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This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascu... See more...
Aliases for PDE3A Gene
Aliases for PDE3A Gene
External Ids for PDE3A Gene
- HGNC: 8778
- Entrez Gene: 5139
- Ensembl: ENSG00000172572
- OMIM: 123805
- UniProtKB: Q14432
Previous GeneCards Identifiers for PDE3A Gene
- GC12P020791
- GC12P020523
- GC12P020422
- GC12P020413
Summaries for PDE3A Gene
-
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for PDE3A Gene
PDE3A (Phosphodiesterase 3A) is a Protein Coding gene. Diseases associated with PDE3A include Hypertension And Brachydactyly Syndrome and Brachydactyly. Among its related pathways are Sweet Taste Signaling and Signal transduction_PKA signaling. Gene Ontology (GO) annotations related to this gene include 3',5'-cyclic-nucleotide phosphodiesterase activity and 3',5'-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE3B.
UniProtKB/Swiss-Prot Summary for PDE3A Gene
-
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
-
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.
Additional gene information for PDE3A Gene
- HGNC(8778)
- Entrez Gene(5139)
- Ensembl(ENSG00000172572)
- OMIM(123805)
- UniProtKB(Q14432)
- Open Targets Platform(ENSG00000172572)
- Monarch Initiative
- Search for PDE3A at DataMed
- Search for PDE3A at HumanCyc
No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDE3A Gene
Genomics for PDE3A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PDE3A Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12J020367 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | +3.5 | 3526 | 8.9 | PRDM10 KDM1A CTCF PRDM1 ZIC2 PATZ1 POLR2A EZH2 ZNF341 CEBPB | ENSG00000256879 PDE3A UBE2L2 SLCO1C1 | |
| GH12J020272 | Promoter | 0.4 | EPDnew | 600.2 | -96.2 | -96177 | 0.1 | NR3C1 | PDE3A HSALNG0089736 lnc-SLCO1A2-2 AEBP2 | |
| GH12J020366 | Enhancer | 0.4 | dbSUPER | 608 | -1.5 | -1544 | 0.5 | RCOR1 CHD2 POLR2A | PDE3A ENSG00000256879 LOC105369688 AEBP2 | |
| GH12J020320 | Promoter | 0.3 | EPDnew | 623.1 | -47.7 | -47741 | 0.1 | PDE3A LOC105369688 HSALNG0089736 AEBP2 | ||
| GH12J020300 | Promoter | 0.3 | EPDnew | 600.2 | -67.8 | -67845 | 0.1 | PDE3A HSALNG0089736 LOC105369688 AEBP2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PDE3A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDE3A
- Top Transcription factor binding sites by QIAGEN in the PDE3A gene promoter:
-
- AP-2alpha
- CUTL1
- Evi-1
- Pax-5
- POU2F1
- POU2F1a
- POU2F1b
- POU2F1c
- RSRFC4
- STAT5B
Genomic Locations for PDE3A Gene
Genomic Locations for PDE3A Gene
- chr12:20,368,537-20,688,583
- (GRCh38/hg38)
- Size:
- 320,047 bases
- Orientation:
- Plus strand
- chr12:20,522,179-20,837,315
- (GRCh37/hg19)
- Size:
- 315,137 bases
- Orientation:
- Plus strand
Genomic View for PDE3A Gene
Genes around PDE3A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p12.2 by HGNC
- 12p12.2 by Entrez Gene
- 12p12.2 by Ensembl
PDE3A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDE3A Gene
Proteins for PDE3A Gene
-
Protein details for PDE3A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14432-PDE3A_HUMAN
- Recommended name:
- cGMP-inhibited 3',5'-cyclic phosphodiesterase A
- Protein Accession:
- Q14432
- O60865
- Q13348
- Q17RD1
Protein attributes for PDE3A Gene
- Size:
- 1141 amino acids
- Molecular mass:
- 124979 Da
- Cofactor:
- Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Quaternary structure:
- No Data Available
Protein Expression for PDE3A Gene
Selected DME Specific Peptides for PDE3A Gene
- Q14432:
-
- SVLENHH
- LYNDRSVLENHH
- TSATGLPT
- LDHVEFK
- AAAMHDYDHPGRTNAFLV
- EFYEQGD
Post-translational modifications for PDE3A Gene
Other Protein References for PDE3A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences PDE3A Antibody (LS-A731) and PDE3A Antibody (LS-A732)
- G Biosciences Immunotag™ PDE3A Antibody
-
Custom Antibody ServicesOriGene Antibodies for PDE3A
- Novus Biologicals Antibodies for PDE3A
-
Abcam antibodies for PDE3A
- Invitrogen Antibodies for PDE3A (AFLGC-PDE3A)
-
Biorbyt antibodies for PDE3A
-
Boster Bio Antibodies for PDE3A
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDE3A
Protein Products
-
OriGene Purified Proteins for PDE3A
- Search Origene for MassSpec and Protein Over-expression Lysates for PDE3A
- Origene Custom Protein Services for PDE3A
- Sino Biological Recombinant Proteins for PDE3A
- Sino Biological Cell Lysates for PDE3A
-
