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Aliases for PDCD7 Gene

Aliases for PDCD7 Gene

  • Programmed Cell Death 7 2 3 5
  • U11/U12 SnRNP 59K 2 3
  • HES18 3 4
  • ES18 3 4
  • Programmed Cell Death Protein 7 3
  • Apoptosis-Related Protein ES18 3

External Ids for PDCD7 Gene

Previous GeneCards Identifiers for PDCD7 Gene

  • GC15M061187
  • GC15M058509
  • GC15M062988
  • GC15M063125
  • GC15M063196
  • GC15M065409
  • GC15M042234

Summaries for PDCD7 Gene

Entrez Gene Summary for PDCD7 Gene

  • This gene encodes a 59 kDa protein that is associated with the U11 small nuclear ribonucleoprotein (snRNP), which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns. [provided by RefSeq, Dec 2010]

GeneCards Summary for PDCD7 Gene

PDCD7 (Programmed Cell Death 7) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Minor Pathway.

UniProtKB/Swiss-Prot for PDCD7 Gene

  • Promotes apoptosis when overexpressed.

Gene Wiki entry for PDCD7 Gene

Additional gene information for PDCD7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD7 Gene

Genomics for PDCD7 Gene

GeneHancer (GH) Regulatory Elements for PDCD7 Gene

Promoters and enhancers for PDCD7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I065132 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.4 357 2.2 PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 PDCD7 TRIP4 PARP16 INTS14 SPG21 CILP GC15M065089
GH15I065609 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 62.2 -477.6 -477576 3.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 INTS14 SLC24A1 PARP16 ENSG00000260773 SNORD16 RPL35AP32 PDCD7 ENSG00000264937 ENSG00000259635 TIPIN
GH15I065303 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 49.5 -170.6 -170635 2.2 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC GC15M065305 RNU5B-1 GC15P068442 PARP16 ZNF609 TRIP4 INTS14 PDCD7 SLC24A1 ENSG00000264937
GH15I065868 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 44 -736.7 -736744 3.7 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 TRQ-CTG1-4 RAB11A PDCD7 PARP16 SLC24A1 INTS14 MTFMT UBAP1L TIPIN SNAPC5
GH15I065295 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 29.2 -163.5 -163531 4.1 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 GC15P068518 RNU5A-1 PARP16 INTS14 ZNF609 TRIP4 ENSG00000264937 ENSG00000259635 PDCD7 CSNK1G1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PDCD7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDCD7 gene promoter:

Genomic Locations for PDCD7 Gene

Genomic Locations for PDCD7 Gene
chr15:65,117,379-65,133,836
(GRCh38/hg38)
Size:
16,458 bases
Orientation:
Minus strand
chr15:65,409,717-65,426,174
(GRCh37/hg19)

Genomic View for PDCD7 Gene

Genes around PDCD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD7 Gene

Proteins for PDCD7 Gene

  • Protein details for PDCD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8D1-PDCD7_HUMAN
    Recommended name:
    Programmed cell death protein 7
    Protein Accession:
    Q8N8D1
    Secondary Accessions:
    • Q96AK8
    • Q9Y6D7

    Protein attributes for PDCD7 Gene

    Size:
    485 amino acids
    Molecular mass:
    54700 Da
    Quaternary structure:
    • Interacts with RBM40. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.

neXtProt entry for PDCD7 Gene

Post-translational modifications for PDCD7 Gene

  • Ubiquitination at isoforms=280
  • Modification sites at PhosphoSitePlus

Other Protein References for PDCD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDCD7 Gene

Domains & Families for PDCD7 Gene

Gene Families for PDCD7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PDCD7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PDCD7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PDCD7: view

No data available for UniProtKB/Swiss-Prot for PDCD7 Gene

Function for PDCD7 Gene

Molecular function for PDCD7 Gene

UniProtKB/Swiss-Prot Function:
Promotes apoptosis when overexpressed.

