This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008] See more...

Aliases for PDCL3 Gene

Aliases for PDCL3 Gene

  • Phosducin Like 3 2 3 5
  • Viral IAP-Associated Factor 1 3 4
  • Phosducin-Like Protein 3 3 4
  • HTPHLP 3 4
  • VIAF-1 3 4
  • PhPL3 3 4
  • VIAF1 3 4
  • IAP-Associated Factor VIAF1 3
  • PHLP2A 3
  • PhLP2A 4
  • PHLP3 3
  • VIAF 3

External Ids for PDCL3 Gene

Previous GeneCards Identifiers for PDCL3 Gene

  • GC02P100801
  • GC02P100637
  • GC02P100534
  • GC02P101179
  • GC02P094944

Summaries for PDCL3 Gene

Entrez Gene Summary for PDCL3 Gene

  • This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDCL3 Gene

PDCL3 (Phosducin Like 3) is a Protein Coding gene. Diseases associated with PDCL3 include Herpetic Whitlow and Neurodegeneration With Brain Iron Accumulation 6. Gene Ontology (GO) annotations related to this gene include protein binding involved in protein folding and vascular endothelial growth factor receptor 2 binding. An important paralog of this gene is PDCL2.

UniProtKB/Swiss-Prot Summary for PDCL3 Gene

  • Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430).

Additional gene information for PDCL3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDCL3 Gene

Genomics for PDCL3 Gene

GeneHancer (GH) Regulatory Elements for PDCL3 Gene

Promoters and enhancers for PDCL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J100561 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 516.4 -0.1 -88 3.1 HNRNPK ZBTB40 ZNF217 EP300 CTCF NRF1 MYC POLR2G NCOR1 GTF2E2 PDCL3 lnc-CHST10-4
GH02J100588 Enhancer 1.3 FANTOM5 Ensembl ENCODE 23.4 +25.7 25745 2.6 JUND FOS ZNF639 EP300 AFF1 TRIM28 JUN TRIM22 ATF2 ZEB1 PDCL3 CHST10 RPL31 HMGN2P22 RF01210-208
GH02J100603 Enhancer 0.8 FANTOM5 Ensembl ENCODE 18.9 +41.0 41045 2 NRF1 PRDM10 JUN POLR2A LINC01849 PDCL3 ENSG00000223947 RPL31 RF00017-3279
GH02J100571 Enhancer 0.7 Ensembl 16.4 +8.9 8945 1 MYC CEBPB GABPA TRIM24 CEBPG SAP130 SMAD4 EP400 BCL6 HOMEZ PDCL3 KR153194-097
GH02J100579 Enhancer 1 FANTOM5 ENCODE 11.1 +18.1 18129 2.2 SIN3A POLR2A TCF12 GABPA MEF2B NBN WRNIP1 ASH2L ELF1 POU2F2 PDCL3 RPL31 RF01210-208 HMGN2P22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDCL3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDCL3

Top Transcription factor binding sites by QIAGEN in the PDCL3 gene promoter:
  • AREB6
  • Lhx3a
  • LHX3b
  • MyoD
  • NF-1
  • NF-1/L
  • p53
  • SRF
  • SRF (504 AA)
  • STAT5A

Genomic Locations for PDCL3 Gene

Genomic Locations for PDCL3 Gene
chr2:100,562,956-100,576,739
(GRCh38/hg38)
Size:
13,784 bases
Orientation:
Plus strand
chr2:101,179,152-101,193,201
(GRCh37/hg19)
Size:
14,050 bases
Orientation:
Plus strand

Genomic View for PDCL3 Gene

Genes around PDCL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCL3 Gene

Proteins for PDCL3 Gene

  • Protein details for PDCL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2J4-PDCL3_HUMAN
    Recommended name:
    Phosducin-like protein 3
    Protein Accession:
    Q9H2J4
    Secondary Accessions:
    • B2RA00
    • Q53S68

    Protein attributes for PDCL3 Gene

    Size:
    239 amino acids
    Molecular mass:
    27614 Da
    Quaternary structure:
    • Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain) (PubMed:23792958, PubMed:26059764). Forms ternary complexes with the chaperonin CCT complex and actin substrate, leading to inhibition of actin folding (PubMed:17429077). Interacts with XIAP (via BIR 3 and RING domain) (PubMed:19012568). Interacts with HSP90AA1 and HSP90AB1 (By similarity).

neXtProt entry for PDCL3 Gene

Post-translational modifications for PDCL3 Gene

  • N-terminal methionine acetylation destabilizes the protein.
  • Ubiquitination at Lys90
  • Modification sites at PhosphoSitePlus

Other Protein References for PDCL3 Gene

No data available for DME Specific Peptides for PDCL3 Gene

Domains & Families for PDCL3 Gene

Gene Families for PDCL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PDCL3 Gene

Suggested Antigen Peptide Sequences for PDCL3 Gene

GenScript: Design optimal peptide antigens:
  • Viral IAP-associated factor 1 (PDCL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H2J4

UniProtKB/Swiss-Prot:

PDCL3_HUMAN :
  • Belongs to the phosducin family.
Family:
  • Belongs to the phosducin family.
genes like me logo Genes that share domains with PDCL3: view

Function for PDCL3 Gene

Molecular function for PDCL3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430).

