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Aliases for PCNX3 Gene

Aliases for PCNX3 Gene

  • Pecanex Homolog 3 2 3 5
  • Pecanex Homolog Protein 3 3 4
  • PCNXL3 3 4
  • Pecanex Homolog 3 (Drosophila) 2
  • Pecanex-Like 3 (Drosophila) 2
  • Pecanex-Like Protein 3 3
  • Pecanex-Like 3 3

External Ids for PCNX3 Gene

Previous HGNC Symbols for PCNX3 Gene

  • PCNXL3

Previous GeneCards Identifiers for PCNX3 Gene

  • GC11P065615

Summaries for PCNX3 Gene

GeneCards Summary for PCNX3 Gene

PCNX3 (Pecanex Homolog 3) is a Protein Coding gene. An important paralog of this gene is PCNX1.

Additional gene information for PCNX3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCNX3 Gene

Genomics for PCNX3 Gene

GeneHancer (GH) Regulatory Elements for PCNX3 Gene

Promoters and enhancers for PCNX3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J065609 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 674.1 -0.3 -323 8.5 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 NFYC SSRP1 MAP3K11 PCNX3 LOC105369352 EIF1AD SF1 ENSG00000254461 SF3B2 RNASEH2C KAT5 ZFPL1
GH11J065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 182 -124.2 -124238 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 POLA2 PCNX3 ZFPL1 EIF1AD SART1 LOC105369352 MUS81 KAT5
GH11J065626 Promoter 0.5 EPDnew 650.4 +12.5 12542 0.1 PCNX3 MAP3K11 MIR4690
GH11J065414 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 101.8 -190.1 -190141 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NEAT1 GC11P065538 ENSG00000278144 ENSG00000278050 ENSG00000277599 SF1 LOC105369352 ZFPL1 POLA2 EIF1AD
GH11J065851 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 96.7 +243.2 243162 12.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MUS81 CFL1 EIF1AD ENSG00000258297 POLA2 RBM14 SART1 PCNX3 RBM4 ZFPL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PCNX3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PCNX3 Gene

Genomic Locations for PCNX3 Gene
23,118 bases
Plus strand
21,667 bases
Plus strand

Genomic View for PCNX3 Gene

Genes around PCNX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCNX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCNX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNX3 Gene

Proteins for PCNX3 Gene

  • Protein details for PCNX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pecanex-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q6MZN8

    Protein attributes for PCNX3 Gene

    2034 amino acids
    Molecular mass:
    222039 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15353.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PCNX3 Gene


neXtProt entry for PCNX3 Gene

Post-translational modifications for PCNX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PCNX3 Gene

Domains & Families for PCNX3 Gene

Gene Families for PCNX3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PCNX3 Gene


Suggested Antigen Peptide Sequences for PCNX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pecanex family.
  • Belongs to the pecanex family.
genes like me logo Genes that share domains with PCNX3: view

Function for PCNX3 Gene

Phenotypes From GWAS Catalog for PCNX3 Gene

genes like me logo Genes that share phenotypes with PCNX3: view

Animal Model Products

CRISPR Products

miRNA for PCNX3 Gene

miRTarBase miRNAs that target PCNX3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCNX3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCNX3 Gene

Localization for PCNX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNX3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCNX3 gene
Compartment Confidence
plasma membrane 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PCNX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCNX3: view

Pathways & Interactions for PCNX3 Gene

SuperPathways for PCNX3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCNX3 Gene


No data available for Pathways by source and SIGNOR curated interactions for PCNX3 Gene

Drugs & Compounds for PCNX3 Gene

No Compound Related Data Available

Transcripts for PCNX3 Gene

mRNA/cDNA for PCNX3 Gene

(9) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCNX3

Alternative Splicing Database (ASD) splice patterns (SP) for PCNX3 Gene

No ASD Table

Relevant External Links for PCNX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCNX3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCNX3 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCNX3 Gene

Orthologs for PCNX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCNX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PCNXL3 34 33
  • 99.54 (n)
(Canis familiaris)
Mammalia PCNXL3 34 33
  • 90.84 (n)
(Bos Taurus)
Mammalia PCNXL3 34 33
  • 90.38 (n)
(Rattus norvegicus)
Mammalia Pcnxl3 33
  • 88.61 (n)
(Mus musculus)
Mammalia Pcnxl3 34 33
  • 88.35 (n)
Pcnx3 16
(Monodelphis domestica)
Mammalia PCNXL3 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia PCNXL3 34
  • 67 (a)
(Anolis carolinensis)
Reptilia PCNXL3 34
  • 62 (a)
(Danio rerio)
Actinopterygii pcnxl3 34
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta pcx 34
  • 24 (a)
(Caenorhabditis elegans)
Secernentea B0511.12 34
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
Species where no ortholog for PCNX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PCNX3 Gene

Gene Tree for PCNX3 (if available)
Gene Tree for PCNX3 (if available)
Evolutionary constrained regions (ECRs) for PCNX3: view image

Paralogs for PCNX3 Gene

Paralogs for PCNX3 Gene

genes like me logo Genes that share paralogs with PCNX3: view

Variants for PCNX3 Gene

Sequence variations from dbSNP and Humsavar for PCNX3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000016935 -- 65,625,718(+) G/A coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant
rs1000204726 -- 65,620,146(+) C/G/T intron_variant
rs1000264077 -- 65,615,806(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000302448 -- 65,630,709(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000439950 -- 65,615,942(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PCNX3 Gene

Variant ID Type Subtype PubMed ID
dgv1969n54 CNV loss 21841781
esv2761680 CNV gain 21179565
nsv951018 CNV deletion 24416366

Variation tolerance for PCNX3 Gene

Residual Variation Intolerance Score: 4.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.31; 90.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCNX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCNX3 Gene

Disorders for PCNX3 Gene

No disorders were found for PCNX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCNX3 Gene

Publications for PCNX3 Gene

  1. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for PCNX3 Gene

Sources for PCNX3 Gene

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