Aliases for PCNX4 Gene

Aliases for PCNX4 Gene

  • Pecanex 4 2 3 5
  • Hepatitis C Virus F Protein-Binding Protein 2 3 4
  • HCV F Protein-Binding Protein 2 3 4
  • Pecanex Homolog Protein 4 3 4
  • Pecanex-Like Protein 4 3 4
  • C14orf135 3 4
  • PCNXL4 3 4
  • FBP2 3 4
  • Chromosome 14 Open Reading Frame 135 2
  • Pecanex-Like Protein C14orf135 3
  • Pecanex Homolog 4 (Drosophila) 2
  • Pecanex-Like 4 (Drosophila) 2
  • HCV F-Interacting Protein 3
  • Pecanex Homolog 4 3
  • Pecanex-Like 4 3

External Ids for PCNX4 Gene

Previous HGNC Symbols for PCNX4 Gene

  • C14orf135
  • PCNXL4

Summaries for PCNX4 Gene

GeneCards Summary for PCNX4 Gene

PCNX4 (Pecanex 4) is a Protein Coding gene. An important paralog of this gene is PCNX2.

Additional gene information for PCNX4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PCNX4 Gene

Genomics for PCNX4 Gene

GeneHancer (GH) Regulatory Elements for PCNX4 Gene

Promoters and enhancers for PCNX4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PCNX4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PCNX4

Genomic Locations for PCNX4 Gene

Genomic Locations for PCNX4 Gene
77,307 bases
Plus strand
77,223 bases
Plus strand

Genomic View for PCNX4 Gene

Genes around PCNX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCNX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCNX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNX4 Gene

Proteins for PCNX4 Gene

  • Protein details for PCNX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pecanex-like protein 4
    Protein Accession:
    Secondary Accessions:
    • A8MXM2
    • Q9BQG8
    • Q9H9F2

    Protein attributes for PCNX4 Gene

    1172 amino acids
    Molecular mass:
    132702 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH33843.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14277.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAB66516.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAH56141.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for PCNX4 Gene

Post-translational modifications for PCNX4 Gene

  • Glycosylation at Asn1120 and Asn1147
  • Ubiquitination at Lys734 and Lys1165
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PCNX4 Gene

Domains & Families for PCNX4 Gene

Gene Families for PCNX4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PCNX4 Gene


Suggested Antigen Peptide Sequences for PCNX4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ12946 fis, clone NT2RP2005254 (B3KMY6_HUMAN)
  • Hepatitis C virus F protein-binding protein 2 (CN135_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pecanex family.
  • Belongs to the pecanex family.
genes like me logo Genes that share domains with PCNX4: view

Function for PCNX4 Gene

Phenotypes From GWAS Catalog for PCNX4 Gene

Gene Ontology (GO) - Molecular Function for PCNX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16237761
genes like me logo Genes that share ontologies with PCNX4: view
genes like me logo Genes that share phenotypes with PCNX4: view

miRNA for PCNX4 Gene

miRTarBase miRNAs that target PCNX4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCNX4 Gene

Localization for PCNX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNX4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCNX4 gene
Compartment Confidence
plasma membrane 3
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PCNX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCNX4: view

Pathways & Interactions for PCNX4 Gene

PathCards logo

SuperPathways for PCNX4 Gene

No Data Available

Interacting Proteins for PCNX4 Gene


Gene Ontology (GO) - Biological Process for PCNX4 Gene


No data available for Pathways by source and SIGNOR curated interactions for PCNX4 Gene

Drugs & Compounds for PCNX4 Gene

No Compound Related Data Available

Transcripts for PCNX4 Gene

mRNA/cDNA for PCNX4 Gene

9 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCNX4 Gene

No ASD Table

Relevant External Links for PCNX4 Gene

GeneLoc Exon Structure for

Expression for PCNX4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PCNX4

Evidence on tissue expression from TISSUES for PCNX4 Gene

  • Nervous system(4.7)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCNX4 Gene

Orthologs for PCNX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCNX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PCNXL4 31 30
  • 99 (n)
(Canis familiaris)
Mammalia PCNXL4 31 30
  • 89.03 (n)
(Bos Taurus)
Mammalia PCNXL4 31 30
  • 88.21 (n)
(Mus musculus)
Mammalia Pcnxl4 31 30
  • 79.19 (n)
Pcnx4 17
(Rattus norvegicus)
Mammalia Pcnxl4 30
  • 77.62 (n)
(Monodelphis domestica)
Mammalia PCNXL4 31
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 52 (a)
-- 31
  • 45 (a)
(Gallus gallus)
Aves C5H14ORF135 30
  • 70.41 (n)
  • 53 (a)
(Anolis carolinensis)
Reptilia PCNXL4 31
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcnxl4 30
  • 63.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398632 30
(Danio rerio)
Actinopterygii pcnxl4 31 30
  • 53.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta pcx 31
  • 5 (a)
(Caenorhabditis elegans)
Secernentea B0511.12 31
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
Species where no ortholog for PCNX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCNX4 Gene

Gene Tree for PCNX4 (if available)
Gene Tree for PCNX4 (if available)
Evolutionary constrained regions (ECRs) for PCNX4: view image

Paralogs for PCNX4 Gene

Paralogs for PCNX4 Gene

genes like me logo Genes that share paralogs with PCNX4: view

Variants for PCNX4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PCNX4 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs12895606 - p.Asp811Tyr
rs167437 - p.Gly1000Ser
rs3742642 - p.Gln770His

Additional dbSNP identifiers (rs#s) for PCNX4 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCNX4 Gene

Variant ID Type Subtype PubMed ID
esv1144667 CNV insertion 17803354
esv2759993 CNV loss 17122850
esv3422540 CNV insertion 20981092
nsv1044390 CNV loss 25217958
nsv1129376 OTHER inversion 24896259

Variation tolerance for PCNX4 Gene

Gene Damage Index Score: 18.08; 98.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCNX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCNX4 Gene

Disorders for PCNX4 Gene

Additional Disease Information for PCNX4

No disorders were found for PCNX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCNX4 Gene

Publications for PCNX4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 54
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54

Products for PCNX4 Gene

Sources for PCNX4 Gene