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Aliases for PDCD2L Gene

Aliases for PDCD2L Gene

  • Programmed Cell Death 2 Like 2 3 5
  • Programmed Cell Death Protein 2-Like 3 4

External Ids for PDCD2L Gene

Previous GeneCards Identifiers for PDCD2L Gene

  • GC19P039588
  • GC19P034895
  • GC19P031401

Summaries for PDCD2L Gene

GeneCards Summary for PDCD2L Gene

PDCD2L (Programmed Cell Death 2 Like) is a Protein Coding gene. An important paralog of this gene is ENSG00000266953.

UniProtKB/Swiss-Prot for PDCD2L Gene

  • Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.

Additional gene information for PDCD2L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD2L Gene

Genomics for PDCD2L Gene

GeneHancer (GH) Regulatory Elements for PDCD2L Gene

Promoters and enhancers for PDCD2L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J034403 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.7 +0.3 303 2.2 ZNF473 ZFX ELF3 MNT NKRF POLR2A MLLT1 CEBPG ZNF384 ZNF687 GC19P034405 PDCD2L ZNF599 ZNF302 WTIP ENSG00000268947 ZNF181 KIAA0355 ENSG00000267219 LSM14A
GH19J034364 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.5 -38.3 -38300 4 HDGF ZFX ZNF148 NKRF POLR2A MLLT1 ZNF121 ZNF24 YY1 SP7 GPI ZNF599 ENSG00000268947 PDCD2L KIAA0355 GC19P034362 ENSG00000266953
GH19J034323 Enhancer 0.7 Ensembl ENCODE 10.7 -80.8 -80782 1.2 ZNF600 PRDM10 ZIC2 ZEB2 SCRT2 USF1 ZBTB33 PDCD2L KIAA0355 GC19P034326 RPL29P33
GH19J034325 Enhancer 0.6 ENCODE 10.7 -78.4 -78367 1.3 ZNF692 ZNF792 SCRT2 ZEB1 ATF2 ZBTB17 ZNF138 ZNF274 ZFP69B BCL6 GC19P034326 LSM14A ZNF792 KIAA0355 PDCD2L RPL29P33
GH19J034443 Enhancer 0.3 Ensembl 11.9 +39.5 39503 0.2 ZNF362 PDCD2L GPI GC19P034452 ENSG00000267024 UBA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDCD2L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDCD2L gene promoter:
  • AML1a
  • AP-4
  • Arnt
  • E47
  • Egr-2
  • Egr-4
  • HNF-4alpha1
  • HOXA5
  • RFX1

Genomic Locations for PDCD2L Gene

Genomic Locations for PDCD2L Gene
chr19:34,404,398-34,426,168
(GRCh38/hg38)
Size:
21,771 bases
Orientation:
Plus strand
chr19:34,895,289-34,917,073
(GRCh37/hg19)
Size:
21,785 bases
Orientation:
Plus strand

Genomic View for PDCD2L Gene

Genes around PDCD2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCD2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCD2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD2L Gene

Proteins for PDCD2L Gene

  • Protein details for PDCD2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRP1-PDD2L_HUMAN
    Recommended name:
    Programmed cell death protein 2-like
    Protein Accession:
    Q9BRP1

    Protein attributes for PDCD2L Gene

    Size:
    358 amino acids
    Molecular mass:
    39417 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDCD2L Gene

Post-translational modifications for PDCD2L Gene

  • Ubiquitination at isoforms=6
  • Modification sites at PhosphoSitePlus

Other Protein References for PDCD2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDCD2L Gene

Domains & Families for PDCD2L Gene

Gene Families for PDCD2L Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for PDCD2L Gene

Suggested Antigen Peptide Sequences for PDCD2L Gene

GenScript: Design optimal peptide antigens:
  • Programmed cell death protein 2-like (PDD2L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PDCD2L: view

No data available for UniProtKB/Swiss-Prot for PDCD2L Gene

Function for PDCD2L Gene

Molecular function for PDCD2L Gene

UniProtKB/Swiss-Prot Function:
Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.
genes like me logo Genes that share phenotypes with PDCD2L: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PDCD2L - Now 50% OFF >
  • * PDCD2L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PDCD2L tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PDCD2L Gene

Localization for PDCD2L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDCD2L gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 0
nucleus 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PDCD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with PDCD2L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDCD2L Gene

Pathways & Interactions for PDCD2L Gene

PathCards logo

SuperPathways for PDCD2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDCD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with PDCD2L: view

