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This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] See more...
Aliases for PDCD4 Gene
Aliases for PDCD4 Gene
External Ids for PDCD4 Gene
- HGNC: 8763
- NCBI Entrez Gene: 27250
- Ensembl: ENSG00000150593
- OMIM®: 608610
- UniProtKB/Swiss-Prot: Q53EL6
Previous GeneCards Identifiers for PDCD4 Gene
- GC10P111524
- GC10P111865
- GC10P112762
- GC10P112296
- GC10P112618
- GC10P106260
Summaries for PDCD4 Gene
-
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
GeneCards Summary for PDCD4 Gene
PDCD4 (Programmed Cell Death 4) is a Protein Coding gene. Diseases associated with PDCD4 include Colorectal Cancer and Tongue Squamous Cell Carcinoma. Among its related pathways are Proteoglycans in cancer and Interferon type I signaling pathways. Gene Ontology (GO) annotations related to this gene include RNA binding and binding.
UniProtKB/Swiss-Prot Summary for PDCD4 Gene
-
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
Additional gene information for PDCD4 Gene
- HGNC (8763)
- NCBI Entrez Gene (27250)
- Ensembl (ENSG00000150593)
- OMIM® (608610)
- UniProtKB/Swiss-Prot (Q53EL6)
- Open Targets Platform(ENSG00000150593)
- Alliance of Genome Resources
- Search for PDCD4 at DataMed
- Search for PDCD4 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDCD4 Gene
Genomics for PDCD4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PDCD4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PDCD4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDCD4
- Top Transcription factor binding sites by QIAGEN in the PDCD4 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- HNF-4alpha1
- HNF-4alpha2
Genomic Locations for PDCD4 Gene
Latest Assembly
- chr10:110,871,795-110,900,006
- (GRCh38/hg38)
- Size:
- 28,212 bases
- Orientation:
- Plus strand
Previous Assembly
- chr10:112,631,686-112,659,764
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 28,079 bases
- Orientation:
- Plus strand
Genomic View for PDCD4 Gene
Genes around PDCD4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q25.2 by HGNC
- 10q25.2 by Entrez Gene
- 10q25.2 by Ensembl
PDCD4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDCD4 Gene
Proteins for PDCD4 Gene
-
Protein details for PDCD4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q53EL6-PDCD4_HUMAN
- Recommended name:
- Programmed cell death protein 4
- Protein Accession:
- Q53EL6
- B2RCV4
- B5ME91
- O15501
- Q5VZS6
- Q6PJI5
- Q8TAR5
- Q99834
Protein attributes for PDCD4 Gene
- Size:
- 469 amino acids
- Molecular mass:
- 51735 Da
- Quaternary structure:
-
- Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.
- SequenceCaution:
-
- Sequence=AAB42218.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH15036.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for PDCD4 Gene
Protein Expression for PDCD4 Gene
Post-translational modifications for PDCD4 Gene
- Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
- Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PDCD4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PDCD4 Antibody (LS-B487) and PDCD4 Antibody (LS-B9458)
- NSJ Bioreagents PDCD4 Antibody
- Novus Biologicals Antibodies for PDCD4
-
Abcam antibodies for PDCD4
- Invitrogen Antibodies for PDCD4 (AFLGC-PDCD4)
-
Custom Antibody ServicesProSci Antibodies for PDCD4
- programmed cell death 4 (neoplastic transformation inhibitor) [3975]
- programmed cell death 4 (neoplastic transformation inhibitor) [18-641]
