Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 200... See more...

Aliases for PDCL Gene

Aliases for PDCL Gene

  • Phosducin Like 2 3 5
  • Phosducin-Like Protein 3 4
  • PhLP 2 3
  • DKFZp564M1863 2
  • PHLOP1 4
  • PhLP1 4
  • PDCL 5
  • PHLP 4

External Ids for PDCL Gene

Previous GeneCards Identifiers for PDCL Gene

  • GC09M116684
  • GC09M117226
  • GC09M119014
  • GC09M120955
  • GC09M122659
  • GC09M124620
  • GC09M125560
  • GC09M095194

Summaries for PDCL Gene

Entrez Gene Summary for PDCL Gene

  • Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDCL Gene

PDCL (Phosducin Like) is a Protein Coding gene. Diseases associated with PDCL include Timothy Grass Allergy and Melon Allergy. Among its related pathways are Metabolism of proteins and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is PDC.

UniProtKB/Swiss-Prot Summary for PDCL Gene

  • Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
  • [Isoform 1]: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.
  • [Isoform 2]: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.

Gene Wiki entry for PDCL Gene

Additional gene information for PDCL Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDCL Gene

Genomics for PDCL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PDCL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J122826 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.9 854 3.3 SP1 CREB1 GATAD2A TEAD4 PRDM10 TFE3 IKZF1 ZNF692 RCOR2 POLR2A PDCL ZBTB26 RC3H2 ZBTB6 ENSG00000261094 MRRF MORN5 STRBP lnc-RC3H2-2 OR1K1
GH09J122819 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 +7.7 7687 5.4 JUND FOXA1 PKNOX1 HDAC1 SOX6 ATF7 EP300 ZNF766 MTA3 CEBPB OR1K1 OR5C1 SNORD90 lnc-RC3H2-2 PDCL
GH09J122902 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.2 -75.7 -75667 3.9 BRCA1 ARHGAP35 CEBPG HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 TFE3 SIX5 RC3H2 lnc-RABGAP1-2 lnc-ZBTB6-1 ZBTB26 SNORD90 RABGAP1 MIR600HG piR-49234 PDCL
GH09J122809 Enhancer 0.9 Ensembl ENCODE 0.4 +18.5 18500 1.8 CTCF FOXA1 ZNF143 REST RAD21 IRF2 TRIM22 YY1 HMBOX1 SMARCA5 OR1K1 lnc-OR1K1-1 PDCL
GH09J122815 Enhancer 0.7 ENCODE dbSUPER 0.4 +12.2 12237 1.8 ZIC2 ZNF600 NR2F2 BCOR ADNP POLR2A JUND ZMYM3 KDM1A lnc-RC3H2-2 lnc-RC3H2-3 lnc-OR1K1-1 OR5C1 SNORD90 PDCL OR1K1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDCL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDCL

Top Transcription factor binding sites by QIAGEN in the PDCL gene promoter:
  • Evi-1
  • GATA-3
  • Lmo2
  • MRF-2
  • POU2F1
  • POU2F1a
  • USF-1
  • USF1

Genomic Locations for PDCL Gene

Genomic Locations for PDCL Gene
chr9:122,798,389-122,828,588
(GRCh38/hg38)
Size:
30,200 bases
Orientation:
Minus strand
chr9:125,560,668-125,590,935
(GRCh37/hg19)
Size:
30,268 bases
Orientation:
Minus strand

Genomic View for PDCL Gene

Genes around PDCL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCL Gene

Proteins for PDCL Gene

  • Protein details for PDCL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13371-PHLP_HUMAN
    Recommended name:
    Phosducin-like protein
    Protein Accession:
    Q13371
    Secondary Accessions:
    • Q4VXB6
    • Q96AF1
    • Q9UEW7
    • Q9UFL0
    • Q9UNX1
    • Q9UNX2

    Protein attributes for PDCL Gene

    Size:
    301 amino acids
    Molecular mass:
    34282 Da
    Quaternary structure:
    • Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin. Interacts with the CCT chaperonin complex.
    Miscellaneous:
    • [Isoform 2]: Expressed ubiquitously, highest levels are found in neural tissues amounting to 10% of total PDCL mRNA.

    Alternative splice isoforms for PDCL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDCL Gene

Post-translational modifications for PDCL Gene

  • Ubiquitination at Lys240
  • Modification sites at PhosphoSitePlus

Other Protein References for PDCL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PDCL
  • Boster Bio Antibodies for PDCL
  • Santa Cruz Biotechnology (SCBT) Antibodies for PDCL

No data available for DME Specific Peptides for PDCL Gene

Domains & Families for PDCL Gene

Gene Families for PDCL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PDCL Gene

Suggested Antigen Peptide Sequences for PDCL Gene

GenScript: Design optimal peptide antigens:
  • Phosducin-like protein (PHLP_HUMAN)
  • Phosducin-like (Q4VXB4_HUMAN)
  • Phosducin-like (Q4VXB5_HUMAN)
  • cDNA, FLJ93968, highly similar to Homo sapiens phosducin-like (PDCL), mRNA (Q4VXB6_HUMAN)
  • Phosducin-like protein (Q9UNX1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13371

UniProtKB/Swiss-Prot:

