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Aliases for PDE1C Gene

Aliases for PDE1C Gene

  • Phosphodiesterase 1C 2 3 5
  • Phosphodiesterase 1C, Calmodulin-Dependent 70kDa 2 3
  • Cam-PDE 1C 3 4
  • HCam-3 3 4
  • Calcium/Calmodulin-Dependent 3,5-Cyclic Nucleotide Phosphodiesterase 1C 3
  • Human 3,5 Cyclic Nucleotide Phosphodiesterase (HSPDE1C1A) 3
  • Phosphodiesterase 1C, Calmodulin-Dependent (70kD) 2
  • EC 4
  • Hcam3 3

External Ids for PDE1C Gene

Previous GeneCards Identifiers for PDE1C Gene

  • GC07M031435
  • GC07M031534
  • GC07M031759

Summaries for PDE1C Gene

Entrez Gene Summary for PDE1C Gene

  • This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]

GeneCards Summary for PDE1C Gene

PDE1C (Phosphodiesterase 1C) is a Protein Coding gene. Among its related pathways are G-Beta Gamma Signaling and Pyrimidine metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include calmodulin binding and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE1A.

UniProtKB/Swiss-Prot for PDE1C Gene

  • Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.

Gene Wiki entry for PDE1C Gene

Additional gene information for PDE1C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE1C Gene

Genomics for PDE1C Gene

GeneHancer (GH) Regulatory Elements for PDE1C Gene

Promoters and enhancers for PDE1C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J032069 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 658.2 +228.7 228702 2.2 MXI1 HDAC2 SUZ12 SIN3A CTBP2 EZH2 PDE1C SNX2P2 PIR50396
GH07J032428 Promoter 1.2 EPDnew 650.1 -128.6 -128647 0.1 MLX ARID4B SIN3A DEAF1 ZBTB40 DNMT3B ZNF48 RFX5 CHAMP1 ZNF614 ENSG00000284839 PDE1C LOC100130673
GH07J032297 Enhancer 0.2 FANTOM5 694.1 +1.6 1560 0.1 PDE1C GC07M032217
GH07J032092 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 10 +205.8 205774 1.4 SP1 JUND GATA3 NFE2 FOSL2 FOS MAFK PDE1C PIR50396 SNX2P2
GH07J032250 Enhancer 0.2 FANTOM5 36.4 +48.4 48375 0.2 PDE1C GC07M032217
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDE1C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDE1C gene promoter:
  • Nkx2-5
  • AP-4
  • HEN1
  • LCR-F1
  • HNF-3beta
  • NCX
  • E47
  • C/EBPalpha
  • RFX1
  • FOXC1

Genomic Locations for PDE1C Gene

Genomic Locations for PDE1C Gene
682,628 bases
Minus strand
548,149 bases
Minus strand

Genomic View for PDE1C Gene

Genes around PDE1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE1C Gene

Proteins for PDE1C Gene

  • Protein details for PDE1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1C
    Protein Accession:
    Secondary Accessions:
    • B3KPC6
    • E9PE92
    • Q14124
    • Q8NB10

    Protein attributes for PDE1C Gene

    709 amino acids
    Molecular mass:
    80760 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for PDE1C Gene

    Alternative splice isoforms for PDE1C Gene


neXtProt entry for PDE1C Gene

Post-translational modifications for PDE1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PDE1C Gene

Domains & Families for PDE1C Gene

Gene Families for PDE1C Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PDE1C Gene

Suggested Antigen Peptide Sequences for PDE1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
genes like me logo Genes that share domains with PDE1C: view

Function for PDE1C Gene

Molecular function for PDE1C Gene

UniProtKB/Swiss-Prot Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.
UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside 3,5-cyclic phosphate + H(2)O = nucleoside 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).

Enzyme Numbers (IUBMB) for PDE1C Gene

Phenotypes From GWAS Catalog for PDE1C Gene

Gene Ontology (GO) - Molecular Function for PDE1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity TAS --
GO:0005516 calmodulin binding IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE1C: view

Phenotypes for PDE1C Gene

genes like me logo Genes that share phenotypes with PDE1C: view

Animal Models for PDE1C Gene

MGI Knock Outs for PDE1C:

Animal Model Products

  • Taconic Biosciences Mouse Models for PDE1C

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDE1C

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PDE1C Gene

Localization for PDE1C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDE1C gene
Compartment Confidence
cytosol 5
nucleus 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PDE1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with PDE1C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE1C Gene

Pathways & Interactions for PDE1C Gene

genes like me logo Genes that share pathways with PDE1C: view

Gene Ontology (GO) - Biological Process for PDE1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with PDE1C: view

No data available for SIGNOR curated interactions for PDE1C Gene

Drugs & Compounds for PDE1C Gene

(12) Drugs for PDE1C Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Trapidil Approved Pharma Target, inhibitor 1
Caffeine Approved Nutra Antagonist, Activator, Target, inhibitor 434
Cafcit Injection Approved September 1999 Pharma 0
Water Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0

(2) Additional Compounds for PDE1C Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PDE1C: view

Transcripts for PDE1C Gene

Unigene Clusters for PDE1C Gene

Phosphodiesterase 1C, calmodulin-dependent 70kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDE1C

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE1C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: - - - - - - - -
SP2: -
SP3: -
SP5: -

ExUns: 23 ^ 24 ^ 25
SP1: -

Relevant External Links for PDE1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDE1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDE1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE1C Gene

This gene is overexpressed in Heart - Left Ventricle (x7.7).