- programmed cell death 4 (neoplastic transformation inhibitor) [18-717]
- programmed cell death 4 (neoplastic transformation inhibitor) [31-081]
- programmed cell death 4 (neoplastic transformation inhibitor) [31-082]
- programmed cell death 4 (neoplastic transformation inhibitor) [49-508]
- programmed cell death 4 (neoplastic transformation inhibitor) [49-547]
- programmed cell death 4 (neoplastic transformation inhibitor) [43-062]
- programmed cell death 4 (neoplastic transformation inhibitor) [43-063]
- programmed cell death 4 (neoplastic transformation inhibitor) [79-977]
- programmed cell death 4 (neoplastic transformation inhibitor) [80-012]
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDCD4
- Sino Biological Antibodies for PDCD4
Protein products for research
- G Biosciences Human PDCD4/Programmed cell death protein 4, Lyophilized
-
OriGene Purified Proteins for PDCD4
- Search Origene for MassSpec and Protein Over-expression Lysates for PDCD4
- Origene Custom Protein Services for PDCD4
- Novus Biologicals proteins for PDCD4
- ProSpec Recombinant Proteins for PDCD4
-
ProSci Proteins for PDCD4
-
Abcam proteins for PDCD4
Assay products for research
- antibodies-online: Show 19 available PDCD4 Elisa Kits ranked by validation data
- Compare Top PDCD4 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for PDCD4 Gene
Domains & Families for PDCD4 Gene
Gene Families for PDCD4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PDCD4 Gene
Suggested Antigen Peptide Sequences for PDCD4 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein 197/15a (PDCD4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q53EL6- Domain:
-
- Binds EIF4A1 via both MI domains.
- Family:
-
- Belongs to the PDCD4 family.
Function for PDCD4 Gene
Molecular function for PDCD4 Gene
- UniProtKB/Swiss-Prot Function:
- Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
- UniProtKB/Swiss-Prot Induction:
- IL2/interleukin-2 stimulation inhibits expression, while IL12/interleukin-12 increases expression.
- GENATLAS Biochemistry:
- programmed cell death (apoptosis),inhibited by topoisomerase inhibitors (TIS)
Phenotypes From GWAS Catalog for PDCD4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 12054647 |
Phenotypes for PDCD4 Gene
- MGI mutant phenotypes for PDCD4:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PDCD4:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- no effect
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in ovarian lineage
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased gamma-H2AX phosphorylation
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PDCD4 - Starting at $85 >
- * PDCD4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PDCD4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDCD4
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDCD4
miRNA for PDCD4 Gene
- miRTarBase miRNAs that target PDCD4
-
- mmu-miR-21a-5p (MIRT000801)
- hsa-miR-16-5p (MIRT000809)
- hsa-miR-15a-5p (MIRT000810)
- rno-miR-21-5p (MIRT001218)
- hsa-miR-1-3p (MIRT002785)
- hsa-miR-21-5p (MIRT003054)
- hsa-miR-200a-3p (MIRT004005)
- hsa-miR-183-5p (MIRT005547)
- hsa-miR-499a-5p (MIRT006699)
- hsa-miR-182-5p (MIRT007155)
- hsa-miR-335-5p (MIRT019086)
- hsa-miR-155-5p (MIRT021056)
- hsa-miR-196a-5p (MIRT026027)
- hsa-miR-197-3p (MIRT048135)
- hsa-miR-10b-5p (MIRT053003)
- hsa-miR-548j-3p (MIRT055342)
- hsa-miR-548x-3p (MIRT055345)
- hsa-miR-548ae-3p (MIRT055348)
