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The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
PCNA (Proliferating Cell Nuclear Antigen) is a Protein Coding gene. Diseases associated with PCNA include Ataxia-Telangiectasia-Like Disorder 2 and Bowen's Disease. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include identical protein binding and damaged DNA binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000701 | purine-specific mismatch base pair DNA N-glycosylase activity | IDA | 11005803 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003682 | chromatin binding | IDA | 23277426 |
GO:0003684 | damaged DNA binding | IDA | 24939902 |
GO:0005515 | protein binding | IPI | 8861913 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | IEA | -- |
GO:0000784 | nuclear chromosome, telomeric region | HDA | 19135898 |
GO:0000785 | chromatin | IDA | 23277426 |
GO:0005634 | nucleus | IBA,IDA | 15494374 |
GO:0005652 | nuclear lamina | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Telomere C-strand (Lagging Strand) Synthesis |
.67
|
Cell cycle Transition and termination of DNA replication
.48
|
2 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | ||
3 | Mismatch repair |
.54
Mismatch Repair in Eukaryotes
.54
.01
|
.01
|
4 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
5 | DNA Double-Strand Break Repair |
.53
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | -- |
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0000723 | telomere maintenance | TAS | -- |
GO:0006260 | DNA replication | IEA | -- |
GO:0006272 | leading strand elongation | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Aspirin | Approved, Vet_approved | Pharma | Channel blocker, Target, downregulator | 1512 | ||
Liothyronine | Approved, Vet_approved | Pharma | Target, antagonist | 0 | ||
Capecitabine | Approved, Investigational | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines | 1669 | ||
Nelarabine | Approved, Investigational | Pharma | Prodrug of ara-G for T-LBL/T-ALL | 0 | ||
Oxaliplatin | Approved, Investigational | Pharma | Antitumor agent, Platinum | 1944 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Adenine sulfate | Sulfate salt form of adenine | 321-30-2 |
Blasticidin S HCl | 3513-03-9 | |
Capecitabine | 154361-50-9 | |
Carmofur | Cytostatic derivative of fluorouracilm,antineoplatic agent | 61422-45-5 |
Gemcitabine HCl | Inhibits DNA synthesis,deoxycytidine analog | 122111-03-9 |
Mercaptopurine (6-MP) | Purine synthesis inhibitor | 50-44-2 |
Nelarabine | Prodrug of ara-G for T-LBL/T-ALL | 121032-29-9 |
Oxaliplatin | Antitumor agent | 61825-94-3 |
Rifaximin (Xifaxan) | RNA synthesis inhibitor, PXR activator | 80621-81-4 |
Uridine | 58-96-8 |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PCNA 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PCNA 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pcna-ps2 31 |
|
OneToMany | |
Pcna 30 17 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | PCNA 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PCNA 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pcna 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | PCNA 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PCNA 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PCNA 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pcna 30 |
|
||
Str.6228 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | pcna-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | pcna 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10814 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | mus209 30 31 32 |
|
OneToMany | |
CG10262 31 32 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010220 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | pcn-1 30 31 32 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADL309W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | POL30 30 31 33 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B12078g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PCNA2 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.431 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0805200 30 |
|
||
Os.3376 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.6407 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.2876 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.531 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU09239 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pcn1 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3511 30 |
|
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711223 | Benign: not provided | 5,115,343(-) | C/T | SYNONYMOUS_VARIANT | |
748972 | Likely Benign: not provided | 5,119,766(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
749190 | Likely Benign: not provided | 5,115,510(-) | A/G | SYNONYMOUS_VARIANT | |
753900 | Likely Benign: not provided | 5,115,543(-) | T/C | SYNONYMOUS_VARIANT | |
786675 | Benign: not provided | 5,115,453(-) | G/C | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
ataxia-telangiectasia-like disorder 2 |
|
|
bowen's disease |
|
|
ataxia-telangiectasia |
|
|
oral leukoplakia |
|
|
leukoplakia |
|