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PCP4 (Purkinje Cell Protein 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calmodulin binding. An important paralog of this gene is PCP4L1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH21J039788 | Promoter/Enhancer | 1.3 | EPDnew ENCODE CraniofacialAtlas | 615.3 | -78.7 | -78664 | 1 | CREB1 CTCF TEAD4 IKZF1 TARDBP FOXA1 ZIC2 REST SP1 GTF2F1 | PCP4 LOC107985500 IGSF5 HSALNG0133155 | |
GH21J039867 | Promoter/Enhancer | 1 | EPDnew ENCODE | 600.7 | -0.1 | -78 | 0.2 | BRCA1 CTCF TEAD4 REST RAD21 ZNF444 USF1 YY1 PKNOX1 ZNF217 | PCP4 HSALNG0133155 IGSF5 | |
GH21J039870 | Promoter | 0.6 | Ensembl | 600.7 | +0.3 | 262 | 0.2 | CTCF RAD21 ZNF217 SIN3A ZNF687 TBP | PCP4 piR-31462-025 DSCAM | |
GH21J039866 | Enhancer | 0.3 | Ensembl | 600.7 | -0.5 | -537 | 0.2 | CTCF | PCP4 HSALNG0133155 IGSF5 | |
GH21J040054 | Enhancer | 0.8 | Ensembl ENCODE | 6.6 | +187.1 | 187118 | 0.6 | ZHX2 FOXA1 RFX1 ESR1 CTBP1 PKNOX1 SIN3A GATA3 DPF2 CTCF | PCP4 lnc-LCA5L-2 piR-37026-384 DSCAM |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005509 | calcium ion binding | IDA | 23204517 |
GO:0005515 | protein binding | IPI | 21044950 |
GO:0005516 | calmodulin binding | IPI | 19106096 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | HDA | 16780588 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | HDA | 16780588 |
GO:0032991 | protein-containing complex | IDA | 19106096 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0045666 | positive regulation of neuron differentiation | IMP | 21491429 |
GO:0099004 | calmodulin dependent kinase signaling pathway | IMP | 21491429 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||
SP2: | - | - | |||||||||||||||||
SP3: | - | - | - | ||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PCP4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PCP4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PCP4 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Pcp4 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Pcp4 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PCP4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PCP4 30 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | pcp4b 31 |
|
OneToMany | |
pcp4a 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3893411 | CNV | loss | 25118596 |
nsv1056677 | CNV | gain | 25217958 |
nsv1061454 | CNV | gain | 25217958 |
nsv3523 | CNV | insertion | 18451855 |
nsv474231 | CNV | novel sequence insertion | 20440878 |
nsv587486 | CNV | loss | 21841781 |
nsv587487 | CNV | loss | 21841781 |
No disorders were found for PCP4 Gene.