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This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008] See more...
Aliases for PDCL3 Gene
Aliases for PDCL3 Gene
External Ids for PDCL3 Gene
- HGNC: 28860
- NCBI Entrez Gene: 79031
- Ensembl: ENSG00000115539
- OMIM®: 611678
- UniProtKB/Swiss-Prot: Q9H2J4
Previous GeneCards Identifiers for PDCL3 Gene
- GC02P100801
- GC02P100637
- GC02P100534
- GC02P101179
- GC02P094944
Summaries for PDCL3 Gene
-
This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for PDCL3 Gene
PDCL3 (Phosducin Like 3) is a Protein Coding gene. Diseases associated with PDCL3 include Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome. Gene Ontology (GO) annotations related to this gene include protein binding involved in protein folding and vascular endothelial growth factor receptor 2 binding. An important paralog of this gene is PDCL2.
UniProtKB/Swiss-Prot Summary for PDCL3 Gene
-
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430).
Additional gene information for PDCL3 Gene
- HGNC (28860)
- NCBI Entrez Gene (79031)
- Ensembl (ENSG00000115539)
- OMIM® (611678)
- UniProtKB/Swiss-Prot (Q9H2J4)
- Open Targets Platform(ENSG00000115539)
- Search for PDCL3 at DataMed
- Search for PDCL3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDCL3 Gene
Genomics for PDCL3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PDCL3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J100561 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 266.4 | -0.1 | -125 | 3.1 | CHD2 TBP MXD4 FEZF1 ZNF217 SIX5 NR2C1 MNT SMAD5 ETS1 | PDCL3 lnc-CHST10-4 NMS | |
| GH02J100588 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE | 23.4 | +25.7 | 25708 | 2.6 | BCL11A CEBPA ZEB1 CEBPB ZNF639 TRIM22 IRF4 MAFF EP300 ELF1 | PDCL3 RPL31 HMGN2P22 SNODB1241 NPAS2 | |
| GH02J100603 | Enhancer | 0.7 | FANTOM5 Ensembl ENCODE | 18.9 | +41.0 | 41008 | 2 | PRDM10 NRF1 POLR2A | LINC01849 PDCL3 ENSG00000223947 RPL31 RF00017-3279 NPAS2 | |
| GH02J100571 | Enhancer | 0.7 | Ensembl | 16.4 | +8.9 | 8908 | 1 | CEBPA HOMEZ CEBPB SMAD4 SAP130 GABPA RARA BCL6 IRF9 ATF1 | PDCL3 KR153194-096 NPAS2 | |
| GH02J100579 | Enhancer | 0.9 | FANTOM5 ENCODE | 11.1 | +18.1 | 18092 | 2.2 | SIN3A GABPA EBF1 BHLHE40 ASH2L POLR2A ELF1 IKZF1 RBBP5 ARID3A | PDCL3 RPL31 SNODB1241 HMGN2P22 NPAS2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PDCL3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDCL3
- Top Transcription factor binding sites by QIAGEN in the PDCL3 gene promoter:
-
- AREB6
- Lhx3a
- LHX3b
- MyoD
- NF-1
- NF-1/L
- p53
- SRF
- SRF (504 AA)
- STAT5A
Genomic Locations for PDCL3 Gene
Latest Assembly
- chr2:100,562,993-100,577,472
- (GRCh38/hg38)
- Size:
- 14,480 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:101,179,455-101,193,201
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 13,747 bases
- Orientation:
- Plus strand
- chr2:101,179,152-101,193,197
- (GRCh37/hg19 by Ensembl)
- Size:
- 14,046 bases
- Orientation:
- Plus strand
Genomic View for PDCL3 Gene
Genes around PDCL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q11.2 by HGNC
- 2q11.2 by Entrez Gene
- 2q11.2 by Ensembl
PDCL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDCL3 Gene
Proteins for PDCL3 Gene
-
Protein details for PDCL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H2J4-PDCL3_HUMAN
- Recommended name:
- Phosducin-like protein 3
- Protein Accession:
- Q9H2J4
- B2RA00
- Q53S68
Protein attributes for PDCL3 Gene
- Size:
- 239 amino acids
- Molecular mass:
- 27614 Da
- Quaternary structure:
-
- Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain) (PubMed:23792958, PubMed:26059764). Forms ternary complexes with the chaperonin CCT complex and actin substrate, leading to inhibition of actin folding (PubMed:17429077). Interacts with XIAP (via BIR 3 and RING domain) (PubMed:19012568). Interacts with HSP90AA1 and HSP90AB1 (By similarity).
Protein Expression for PDCL3 Gene
Post-translational modifications for PDCL3 Gene
- N-terminal methionine acetylation destabilizes the protein.
