Aliases for PDCD4 Gene
Aliases for PDCD4 Gene
External Ids for PDCD4 Gene
- HGNC: 8763
- Entrez Gene: 27250
- Ensembl: ENSG00000150593
- OMIM: 608610
- UniProtKB: Q53EL6
Previous GeneCards Identifiers for PDCD4 Gene
- GC10P111524
- GC10P111865
- GC10P112762
- GC10P112296
- GC10P112618
- GC10P106260
Summaries for PDCD4 Gene
-
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
GeneCards Summary for PDCD4 Gene
PDCD4 (Programmed Cell Death 4) is a Protein Coding gene. Diseases associated with PDCD4 include Bardet-Biedl Syndrome 18 and Colorectal Cancer. Among its related pathways are MicroRNAs in cancer and Translational Control. Gene Ontology (GO) annotations related to this gene include RNA binding and binding.
UniProtKB/Swiss-Prot for PDCD4 Gene
-
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD4 Gene
Genomics for PDCD4 Gene
GeneHancer (GH) Regulatory Elements for PDCD4 Gene
Promoters and enhancers for PDCD4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PDCD4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PDCD4 gene promoter:
-
- HNF-4alpha2
- HNF-4alpha1
- AP-1
- c-Jun
- ATF-2
Regulatory Element Products
Genomic Locations for PDCD4 Gene
Genomic Locations for PDCD4 Gene
- chr10:110,871,795-110,900,006
- (GRCh38/hg38)
- Size:
- 28,212 bases
- Orientation:
- Plus strand
- chr10:112,631,553-112,659,764
- (GRCh37/hg19)
- Size:
- 28,212 bases
- Orientation:
- Plus strand
Genomic View for PDCD4 Gene
Genes around PDCD4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q25.2 by Entrez Gene
- 10q25.2 by HGNC
- 10q25.2 by Ensembl
PDCD4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDCD4 Gene
Proteins for PDCD4 Gene
-
Protein details for PDCD4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q53EL6-PDCD4_HUMAN
- Recommended name:
- Programmed cell death protein 4
- Protein Accession:
- Q53EL6
- B2RCV4
- B5ME91
- O15501
- Q5VZS6
- Q6PJI5
- Q8TAR5
- Q99834
Protein attributes for PDCD4 Gene
- Size:
- 469 amino acids
- Molecular mass:
- 51735 Da
- Quaternary structure:
-
- Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.
- SequenceCaution:
-
- Sequence=AAB42218.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH15036.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for PDCD4 Gene
Protein Expression for PDCD4 Gene
Post-translational modifications for PDCD4 Gene
- Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
- Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PDCD4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PDCD4 (PDCD4)
-
Custom Antibody ServicesOriGene Antibodies for PDCD4
- Novus Biologicals Antibodies for PDCD4
- Invitrogen Antibodies for PDCD4
- GeneTex PDCD4 Antibody for PDCD4
-
Custom Antibody ServicesProSci Antibodies for PDCD4
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDCD4
- Sino Biological Antibodies for PDCD4
Protein Products
-
OriGene Purified Proteins for PDCD4
- Search Origene for MassSpec and Protein Over-expression Lysates for PDCD4
- Origene Custom Protein Services for PDCD4
- ProSpec Recombinant Proteins for PDCD4
- Search GeneTex for Proteins for PDCD4
-
ProSci Proteins for PDCD4
Assay Products
No data available for DME Specific Peptides for PDCD4 Gene
Domains & Families for PDCD4 Gene
Gene Families for PDCD4 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PDCD4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PDCD4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q53EL6- Domain:
-
- Binds EIF4A1 via both MI domains.
- Family:
-
- Belongs to the PDCD4 family.
Function for PDCD4 Gene
Molecular function for PDCD4 Gene
- UniProtKB/Swiss-Prot Function:
- Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
- UniProtKB/Swiss-Prot Induction:
- IL2/interleukin-2 stimulation inhibits expression, while IL12/interleukin-12 increases expression.