Protein differential expression in normal tissues from HIPED for PDE1C Gene

This gene is overexpressed in Bone (38.1) and Frontal cortex (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDE1C Gene

Protein tissue co-expression partners for PDE1C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PDE1C Gene:


SOURCE GeneReport for Unigene cluster for PDE1C Gene:


mRNA Expression by UniProt/SwissProt for PDE1C Gene:

Tissue specificity: Expressed in several tissues, including brain and heart.

Evidence on tissue expression from TISSUES for PDE1C Gene

  • Heart(4.5)
  • Nervous system(3.5)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with PDE1C: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PDE1C Gene

Orthologs for PDE1C Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE1C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PDE1C 34 33
  • 99.44 (n)
(Canis familiaris)
Mammalia PDE1C 34 33
  • 91.55 (n)
(Bos Taurus)
Mammalia PDE1C 34 33
  • 91.24 (n)
(Ornithorhynchus anatinus)
Mammalia PDE1C 34
  • 91 (a)
(Monodelphis domestica)
Mammalia PDE1C 34
  • 90 (a)
(Rattus norvegicus)
Mammalia Pde1c 33
  • 88.54 (n)
(Mus musculus)
Mammalia Pde1c 16 34 33
  • 88.17 (n)
(Gallus gallus)
Aves PDE1C 34 33
  • 75.62 (n)
(Anolis carolinensis)
Reptilia PDE1C 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pde1c 33
  • 71.02 (n)
Str.17555 33
(Danio rerio)
Actinopterygii PDE1C (1 of 2) 34
  • 81 (a)
PDE1C (2 of 2) 34
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14940 35
  • 57 (a)
Pde1c 34
  • 24 (a)
(Caenorhabditis elegans)
Secernentea T04D3.3 35
  • 55 (a)
pde-1 34 33
  • 54.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
Species where no ortholog for PDE1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE1C Gene

Gene Tree for PDE1C (if available)
Gene Tree for PDE1C (if available)
Evolutionary constrained regions (ECRs) for PDE1C: view image

Paralogs for PDE1C Gene

(8) SIMAP similar genes for PDE1C Gene using alignment to 5 proteins:

  • F8W905_HUMAN
  • Q75MP2_HUMAN
  • Q75MW3_HUMAN
genes like me logo Genes that share paralogs with PDE1C: view

Variants for PDE1C Gene

Sequence variations from dbSNP and Humsavar for PDE1C Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs193921048 uncertain-significance, Malignant tumor of prostate 31,879,086(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs36047130 benign, not specified 31,692,470(-) T/A/C/G genic_downstream_transcript_variant, intron_variant
rs1000002874 -- 32,039,144(-) T/A intron_variant
rs1000003265 -- 32,210,527(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000003515 -- 32,206,410(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PDE1C Gene

Variant ID Type Subtype PubMed ID
dgv11269n54 CNV gain 21841781
dgv6318n100 CNV gain 25217958
esv1014975 CNV deletion 17803354
esv1399325 CNV insertion 17803354
esv2105969 CNV deletion 18987734
esv2225343 CNV deletion 18987734
esv2271605 CNV deletion 18987734
esv2428975 CNV insertion 19546169
esv2513864 CNV deletion 19546169
esv2608247 CNV deletion 19546169
esv2665337 CNV deletion 23128226
esv2670779 CNV deletion 23128226
esv2677609 CNV deletion 23128226
esv2678586 CNV deletion 23128226
esv2734209 CNV deletion 23290073
esv2734210 CNV deletion 23290073
esv2734211 CNV deletion 23290073
esv2734212 CNV deletion 23290073
esv2734213 CNV deletion 23290073
esv2734214 CNV deletion 23290073
esv2734215 CNV deletion 23290073
esv2752156 CNV gain 17911159
esv2761317 CNV loss 21179565
esv3307668 CNV mobile element insertion 20981092
esv33248 CNV gain 17666407
esv3325280 CNV insertion 20981092
esv3351023 CNV insertion 20981092
esv3402198 CNV insertion 20981092
esv3412909 CNV duplication 20981092
esv3414 CNV loss 18987735
esv3541432 CNV deletion 23714750
esv3541434 CNV deletion 23714750
esv3612723 CNV gain 21293372
esv3612727 CNV loss 21293372
esv3612730 CNV loss 21293372
esv3612731 CNV loss 21293372
esv3612732 CNV loss 21293372
esv3612734 CNV loss 21293372
esv6080 CNV loss 19470904
esv6756 CNV gain 19470904
nsv1068321 OTHER inversion 25765185
nsv1137207 CNV deletion 24896259
nsv1148830 OTHER inversion 26484159
nsv436557 CNV deletion 17901297
nsv464420 CNV loss 19166990
nsv464421 CNV gain 19166990
nsv476359 CNV novel sequence insertion 20440878
nsv512909 CNV insertion 21212237
nsv523567 CNV gain 19592680
nsv527840 CNV loss 19592680
nsv528955 CNV loss 19592680
nsv5688 CNV insertion 18451855
nsv5689 CNV insertion 18451855
nsv606589 CNV loss 21841781
nsv606590 CNV loss 21841781
nsv824052 CNV loss 20364138
nsv824053 CNV loss 20364138
nsv824055 CNV loss 20364138

Variation tolerance for PDE1C Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDE1C Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE1C Gene

Disorders for PDE1C Gene

Additional Disease Information for PDE1C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PDE1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDE1C Gene

Publications for PDE1C Gene

  1. Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases. (PMID: 8557689) Loughney K … Ferguson K (The Journal of biological chemistry 1996) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  4. Subcellular localization and regulation of type-1C and type-5 phosphodiesterases. (PMID: 16455054) Dolci S … Jannini EA (Biochemical and biophysical research communications 2006) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for PDE1C Gene

Sources for PDE1C Gene

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