PHLP_HUMAN :
  • Belongs to the phosducin family.
Family:
  • Belongs to the phosducin family.
genes like me logo Genes that share domains with PDCL: view

Function for PDCL Gene

Molecular function for PDCL Gene

UniProtKB/Swiss-Prot Function:
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
UniProtKB/Swiss-Prot Function:
[Isoform 1]: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.
GENATLAS Biochemistry:
phosducin-like protein,a putative heterotrimeric G protein modulator

Phenotypes From GWAS Catalog for PDCL Gene

Gene Ontology (GO) - Molecular Function for PDCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0044877 protein-containing complex binding IEA --
genes like me logo Genes that share ontologies with PDCL: view
genes like me logo Genes that share phenotypes with PDCL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDCL Gene

Localization for PDCL Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDCL Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDCL gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
extracellular 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005929 cilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with PDCL: view

Pathways & Interactions for PDCL Gene

genes like me logo Genes that share pathways with PDCL: view

SIGNOR curated interactions for PDCL Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PDCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA,TAS --
GO:0007165 signal transduction NAS 10524200
GO:0007601 visual perception IEA --
GO:0008277 regulation of G protein-coupled receptor signaling pathway TAS 10095058
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with PDCL: view

Drugs & Compounds for PDCL Gene

(1) Drugs for PDCL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PDCL: view

Transcripts for PDCL Gene

mRNA/cDNA for PDCL Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCL

Alternative Splicing Database (ASD) splice patterns (SP) for PDCL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for PDCL Gene

GeneLoc Exon Structure for
PDCL

Expression for PDCL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PDCL Gene

Protein differential expression in normal tissues from HIPED for PDCL Gene

This gene is overexpressed in Breast (34.7), Fetal ovary (7.6), and Retina (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDCL Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDCL

SOURCE GeneReport for Unigene cluster for PDCL Gene:

Hs.271749

Evidence on tissue expression from TISSUES for PDCL Gene

  • Nervous system(4.6)
  • Spleen(2.4)
  • Blood(2.3)
  • Lung(2.2)
  • Skin(2.2)
  • Lymph node(2.1)
  • Eye(2)
genes like me logo Genes that share expression patterns with PDCL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCL Gene

Orthologs for PDCL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDCL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PDCL 30 31
  • 99.45 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PDCL 30 31
  • 90.14 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pdcl 30
  • 89.15 (n)
Mouse
(Mus musculus)
Mammalia Pdcl 30 17 31
  • 89.04 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PDCL 30 31
  • 87.15 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PDCL 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PDCL 30 31
  • 73.29 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PDCL 31
  • 51 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pdcl 30
  • 66.89 (n)
Str.6339 30
Zebrafish
(Danio rerio)
Actinopterygii pdcl 30 31
  • 62.68 (n)
OneToOne
wufc06a08 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG7650 30 31 32
  • 54.72 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004468 30
  • 54.37 (n)
Worm
(Caenorhabditis elegans)
Secernentea mau-8 31
  • 30 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLP2 31
  • 16 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
OneToMany
Species where no ortholog for PDCL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PDCL Gene

ENSEMBL:
Gene Tree for PDCL (if available)
TreeFam:
Gene Tree for PDCL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PDCL: view image

Paralogs for PDCL Gene

Paralogs for PDCL Gene

(1) SIMAP similar genes for PDCL Gene using alignment to 3 proteins:

  • PHLP_HUMAN
  • H0Y3M0_HUMAN
  • H0Y5D3_HUMAN
genes like me logo Genes that share paralogs with PDCL: view

Variants for PDCL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDCL Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
785296 Benign: not provided 122,826,662(-) C/A SYNONYMOUS_VARIANT
rs4466466 - p.Lys218Asn

Additional dbSNP identifiers (rs#s) for PDCL Gene

Structural Variations from Database of Genomic Variants (DGV) for PDCL Gene

Variant ID Type Subtype PubMed ID
nsv615270 CNV gain 21841781

Variation tolerance for PDCL Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDCL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDCL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCL Gene

Disorders for PDCL Gene

MalaCards: The human disease database

(20) MalaCards diseases for PDCL Gene - From: DISEASES

Disorder Aliases PubMed IDs
timothy grass allergy
melon allergy
  • cucumis melo fruit allergy
tomato allergy
  • solanum lycopersicum fruit allergy
apple allergy
  • malus domestica fruit allergy
orange allergy
  • citrus sinensis fruit allergy
- elite association - COSMIC cancer census association via MalaCards
Search PDCL in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with PDCL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDCL Gene

Publications for PDCL Gene

  1. Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization. (PMID: 10095058) Thibault C … Miles MF (Biochimica et biophysica acta 1999) 2 3 4 23
  2. Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins. (PMID: 23888055) Gao X … Sokolov M (The Journal of biological chemistry 2013) 3 4
  3. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. (PMID: 19376773) Howlett AC … Willardson BM (The Journal of biological chemistry 2009) 3 4
  4. Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis. (PMID: 19403526) Guzmán-Hernández ML … Vázquez-Prado J (The Journal of biological chemistry 2009) 3 23
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4

Products for PDCL Gene

  • Signalway Proteins for PDCL

Sources for PDCL Gene