- GENATLAS Biochemistry:
- programmed cell death (apoptosis),inhibited by topoisomerase inhibitors (TIS)
Phenotypes From GWAS Catalog for PDCD4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005488 | binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 12054647 |
Phenotypes for PDCD4 Gene
- MGI mutant phenotypes for PDCD4:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PDCD4:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Increased viability
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PDCD4
-
CRISPR Products
-
OriGene CRISPR knockouts for PDCD4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDCD4
- genomics-online: gRNA clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
- Applied Biological Materials CRISPR for PDCD4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDCD4
- GenScript: Design CRISPR guide RNA sequences for PDCD4
miRNA for PDCD4 Gene
- miRTarBase miRNAs that target PDCD4
-
- hsa-mir-16-5p (MIRT000809)
- hsa-mir-15a-5p (MIRT000810)
- hsa-mir-1-3p (MIRT002785)
- hsa-mir-21-5p (MIRT003054)
- hsa-mir-200a-3p (MIRT004005)
- hsa-mir-183-5p (MIRT005547)
- hsa-mir-499a-5p (MIRT006699)
- hsa-mir-182-5p (MIRT007155)
- hsa-mir-335-5p (MIRT019086)
- hsa-mir-155-5p (MIRT021056)
- hsa-mir-196a-5p (MIRT026027)
- hsa-mir-197-3p (MIRT048135)
- hsa-mir-10b-5p (MIRT053003)
- hsa-mir-548j-3p (MIRT055342)
- hsa-mir-548x-3p (MIRT055345)
- hsa-mir-548ae-3p (MIRT055348)
- hsa-mir-548ah-3p (MIRT055349)
- hsa-mir-548aj-3p (MIRT055350)
- hsa-mir-548am-3p (MIRT055351)
- hsa-mir-548aq-3p (MIRT055352)
- hsa-mir-5582-3p (MIRT055354)
- hsa-mir-548c-3p (MIRT055360)
- hsa-mir-513b-3p (MIRT055361)
- hsa-mir-3163 (MIRT055362)
- hsa-mir-3662 (MIRT055363)
- hsa-mir-6826-3p (MIRT055365)
- hsa-mir-590-5p (MIRT055366)
- hsa-mir-548m (MIRT055367)
- hsa-mir-3653-3p (MIRT055368)
- hsa-mir-3658 (MIRT055369)
- hsa-mir-4436b-5p (MIRT055371)
- hsa-mir-5197-3p (MIRT055372)
- hsa-mir-5579-3p (MIRT055373)
- hsa-mir-6509-3p (MIRT055374)
- hsa-mir-15b-5p (MIRT125922)
- hsa-mir-195-5p (MIRT125925)
- hsa-mir-320a (MIRT125926)
- hsa-mir-4804-3p (MIRT125944)
- hsa-mir-655-5p (MIRT329824)
- hsa-mir-5003-3p (MIRT329826)
- gga-mir-21-5p (MIRT438450)
- hsa-mir-524-5p (MIRT555729)
- hsa-mir-520d-5p (MIRT555730)
- hsa-mir-6756-3p (MIRT566476)
- hsa-mir-3127-3p (MIRT566477)
- hsa-mir-329-5p (MIRT566478)
- hsa-mir-4748 (MIRT566479)
- hsa-mir-4464 (MIRT566480)
- hsa-mir-340-5p (MIRT566481)
- hsa-mir-218-5p (MIRT611737)
- hsa-mir-4720-3p (MIRT611738)
- hsa-mir-5089-5p (MIRT678636)
- hsa-mir-4279 (MIRT678637)
- hsa-mir-6778-3p (MIRT678638)
- hsa-mir-6506-5p (MIRT678639)
- hsa-mir-619-5p (MIRT678640)
- hsa-mir-1976 (MIRT678641)
- hsa-mir-3653-5p (MIRT678642)
- hsa-mir-150-5p (MIRT678643)
- hsa-mir-6747-3p (MIRT678644)
- hsa-mir-6727-3p (MIRT678645)
- hsa-mir-4722-3p (MIRT678646)
- hsa-mir-6814-5p (MIRT678647)
- hsa-mir-5697 (MIRT678648)
- hsa-mir-5571-5p (MIRT678649)
- hsa-mir-562 (MIRT678650)
- hsa-mir-93-3p (MIRT731482)
- hsa-mir-202-3p (MIRT731769)
- rno-mir-499-5p (MIRT731835)
- hsa-mir-21-3p (MIRT732883)
- hsa-mir-181b-5p (MIRT733056)
- hsa-mir-93-5p (MIRT733146)
- hsa-mir-208a-3p (MIRT733324)
- hsa-mir-744-3p (MIRT734420)
- hsa-mir-330-3p (MIRT735170)
- hsa-mir-129-1-3p (MIRT762288)
- hsa-mir-129-2-3p (MIRT762311)
- hsa-mir-216a-5p (MIRT763882)
- hsa-mir-4763-5p (MIRT772027)
- hsa-mir-938 (MIRT782777)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDCD4
- Browse OriGene Inhibitory RNA Products For PDCD4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCD4