Abcam proteins for PDE3A
Assay Products
- antibodies-online: Show 7 available PDE3A Elisa Kits ranked by validation data
- Compare Top PDE3A Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for PDE3A
Domains & Families for PDE3A Gene
Gene Families for PDE3A Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted membrane proteins
Protein Domains for PDE3A Gene
- InterPro:
- Blocks:
-
- Aminotransferase, class-II
- ProtoNet:
Suggested Antigen Peptide Sequences for PDE3A Gene
- GenScript: Design optimal peptide antigens:
-
- Cyclic GMP-inhibited phosphodiesterase A (PDE3A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14432UniProtKB/Swiss-Prot:
PDE3A_HUMAN :- Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
- Family:
-
- Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
Function for PDE3A Gene
Molecular function for PDE3A Gene
- UniProtKB/Swiss-Prot Function:
- Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+); Xref=Rhea:RHEA:14653, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57867, ChEBI:CHEBI:58464; EC=3.1.4.17;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by cGMP.
- GENATLAS Biochemistry:
- cAMP,cGMP inhibited nucleotide phosphodiesterase 3A homolog,involved in fat metabolism
Enzyme Numbers (IUBMB) for PDE3A Gene
Phenotypes From GWAS Catalog for PDE3A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | IEA | -- |
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | IEA,IBA | 21873635 |
| GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity | TAS | 9173884 |
| GO:0005515 | protein binding | IPI | 19332778 |
| GO:0008081 | phosphoric diester hydrolase activity | IEA | -- |
Phenotypes for PDE3A Gene
- MGI mutant phenotypes for PDE3A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PDE3A:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Synthetic lethal with Ras
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased homologous recombination repair frequency
- Synthetic lethal with paclitaxel
- Increased viability after borna disease (rVSVΔG*/BDVG) virus infection
- Increased mitotic delay (prometaphase or metaphase alignment problems, MAP), polylobed nuclei, many micronuclei (grape)
Animal Model Products
-
Taconic Biosciences Mouse Models for PDE3A
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PDE3A - Select products 50% OFF >
- * PDE3A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PDE3A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDE3A
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDE3A
miRNA for PDE3A Gene
- miRTarBase miRNAs that target PDE3A
-
- hsa-miR-155-5p (MIRT001528)
- hsa-miR-128-3p (MIRT022078)
- hsa-miR-211-5p (MIRT054450)
- hsa-miR-3680-3p (MIRT450769)
- hsa-miR-4666b (MIRT450770)
- hsa-miR-5011-3p (MIRT450771)
- hsa-miR-6858-5p (MIRT450772)
- hsa-miR-4689 (MIRT450773)
- hsa-miR-3915 (MIRT450774)
- hsa-miR-1224-5p (MIRT450775)
- hsa-miR-6797-3p (MIRT450776)
- hsa-miR-6076 (MIRT450777)
- hsa-miR-3928-3p (MIRT450778)
- hsa-miR-5582-3p (MIRT450779)
- hsa-miR-8055 (MIRT573353)
- hsa-miR-129-5p (MIRT573354)
- hsa-miR-4776-3p (MIRT573355)
- hsa-miR-1304-5p (MIRT573356)
- hsa-miR-4677-5p (MIRT573357)
- hsa-miR-192-3p (MIRT573358)
- hsa-miR-2116-5p (MIRT573359)
- hsa-miR-22-5p (MIRT573360)
- hsa-miR-3613-3p (MIRT573361)
- mmu-miR-760-5p (MIRT581967)
- hsa-miR-3681-3p (MIRT607857)
- hsa-miR-216a-3p (MIRT607858)
- hsa-miR-8485 (MIRT607860)
- hsa-miR-7150 (MIRT612696)
- hsa-miR-4736 (MIRT612697)
- hsa-miR-4763-3p (MIRT612698)
- hsa-miR-1207-5p (MIRT612699)
- hsa-miR-7843-3p (MIRT667024)
- hsa-miR-5585-5p (MIRT667026)
- hsa-miR-3191-5p (MIRT667027)
- hsa-miR-548ax (MIRT667028)
- hsa-miR-548ao-5p (MIRT667029)
- hsa-miR-942-5p (MIRT667030)
- hsa-miR-5588-5p (MIRT667031)
- hsa-miR-4799-3p (MIRT667032)
- hsa-miR-4720-5p (MIRT667033)
- hsa-miR-3128 (MIRT667034)
- hsa-miR-6824-3p (MIRT667035)
- hsa-miR-6764-3p (MIRT667036)
- hsa-miR-330-5p (MIRT667037)
- hsa-miR-326 (MIRT667038)
- hsa-miR-518c-5p (MIRT667039)
- hsa-miR-6814-5p (MIRT667040)
- hsa-miR-3614-3p (MIRT667041)
- hsa-miR-7849-3p (MIRT667042)
- hsa-miR-6818-3p (MIRT671838)
- hsa-miR-4753-3p (MIRT671839)
- hsa-miR-6873-3p (MIRT671840)
- hsa-miR-377-3p (MIRT671841)
- hsa-miR-593-3p (MIRT671842)
- hsa-miR-6895-3p (MIRT671843)
- hsa-miR-130b-5p (MIRT671844)
- hsa-miR-6817-3p (MIRT671845)
- hsa-miR-7110-3p (MIRT671846)
- hsa-miR-6846-3p (MIRT673284)
- hsa-miR-4743-3p (MIRT673285)
- hsa-miR-6888-3p (MIRT673286)
