Aliases for PDE1A Gene
External Ids for PDE1A Gene
Previous GeneCards Identifiers for PDE1A Gene
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]
GeneCards Summary for PDE1A Gene
PDE1A (Phosphodiesterase 1A) is a Protein Coding gene. Diseases associated with PDE1A include Fraser Syndrome 1 and Nephrolithiasis. Among its related pathways are DAG and IP3 signaling and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include calmodulin binding and cGMP binding. An important paralog of this gene is PDE1C.
UniProtKB/Swiss-Prot Summary for PDE1A Gene
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.