This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c back... See more...

Aliases for PDCD1 Gene

Aliases for PDCD1 Gene

  • Programmed Cell Death 1 2 3 5
  • PD1 2 3 4
  • Systemic Lupus Erythematosus Susceptibility 2 2 3
  • Programmed Cell Death Protein 1 3 4
  • Protein PD-1 3 4
  • CD279 2 3
  • HPD-1 3 4
  • HSLE1 2 3
  • PD-1 2 3
  • Programmed Cell Death 1 Protein 3
  • CD279 Antigen 4
  • SLEB2 3
  • HPD-L 3
  • PDCD1 5

External Ids for PDCD1 Gene

Previous HGNC Symbols for PDCD1 Gene

  • SLEB2

Previous GeneCards Identifiers for PDCD1 Gene

  • GC02U990074
  • GC02P241575
  • GC02P9D0113
  • GC02M242440
  • GC02M242792
  • GC02M234541

Summaries for PDCD1 Gene

Entrez Gene Summary for PDCD1 Gene

  • This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDCD1 Gene

PDCD1 (Programmed Cell Death 1) is a Protein Coding gene. Diseases associated with PDCD1 include Systemic Lupus Erythematosus 2 and Multiple Sclerosis. Among its related pathways are T cell receptor signaling pathway and Innate Immune System. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity.

UniProtKB/Swiss-Prot Summary for PDCD1 Gene

  • Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).
  • The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28951311). The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:28951311). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:22658127, PubMed:25034862, PubMed:25399552).

Gene Wiki entry for PDCD1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDCD1 Gene

Genomics for PDCD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PDCD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDCD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDCD1

Top Transcription factor binding sites by QIAGEN in the PDCD1 gene promoter:
  • AML1a

Genomic Locations for PDCD1 Gene

Genomic Locations for PDCD1 Gene
chr2:241,849,881-241,858,908
(GRCh38/hg38)
Size:
9,028 bases
Orientation:
Minus strand
chr2:242,792,033-242,801,060
(GRCh37/hg19)
Size:
9,028 bases
Orientation:
Minus strand

Genomic View for PDCD1 Gene

Genes around PDCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD1 Gene

Proteins for PDCD1 Gene

  • Protein details for PDCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15116-PDCD1_HUMAN
    Recommended name:
    Programmed cell death protein 1
    Protein Accession:
    Q15116
    Secondary Accessions:
    • O00517
    • Q8IX89

    Protein attributes for PDCD1 Gene

    Size:
    288 amino acids
    Molecular mass:
    31647 Da
    Quaternary structure:
    • Monomer (PubMed:26602187). Interacts with CD274/PDCD1L1 (PubMed:26602187). Interacts with CD273/PDCD1LG2 (By similarity). Interacts with FBXO38; leading to ubiquitination and degradation of PDCD1 by the proteasome (PubMed:30487606).

    Three dimensional structures from OCA and Proteopedia for PDCD1 Gene

neXtProt entry for PDCD1 Gene

Post-translational modifications for PDCD1 Gene

  • Ubiquitinated at Lys-233 by the SCF(FBXO38) complex, leading to its proteasomal degradation (PubMed:30487606). Ubiquitinated via 'Lys-48'-linked polyubiquitin chains (PubMed:30487606).
  • Tyrosine phosphorylated at Tyr-223 (within ITIM motif) and Tyr-248 (ITSM motif) upon ligand binding. Phosphorylation at Tyr-248 promotes the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta.
  • N-glycosylation at Asn-58 consists of two N-acetylglucosamine units and one fucose (PubMed:28165004). N-glycosylation does not affect binding to nivolumab drug (PubMed:28165004).
  • Glycosylation at Asn49, Asn58, Asn74, and Asn116
  • Ubiquitination at Lys233
  • Modification sites at PhosphoSitePlus

Other Protein References for PDCD1 Gene

Antibody Products

  • Abcam antibodies for PDCD1

Protein Products

  • Abcam proteins for PDCD1

No data available for DME Specific Peptides for PDCD1 Gene

Domains & Families for PDCD1 Gene

Gene Families for PDCD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PDCD1 Gene

InterPro:
Blocks:
  • Immunoglobulin V-set
  • Immunoglobulin V-type
ProtoNet:

