Aliases for PDCD10 Gene
External Ids for PDCD10 Gene
Previous HGNC Symbols for PDCD10 Gene
Previous GeneCards Identifiers for PDCD10 Gene
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for PDCD10 Gene
PDCD10 (Programmed Cell Death 10) is a Protein Coding gene. Diseases associated with PDCD10 include Cerebral Cavernous Malformations 3 and Cerebral Cavernous Malformation, Familial. Among its related pathways are Validated targets of C-MYC transcriptional activation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein N-terminus binding.
UniProtKB/Swiss-Prot Summary for PDCD10 Gene
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).