Aliases for PDCD4 Gene
External Ids for PDCD4 Gene
Previous GeneCards Identifiers for PDCD4 Gene
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
GeneCards Summary for PDCD4 Gene
PDCD4 (Programmed Cell Death 4) is a Protein Coding gene. Diseases associated with PDCD4 include Colorectal Cancer and Tongue Cancer. Among its related pathways are MAPK Signaling: Mitogen Stimulation Pathway and mTOR signaling pathway (Pathway Interaction Database). Gene Ontology (GO) annotations related to this gene include RNA binding and binding.
UniProtKB/Swiss-Prot Summary for PDCD4 Gene
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).