- hsa-miR-3182 (MIRT673287)
- hsa-miR-3120-5p (MIRT673288)
- hsa-miR-1237-3p (MIRT673289)
- hsa-miR-607 (MIRT700988)
- hsa-miR-3671 (MIRT700989)
- hsa-miR-361-5p (MIRT700990)
- hsa-miR-3171 (MIRT700991)
- hsa-miR-2115-3p (MIRT700992)
- hsa-miR-1265 (MIRT700993)
- hsa-miR-5692a (MIRT700994)
- hsa-miR-106a-3p (MIRT722777)
- hsa-miR-6844 (MIRT722778)
- hsa-miR-4684-3p (MIRT722779)
- hsa-miR-103a-2-5p (MIRT722780)
- hsa-miR-8066 (MIRT722781)
- hsa-miR-1267 (MIRT783263)
- hsa-miR-3147 (MIRT784655)
- hsa-miR-367-5p (MIRT785198)
- hsa-miR-4328 (MIRT785772)
- hsa-miR-4425 (MIRT785824)
- hsa-miR-450a-1-3p (MIRT786042)
- hsa-miR-4652-3p (MIRT786310)
- hsa-miR-4747-5p (MIRT786607)
- hsa-miR-5196-5p (MIRT787228)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDE3A
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Clone Products
- Applied Biological Materials (abm): Clones for PDE3A - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PDE3A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDE3A
Cell Line Products
-
Horizon Cell Lines for PDE3A
No data available for Transcription Factor Targets and HOMER Transcription for PDE3A Gene
Localization for PDE3A Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDE3A Gene
- Membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| mitochondrion | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | IEA,TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for PDE3A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
| 2 | Sweet Taste Signaling |
Sweet Taste Signaling
.72
Cellular Effects of Sildenafil
.46
|
Bitter Taste Signaling
.44
Sperm Motility
.37
|
| 3 | Signaling by GPCR | ||
| 4 | Nitric oxide stimulates guanylate cyclase |
.01
|
|
| 5 | cAMP signaling pathway | ||
Pathways by source for PDE3A Gene
8 Reactome pathways for PDE3A Gene
1 PharmGKB pathway for PDE3A Gene
6 KEGG pathways for PDE3A Gene
2 GeneGo (Thomson Reuters) pathways for PDE3A Gene
- Development Beta-adrenergic receptors signaling via cAMP
- Signal transduction_PKA signaling
10 Qiagen pathways for PDE3A Gene
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
- Bitter Taste Signaling
- cAMP Pathway
Interacting Proteins for PDE3A Gene
Selected Interacting proteins:
Q14432-PDE3A_HUMAN
ENSP00000351957
for PDE3A Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PDE3A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001556 | oocyte maturation | IBA | 21873635 |
| GO:0006629 | lipid metabolic process | TAS | 8921398 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0019933 | cAMP-mediated signaling | IBA,IMP | 17704206 |
Drugs & Compounds for PDE3A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Milrinone | Approved | Pharma | Inhibitor, Inhibition, Target, inhibitor | PDE-3 inhibitor | 49 | |
| Cilostazol | Approved, Investigational | Pharma | Target, inhibitor | PDE3 inhibitor | 126 | |
| Amrinone | Approved | Pharma | Target, inhibitor | 0 | ||
| Anagrelide | Approved | Pharma | Target, inhibitor | 27 | ||
| Enoximone | Approved, Investigational | Pharma | Target, inhibitor | 6 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Eggmanone |
|
505068-32-6 |
|
|
||
| Etazolate hydrochloride |
|
35838-58-5 |
|
|
||
| IBMX |
|
Antagonist | 28822-58-4 |
|
|
|
| MY-5445 |
|
78351-75-4 |
|
|
||
| Ro 20-1724 |
|
29925-17-5 |
|
|
(5) Tocris Compounds for PDE3A Gene
| Compound | Action | Cas Number |
|---|---|---|
| Eggmanone | Potent and selective PDE4 inhibitor; suppresses hedgehog signaling | 505068-32-6 |
| Etazolate hydrochloride | PDE4 inhibitor | 35838-58-5 |
| IBMX | PDE inhibitor (non-selective) | 28822-58-4 |
| MY-5445 | PDE5 inhibitor | 78351-75-4 |
| Ro 20-1724 | PDE4 inhibitor | 29925-17-5 |
(7) ApexBio Compounds for PDE3A Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cilostazol | PDE3 inhibitor | 73963-72-1 |
| Dipyridamole | 58-32-2 | |
| Milrinone | PDE-3 inhibitor | 78415-72-2 |
| Olprinone Hydrochloride | Phosphodiesterase 3 (PDE3) inhibitor, selective | 119615-63-3 |
| Pimobendan | Selective PDE3 inhibitor.Ca2+ channel sensitizer | 74150-27-9 |
| Sildenafil Citrate | Treat erectile dysfunction and PAH | 171599-83-0 |
| Zardaverine | PDE III and IV inhibitor | 101975-10-4 |
Transcripts for PDE3A Gene
mRNA/cDNA for PDE3A Gene
- 5 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000359062 7576 nts (view in UCSC)
- ENST00000542675 685 nts (view in UCSC)