- genomics-online: shRNA clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PDCD4
- VectorBuilder custom plasmid, inducible vectors for PDCD4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDCD4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PDCD4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDCD4
- Applied Biological Materials Clones for PDCD4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PDCD4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDCD4 Gene
Localization for PDCD4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDCD4 Gene
- Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). {ECO:0000269 PubMed:16357133}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005737 | cytoplasm | IMP | 16357133 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PDCD4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MAPK Signaling: Mitogen Stimulation Pathway | ||
| 2 | MicroRNAs in cancer | ||
| 3 | Proteoglycans in cancer | ||
| 4 | Apoptosis and Autophagy | ||
| 5 | Translational Control | ||
Pathways by source for PDCD4 Gene
1 GeneTex pathway for PDCD4 Gene
2 BioSystems pathways for PDCD4 Gene
2 KEGG pathways for PDCD4 Gene
3 R&D Systems pathways for PDCD4 Gene
2 Cell Signaling Technology pathways for PDCD4 Gene
Interacting Proteins for PDCD4 Gene
Selected Interacting proteins:
Q53EL6-PDCD4_HUMAN
ENSP00000280154
for PDCD4 Gene via
IID
UniProtKB
STRING
GPS-Prot Interaction Network for PDCD4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | TAS,NAS | 12054647 |
| GO:0007569 | cell aging | IDA | 12054647 |
| GO:0030509 | BMP signaling pathway | IDA | 18548003 |
| GO:0034393 | positive regulation of smooth muscle cell apoptotic process | IEA | -- |
| GO:0035722 | interleukin-12-mediated signaling pathway | TAS | -- |
Transcripts for PDCD4 Gene
mRNA/cDNA for PDCD4 Gene
- (3) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (434) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000280154 3602 bps (uc001kzh.4)
- ENST00000393104 3697 bps (uc001kzg.4)
- ENST00000444997 819 bps (uc057vze.1)
- ENST00000462577 789 bps (uc057vzh.1)
- ENST00000467574 735 bps (uc057vzc.1)
Unigene Clusters for PDCD4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PDCD4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDCD4
- genomics-online: gRNA clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
- Applied Biological Materials CRISPR for PDCD4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDCD4
- GenScript: Design CRISPR guide RNA sequences for PDCD4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDCD4
- Browse OriGene Inhibitory RNA Products For PDCD4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCD4
- genomics-online: shRNA clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PDCD4
- VectorBuilder custom plasmid, inducible vectors for PDCD4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDCD4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PDCD4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDCD4
- Applied Biological Materials Clones for PDCD4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | |||||||||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | |||||||||||||||||||||
| SP9: | |||||||||||||||||||||
| SP10: | |||||||||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: | |||||||||||||||||||||
| SP13: | - | ||||||||||||||||||||
| SP14: | |||||||||||||||||||||
| SP15: | |||||||||||||||||||||
| SP16: |
Expression for PDCD4 Gene
mRNA differential expression in normal tissues according to GTEx for PDCD4 Gene
This gene is overexpressed in Pancreas (x8.8).
