External Ids for PDCL Gene
Previous GeneCards Identifiers for PDCL Gene
Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for PDCL Gene
PDCL (Phosducin Like) is a Protein Coding gene. Diseases associated with PDCL include Tomato Allergy and Timothy Grass Allergy. Among its related pathways are Metabolism of proteins and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is PDC.
UniProtKB/Swiss-Prot for PDCL Gene
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.
Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.