Suggested Antigen Peptide Sequences for PDCD1 Gene

GenScript: Design optimal peptide antigens:
  • Programmed cell death protein 1 (PDCD1_HUMAN)
  • cDNA, FLJ94476, highly similar to Homo sapiens programmed cell death 1 (PDCD1), mRNA (Q8IX89_HUMAN)
genes like me logo Genes that share domains with PDCD1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PDCD1 Gene

Function for PDCD1 Gene

Molecular function for PDCD1 Gene

UniProtKB/Swiss-Prot Function:
Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).
UniProtKB/Swiss-Prot Function:
The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28951311). The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:28951311). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:22658127, PubMed:25034862, PubMed:25399552).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by pembrolizumab (also named MK-3475 or lambrolizumab), a monoclonal antibody that prevents the interaction with CD274/PDCD1L1 (PubMed:27734966, PubMed:27325296). Inhibited by nivolumab (also named ONO-4538, BMS-936558 or Opdivo), a monoclonal antibody that prevents the interaction with CD274/PDCD1L1 (PubMed:28165004). The interaction with nivolumab is not dependent on glycosylation and depends on a loop at the N-terminus (N-terminal loop, corresponding to residues 25-34) (PubMed:28165004). Targeting the interaction between PDCD1 and CD274/PDCD1L1 with pembrolizumab and nivolumab antibodies has demonstrated great promise as a strategy for controlling and eradicating cancer (PubMed:22658127, PubMed:25034862, PubMed:25399552). Pembrolizumab and nivolumab are used for treatment of patients with advanced melanoma (PubMed:25034862, PubMed:25399552). These antibodies are also effective against other cancers, such as non-small cell lung cancer, renal cell carcinoma, bladder cancer and Hodgkin's lymphoma (PubMed:25034862).
GENATLAS Biochemistry:
programmed cell death (apoptosis) 1,mouse PD1 homolog

Phenotypes From GWAS Catalog for PDCD1 Gene

Gene Ontology (GO) - Molecular Function for PDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15240681
genes like me logo Genes that share ontologies with PDCD1: view
genes like me logo Genes that share phenotypes with PDCD1: view

Human Phenotype Ontology for PDCD1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PDCD1 Gene

MGI Knock Outs for PDCD1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCD1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PDCD1 Gene

Localization for PDCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDCD1 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDCD1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PDCD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PDCD1 Gene

Pathways & Interactions for PDCD1 Gene

genes like me logo Genes that share pathways with PDCD1: view

SIGNOR curated interactions for PDCD1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002644 negative regulation of tolerance induction IEA --
GO:0006915 apoptotic process TAS,IEA --
GO:0006959 humoral immune response TAS 9332365
genes like me logo Genes that share ontologies with PDCD1: view

Drugs & Compounds for PDCD1 Gene

(10) Drugs for PDCD1 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
nivolumab Approved Pharma Target, antibody, immunotherapy, inhibitor Therapeutic Antibodies, Immunotherapies 1165
Pembrolizumab Approved Pharma Target, antagonist, antibody 1266
Cemiplimab Approved, Investigational Pharma Target, inhibitor 56
CT-011 Investigational Pharma Target, Antibody 0
Pidilizumab Investigational Pharma antibody, immunotherapy Therapeutic Antibodies, Immunotherapies 15

(1) Additional Compounds for PDCD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PDCD1: view

Transcripts for PDCD1 Gene

mRNA/cDNA for PDCD1 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDCD1

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD1 Gene

No ASD Table

Relevant External Links for PDCD1 Gene

GeneLoc Exon Structure for
PDCD1

Expression for PDCD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PDCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDCD1 Gene

This gene is overexpressed in Whole Blood (x6.8), Heart - Atrial Appendage (x5.4), and Spleen (x5.3).

