Aliases for PDCD4 Gene
External Ids for PDCD4 Gene
Previous GeneCards Identifiers for PDCD4 Gene
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
GeneCards Summary for PDCD4 Gene
PDCD4 (Programmed Cell Death 4) is a Protein Coding gene. Diseases associated with PDCD4 include Colorectal Cancer and Tongue Squamous Cell Carcinoma. Among its related pathways are mTOR signaling pathway (Pathway Interaction Database) and Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include RNA binding and binding.
UniProtKB/Swiss-Prot Summary for PDCD4 Gene
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).