Phenotypes From GWAS Catalog for PDCL3 Gene

Gene Ontology (GO) - Molecular Function for PDCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15371430
GO:0043184 vascular endothelial growth factor receptor 2 binding IEA --
GO:0044183 protein binding involved in protein folding IPI,IEA 23792958
genes like me logo Genes that share ontologies with PDCL3: view
genes like me logo Genes that share phenotypes with PDCL3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCL3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDCL3 Gene

Localization for PDCL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDCL3 Gene

Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDCL3 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 5
plasma membrane 2
cytoskeleton 2
extracellular 1
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 15371430
GO:0005783 endoplasmic reticulum IDA 26059764
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with PDCL3: view

Pathways & Interactions for PDCL3 Gene

PathCards logo

SuperPathways for PDCL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IMP 26059764
GO:0001938 positive regulation of endothelial cell proliferation IMP 23792958
GO:0006457 protein folding IEA --
GO:0006915 apoptotic process IEA --
GO:0010628 positive regulation of gene expression IEA,IMP 26059764
genes like me logo Genes that share ontologies with PDCL3: view

No data available for Pathways by source and SIGNOR curated interactions for PDCL3 Gene

Drugs & Compounds for PDCL3 Gene

No Compound Related Data Available

Transcripts for PDCL3 Gene

mRNA/cDNA for PDCL3 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCL3

Alternative Splicing Database (ASD) splice patterns (SP) for PDCL3 Gene

No ASD Table

Relevant External Links for PDCL3 Gene

GeneLoc Exon Structure for
PDCL3

Expression for PDCL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PDCL3 Gene

Protein differential expression in normal tissues from HIPED for PDCL3 Gene

This gene is overexpressed in Heart (13.8), Peripheral blood mononuclear cells (9.1), and Pancreas (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDCL3 Gene



Protein tissue co-expression partners for PDCL3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDCL3

SOURCE GeneReport for Unigene cluster for PDCL3 Gene:

Hs.469459

mRNA Expression by UniProt/SwissProt for PDCL3 Gene:

Q9H2J4-PDCL3_HUMAN
Tissue specificity: Expressed in endothelial cells (at protein level) (PubMed:26059764). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon (PubMed:15371430).

Evidence on tissue expression from TISSUES for PDCL3 Gene

  • Eye(4.2)
  • Lymph node(4.2)
  • Spleen(4.2)
  • Blood(4.1)
  • Intestine(4.1)
  • Stomach(3.9)
genes like me logo Genes that share expression patterns with PDCL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCL3 Gene

Orthologs for PDCL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDCL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDCL3 30
  • 99.16 (n)
dog
(Canis familiaris)
Mammalia PDCL3 31 30
  • 89.96 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDCL3 31
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDCL3 31 30
  • 86.75 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDCL3 31
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdcl3 17 31 30
  • 84.66 (n)
rat
(Rattus norvegicus)
Mammalia Pdcl3 30
  • 83.12 (n)
chicken
(Gallus gallus)
Aves PDCL3 31 30
  • 75.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDCL3 31
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcl3 30
  • 72.43 (n)
Str.6268 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24733 30
zebrafish
(Danio rerio)
Actinopterygii pdcl3 30
  • 69.2 (n)
PDCL3 31
  • 62 (a)
OneToOne
Dr.23662 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9370 30
fruit fly
(Drosophila melanogaster)
Insecta viaf 31 30
  • 56.93 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010477 30
  • 54.8 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR552C 30
  • 45.69 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06952g 30
  • 45.01 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLP2 31 30
  • 44.16 (n)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G14240 30
  • 46.13 (n)
rice
(Oryza sativa)
Liliopsida Os01g0184800 30
  • 48.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2778 31
  • 57 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2A9.09 30
  • 49.57 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00617 30
  • 45.79 (n)
Species where no ortholog for PDCL3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDCL3 Gene

ENSEMBL:
Gene Tree for PDCL3 (if available)
TreeFam:
Gene Tree for PDCL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PDCL3: view image

Paralogs for PDCL3 Gene

Paralogs for PDCL3 Gene

(1) SIMAP similar genes for PDCL3 Gene using alignment to 3 proteins:

  • PDCL3_HUMAN
  • C9JST4_HUMAN
  • H7BZP2_HUMAN
genes like me logo Genes that share paralogs with PDCL3: view

Variants for PDCL3 Gene

Additional dbSNP identifiers (rs#s) for PDCL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PDCL3 Gene

Variant ID Type Subtype PubMed ID
esv2720442 CNV deletion 23290073
esv3583989 CNV loss 25503493
esv3591755 CNV loss 21293372
nsv2849 CNV insertion 18451855
nsv582531 CNV gain 21841781
nsv582532 CNV gain 21841781
nsv834312 CNV loss 17160897
nsv961462 CNV duplication 23825009
nsv961463 CNV duplication 23825009
nsv963674 CNV duplication 23825009

Variation tolerance for PDCL3 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDCL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDCL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDCL3 Gene

Disorders for PDCL3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PDCL3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
herpetic whitlow
  • herpetic felon
neurodegeneration with brain iron accumulation 6
  • nbia6
- elite association - COSMIC cancer census association via MalaCards
Search PDCL3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PDCL3

genes like me logo Genes that share disorders with PDCL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDCL3 Gene

Publications for PDCL3 Gene

  1. Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. (PMID: 26059764) Srinivasan S … Rahimi N (Angiogenesis 2015) 3 4 54
  2. Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2. (PMID: 23792958) Srinivasan S … Rahimi N (The Journal of biological chemistry 2013) 3 4 54
  3. Binding properties of the C-terminal domain of VIAF. (PMID: 19012568) Bisson WH … Pellecchia M (Chemical biology & drug design 2008) 3 4 54
  4. Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression. (PMID: 17429077) Stirling PC … Leroux MR (Molecular biology of the cell 2007) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for PDCL3 Gene

Sources for PDCL3 Gene