Protein differential expression in normal tissues from HIPED for PDCD1 Gene

This gene is overexpressed in Vitreous humor (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDCD1 Gene



Protein tissue co-expression partners for PDCD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDCD1

SOURCE GeneReport for Unigene cluster for PDCD1 Gene:

Hs.158297

Evidence on tissue expression from TISSUES for PDCD1 Gene

  • Lymph node(3.5)
  • Intestine(3.4)
  • Blood(3.4)
  • Spleen(3.2)
  • Liver(2.8)
  • Kidney(2.7)
  • Bone marrow(2.6)
  • Lung(2.4)
  • Nervous system(2.4)
  • Skin(2.4)
  • Heart(2.3)
  • Thyroid gland(2.2)
  • Muscle(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with PDCD1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCD1 Gene

Orthologs for PDCD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDCD1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PDCD1 30
  • 98.37 (n)
Dog
(Canis familiaris)
Mammalia PDCD1 30 31
  • 75.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PDCD1 30 31
  • 75 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC102550808 30
  • 70.57 (n)
Mouse
(Mus musculus)
Mammalia Pdcd1 30 17 31
  • 70.16 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PDCD1 31
  • 30 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PDCD1 31
  • 18 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PDCD1 30 31
  • 50.78 (n)
OneToOne
Species where no ortholog for PDCD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PDCD1 Gene

ENSEMBL:
Gene Tree for PDCD1 (if available)
TreeFam:
Gene Tree for PDCD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PDCD1: view image

Paralogs for PDCD1 Gene

(1) SIMAP similar genes for PDCD1 Gene using alignment to 3 proteins:

  • PDCD1_HUMAN
  • E7ER21_HUMAN
  • H0Y2W6_HUMAN
genes like me logo Genes that share paralogs with PDCD1: view

No data available for Paralogs for PDCD1 Gene

Variants for PDCD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDCD1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
790522 Benign: not provided 241,858,753(-) C/T INTRON_VARIANT
rs11568821 Risk Factor: Systemic lupus erythematosus, association wit 2; Multiple sclerosis modifier of disease progression 241,851,760(-) C/G INTRON_VARIANT
rs2227982 - p.Ala215Val

Additional dbSNP identifiers (rs#s) for PDCD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PDCD1 Gene

Variant ID Type Subtype PubMed ID
dgv165e55 CNV loss 17911159
dgv4200n100 CNV loss 25217958
dgv4201n100 CNV gain 25217958
esv3893582 CNV gain 25118596
nsv1002941 CNV gain 25217958
nsv470533 CNV loss 18288195
nsv584991 CNV loss 21841781
nsv821942 CNV gain 20364138
nsv955302 CNV deletion 24416366
nsv997984 CNV gain 25217958
nsv998059 CNV loss 25217958

Variation tolerance for PDCD1 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.80; 73.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDCD1 Gene

Human Gene Mutation Database (HGMD)
PDCD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDCD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD1 Gene

Disorders for PDCD1 Gene

MalaCards: The human disease database

(59) MalaCards diseases for PDCD1 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematosus 2
  • systemic lupus erythematosus, susceptibility to, 2
multiple sclerosis
  • multiple sclerosis, susceptibility to
systemic lupus erythematosus
  • sle
lupus erythematosus
  • systemic lupus erythematosus
testicular lymphoma
  • lymphoma of the testis
- elite association - COSMIC cancer census association via MalaCards
Search PDCD1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PDCD1_HUMAN
  • Systemic lupus erythematosus 2 (SLEB2) [MIM:605218]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:12402038}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for PDCD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PDCD1: view

No data available for Genatlas for PDCD1 Gene

Publications for PDCD1 Gene

  1. A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. (PMID: 12402038) Prokunina L … Alarcón-Riquelme ME (Nature genetics 2002) 2 3 4 23 41
  2. Programmed death-1 (PD-1) gene polymorphisms lodged in the genetic predispositions of Kawasaki Disease. (PMID: 19468750) Chun JK … Kim DS (European journal of pediatrics 2010) 3 23 41
  3. [Interactions between susceptible genes and risk environmental factors in Chinese females with systemic lupus erythematosus]. (PMID: 20388336) Peng CL … Meng W (Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 2010) 3 23 41
  4. Association between a polymorphism in the human programmed death-1 (PD-1) gene and cytomegalovirus infection after kidney transplantation. (PMID: 19581275) Hoffmann TW … Baron C (Journal of medical genetics 2010) 3 23 41
  5. Association between the PD1.3A/G polymorphism of the PDCD1 gene and systemic lupus erythematosus in European populations: a meta-analysis. (PMID: 19220647) Liu JL … Zhang XJ (Journal of the European Academy of Dermatology and Venereology : JEADV 2009) 3 23 41

Products for PDCD1 Gene

  • Addgene plasmids for PDCD1

Sources for PDCD1 Gene