- ENST00000544307 2969 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PDE3A - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PDE3A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDE3A
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDE3A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDE3A
- Browse OriGene Inhibitory RNA Products For PDE3A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDE3A
Clone Products
- Applied Biological Materials (abm): Clones for PDE3A - Select products 50% OFF >
- * PDE3A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PDE3A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDE3A
Relevant External Links for PDE3A Gene
- GeneLoc Exon Structure for
- PDE3A
Expression for PDE3A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Medullary Stroma Cells Interstitial Stroma
- Interstitial Stroma
- Metanephros
- Brain (Nervous System)
- Bone (Muscoskeletal System)
- Gut Tube (Gastrointestinal Tract)
- Lung (Respiratory System)
- Neural Tube (Nervous System)
- Heart (Cardiovascular System)
- NULL (Uncategorized)
-
Larynx (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for PDE3A Gene
This gene is overexpressed in Heart - Left Ventricle (x9.2), Artery - Tibial (x5.2), and Heart - Atrial Appendage (x4.1).
This gene is overexpressed in Heart (11.4), Platelet (10.7), Peripheral blood mononuclear cells (10.0), and Uterus (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDE3A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDE3A
SOURCE GeneReport for Unigene cluster for PDE3A Gene:
Hs.386791Evidence on tissue expression from TISSUES for PDE3A Gene
- Heart(4.7)
- Muscle(4.6)
- Blood(4.5)
- Liver(4.4)
- Nervous system(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PDE3A Gene
Germ Layers:
- mesoderm
Systems:
- cardiovascular
- skeleton
Regions:
Head and neck:
- ear
Thorax:
- heart
Limb:
- digit
- finger
- foot
- hand
- lower limb
- toe
- upper limb
General:
- blood vessel
Primer Products
-
OriGene qPCR primer pairs for PDE3A
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PDE3A Gene
Orthologs for PDE3A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PDE3A 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PDE3A 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PDE3A 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pde3a 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pde3a 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PDE3A 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PDE3A 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PDE3A 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PDE3A 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | pde3a 30 31 |
|
OneToOne | |
| Dr.11181 30 |
|
||||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for PDE3A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PDE3A Gene
- ENSEMBL:
- Gene Tree for PDE3A (if available)
- TreeFam:
- Gene Tree for PDE3A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PDE3A: view image
Paralogs for PDE3A Gene
Paralogs for PDE3A Gene
Variants for PDE3A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDE3A Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 690366 | Likely Pathogenic: Brachydactyly-arterial hypertension syndrome | 20,616,283(+) | GACC/G | INFRAME_DELETION | |
| 709508 | Benign: not provided | 20,621,383(+) | T/C | SYNONYMOUS_VARIANT | |
| 713015 | Benign: not provided | 20,648,864(+) | T/C | SYNONYMOUS_VARIANT | |
| 717258 | Benign: not provided | 20,369,515(+) | G/A | SYNONYMOUS_VARIANT | |
| 717311 | Benign: not provided | 20,369,602(+) | A/G | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv258e214 | CNV | gain | 21293372 |
| dgv775e59 | CNV | tandem duplication | 20981092 |
| esv1015874 | CNV | deletion | 17803354 |
| esv1326828 | CNV | insertion | 17803354 |
| esv1692681 | CNV | insertion | 17803354 |
| esv2218919 | CNV | deletion | 18987734 |
| esv2663850 | CNV | deletion | 23128226 |
| esv2668063 | CNV | deletion | 23128226 |
| esv2674271 | CNV | deletion | 23128226 |
| esv2745621 | CNV | deletion | 23290073 |
| esv3405393 | CNV | duplication | 20981092 |
| esv3580173 | CNV | loss | 25503493 |
| esv3628787 | CNV | loss | 21293372 |
| esv5808 | CNV | gain | 19470904 |
| nsv1042315 | CNV | gain | 25217958 |
| nsv1054997 | CNV | gain | 25217958 |
| nsv1159988 | CNV | duplication | 26073780 |
| nsv469158 | CNV | loss | 19166990 |