This gene is overexpressed in Lymph node (8.1), Tlymphocyte (7.1), and Peripheral blood mononuclear cells (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDCD4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PDCD4 Gene:
PDCD4SOURCE GeneReport for Unigene cluster for PDCD4 Gene:
Hs.711490mRNA Expression by UniProt/SwissProt for PDCD4 Gene:
Q53EL6-PDCD4_HUMAN
Tissue specificity:
Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
Evidence on tissue expression from TISSUES for PDCD4 Gene
- Nervous system(4.8)
- Blood(4.6)
- Liver(4.5)
- Skin(4.5)
- Spleen(4.5)
- Intestine(3.2)
- Lung(2.9)
- Pancreas(2.9)
- Heart(2.8)
- Lymph node(2.6)
- Muscle(2.6)
- Thyroid gland(2.2)
- Stomach(2.1)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for PDCD4
-
OriGene qPCR primer pairs for PDCD4
- genomics-online: primer clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCD4 Gene
Orthologs for PDCD4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PDCD4 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PDCD4 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PDCD4 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PDCD4 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Pdcd4 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pdcd4 33 |
|
||
| chicken (Gallus gallus) |
Aves | PDCD4 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PDCD4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pdcd4 33 |
|
||
| Str.6786 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | pdcd4-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pdcd4b 34 33 |
|
OneToOne | |
| pdcd4 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1132 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000378 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Pdcd4 34 33 |
|
OneToOne | |
| CG10990 35 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G24800 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os08g0120500 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2910 34 |
|
OneToOne | |
| Cin.4897 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4897 33 |
|
- Species where no ortholog for PDCD4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PDCD4 Gene
- ENSEMBL:
- Gene Tree for PDCD4 (if available)
- TreeFam:
- Gene Tree for PDCD4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PDCD4: view image
Paralogs for PDCD4 Gene
No data available for Paralogs for PDCD4 Gene
Variants for PDCD4 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs515726134 | pathogenic, Bardet-Biedl syndrome, Bardet-Biedl syndrome 18 | 110,900,466(+) | A/C | downstream_transcript_variant | |
| VAR_036375 | A breast cancer sample | p.Gly120Arg | |||
| rs1000017355 | -- | 110,871,845(+) | C/G | 5_prime_UTR_variant | |
| rs1000056963 | -- | 110,873,634(+) | C/T | intron_variant | |
| rs1000072080 | -- | 110,871,624(+) | C/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.25;
24.97% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PDCD4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD4 Gene
Disorders for PDCD4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bardet-biedl syndrome 18 |
|
|
| colorectal cancer |
|
|
| bardet-biedl syndrome |
|
|
Search PDCD4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PDCD4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PDCD4 Gene
Publications for PDCD4 Gene
- Structural basis for translational inhibition by the tumour suppressor Pdcd4. (PMID: 19153607) Loh PG … Song H (The EMBO journal 2009) 3 4 22 58
- Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. (PMID: 16449643) Yang HS … Colburn NH (Molecular and cellular biology 2006) 3 4 22 58
- Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. (PMID: 16357133) Palamarchuk A … Pekarsky Y (Cancer research 2005) 3 4 22 58
- Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody. (PMID: 10632927) Yoshinaga H … Masaki Z (Pathology international 1999) 3 4 22 58
- Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. (PMID: 9759869) Azzoni L … Perussia B (Journal of immunology (Baltimore, Md. : 1950) 1998) 2 3 4 58
Products for PDCD4 Gene
- R&D Systems Antibodies for PDCD4 (PDCD4)
- Browse R&D Systems for Human Recombinant Proteins
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- Browse Human Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for PDCD4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PDCD4
- Search Origene for MassSpec and Protein Over-expression Lysates for PDCD4
- Origene Custom Protein Services for PDCD4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PDCD4
- Browse OriGene Inhibitory RNA Products For PDCD4
- OriGene qPCR primer pairs and template standards for PDCD4
- OriGene qPCR primer pairs for PDCD4
- OriGene CRISPR knockouts for PDCD4
- OriGene ORF clones in human for PDCD4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PDCD4
- GenScript: Next-day shipping of latest version cDNA ORF clones for PDCD4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PDCD4
- GenScript Custom Assay Services for PDCD4
- GenScript Custom overexpressing Cell Line Services for PDCD4
- GenScript: Design CRISPR guide RNA sequences for PDCD4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PDCD4
- Sino Biological Human cDNA Clone for PDCD4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for PDCD4
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PDCD4
- Novus Biologicals proteins and lysates for PDCD4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for PDCD4
- VectorBuilder custom plasmid, inducible vectors for PDCD4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDCD4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PDCD4
- antibodies-online: Search results for 252 available PDCD4 Antibodies ranked by validation data
- Compare Top PDCD4 Antibodies
- antibodies-online: Search results for 18 available PDCD4 Elisa Kits ranked by validation data
- Compare Top PDCD4 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 14 available PDCD4 Proteins ranked by validation data
- Compare Top PDCD4 Proteins
- GeneTex PDCD4 Antibody for PDCD4
- Search GeneTex for Proteins for PDCD4
- Santa Cruz Biotechnology (SCBT) Antibodies for PDCD4
- Search Santa Cruz Biotechnology (SCBT) for PDCD4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PDCD4
- Custom Antibody ServicesProSci Antibodies for PDCD4
- ProSci Proteins for PDCD4
- Horizon Cell Lines for PDCD4
- genomics-online: cdna clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
- orf clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
- genomics-online: gRNA clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
- genomics-online: primer clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
- genomics-online: shRNA clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PDCD4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PDCD4
- GeneCopoeia miRNA 3'UTR Target clone products for PDCD4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCD4
Sources for PDCD4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt