The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010] See more...

Aliases for PDAP1 Gene

Aliases for PDAP1 Gene

  • PDGFA Associated Protein 1 2 3 5
  • HASPP28 2 3 4
  • PAP1 2 3 4
  • PAP 2 3 4
  • 28 KDa Heat- And Acid-Stable Phosphoprotein 3 4
  • PDGF-Associated Protein 3 4
  • PDGFA-Associated Protein 1 4
  • PDGF Associated Protein 2
  • PDAP1 5

External Ids for PDAP1 Gene

Previous GeneCards Identifiers for PDAP1 Gene

  • GC07M097528
  • GC07M098591
  • GC07M098605
  • GC07M098638
  • GC07M098830
  • GC07M098989
  • GC07M093628

Summaries for PDAP1 Gene

Entrez Gene Summary for PDAP1 Gene

  • The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010]

GeneCards Summary for PDAP1 Gene

PDAP1 (PDGFA Associated Protein 1) is a Protein Coding gene. Among its related pathways are Tyrosine Kinases / Adaptors and Innate Immune System.

UniProtKB/Swiss-Prot Summary for PDAP1 Gene

  • Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.

Gene Wiki entry for PDAP1 Gene

Additional gene information for PDAP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PDAP1 Gene

Genomics for PDAP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PDAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDAP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PDAP1

Top Transcription factor binding sites by QIAGEN in the PDAP1 gene promoter:
  • c-Ets-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • LCR-F1

Genomic Locations for PDAP1 Gene

Genomic Locations for PDAP1 Gene
chr7:99,392,048-99,408,597
(GRCh38/hg38)
Size:
16,550 bases
Orientation:
Minus strand
chr7:98,989,671-99,006,452
(GRCh37/hg19)
Size:
16,782 bases
Orientation:
Minus strand

Genomic View for PDAP1 Gene

Genes around PDAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDAP1 Gene

Proteins for PDAP1 Gene

  • Protein details for PDAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13442-HAP28_HUMAN
    Recommended name:
    28 kDa heat- and acid-stable phosphoprotein
    Protein Accession:
    Q13442
    Secondary Accessions:
    • D6W5S5
    • Q92906

    Protein attributes for PDAP1 Gene

    Size:
    181 amino acids
    Molecular mass:
    20630 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDAP1 Gene

Post-translational modifications for PDAP1 Gene

  • Ubiquitination at Lys105
  • Modification sites at PhosphoSitePlus

Other Protein References for PDAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDAP1 Gene

Domains & Families for PDAP1 Gene

Gene Families for PDAP1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PDAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PDAP1 Gene

GenScript: Design optimal peptide antigens:
  • PDGFA-associated protein 1 (HAP28_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13442

UniProtKB/Swiss-Prot:

HAP28_HUMAN :
  • Belongs to the PDAP1 family.
Family:
  • Belongs to the PDAP1 family.
genes like me logo Genes that share domains with PDAP1: view

Function for PDAP1 Gene

Molecular function for PDAP1 Gene

UniProtKB/Swiss-Prot Function:
Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.

Phenotypes From GWAS Catalog for PDAP1 Gene

Gene Ontology (GO) - Molecular Function for PDAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
genes like me logo Genes that share ontologies with PDAP1: view
genes like me logo Genes that share phenotypes with PDAP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDAP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDAP1 Gene

Localization for PDAP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDAP1 gene
Compartment Confidence
plasma membrane 4
extracellular 4
cytosol 4
nucleus 3
cytoskeleton 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with PDAP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDAP1 Gene

Pathways & Interactions for PDAP1 Gene

genes like me logo Genes that share pathways with PDAP1: view

Pathways by source for PDAP1 Gene

3 Reactome pathways for PDAP1 Gene
1 Cell Signaling Technology pathway for PDAP1 Gene

Gene Ontology (GO) - Biological Process for PDAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8780057
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with PDAP1: view

No data available for SIGNOR curated interactions for PDAP1 Gene

Drugs & Compounds for PDAP1 Gene

No Compound Related Data Available

Transcripts for PDAP1 Gene

mRNA/cDNA for PDAP1 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDAP1

Alternative Splicing Database (ASD) splice patterns (SP) for PDAP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP2:
SP3: -

Relevant External Links for PDAP1 Gene

GeneLoc Exon Structure for
PDAP1

Expression for PDAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PDAP1 Gene

Protein differential expression in normal tissues from HIPED for PDAP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.6) and Fetal Brain (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PDAP1 Gene



Protein tissue co-expression partners for PDAP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PDAP1

SOURCE GeneReport for Unigene cluster for PDAP1 Gene:

Hs.632296

Evidence on tissue expression from TISSUES for PDAP1 Gene

  • Kidney(4.4)
  • Blood(4.4)
  • Liver(4.4)
  • Eye(4.4)
  • Nervous system(2.7)
  • Muscle(2.4)
  • Skin(2.3)
  • Heart(2.2)
  • Pancreas(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with PDAP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDAP1 Gene

Orthologs for PDAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PDAP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PDAP1 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PDAP1 31
  • 92 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia PDAP1 30 31
  • 90.98 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pdap1 30
  • 90.42 (n)
Mouse
(Mus musculus)
Mammalia Pdap1 30 17 31
  • 89.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PDAP1 30 31
  • 88.77 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PDAP1 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PDAP1 30 31
  • 80 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PDAP1 31
  • 88 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100135404 30
  • 71.14 (n)
Str.1709 30
Zebrafish
(Danio rerio)
Actinopterygii pdap1b 30 31
  • 66.44 (n)
OneToOne
zgc56213 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG11444 31
  • 37 (a)
OneToMany
CG4438 31
  • 35 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1447 31
  • 49 (a)
OneToOne
Species where no ortholog for PDAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PDAP1 Gene

ENSEMBL:
Gene Tree for PDAP1 (if available)
TreeFam:
Gene Tree for PDAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PDAP1: view image

Paralogs for PDAP1 Gene

Pseudogenes.org Pseudogenes for PDAP1 Gene

genes like me logo Genes that share paralogs with PDAP1: view

No data available for Paralogs for PDAP1 Gene

Variants for PDAP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PDAP1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
715577 Benign: not provided 99,396,696(-) A/G MISSENSE_VARIANT
780698 Benign: not provided 99,404,853(-) C/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for PDAP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PDAP1 Gene

Variant ID Type Subtype PubMed ID
nsv831068 CNV loss 17160897
nsv831069 CNV loss 17160897
nsv951379 CNV deletion 24416366

Variation tolerance for PDAP1 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDAP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDAP1 Gene

Disorders for PDAP1 Gene

No disorders were found for PDAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDAP1 Gene

Publications for PDAP1 Gene

  1. Characterization of a novel platelet-derived growth factor-associated protein. (PMID: 8780057) Fischer WH … Schubert D (Journal of neurochemistry 1996) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
  4. BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion. (PMID: 31519766) Chan CJ … Melançon P (Molecular & cellular proteomics : MCP 2019) 3
  5. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. (PMID: 31452512) Pech MF … Settleman J (eLife 2019) 3

Products for PDAP1 Gene

Sources for PDAP1 Gene