Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PCSK7 Gene

Aliases for PCSK7 Gene

  • Proprotein Convertase Subtilisin/Kexin Type 7 2 3 3 5
  • Subtilisin/Kexin-Like Protease PC7 3 4
  • Lymphoma Proprotein Convertase 3 4
  • Prohormone Convertase 7 3 4
  • Proprotein Convertase 7 3 4
  • Proprotein Convertase 8 3 4
  • SPC7 3 4
  • LPC 3 4
  • PC7 3 4
  • PC8 3 4
  • Proprotein Convertase Subtilisin/Kexin Type 7 Precursor Variant 2 3
  • Prohormone Convertase PC7 3
  • Proprotein Convertase PC7 3
  • EC 3.4.21.- 4
  • HPC8 4

External Ids for PCSK7 Gene

Previous GeneCards Identifiers for PCSK7 Gene

  • GC11M119428
  • GC11M118587
  • GC11M117109
  • GC11M116613
  • GC11M116581
  • GC11M113008
  • GC11M117075

Summaries for PCSK7 Gene

Entrez Gene Summary for PCSK7 Gene

  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]

GeneCards Summary for PCSK7 Gene

PCSK7 (Proprotein Convertase Subtilisin/Kexin Type 7) is a Protein Coding gene. Diseases associated with PCSK7 include Plantar Fasciitis and Leber Congenital Amaurosis 4. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is PCSK5.

UniProtKB/Swiss-Prot for PCSK7 Gene

  • Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.

Gene Wiki entry for PCSK7 Gene

Additional gene information for PCSK7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCSK7 Gene

Genomics for PCSK7 Gene

GeneHancer (GH) Regulatory Elements for PCSK7 Gene

Promoters and enhancers for PCSK7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J117229 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 723 5.3 ATF1 FOXA2 ARNT ZFP64 ARID4B SIN3A YY1 POLR2B GLIS2 ZNF213 PCSK7 RNF214 LOC653303 BACE1 APOA1 ENSG00000280143
GH11J117197 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 19.7 +30.7 30710 9.3 BCOR CTCF KLF1 ZBTB6 SIN3A ZMYM3 KLF14 ZIC2 ZBTB40 RAD21 TAGLN LOC100652768 LOC653303 PCSK7 APOA1 RNF214 SIDT2 ENSG00000280143
GH11J117143 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.6 +87.3 87265 3.6 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B PAFAH1B2 ENSG00000254678 LOC653303 BUD13 SIK3 ENSG00000224077 CEP164 PCSK7 RNF214 ZPR1
GH11J117327 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.6 -95.7 -95693 2.2 HDGF PKNOX1 ARNT ARID4B SIN3A ZBTB7B YY1 POLR2B ZNF766 ZNF207 ENSG00000250699 CEP164 RNF214 BUD13 ZPR1 PCSK7 ENSG00000252992 RPS27P19 BACE1 GC11M117336
GH11J116851 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10 +379.1 379060 4.9 HDGF PKNOX1 FEZF1 YY1 ZNF213 ZNF207 ZNF143 ATF7 KLF7 FOS LOC653303 SIK3 APOA1 APOC3 APOA4 ENSG00000236267 APOA5 ZPR1 ENSG00000224077 BUD13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PCSK7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PCSK7 gene promoter:
  • AML1a

Genomic Locations for PCSK7 Gene

Genomic Locations for PCSK7 Gene
28,189 bases
Minus strand
28,189 bases
Minus strand

Genomic View for PCSK7 Gene

Genes around PCSK7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCSK7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCSK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCSK7 Gene

Proteins for PCSK7 Gene

  • Protein details for PCSK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proprotein convertase subtilisin/kexin type 7
    Protein Accession:
    Secondary Accessions:
    • B0YJ60
    • Q3C1X1
    • Q53GM4
    • Q96FK8
    • Q9UL57

    Protein attributes for PCSK7 Gene

    785 amino acids
    Molecular mass:
    86247 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PCSK7 Gene

Post-translational modifications for PCSK7 Gene

No data available for DME Specific Peptides for PCSK7 Gene

Domains & Families for PCSK7 Gene

Gene Families for PCSK7 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S8 family.
  • Belongs to the peptidase S8 family.
genes like me logo Genes that share domains with PCSK7: view

Function for PCSK7 Gene

Molecular function for PCSK7 Gene

UniProtKB/Swiss-Prot Function:
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by zinc and copper.
GENATLAS Biochemistry:
proprotein convertase subtilisin/Rev in type 7,widely expressed

Enzyme Numbers (IUBMB) for PCSK7 Gene

Phenotypes From GWAS Catalog for PCSK7 Gene

Gene Ontology (GO) - Molecular Function for PCSK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IDA 15606899
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PCSK7: view
genes like me logo Genes that share phenotypes with PCSK7: view

Animal Models for PCSK7 Gene

MGI Knock Outs for PCSK7:

Animal Model Products

  • Taconic Biosciences Mouse Models for PCSK7

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCSK7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCSK7 Gene

Localization for PCSK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCSK7 Gene

Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Seems to be localized intracellularly to the trans Golgi network. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCSK7 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
nucleus 3
extracellular 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (1)
  • Nucleoli (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PCSK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030173 integral component of Golgi membrane IDA 9341152
genes like me logo Genes that share ontologies with PCSK7: view

