Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008] See more...

Aliases for PCYOX1 Gene

Aliases for PCYOX1 Gene

  • Prenylcysteine Oxidase 1 2 3 4 5
  • PCL1 2 3 4
  • Prenylcysteine Lyase 3 4
  • EC 1.8.3.5 4 51
  • KIAA0908 2 4
  • PCYOX1 5

External Ids for PCYOX1 Gene

Previous GeneCards Identifiers for PCYOX1 Gene

  • GC02P070442
  • GC02P070459
  • GC02P070396
  • GC02P070484
  • GC02P070222

Summaries for PCYOX1 Gene

Entrez Gene Summary for PCYOX1 Gene

  • Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PCYOX1 Gene

PCYOX1 (Prenylcysteine Oxidase 1) is a Protein Coding gene. Among its related pathways are Terpenoid backbone biosynthesis. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor. An important paralog of this gene is PCYOX1L.

UniProtKB/Swiss-Prot Summary for PCYOX1 Gene

  • Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine.

Gene Wiki entry for PCYOX1 Gene

Additional gene information for PCYOX1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PCYOX1 Gene

Genomics for PCYOX1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PCYOX1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PCYOX1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PCYOX1

Top Transcription factor binding sites by QIAGEN in the PCYOX1 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • HEN1
  • LyF-1
  • Pax-5
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • Sox5

Genomic Locations for PCYOX1 Gene

Genomic Locations for PCYOX1 Gene
chr2:70,257,386-70,281,185
(GRCh38/hg38)
Size:
23,800 bases
Orientation:
Plus strand
chr2:70,484,518-70,508,323
(GRCh37/hg19)
Size:
23,806 bases
Orientation:
Plus strand

Genomic View for PCYOX1 Gene

Genes around PCYOX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCYOX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCYOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCYOX1 Gene

Proteins for PCYOX1 Gene

  • Protein details for PCYOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHG3-PCYOX_HUMAN
    Recommended name:
    Prenylcysteine oxidase 1
    Protein Accession:
    Q9UHG3
    Secondary Accessions:
    • B2RB14
    • B7Z9P8
    • O94982
    • Q8N4N5
    • Q96QM8

    Protein attributes for PCYOX1 Gene

    Size:
    505 amino acids
    Molecular mass:
    56640 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74931.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PCYOX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCYOX1 Gene

Selected DME Specific Peptides for PCYOX1 Gene

Q9UHG3:
  • PLNRKMSNITF
  • LDKFMRIYRYQSHDYAFSSVEKL
  • SNLISGSVM
  • KMYEVVY
  • MEMSAIA
  • FLNEMIAPVM
  • INVIKLVWRYGFQSLRMHMWVED
  • VCSGLLQAS
  • KCPSIILHDRLYYLNGIE
  • SDFYDIV
  • NFDPPIEEF
  • KLFLSYDYAV

Post-translational modifications for PCYOX1 Gene

  • The protein is glycosylated at one or more potential N-glycosylation sites.
  • Glycosylation at Asn196, Asn323, and Asn353
  • Ubiquitination at Lys205
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PCYOX_HUMAN (1624)

Other Protein References for PCYOX1 Gene

Domains & Families for PCYOX1 Gene

Gene Families for PCYOX1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PCYOX1 Gene

Suggested Antigen Peptide Sequences for PCYOX1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51879, highly similar to Prenylcysteine oxidase (EC 1.8.3.5) (B7Z3Y2_HUMAN)
  • cDNA, FLJ78912, highly similar to Prenylcysteine oxidase (EC 1.8.3.5) (B7Z9P8_HUMAN)
  • Prenylcysteine lyase (PCYOX_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UHG3

UniProtKB/Swiss-Prot:

PCYOX_HUMAN :
  • Belongs to the prenylcysteine oxidase family.
Family:
  • Belongs to the prenylcysteine oxidase family.
genes like me logo Genes that share domains with PCYOX1: view

Function for PCYOX1 Gene

Molecular function for PCYOX1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an S-prenyl-L-cysteine + H2O + O2 = a prenal + H2O2 + L-cysteine; Xref=Rhea:RHEA:53892, Rhea:RHEA-COMP:13675, Rhea:RHEA-COMP:13676, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:35235, ChEBI:CHEBI:137934, ChEBI:CHEBI:137935; EC=1.8.3.5;.

Enzyme Numbers (IUBMB) for PCYOX1 Gene

Phenotypes From GWAS Catalog for PCYOX1 Gene

Gene Ontology (GO) - Molecular Function for PCYOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001735 prenylcysteine oxidase activity IEA,IDA 10585463
GO:0008555 chloride-transporting ATPase activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor IEA --
genes like me logo Genes that share ontologies with PCYOX1: view
genes like me logo Genes that share phenotypes with PCYOX1: view

Animal Models for PCYOX1 Gene

MGI Knock Outs for PCYOX1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCYOX1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCYOX1 Gene

Localization for PCYOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCYOX1 Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCYOX1 gene
Compartment Confidence
lysosome 5
extracellular 4
plasma membrane 2
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PCYOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 10585463
GO:0005886 plasma membrane IEA --
GO:0034361 very-low-density lipoprotein particle IDA 17154273
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with PCYOX1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PCYOX1 Gene

Pathways & Interactions for PCYOX1 Gene

PathCards logo

SuperPathways for PCYOX1 Gene

genes like me logo Genes that share pathways with PCYOX1: view

Pathways by source for PCYOX1 Gene

1 KEGG pathway for PCYOX1 Gene

Gene Ontology (GO) - Biological Process for PCYOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006821 chloride transport IEA --
GO:0030327 prenylated protein catabolic process NAS 9287348
GO:0030328 prenylcysteine catabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with PCYOX1: view