- hsa-miR-548ah-3p (MIRT055349)
- hsa-miR-548aj-3p (MIRT055350)
- hsa-miR-548am-3p (MIRT055351)
- hsa-miR-548aq-3p (MIRT055352)
- hsa-miR-5582-3p (MIRT055354)
- hsa-miR-548c-3p (MIRT055360)
- hsa-miR-513b-3p (MIRT055361)
- hsa-miR-3163 (MIRT055362)
- hsa-miR-3662 (MIRT055363)
- hsa-miR-6826-3p (MIRT055365)
- hsa-miR-590-5p (MIRT055366)
- hsa-miR-548m (MIRT055367)
- hsa-miR-3653-3p (MIRT055368)
- hsa-miR-3658 (MIRT055369)
- hsa-miR-4436b-5p (MIRT055371)
- hsa-miR-5197-3p (MIRT055372)
- hsa-miR-5579-3p (MIRT055373)
- hsa-miR-6509-3p (MIRT055374)
- hsa-miR-15b-5p (MIRT125922)
- hsa-miR-195-5p (MIRT125925)
- hsa-miR-320a (MIRT125926)
- hsa-miR-4804-3p (MIRT125944)
- hsa-miR-655-5p (MIRT329824)
- hsa-miR-5003-3p (MIRT329826)
- gga-miR-21-5p (MIRT438450)
- hsa-miR-524-5p (MIRT555729)
- hsa-miR-520d-5p (MIRT555730)
- hsa-miR-6756-3p (MIRT566476)
- hsa-miR-3127-3p (MIRT566477)
- hsa-miR-329-5p (MIRT566478)
- hsa-miR-4748 (MIRT566479)
- hsa-miR-4464 (MIRT566480)
- hsa-miR-340-5p (MIRT566481)
- mmu-miR-466l-5p (MIRT589309)
- mmu-miR-466i-5p (MIRT589310)
- mmu-miR-466k (MIRT589311)
- mmu-miR-466d-5p (MIRT589312)
- mmu-miR-290a-5p (MIRT589313)
- mmu-miR-292a-5p (MIRT589314)
- hsa-miR-218-5p (MIRT611737)
- hsa-miR-4720-3p (MIRT611738)
- hsa-miR-5089-5p (MIRT678636)
- hsa-miR-4279 (MIRT678637)
- hsa-miR-6778-3p (MIRT678638)
- hsa-miR-6506-5p (MIRT678639)
- hsa-miR-619-5p (MIRT678640)
- hsa-miR-1976 (MIRT678641)
- hsa-miR-3653-5p (MIRT678642)
- hsa-miR-150-5p (MIRT678643)
- hsa-miR-6747-3p (MIRT678644)
- hsa-miR-6727-3p (MIRT678645)
- hsa-miR-4722-3p (MIRT678646)
- hsa-miR-6814-5p (MIRT678647)
- hsa-miR-5697 (MIRT678648)
- hsa-miR-5571-5p (MIRT678649)
- hsa-miR-562 (MIRT678650)
- hsa-miR-93-3p (MIRT731482)
- hsa-miR-202-3p (MIRT731769)
- rno-miR-499-5p (MIRT731835)
- rno-miR-499-5p (MIRT732428)
- hsa-miR-21-3p (MIRT732883)
- hsa-miR-181b-5p (MIRT733056)
- hsa-miR-93-5p (MIRT733146)
- hsa-miR-208a-3p (MIRT733324)
- hsa-miR-744-3p (MIRT734420)
- hsa-miR-330-3p (MIRT735170)
- hsa-miR-129-1-3p (MIRT762288)
- hsa-miR-129-2-3p (MIRT762311)
- hsa-miR-216a-5p (MIRT763882)
- hsa-miR-4763-5p (MIRT772027)
- hsa-miR-938 (MIRT782777)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDCD4
- Browse OriGene Inhibitory RNA Products For PDCD4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCD4
Clone products for research
- Applied Biological Materials (abm): Clones for PDCD4 - Starting at $45 >
- * PDCD4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG207500
- MG216227
- MG217744
- MR207500
- MR207500L3
- MR207500L4
- MR216227
- MR216227L3
- MR216227L4
- MR217744
- MR217744L3
- MR217744L4
- RC206016
- RC206016L1
- RC206016L2
- RC206016L3
- RC206016L4
- RC222260
- RC222260L3
- RC222260L4
- RC232775
- RG206016
- RG222260
- RG232775
- RR208806
- RR208806L3
- RR208806L4
- MR207500L3V
- MR207500L4V
- MR216227L3V
- MR216227L4V
- MR217744L3V
- MR217744L4V
- RC206016L1V
- RC206016L2V
- RC206016L3V
- RC206016L4V
- RC222260L3V
- RC222260L4V
- RR208806L3V
- RR208806L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PDCD4
- Addgene plasmids for PDCD4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDCD4
Cell Lines for research
-
Horizon Cell Lines for PDCD4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDCD4 Gene
Localization for PDCD4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDCD4 Gene
- Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). {ECO:0000269 PubMed:16357133}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,ISS | -- |