Pathways & Interactions for PCSK7 Gene

SuperPathways for PCSK7 Gene

No Data Available

SIGNOR curated interactions for PCSK7 Gene


Gene Ontology (GO) - Biological Process for PCSK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016485 protein processing IDA 15606899
GO:0016486 peptide hormone processing NAS 9341152
genes like me logo Genes that share ontologies with PCSK7: view

No data available for Pathways by source for PCSK7 Gene

Drugs & Compounds for PCSK7 Gene

(4) Drugs for PCSK7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Copper Approved, Investigational Pharma 202
genes like me logo Genes that share compounds with PCSK7: view

Transcripts for PCSK7 Gene

mRNA/cDNA for PCSK7 Gene

Unigene Clusters for PCSK7 Gene

Proprotein convertase subtilisin/kexin type 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCSK7

Alternative Splicing Database (ASD) splice patterns (SP) for PCSK7 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ·
SP1: - - -
SP2: -
SP7: -
SP8: - - -
SP10: - - - - -
SP11: - - - - - - - - - -
SP13: - - - - - -
SP15: - - - - -
SP16: -

ExUns: 13c · 13d ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b · 25c
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: - -
SP14: - - - -
SP18: - - -

Relevant External Links for PCSK7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCSK7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCSK7 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PCSK7 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCSK7 Gene:


SOURCE GeneReport for Unigene cluster for PCSK7 Gene:


mRNA Expression by UniProt/SwissProt for PCSK7 Gene:

Tissue specificity: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte.

Evidence on tissue expression from TISSUES for PCSK7 Gene

  • Nervous system(4.6)
  • Kidney(4.4)
  • Eye(4.1)
  • Lung(2.9)
  • Intestine(2.5)
  • Heart(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with PCSK7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCSK7 Gene

Orthologs for PCSK7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PCSK7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PCSK7 34 33
  • 99.24 (n)
(Canis familiaris)
Mammalia PCSK7 34 33
  • 88.87 (n)
(Bos Taurus)
Mammalia PCSK7 34 33
  • 87.37 (n)
(Ornithorhynchus anatinus)
Mammalia PCSK7 34
  • 87 (a)
(Mus musculus)
Mammalia Pcsk7 16 34 33
  • 86.39 (n)
(Rattus norvegicus)
Mammalia Pcsk7 33
  • 85.96 (n)
(Monodelphis domestica)
Mammalia PCSK7 34
  • 82 (a)
(Gallus gallus)
Aves PC7 34
  • 78 (a)
PCSK7 33
  • 76.96 (n)
(Anolis carolinensis)
Reptilia PCSK7 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcsk7 33
  • 67.65 (n)
(Danio rerio)
Actinopterygii pcsk7 34 33
  • 68.21 (n)
(Caenorhabditis elegans)
Secernentea aex-5 35
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KEX2 36 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
Species where no ortholog for PCSK7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCSK7 Gene

Gene Tree for PCSK7 (if available)
Gene Tree for PCSK7 (if available)
Evolutionary constrained regions (ECRs) for PCSK7: view image

Paralogs for PCSK7 Gene

Paralogs for PCSK7 Gene

(6) SIMAP similar genes for PCSK7 Gene using alignment to 5 proteins:

  • E9PMC0_HUMAN Pseudogenes for PCSK7 Gene

genes like me logo Genes that share paralogs with PCSK7: view

Variants for PCSK7 Gene

Sequence variations from dbSNP and Humsavar for PCSK7 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000098848 -- 117,220,060(-) C/G intron_variant
rs1000233876 -- 117,213,875(-) A/C intron_variant
rs1000348462 -- 117,230,936(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000400902 -- 117,231,271(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000444655 -- 117,229,257(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PCSK7 Gene

Variant ID Type Subtype PubMed ID
dgv2186n54 CNV loss 21841781
dgv416e212 CNV loss 25503493
dgv708e59 CNV duplication 20981092
dgv730n106 OTHER inversion 24896259
esv3419020 CNV duplication 20981092
esv3579921 CNV loss 25503493
nsv1078301 OTHER inversion 25765185
nsv1139559 CNV duplication 24896259
nsv524270 CNV loss 19592680
nsv7223 OTHER inversion 18451855
nsv983065 CNV duplication 23825009

Variation tolerance for PCSK7 Gene

Residual Variation Intolerance Score: 31.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCSK7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCSK7 Gene

Disorders for PCSK7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PCSK7 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
plantar fasciitis
  • fasciitis, plantar
leber congenital amaurosis 4
  • cone-rod dystrophy
nerve compression syndrome
  • compression neuropathy
- elite association - COSMIC cancer census association via MalaCards
Search PCSK7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PCSK7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PCSK7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCSK7 Gene

Publications for PCSK7 Gene

  1. PC8 [corrected], a new member of the convertase family. (PMID: 8615762) Bruzzaniti A … Gillespie MT (The Biochemical journal 1996) 2 3 4 22 58
  2. Molecular analysis of an unstable genomic region at chromosome band 11q23 reveals a disruption of the gene encoding the alpha2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) in human lymphoma. (PMID: 10362256) Lecointe N … Young BD (Oncogene 1999) 3 4 22 58
  3. Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase. (PMID: 9341152) van de Loo JW … Van de Ven WJ (The Journal of biological chemistry 1997) 3 4 22 58
  4. A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas. (PMID: 8564950) Meerabux J … Young BD (Cancer research 1996) 3 4 22 58
  5. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. (PMID: 21943158) Middelberg RP … Whitfield JB (BMC medical genetics 2011) 3 44 58

Products for PCSK7 Gene

Sources for PCSK7 Gene

Loading form....