Aliases for PCNX3 Gene

Aliases for PCNX3 Gene

  • Pecanex 3 2 3 5
  • Pecanex Homolog Protein 3 3 4
  • Pecanex-Like Protein 3 3 4
  • PCNXL3 3 4
  • Pecanex Homolog 3 (Drosophila) 2
  • Pecanex-Like 3 (Drosophila) 2
  • Pecanex Homolog 3 3
  • Pecanex-Like 3 3
  • FLJ22427 2
  • PCNX3 5

External Ids for PCNX3 Gene

Previous HGNC Symbols for PCNX3 Gene

  • PCNXL3

Previous GeneCards Identifiers for PCNX3 Gene

  • GC11P065616
  • GC11P065615
  • GC11P065635
  • GC11P065830
  • GC11P065914

Summaries for PCNX3 Gene

GeneCards Summary for PCNX3 Gene

PCNX3 (Pecanex 3) is a Protein Coding gene. Diseases associated with PCNX3 include Comedo Carcinoma and Cardiomyopathy, Dilated, 1E. An important paralog of this gene is PCNX1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PCNX3 Gene

Genomics for PCNX3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PCNX3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PCNX3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PCNX3

Genomic Locations for PCNX3 Gene

Latest Assembly
chr11:65,614,311-65,637,439
(GRCh38/hg38)
Size:
23,129 bases
Orientation:
Plus strand

Previous Assembly
chr11:65,383,247-65,404,910
(GRCh37/hg19 by Entrez Gene)
Size:
21,664 bases
Orientation:
Plus strand

chr11:65,383,244-65,404,910
(GRCh37/hg19 by Ensembl)
Size:
21,667 bases
Orientation:
Plus strand

Genomic View for PCNX3 Gene

Genes around PCNX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCNX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCNX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNX3 Gene

Proteins for PCNX3 Gene

  • Protein details for PCNX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6A9-PCX3_HUMAN
    Recommended name:
    Pecanex-like protein 3
    Protein Accession:
    Q9H6A9
    Secondary Accessions:
    • Q6MZN8

    Protein attributes for PCNX3 Gene

    Size:
    2034 amino acids
    Molecular mass:
    222039 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15353.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PCNX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCNX3 Gene

Post-translational modifications for PCNX3 Gene

  • Glycosylation at Asn319 and Asn1770
  • Ubiquitination at Lys1307, Lys762, Lys1935, and Lys1040
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PCNX3 Gene

Domains & Families for PCNX3 Gene

Gene Families for PCNX3 Gene

Protein Domains for PCNX3 Gene

InterPro:

Suggested Antigen Peptide Sequences for PCNX3 Gene

GenScript: Design optimal peptide antigens:
  • Pecanex-like protein 3 (PCX3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H6A9

UniProtKB/Swiss-Prot:

PCX3_HUMAN :
  • Belongs to the pecanex family.
Family:
  • Belongs to the pecanex family.
genes like me logo Genes that share domains with PCNX3: view

Function for PCNX3 Gene

Phenotypes From GWAS Catalog for PCNX3 Gene

genes like me logo Genes that share phenotypes with PCNX3: view

miRNA for PCNX3 Gene

miRTarBase miRNAs that target PCNX3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCNX3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCNX3 Gene

Localization for PCNX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNX3 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCNX3 gene
Compartment Confidence
plasma membrane 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PCNX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCNX3: view

Pathways & Interactions for PCNX3 Gene

PathCards logo

SuperPathways for PCNX3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCNX3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCNX3 Gene

Drugs & Compounds for PCNX3 Gene

No Compound Related Data Available

Transcripts for PCNX3 Gene

mRNA/cDNA for PCNX3 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCNX3

Alternative Splicing Database (ASD) splice patterns (SP) for PCNX3 Gene

No ASD Table

Relevant External Links for PCNX3 Gene

GeneLoc Exon Structure for
PCNX3

Expression for PCNX3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PCNX3

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCNX3 Gene

Orthologs for PCNX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCNX3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PCNXL3 29 30
  • 99.54 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PCNXL3 29 30
  • 90.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PCNXL3 29 30
  • 90.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pcnxl3 29
  • 88.61 (n)
Mouse
(Mus musculus)
Mammalia Pcnxl3 29 30
  • 88.35 (n)
OneToOne
Pcnx3 16
Oppossum
(Monodelphis domestica)
Mammalia PCNXL3 30
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PCNXL3 30
  • 67 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PCNXL3 30
  • 62 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii pcnxl3 30
  • 59 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta pcx 30
  • 24 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea B0511.12 30
  • 29 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 27 (a)
ManyToMany
Species where no ortholog for PCNX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for PCNX3 Gene

ENSEMBL:
Gene Tree for PCNX3 (if available)
TreeFam:
Gene Tree for PCNX3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PCNX3: view image
Alliance of Genome Resources:
Additional Orthologs for PCNX3

Paralogs for PCNX3 Gene

Paralogs for PCNX3 Gene

genes like me logo Genes that share paralogs with PCNX3: view

Variants for PCNX3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PCNX3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
982224 Likely Pathogenic: Moyamoya angiopathy 65,616,897(+) CTG/C
NM_032223.3:c.229_230delGT
FRAMESHIFT
rs1144790 -- p.Lys813Asn
rs1151489 -- p.Gln258Arg
rs1193851 -- p.Ser458Cys
rs56232198 -- p.Gly564Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PCNX3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PCNX3 Gene

Variant ID Type Subtype PubMed ID
dgv1969n54 CNV loss 21841781
esv2761680 CNV gain 21179565
nsv951018 CNV deletion 24416366

Variation tolerance for PCNX3 Gene

Residual Variation Intolerance Score: 4.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.31; 90.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCNX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCNX3
Leiden Open Variation Database (LOVD)
PCNX3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCNX3 Gene

Disorders for PCNX3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PCNX3 Gene - From: COP

Disorder Aliases PubMed IDs
comedo carcinoma
  • comedocarcinoma
cardiomyopathy, dilated, 1e
  • cmd1e
- elite association - COSMIC cancer census association via MalaCards
Search PCNX3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PCNX3

genes like me logo Genes that share disorders with PCNX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCNX3 Gene

Publications for PCNX3 Gene

  1. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 2 3
  2. The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei. (PMID: 31527615) Nassa G … Weisz A (Scientific data 2019) 3
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response. (PMID: 30404004) Chen LL … Guan KL (Cell reports 2018) 3
  5. Agrin has a pathological role in the progression of oral cancer. (PMID: 29872149) Rivera C … Paes Leme AF (British journal of cancer 2018) 3

Products for PCNX3 Gene

Sources for PCNX3 Gene