-
Ubiquitination at Lys90
- NX_Q9H2J4 (NX_Q9H2J4-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PDCL3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PDCL3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for PDCL3
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-
Abcam antibodies for PDCL3
- Invitrogen Antibodies for PDCL3 (AFLGC-PDCL3)
-
Boster Bio Antibodies for PDCL3
-
Custom Antibody ServicesProSci Antibodies for PDCL3
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDCL3
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PDCL3
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- ProSpec Recombinant Proteins for PDCL3
- antibodies-online: Show 8 available PDCL3 Proteins ranked by validation data
- Compare Top PDCL3 Proteins
-
Quality Products:
-
Abcam proteins for PDCL3
Assay products for research
No data available for DME Specific Peptides for PDCL3 Gene
Domains & Families for PDCL3 Gene
Gene Families for PDCL3 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PDCL3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PDCL3 Gene
- GenScript: Design optimal peptide antigens:
-
- Viral IAP-associated factor 1 (PDCL3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9H2J4- Family:
-
- Belongs to the phosducin family.
Function for PDCL3 Gene
Molecular function for PDCL3 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430).
Phenotypes From GWAS Catalog for PDCL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15371430 |
| GO:0043184 | vascular endothelial growth factor receptor 2 binding | IEA | -- |
| GO:0044183 | protein binding involved in protein folding | IEA,IPI | 23792958 |
Phenotypes for PDCL3 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PDCL3 - Starting at $85 >
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- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for PDCL3
miRNA for PDCL3 Gene
- miRTarBase miRNAs that target PDCL3
-
- mmu-miR-190a-5p (MIRT013662)
- hsa-miR-26b-5p (MIRT030318)
- hsa-miR-125a-5p (MIRT045741)
- hsa-let-7b-5p (MIRT052304)
- hsa-miR-545-3p (MIRT296909)
- hsa-miR-766-3p (MIRT296911)
- hsa-miR-550b-2-5p (MIRT622879)
- hsa-miR-7703 (MIRT622880)
- hsa-miR-6720-5p (MIRT622881)
- hsa-miR-6512-3p (MIRT622882)
- hsa-miR-1227-3p (MIRT622883)
- hsa-miR-4252 (MIRT622884)
- hsa-miR-4793-3p (MIRT622885)
- hsa-miR-6849-3p (MIRT622886)
- hsa-miR-1273g-3p (MIRT622887)
- hsa-miR-508-5p (MIRT622888)
- hsa-miR-665 (MIRT635765)
- hsa-miR-7977 (MIRT635766)
- hsa-miR-3686 (MIRT635767)
- hsa-miR-4268 (MIRT635768)
- hsa-miR-3607-3p (MIRT635769)
- hsa-miR-3664-3p (MIRT635770)
- hsa-miR-4267 (MIRT635771)
- hsa-miR-4433a-3p (MIRT635772)
- hsa-miR-4459 (MIRT635773)
- hsa-miR-4768-3p (MIRT635774)
- hsa-miR-6736-3p (MIRT635775)
- hsa-miR-4695-5p (MIRT635776)
- hsa-miR-4487 (MIRT637850)
- hsa-miR-558 (MIRT637851)
- hsa-miR-3160-3p (MIRT637852)
- hsa-miR-5186 (MIRT637853)
- hsa-miR-1247-3p (MIRT736388)
- hsa-miR-1273e (MIRT736776)
- hsa-miR-219b-3p (MIRT739060)
- hsa-miR-302f (MIRT739681)
- hsa-miR-3689d (MIRT742480)
- hsa-miR-455-3p (MIRT746201)
- hsa-miR-6134 (MIRT752450)
- hsa-miR-6499-3p (MIRT752822)
- hsa-miR-6516-5p (MIRT753361)
- hsa-miR-6799-5p (MIRT756320)
- hsa-miR-6851-5p (MIRT757603)
- hsa-miR-6880-5p (MIRT758316)
- hsa-miR-7847-3p (MIRT759855)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDCL3
- Browse OriGene Inhibitory RNA Products For PDCL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCL3
Clone products for research
- Applied Biological Materials (abm): Clones for PDCL3 - Starting at $45 >
- * PDCL3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PDCL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDCL3
Cell Lines for research
-
Horizon Cell Lines for PDCL3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDCL3 Gene
Localization for PDCL3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDCL3 Gene
- Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 15371430 |
| GO:0005783 | endoplasmic reticulum | IEA,IDA | 26059764 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0032991 | protein-containing complex | IEA | -- |
Pathways & Interactions for PDCL3 Gene
Interacting Proteins for PDCL3 Gene
GPS-Prot Interaction Network for PDCL3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IMP | 26059764 |
| GO:0001938 | positive regulation of endothelial cell proliferation | IMP | 23792958 |
| GO:0006457 | protein folding | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0010628 | positive regulation of gene expression | IEA,IMP | 26059764 |
No data available for Pathways by source and SIGNOR curated interactions for PDCL3 Gene
Transcripts for PDCL3 Gene
mRNA/cDNA for PDCL3 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000264254 1038 nts (view in UCSC)
- ENST00000416255 657 nts (view in UCSC)
- ENST00000450127 662 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PDCL3 - Starting at $85 >
- * PDCL3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PDCL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDCL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDCL3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDCL3
- Browse OriGene Inhibitory RNA Products For PDCL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCL3
Clone products for research
- Applied Biological Materials (abm): Clones for PDCL3 - Starting at $45 >
- * PDCL3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PDCL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDCL3
Relevant External Links for PDCL3 Gene
- GeneLoc Exon Structure for
- PDCL3
Expression for PDCL3 Gene
This gene is overexpressed in Heart (13.8), Peripheral blood mononuclear cells (9.1), and Pancreas (8.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDCL3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDCL3
SOURCE GeneReport for Unigene cluster for PDCL3 Gene:
Hs.469459mRNA Expression by UniProt/SwissProt for PDCL3 Gene:
Q9H2J4-PDCL3_HUMAN
Tissue specificity:
Expressed in endothelial cells (at protein level) (PubMed:26059764). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon (PubMed:15371430).