No data available for Pathways by source and SIGNOR curated interactions for PDCD2L Gene

Drugs & Compounds for PDCD2L Gene

No Compound Related Data Available

Transcripts for PDCD2L Gene

mRNA/cDNA for PDCD2L Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1209) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for PDCD2L Gene

Programmed cell death 2-like:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PDCD2L - Now 50% OFF >
  • * PDCD2L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PDCD2L tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD2L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for PDCD2L Gene

GeneLoc Exon Structure for
PDCD2L
ECgene alternative splicing isoforms for
PDCD2L

Expression for PDCD2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDCD2L Gene

Protein differential expression in normal tissues from HIPED for PDCD2L Gene

This gene is overexpressed in Ovary (14.6), Bone marrow stromal cell (11.5), and Breast (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDCD2L Gene



Protein tissue co-expression partners for PDCD2L Gene

NURSA nuclear receptor signaling pathways regulating expression of PDCD2L Gene:

PDCD2L

SOURCE GeneReport for Unigene cluster for PDCD2L Gene:

Hs.515344

mRNA Expression by UniProt/SwissProt for PDCD2L Gene:

Q9BRP1-PDD2L_HUMAN
Tissue specificity: Higher expression in lung, colon, mammary gland, cervix, stomach and small intestine.

Evidence on tissue expression from TISSUES for PDCD2L Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with PDCD2L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCD2L Gene

Orthologs for PDCD2L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDCD2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDCD2L 35 34
  • 98.98 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PDCD2L 34
  • 86.59 (n)
cow
(Bos Taurus)
Mammalia PDCD2L 35 34
  • 85.01 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Pdcd2l 17 35 34
  • 79.31 (n)
rat
(Rattus norvegicus)
Mammalia Pdcd2l 34
  • 78.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves PDCD2L 35 34
  • 63.76 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcd2l 34
  • 54.73 (n)
zebrafish
(Danio rerio)
Actinopterygii pdcd2l 34 35
  • 52.85 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta trus 34 35
  • 48.4 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001972 34
  • 48.26 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSR4 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G64830 34
  • 45.29 (n)
rice
(Oryza sativa)
Liliopsida Os04g0640800 34
  • 43.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToMany
Species where no ortholog for PDCD2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDCD2L Gene

ENSEMBL:
Gene Tree for PDCD2L (if available)
TreeFam:
Gene Tree for PDCD2L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PDCD2L: view image

Paralogs for PDCD2L Gene

Paralogs for PDCD2L Gene

Pseudogenes.org Pseudogenes for PDCD2L Gene

genes like me logo Genes that share paralogs with PDCD2L: view

Variants for PDCD2L Gene

Sequence variations from dbSNP and Humsavar for PDCD2L Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000118141 -- 34,417,244(+) A/C/G intron_variant
rs1000421670 -- 34,423,490(+) T/C intron_variant
rs1000547548 -- 34,412,095(+) T/C intron_variant
rs1000573407 -- 34,410,820(+) C/G/T intron_variant
rs1000630128 -- 34,412,367(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PDCD2L Gene

Variant ID Type Subtype PubMed ID
nsv509738 CNV insertion 20534489
nsv479414 CNV novel sequence insertion 20440878
nsv479153 CNV novel sequence insertion 20440878
nsv473900 CNV novel sequence insertion 20440878
nsv472210 CNV novel sequence insertion 20440878
nsv1127676 CNV deletion 24896259
esv3644206 CNV loss 21293372

Variation tolerance for PDCD2L Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDCD2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDCD2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD2L Gene

Disorders for PDCD2L Gene

Additional Disease Information for PDCD2L

No disorders were found for PDCD2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDCD2L Gene

Publications for PDCD2L Gene

  1. Analysis of two domains with novel RNA-processing activities throws light on the complex evolution of ribosomal RNA biogenesis. (PMID: 25566315) Burroughs AM … Aravind L (Frontiers in genetics 2014) 2 3 58
  2. The novel MGC13096 protein is correlated with proliferation. (PMID: 17393540) Chen Q … Qian K (Cell biochemistry and function 2008) 3 4 58
  3. Cloning of cDNAs with PDCD2(C) domain and their expressions during apoptosis of HEK293T cells. (PMID: 16311922) Chen Q … Yan C (Molecular and cellular biochemistry 2005) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for PDCD2L Gene

Sources for PDCD2L Gene

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