| nsv557701 | CNV | loss | 21841781 |
| nsv557702 | CNV | loss | 21841781 |
| nsv557703 | CNV | loss | 21841781 |
| nsv634 | CNV | insertion | 18451855 |
| nsv976582 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
5.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.01;
84.20% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PDE3A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE3A Gene
Disorders for PDE3A Gene
(8) MalaCards diseases for PDE3A Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypertension and brachydactyly syndrome |
|
|
| brachydactyly |
|
|
| impotence |
|
|
| acrodysostosis |
|
|
| familial hypertension |
|
|
Search PDE3A in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PDE3A_HUMAN- Hypertension and brachydactyly syndrome (HTNB) [MIM:112410]: A syndrome characterized by brachydactyly type E, severe salt-independent but age-dependent hypertension, an increased fibroblast growth rate, neurovascular contact at the rostral-ventrolateral medulla, and altered baroreflex blood pressure regulation. It results in death from stroke before age 50 years when untreated. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals. {ECO:0000269 PubMed:25961942}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for PDE3A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for PDE3A Gene
Publications for PDE3A Gene
- Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase. (PMID: 1315035) Meacci E … Manganiello V (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 23
- Cardiac type cGMP-inhibited phosphodiesterase (PDE3A) gene structure: similarity and difference to adipocyte type PDE3B gene. (PMID: 10679291) Kasuya J … Fujita-Yamaguchi Y (Biochemical and biophysical research communications 2000) 2 3 23
- Molecular biological characterization of phosphodiesterase 3A from human corpus cavernosum. (PMID: 10421499) Küthe A … Mägert HJ (Chemico-biological interactions 1999) 3 4 23
- Human platelet cGI-PDE: expression in yeast and localization of the catalytic domain by deletion mutagenesis. (PMID: 8695850) Cheung PP … Colman RW (Blood 1996) 3 4 23
- Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase. (PMID: 8155697) Degerman E … Manganiello V (Biochimica et biophysica acta 1994) 3 4 23
ExternalLinks
Products for PDE3A Gene
- Custom Antibody ServicesOriGene Antibodies for PDE3A
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDE3A
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for PDE3A
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- Novus Biologicals proteins and lysates for PDE3A
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- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Invitrogen Antibodies for PDE3A (AFLGC-PDE3A)
- ApexBio compounds for PDE3A
- VectorBuilder Custom and pre-made DNA vectors for PDE3A (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PDE3A (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PDE3A (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PDE3A CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PDE3A
- antibodies-online: Show 15 available PDE3A Antibodies ranked by validation data
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- antibodies-online: Show 7 available PDE3A Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 9 available PDE3A Proteins ranked by validation data
- Compare Top PDE3A Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PDE3A
- Search Santa Cruz Biotechnology (SCBT) for PDE3A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PDE3A
- Horizon Cell Lines for PDE3A
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDE3A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDE3A
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDE3A
- Boster Bio Antibodies for PDE3A
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for PDE3A
- Signalway ELISA kits for PDE3A
Sources for PDE3A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
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- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
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- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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- (135) abm
- (136) Human Protein Atlas
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- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
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- (178) MirGeneDB