Aliases for PDE1A Gene
External Ids for PDE1A Gene
Previous GeneCards Identifiers for PDE1A Gene
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]
GeneCards Summary for PDE1A Gene
PDE1A (Phosphodiesterase 1A) is a Protein Coding gene. Among its related pathways are DAG and IP3 signaling and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include calmodulin binding and cGMP binding. An important paralog of this gene is PDE1C.
UniProtKB/Swiss-Prot for PDE1A Gene
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.