Aliases for PDCD11 Gene
External Ids for PDCD11 Gene
Previous GeneCards Identifiers for PDCD11 Gene
PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008]
GeneCards Summary for PDCD11 Gene
PDCD11 (Programmed Cell Death 11) is a Protein Coding gene. Diseases associated with PDCD11 include Epididymo-Orchitis. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription factor binding.
UniProtKB/Swiss-Prot for PDCD11 Gene
Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.
Involved in the biogenesis of rRNA.