Aliases for PDCL3 Gene
External Ids for PDCL3 Gene
Previous GeneCards Identifiers for PDCL3 Gene
This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for PDCL3 Gene
PDCL3 (Phosducin Like 3) is a Protein Coding gene. Diseases associated with PDCL3 include Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome. Gene Ontology (GO) annotations related to this gene include protein binding involved in protein folding and vascular endothelial growth factor receptor 2 binding. An important paralog of this gene is PDCL2.
UniProtKB/Swiss-Prot Summary for PDCL3 Gene
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430).