Aliases for PDE1C Gene
- Phosphodiesterase 1C 2 3 5
- Hcam3 2 3 4
- Calcium/Calmodulin-Dependent 3',5'-Cyclic Nucleotide Phosphodiesterase 1C 3 4
- Phosphodiesterase 1C, Calmodulin-Dependent 70kDa 2 3
- 3',5'-Cyclic-AMP Phosphodiesterase 3 4
- 3',5'-Cyclic-GMP Phosphodiesterase 3 4
- Cam-PDE 1C 3 4
- Human 3',5' Cyclic Nucleotide Phosphodiesterase (HSPDE1C1A) 3
External Ids for PDE1C Gene
Previous GeneCards Identifiers for PDE1C Gene
This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]
GeneCards Summary for PDE1C Gene
PDE1C (Phosphodiesterase 1C) is a Protein Coding gene. Diseases associated with PDE1C include Deafness, Autosomal Dominant 74 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are Signaling by GPCR and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include calmodulin binding and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE1A.
UniProtKB/Swiss-Prot Summary for PDE1C Gene
Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8557689, PubMed:29860631). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).