Evidence on tissue expression from TISSUES for PDCL3 Gene
- Eye(4.3)
- Blood(4.2)
- Spleen(4.2)
- Lymph node(4.2)
- Intestine(4.1)
- Stomach(3.9)
Primer products for research
-
OriGene qPCR primer pairs for PDCL3
-
OriGene qPCR primer pairs and template standards for PDCL3
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCL3 Gene
Orthologs for PDCL3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PDCL3 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | PDCL3 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PDCL3 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PDCL3 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PDCL3 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pdcl3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pdcl3 30 |
|
||
| Chicken (Gallus gallus) |
Aves | PDCL3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PDCL3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pdcl3 30 |
|
||
| Str.6268 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24733 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | pdcl3 30 |
|
||
| PDCL3 31 |
|
OneToOne | |||
| Dr.23662 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9370 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | viaf 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010477 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR552C 30 |
|
||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C06952g 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PLP2 30 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G14240 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os01g0184800 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2778 31 |
|
OneToMany | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC2A9.09 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU00617 30 |
|
- Species where no ortholog for PDCL3 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PDCL3 Gene
- ENSEMBL:
- Gene Tree for PDCL3 (if available)
- TreeFam:
- Gene Tree for PDCL3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PDCL3: view image
Paralogs for PDCL3 Gene
(1) SIMAP similar genes for PDCL3 Gene using alignment to 3 proteins:
- PDCL3_HUMAN
- C9JST4_HUMAN
- H7BZP2_HUMAN
Pseudogenes.org Pseudogenes for PDCL3 Gene
Variants for PDCL3 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2720442 | CNV | deletion | 23290073 |
| esv3583989 | CNV | loss | 25503493 |
| esv3591755 | CNV | loss | 21293372 |
| nsv2849 | CNV | insertion | 18451855 |
| nsv582531 | CNV | gain | 21841781 |
| nsv582532 | CNV | gain | 21841781 |
| nsv834312 | CNV | loss | 17160897 |
| nsv961462 | CNV | duplication | 23825009 |
| nsv961463 | CNV | duplication | 23825009 |
| nsv963674 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.33;
26.33% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PDCL3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PDCL3
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDCL3 Gene
Disorders for PDCL3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| megacystis-microcolon-intestinal hypoperistalsis syndrome |
|
|
Search PDCL3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PDCL3
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PDCL3 Gene
Publications for PDCL3 Gene
- Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. (PMID: 26059764) Srinivasan S … Rahimi N (Angiogenesis 2015) 3 4
- Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2. (PMID: 23792958) Srinivasan S … Rahimi N (The Journal of biological chemistry 2013) 3 4
- Binding properties of the C-terminal domain of VIAF. (PMID: 19012568) Bisson WH … Pellecchia M (Chemical biology & drug design 2008) 3 4
- Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression. (PMID: 17429077) Stirling PC … Leroux MR (Molecular biology of the cell 2007) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
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- Browse ELISA Kits
- Abcam antibodies for PDCL3
- Abcam proteins for PDCL3
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- VectorBuilder Custom and pre-made DNA vectors for PDCL3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PDCL3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PDCL3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PDCL3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PDCL3
- antibodies-online: Show 13 available PDCL3 Antibodies ranked by validation data
- Compare Top PDCL3 Antibodies
- antibodies-online: Search results for available PDCL3 related products ranked by validation data
- antibodies-online: Show 8 available PDCL3 Proteins ranked by validation data
- Compare Top PDCL3 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for PDCL3
- Search Santa Cruz Biotechnology (SCBT) for PDCL3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PDCL3
- Custom Antibody ServicesProSci Antibodies for PDCL3
- Search for PDCL3 Proteins at ProSci
- Horizon Cell Lines for PDCL3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDCL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDCL3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PDCL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCL3
- Boster Bio Antibodies for PDCL3
- Browse Boster Bio ELISA Kits
Sources for PDCL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB