119615-63-3
Pimobendan Selective PDE3 inhibitor.Ca2+ channel sensitizer 74150-27-9
Sildenafil Citrate Treat erectile dysfunction and PAH 171599-83-0
Zardaverine PDE III and IV inhibitor 101975-10-4
genes like me logo Genes that share compounds with PDE3A: view

Drug Products

Transcripts for PDE3A Gene

mRNA/cDNA for PDE3A Gene

Unigene Clusters for PDE3A Gene

Phosphodiesterase 3A, cGMP-inhibited:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE3A Gene

No ASD Table

Relevant External Links for PDE3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDE3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDE3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE3A Gene

This gene is overexpressed in Heart - Left Ventricle (x9.2), Artery - Tibial (x5.2), and Heart - Atrial Appendage (x4.1).

Protein differential expression in normal tissues from HIPED for PDE3A Gene

This gene is overexpressed in Heart (11.4), Platelet (10.7), Peripheral blood mononuclear cells (10.0), and Uterus (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDE3A Gene

NURSA nuclear receptor signaling pathways regulating expression of PDE3A Gene:


SOURCE GeneReport for Unigene cluster for PDE3A Gene:


Evidence on tissue expression from TISSUES for PDE3A Gene

  • Heart(4.6)
  • Muscle(4.5)
  • Blood(4.4)
  • Liver(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PDE3A Gene

Germ Layers:
  • mesoderm
  • cardiovascular
  • skeleton
Head and neck:
  • ear
  • heart
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • toe
  • upper limb
  • blood vessel
genes like me logo Genes that share expression patterns with PDE3A: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PDE3A Gene

Orthologs for PDE3A Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDE3A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PDE3A 34 33
  • 99.62 (n)
(Canis familiaris)
Mammalia PDE3A 34 33
  • 91.56 (n)
(Bos Taurus)
Mammalia PDE3A 34 33
  • 90.29 (n)
(Mus musculus)
Mammalia Pde3a 16 34 33
  • 83.58 (n)
(Rattus norvegicus)
Mammalia Pde3a 33
  • 83.17 (n)
(Monodelphis domestica)
Mammalia PDE3A 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia PDE3A 34
  • 74 (a)
(Gallus gallus)
Aves PDE3A 34 33
  • 76.34 (n)
(Anolis carolinensis)
Reptilia PDE3A 34
  • 78 (a)
(Danio rerio)
Actinopterygii pde3a 34 33
  • 66.49 (n)
Dr.11181 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
Species where no ortholog for PDE3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDE3A Gene

Gene Tree for PDE3A (if available)
Gene Tree for PDE3A (if available)
Evolutionary constrained regions (ECRs) for PDE3A: view image

Paralogs for PDE3A Gene

(3) SIMAP similar genes for PDE3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PDE3A: view

Variants for PDE3A Gene

Sequence variations from dbSNP and Humsavar for PDE3A Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs567843370 uncertain-significance, Malignant tumor of prostate 20,650,507(+) G/A/C/T coding_sequence_variant, missense_variant
rs794726864 pathogenic, Brachydactyly with hypertension, Hypertension and brachydactyly syndrome (HTNB) [MIM:112410], Hypertension and brachydactyly syndrome (HTNB) [MIM:112410] 20,616,294(+) C/A/G coding_sequence_variant, missense_variant
rs794726865 pathogenic, Brachydactyly with hypertension, Hypertension and brachydactyly syndrome (HTNB) [MIM:112410] 20,616,293(+) A/G coding_sequence_variant, missense_variant
rs794726866 pathogenic, Brachydactyly with hypertension, Hypertension and brachydactyly syndrome (HTNB) [MIM:112410] 20,616,299(+) G/A coding_sequence_variant, missense_variant
rs794726867 pathogenic, Brachydactyly with hypertension, Hypertension and brachydactyly syndrome (HTNB) [MIM:112410] 20,616,300(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for PDE3A Gene

Variant ID Type Subtype PubMed ID
dgv258e214 CNV gain 21293372
dgv775e59 CNV tandem duplication 20981092
esv1015874 CNV deletion 17803354
esv1326828 CNV insertion 17803354
esv1692681 CNV insertion 17803354
esv2218919 CNV deletion 18987734
esv2663850 CNV deletion 23128226
esv2668063 CNV deletion 23128226
esv2674271 CNV deletion 23128226
esv2745621 CNV deletion 23290073
esv3405393 CNV duplication 20981092
esv3580173 CNV loss 25503493
esv3628787 CNV loss 21293372
esv5808 CNV gain 19470904
nsv1042315 CNV gain 25217958
nsv1054997 CNV gain 25217958
nsv1159988 CNV duplication 26073780
nsv469158 CNV loss 19166990
nsv557701 CNV loss 21841781
nsv557702 CNV loss 21841781
nsv557703 CNV loss 21841781
nsv634 CNV insertion 18451855
nsv976582 CNV duplication 23825009

Variation tolerance for PDE3A Gene

Residual Variation Intolerance Score: 5.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.01; 84.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDE3A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE3A Gene

Disorders for PDE3A Gene

MalaCards: The human disease database

(4) MalaCards diseases for PDE3A Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypertension and brachydactyly syndrome
  • htnb
familial hypertension
  • genetic hypertension
  • erectile dysfunction
- elite association - COSMIC cancer census association via MalaCards
Search PDE3A in MalaCards View complete list of genes associated with diseases


  • Hypertension and brachydactyly syndrome (HTNB) [MIM:112410]: A syndrome characterized by brachydactyly type E, severe salt-independent but age-dependent hypertension, an increased fibroblast growth rate, neurovascular contact at the rostral-ventrolateral medulla, and altered baroreflex blood pressure regulation. It results in death from stroke before age 50 years when untreated. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals. {ECO:0000269 PubMed:25961942}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PDE3A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PDE3A: view

No data available for Genatlas for PDE3A Gene

Publications for PDE3A Gene

  1. Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase. (PMID: 1315035) Meacci E … Manganiello V (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 22 58
  2. Cardiac type cGMP-inhibited phosphodiesterase (PDE3A) gene structure: similarity and difference to adipocyte type PDE3B gene. (PMID: 10679291) Kasuya J … Fujita-Yamaguchi Y (Biochemical and biophysical research communications 2000) 2 3 22 58
  3. Molecular biological characterization of phosphodiesterase 3A from human corpus cavernosum. (PMID: 10421499) Küthe A … Mägert HJ (Chemico-biological interactions 1999) 3 4 22 58
  4. Human platelet cGI-PDE: expression in yeast and localization of the catalytic domain by deletion mutagenesis. (PMID: 8695850) Cheung PP … Colman RW (Blood 1996) 3 4 22 58
  5. Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase. (PMID: 8155697) Degerman E … Manganiello V (Biochimica et biophysica acta 1994) 3 4 22 58

Products for PDE3A Gene

Sources for PDE3A Gene

Loading form....