Aliases for PDE2A Gene
External Ids for PDE2A Gene
Previous GeneCards Identifiers for PDE2A Gene
GeneCards Summary for PDE2A Gene
PDE2A (Phosphodiesterase 2A) is a Protein Coding gene. Diseases associated with PDE2A include Intellectual Developmental Disorder With Paroxysmal Dyskinesia Or Seizures and Choreatic Disease. Among its related pathways are Signaling by GPCR and cGMP-PKG signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and calcium channel activity. An important paralog of this gene is PDE11A.
UniProtKB/Swiss-Prot Summary for PDE2A Gene
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027).
[Isoform PDE2A2]: Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107).
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.