Aliases for PDCL3 Gene
External Ids for PDCL3 Gene
Previous GeneCards Identifiers for PDCL3 Gene
This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for PDCL3 Gene
PDCL3 (Phosducin Like 3) is a Protein Coding gene. Diseases associated with PDCL3 include Herpetic Whitlow and Neurodegeneration With Brain Iron Accumulation 6. Gene Ontology (GO) annotations related to this gene include protein binding involved in protein folding and vascular endothelial growth factor receptor 2 binding. An important paralog of this gene is PDCL2.
UniProtKB/Swiss-Prot Summary for PDCL3 Gene
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430).