No data available for SIGNOR curated interactions for PCYOX1 Gene

Drugs & Compounds for PCYOX1 Gene

(5) Drugs for PCYOX1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteine Approved Nutra 250
FAD Approved Pharma 0
Hydrogen peroxide Approved, Vet_approved Pharma 115
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0

(3) Additional Compounds for PCYOX1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-trans,6-trans-Farnesal
  • (2-trans,6-trans)-3,7,11-Trimethyldodeca-2,6,10-trienal
  • (2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienal
  • (2E,6E)-Farnesal
  • (e,e)-3,7,11-Trimethyl-2,6,10-dodecatrienal
  • e,e-Farnesal
Farnesylcysteine
  • S-(2E,6E)-Farnesyl-L-cysteine
  • (e,e)-L-S-(3,7,11-Trimethyl-2,6,10-dodecatrienyl)-cysteine
  • S-all-trans-Farnesyl-L-cysteine
  • S-trans-trans-Farnesylcysteine
  • S-[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]-L-cysteine
68000-92-0
genes like me logo Genes that share compounds with PCYOX1: view

Transcripts for PCYOX1 Gene

mRNA/cDNA for PCYOX1 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCYOX1

Alternative Splicing Database (ASD) splice patterns (SP) for PCYOX1 Gene

No ASD Table

Relevant External Links for PCYOX1 Gene

GeneLoc Exon Structure for
PCYOX1

Expression for PCYOX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PCYOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PCYOX1 Gene

This gene is overexpressed in Nasopharynx (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PCYOX1 Gene



Protein tissue co-expression partners for PCYOX1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PCYOX1

SOURCE GeneReport for Unigene cluster for PCYOX1 Gene:

Hs.567502

mRNA Expression by UniProt/SwissProt for PCYOX1 Gene:

Q9UHG3-PCYOX_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PCYOX1 Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Heart(4.4)
  • Lung(4.3)
  • Bone marrow(4)
  • Kidney(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with PCYOX1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCYOX1 Gene

Orthologs for PCYOX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PCYOX1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PCYOX1 30 31
  • 99.38 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PCYOX1 30 31
  • 85.6 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PCYOX1 31
  • 85 (a)
OneToOne
LOC481418 30
  • 84.49 (n)
Mouse
(Mus musculus)
Mammalia Pcyox1 30 17 31
  • 77.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pcyox1 30
  • 76.65 (n)
Oppossum
(Monodelphis domestica)
Mammalia PCYOX1 31
  • 71 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PCYOX1 31
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PCYOX1 30 31
  • 64.59 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PCYOX1 31
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pcyox1 30
  • 62.18 (n)
Zebrafish
(Danio rerio)
Actinopterygii pcyox1 30 31
  • 57.47 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons FCLY 30
  • 47.3 (n)
Rice
(Oryza sativa)
Liliopsida Os04g0692800 30
  • 53.82 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToMany
Species where no ortholog for PCYOX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PCYOX1 Gene

ENSEMBL:
Gene Tree for PCYOX1 (if available)
TreeFam:
Gene Tree for PCYOX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PCYOX1: view image

Paralogs for PCYOX1 Gene

Paralogs for PCYOX1 Gene

(1) SIMAP similar genes for PCYOX1 Gene using alignment to 9 proteins:

  • PCYOX_HUMAN
  • B7Z3Y2_HUMAN
  • B7Z9P8_HUMAN
  • C9JGT6_HUMAN
  • C9JM55_HUMAN
  • C9K055_HUMAN
  • F8W8W4_HUMAN
  • Q53ST0_HUMAN
  • Q584P1_HUMAN

Pseudogenes.org Pseudogenes for PCYOX1 Gene

genes like me logo Genes that share paralogs with PCYOX1: view

Variants for PCYOX1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PCYOX1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
772846 Benign: not provided 70,277,267(+) A/G MISSENSE_VARIANT
rs17005441 - p.Thr414Ser
rs2706762 - p.Ser149Phe
rs34041544 - p.Ser465Gly

Additional dbSNP identifiers (rs#s) for PCYOX1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCYOX1 Gene

Variant ID Type Subtype PubMed ID
esv2523050 CNV deletion 19546169
esv2667817 CNV deletion 23128226
esv2760537 CNV gain 21179565
esv3591205 CNV loss 21293372
nsv518294 CNV loss 19592680
nsv961415 CNV duplication 23825009
nsv979016 CNV duplication 23825009

Variation tolerance for PCYOX1 Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.07; 68.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCYOX1 Gene

Human Gene Mutation Database (HGMD)
PCYOX1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCYOX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCYOX1 Gene

Disorders for PCYOX1 Gene

No disorders were found for PCYOX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCYOX1 Gene

Publications for PCYOX1 Gene

  1. Cloning, expression, and cellular localization of a human prenylcysteine lyase. (PMID: 10585463) Tschantz WR … Casey PJ (The Journal of biological chemistry 1999) 2 3 4 23
  2. Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase. (PMID: 12186880) Digits JA … Casey PJ (The Journal of biological chemistry 2002) 2 3 23
  3. Proteomic analysis of human low-density lipoprotein reveals the presence of prenylcysteine lyase, a hydrogen peroxide-generating enzyme. (PMID: 19253276) Banfi C … Tremoli E (Proteomics 2009) 3 23
  4. Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. (PMID: 17154273) Mancone C … Alonzi T (Proteomics 2007) 3 23
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4

Products for PCYOX1 Gene

  • Signalway ELISA kits for PCYOX1

Sources for PCYOX1 Gene