| GO:0005737 | cytoplasm | IMP | 16357133 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PDCD4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MAPK Signaling: Mitogen Stimulation Pathway | ||
| 2 | Apoptosis and Autophagy | ||
| 3 | Translational Control | ||
| 4 | MicroRNAs in cancer | ||
| 5 | Proteoglycans in cancer | ||
Pathways by source for PDCD4 Gene
2 BioSystems pathways for PDCD4 Gene
2 KEGG pathways for PDCD4 Gene
3 R&D Systems pathways for PDCD4 Gene
2 Cell Signaling Technology pathways for PDCD4 Gene
1 GeneTex pathway for PDCD4 Gene
Interacting Proteins for PDCD4 Gene
Selected Interacting proteins:
Q53EL6-PDCD4_HUMAN
ENSP00000280154
for PDCD4 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PDCD4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | TAS,NAS | 12054647 |
| GO:0007569 | cell aging | IDA | 12054647 |
| GO:0030509 | BMP signaling pathway | IDA | 18548003 |
| GO:0034393 | positive regulation of smooth muscle cell apoptotic process | IEA | -- |
| GO:0035722 | interleukin-12-mediated signaling pathway | TAS | -- |
Drugs & Compounds for PDCD4 Gene
No Compound Related Data Available
Drug products for research
- G Biosciences Human PDCD4/Programmed cell death protein 4, Lyophilized
Transcripts for PDCD4 Gene
mRNA/cDNA for PDCD4 Gene
- 3 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000280154 3481 nts (view in UCSC)
- ENST00000393104 3697 nts (view in UCSC)
- ENST00000444997 819 nts (view in UCSC)
- ENST00000462577 789 nts (view in UCSC)
- ENST00000467574 735 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PDCD4 - Starting at $85 >
- * PDCD4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PDCD4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDCD4
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDCD4
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDCD4
- Browse OriGene Inhibitory RNA Products For PDCD4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCD4
Clone products for research
- Applied Biological Materials (abm): Clones for PDCD4 - Starting at $45 >
- * PDCD4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG207500
- MG216227
- MG217744
- MR207500
- MR207500L3
- MR207500L4
- MR216227
- MR216227L3
- MR216227L4
- MR217744
- MR217744L3
- MR217744L4
- RC206016
- RC206016L1
- RC206016L2
- RC206016L3
- RC206016L4
- RC222260
- RC222260L3
- RC222260L4
- RC232775
- RG206016
- RG222260
- RG232775
- RR208806
- RR208806L3
- RR208806L4
- MR207500L3V
- MR207500L4V
- MR216227L3V
- MR216227L4V
- MR217744L3V
- MR217744L4V
- RC206016L1V
- RC206016L2V
- RC206016L3V
- RC206016L4V
- RC222260L3V
- RC222260L4V
- RR208806L3V
- RR208806L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PDCD4
- Addgene plasmids for PDCD4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDCD4
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | |||||||||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | |||||||||||||||||||||
| SP9: | |||||||||||||||||||||
| SP10: | |||||||||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: | |||||||||||||||||||||
| SP13: | - | ||||||||||||||||||||
| SP14: | |||||||||||||||||||||
| SP15: | |||||||||||||||||||||
| SP16: |
Relevant External Links for PDCD4 Gene
- GeneLoc Exon Structure for
- PDCD4
Expression for PDCD4 Gene
mRNA differential expression in normal tissues according to GTEx for PDCD4 Gene
This gene is overexpressed in Pancreas (x8.8).