Phenotypes From GWAS Catalog for PDCD7 Gene

genes like me logo Genes that share phenotypes with PDCD7: view

Animal Model Products

CRISPR Products

miRNA for PDCD7 Gene

miRTarBase miRNAs that target PDCD7

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDCD7 Gene

Localization for PDCD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDCD7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDCD7 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDCD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005689 U12-type spliceosomal complex IDA 15146077
genes like me logo Genes that share ontologies with PDCD7: view

Pathways & Interactions for PDCD7 Gene

genes like me logo Genes that share pathways with PDCD7: view

Pathways by source for PDCD7 Gene

Gene Ontology (GO) - Biological Process for PDCD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006915 apoptotic process IEA --
GO:0008380 RNA splicing IC 15146077
GO:0051384 response to glucocorticoid ISS 10037816
genes like me logo Genes that share ontologies with PDCD7: view

No data available for SIGNOR curated interactions for PDCD7 Gene

Drugs & Compounds for PDCD7 Gene

No Compound Related Data Available

Transcripts for PDCD7 Gene

mRNA/cDNA for PDCD7 Gene

Unigene Clusters for PDCD7 Gene

Programmed cell death 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD7 Gene

No ASD Table

Relevant External Links for PDCD7 Gene

GeneLoc Exon Structure for
PDCD7
ECgene alternative splicing isoforms for
PDCD7

Expression for PDCD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDCD7 Gene

Protein differential expression in normal tissues from HIPED for PDCD7 Gene

This gene is overexpressed in Liver, secretome (55.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDCD7 Gene



Protein tissue co-expression partners for PDCD7 Gene

NURSA nuclear receptor signaling pathways regulating expression of PDCD7 Gene:

PDCD7

SOURCE GeneReport for Unigene cluster for PDCD7 Gene:

Hs.458596

Evidence on tissue expression from TISSUES for PDCD7 Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with PDCD7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCD7 Gene

Orthologs for PDCD7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDCD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDCD7 33 34
  • 97.91 (n)
dog
(Canis familiaris)
Mammalia PDCD7 33 34
  • 91.35 (n)
cow
(Bos Taurus)
Mammalia PDCD7 33 34
  • 89.97 (n)
rat
(Rattus norvegicus)
Mammalia Pdcd7 33
  • 89.72 (n)
mouse
(Mus musculus)
Mammalia Pdcd7 33 16 34
  • 86.57 (n)
oppossum
(Monodelphis domestica)
Mammalia PDCD7 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDCD7 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDCD7 34
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDCD7 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16005 33
zebrafish
(Danio rerio)
Actinopterygii pdcd7 33 34
  • 53.82 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3428 33
Species where no ortholog for PDCD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDCD7 Gene

ENSEMBL:
Gene Tree for PDCD7 (if available)
TreeFam:
Gene Tree for PDCD7 (if available)

Paralogs for PDCD7 Gene

No data available for Paralogs for PDCD7 Gene

Variants for PDCD7 Gene

Sequence variations from dbSNP and Humsavar for PDCD7 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000071942 -- 65,135,277(-) G/A upstream_transcript_variant
rs1000171767 -- 65,130,526(-) C/T intron_variant
rs1000318788 -- 65,135,498(-) T/C upstream_transcript_variant
rs1000509230 -- 65,131,839(-) C/G intron_variant
rs1000578352 -- 65,117,782(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PDCD7 Gene

Variant ID Type Subtype PubMed ID
esv2763104 CNV gain 21179565

Variation tolerance for PDCD7 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 62.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDCD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDCD7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD7 Gene

Disorders for PDCD7 Gene

Additional Disease Information for PDCD7

No disorders were found for PDCD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDCD7 Gene

Publications for PDCD7 Gene

  1. Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells. (PMID: 10037816) Park EJ … Hong SH (Nucleic acids research 1999) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will CL … Lührmann R (RNA (New York, N.Y.) 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for PDCD7 Gene

Sources for PDCD7 Gene

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