Aliases for PCYT2 Gene
External Ids for PCYT2 Gene
Previous GeneCards Identifiers for PCYT2 Gene
This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
GeneCards Summary for PCYT2 Gene
PCYT2 (Phosphate Cytidylyltransferase 2, Ethanolamine) is a Protein Coding gene. Diseases associated with PCYT2 include Spastic Paraplegia 82, Autosomal Recessive and Complex Hereditary Spastic Paraplegia. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include ethanolamine-phosphate cytidylyltransferase activity. An important paralog of this gene is PCYT1A.
UniProtKB/Swiss-Prot Summary for PCYT2 Gene
Ethanolamine-phosphate cytidylyltransferase that catalyzes the second step in the synthesis of phosphatidylethanolamine (PE) from ethanolamine via the CDP-ethanolamine pathway (PubMed:9083101, PubMed:31637422). Phosphatidylethanolamine is a dominant inner-leaflet phospholipid in cell membranes, where it plays a role in membrane function by structurally stabilizing membrane-anchored proteins, and participates in important cellular processes such as cell division, cell fusion, blood coagulation, and apoptosis (PubMed:9083101).