This gene is overexpressed in Lymph node (8.1), Tlymphocyte (7.1), and Peripheral blood mononuclear cells (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDCD4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDCD4
SOURCE GeneReport for Unigene cluster for PDCD4 Gene:
Hs.711490mRNA Expression by UniProt/SwissProt for PDCD4 Gene:
Q53EL6-PDCD4_HUMAN
Tissue specificity:
Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
Evidence on tissue expression from TISSUES for PDCD4 Gene
- Nervous system(4.9)
- Blood(4.7)
- Spleen(4.7)
- Skin(4.6)
- Liver(4.6)
- Intestine(3.5)
- Pancreas(3.4)
- Heart(3.2)
- Lung(3.1)
- Lymph node(3.1)
- Kidney(3)
- Muscle(3)
- Stomach(3)
- Thyroid gland(2.9)
- Bone marrow(2.9)
- Adrenal gland(2.1)
- Gall bladder(2.1)
- Eye(2)
Primer products for research
-
OriGene qPCR primer pairs for PDCD4
-
OriGene qPCR primer pairs and template standards for PDCD4
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCD4 Gene
Orthologs for PDCD4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PDCD4 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PDCD4 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PDCD4 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PDCD4 29 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Pdcd4 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pdcd4 29 |
|
||
| Chicken (Gallus gallus) |
Aves | PDCD4 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PDCD4 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pdcd4 29 |
|
||
| Str.6786 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | pdcd4-prov 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | pdcd4b 29 30 |
|
OneToOne | |
| pdcd4 29 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1132 29 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000378 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Pdcd4 29 30 |
|
OneToOne | |
| CG10990 31 |
|
|
|||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G24800 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os08g0120500 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2910 30 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4897 29 |
|
- Species where no ortholog for PDCD4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PDCD4 Gene
- ENSEMBL:
- Gene Tree for PDCD4 (if available)
- TreeFam:
- Gene Tree for PDCD4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PDCD4: view image
- Alliance of Genome Resources:
- Additional Orthologs for PDCD4
Paralogs for PDCD4 Gene
No data available for Paralogs for PDCD4 Gene
Variants for PDCD4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDCD4 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs140217953 | Benign: not provided | 110,881,291(+) |
G/A NM_014456.5(PDCD4):c.102G>A (p.Glu34=) |
SYNONYMOUS | |
| rs41292602 | Benign: not provided | 110,894,480(+) |
C/T NM_014456.5(PDCD4):c.1167C>T (p.Ser389=) |
SYNONYMOUS | |
| VAR_036375 | A breast cancer sample |
p.Gly120Arg |
|||
| rs11548765 | -- |
p.Ser48Tyr |
|||
| rs7081726 | -- |
p.Ile36Val |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.25;
24.97% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PDCD4 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD4 Gene
Disorders for PDCD4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colorectal cancer |
|
|
| tongue squamous cell carcinoma |
|
|
| lung cancer |
|
|
| breast cancer |
|
|
| skin papilloma |
|
|
Search PDCD4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PDCD4
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PDCD4 Gene
Publications for PDCD4 Gene
- Structural basis for translational inhibition by the tumour suppressor Pdcd4. (PMID: 19153607) Loh PG … Song H (The EMBO journal 2009) 3 4 22
- Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. (PMID: 16449643) Yang HS … Colburn NH (Molecular and cellular biology 2006) 3 4 22
- Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. (PMID: 16357133) Palamarchuk A … Pekarsky Y (Cancer research 2005) 3 4 22
- Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody. (PMID: 10632927) Yoshinaga H … Masaki Z (Pathology international 1999) 3 4 22
- Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. (PMID: 9759869) Azzoni L … Perussia B (Journal of immunology (Baltimore, Md. : 1950) 1998) 2 3 4
ExternalLinks
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- Custom Antibody ServicesProSci Antibodies for PDCD4
- programmed cell death 4 (neoplastic transformation inhibitor) [3975]
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Sources for PDCD4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
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- (120) ENCODE
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- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
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- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources