Aliases for PCNA Gene
Aliases for PCNA Gene
External Ids for PCNA Gene
- HGNC: 8729
- Entrez Gene: 5111
- Ensembl: ENSG00000132646
- OMIM: 176740
- UniProtKB: P12004
Previous GeneCards Identifiers for PCNA Gene
- GC20M005083
- GC20M005090
- GC20M005043
- GC20M005095
Summaries for PCNA Gene
-
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
GeneCards Summary for PCNA Gene
PCNA (Proliferating Cell Nuclear Antigen) is a Protein Coding gene. Diseases associated with PCNA include Ataxia-Telangiectasia-Like Disorder 2 and Bowen's Disease. Among its related pathways are Mismatch repair and SUMOylation. Gene Ontology (GO) annotations related to this gene include identical protein binding and damaged DNA binding.
UniProtKB/Swiss-Prot for PCNA Gene
-
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerases processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3-5 exonuclease and 3-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while Lys-63-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Additional gene information for PCNA Gene
- Monarch Initiative
- Search for PCNA at DataMed
- Search for PCNA at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCNA Gene
Genomics for PCNA Gene
GeneHancer (GH) Regulatory Elements for PCNA Gene
Promoters and enhancers for PCNA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PCNA on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PCNA gene promoter:
Regulatory Element Products
Genomic Locations for PCNA Gene
Genomic Locations for PCNA Gene
- chr20:5,114,953-5,126,626
- (GRCh38/hg38)
- Size:
- 11,674 bases
- Orientation:
- Minus strand
- chr20:5,095,599-5,107,272
- (GRCh37/hg19)
Genomic View for PCNA Gene
Genes around PCNA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20p12.3 by Ensembl
- 20p12.3 by Entrez Gene
- 20p12.3 by HGNC
PCNA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PCNA Gene
Proteins for PCNA Gene
-
Protein details for PCNA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P12004-PCNA_HUMAN
- Recommended name:
- Proliferating cell nuclear antigen
- Protein Accession:
- P12004
- B2R897
- D3DW02
Protein attributes for PCNA Gene
- Size:
- 261 amino acids
- Molecular mass:
- 28769 Da
- Quaternary structure:
-
- Homotrimer (PubMed:24939902). Interacts with p300/EP300; the interaction occurs on chromatin in UV-irradiated damaged cells (PubMed:24939902). Interacts with CREBBP (via transactivation domain and C-terminus); the interaction occurs on chromatin in UV-irradiated damaged cells (PubMed:24939902). Directly interacts with POLD1, POLD3 and POLD4 subunits of the DNA polymerase delta complex, POLD3 being the major interacting partner; the interaction with POLD3 is inhibited by CDKN1A/p21(CIP1) (PubMed:11595739, PubMed:16510448, PubMed:22148433, PubMed:24939902). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with EXO1, POLH, POLK, DNMT1, ERCC5, FEN1, CDC6 and POLDIP2 (PubMed:9305916, PubMed:9302295, PubMed:9566895, PubMed:11784855, PubMed:12522211, PubMed:15225546, PubMed:15149598, PubMed:24911150, PubMed:15616578). Interacts with APEX2; this interaction is triggered by reactive oxygen species and increased by misincorporation of uracil in nuclear DNA (PubMed:11376153, PubMed:19443450). Forms a ternary complex with DNTTIP2 and core histone (PubMed:12786946). Interacts with KCTD10 and PPP1R15A (By similarity). Directly interacts with BAZ1B (PubMed:15543136). Interacts with HLTF and SHPRH (PubMed:17130289, PubMed:18316726, PubMed:18719106). Interacts with NUDT15; this interaction is disrupted in response to UV irradiation and acetylation (PubMed:19419956). Interacts with CDKN1A/p21(CIP1) and CDT1; interacts via their PIP-box which also recruits the DCX(DTL) complex. The interaction with CDKN1A inhibits POLD3 binding (PubMed:11595739, PubMed:16949367, PubMed:18794347, PubMed:18703516). Interacts with DDX11 (PubMed:18499658). Interacts with EGFR; positively regulates PCNA (PubMed:17115032). Interacts with PARPBP (PubMed:22153967). Interacts (when ubiquitinated) with SPRTN; leading to enhance RAD18-mediated PCNA ubiquitination (PubMed:22681887). Interacts (when polyubiquitinated) with ZRANB3 (PubMed:22704558, PubMed:22705370, PubMed:22759634). Interacts with SMARCAD1 (PubMed:21549307). Interacts with CDKN1C (PubMed:22634751). Interacts with PCLAF (via PIP-box) (PubMed:21628590, PubMed:23000965). Interacts with RTEL1 (via PIP-box); the interaction is direct and essential for the suppression of telomere fragility (PubMed:24115439). Interacts with FAM111A (via PIP-box); the interaction is direct and required for PCNA loading on chromatin binding (PubMed:24561620). Interacts with LIG1 (PubMed:24911150). Interacts with SETMAR (PubMed:20457750). Interacts with ANKRD17 (PubMed:23711367). Interacts with FBXO18/FBH1 (via PIP-box); the interaction recruits the DCX(DTL) complex and promotes ubiquitination and degradation of FBXO18/FBH1 (PubMed:23677613). Interacts with POLN (PubMed:19995904). Interacts with SDE2 (via PIP-box); the interaction is direct and prevents ultraviolet light induced monoubiquitination (PubMed:27906959). Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR; interaction at least with PCNA occurs during DNA replication (PubMed:28191891).
- Miscellaneous:
-
- Antibodies against PCNA are present in sera from patients with systemic lupus erythematosus.
Protein Expression for PCNA Gene
Post-translational modifications for PCNA Gene
- Acetylated by CREBBP and p300/EP300; preferentially acetylated by CREBBP on Lys-80, Lys-13 and Lys-14 and on Lys-77 by p300/EP300 upon loading on chromatin in response to UV irradiation (PubMed:24939902, PubMed:19419956). Lysine acetylation disrupts association with chromatin, hence promoting PCNA ubiquitination and proteasomal degradation in response to UV damage in a CREBBP- and EP300-dependent manner (PubMed:24939902). Acetylation disrupts interaction with NUDT15 and promotes degradation (PubMed:19419956).
- Methylated on glutamate residues by ARMT1/C6orf211.
- Phosphorylated. Phosphorylation at Tyr-211 by EGFR stabilizes chromatin-associated PCNA.
- Ubiquitinated (PubMed:24939902, PubMed:20227374). Following DNA damage, can be either monoubiquitinated to stimulate direct bypass of DNA lesions by specialized DNA polymerases or polyubiquitinated to promote recombination-dependent DNA synthesis across DNA lesions by template switching mechanisms. Following induction of replication stress, monoubiquitinated by the UBE2B-RAD18 complex on Lys-164, leading to recruit translesion (TLS) polymerases, which are able to synthesize across DNA lesions in a potentially error-prone manner. An error-free pathway also exists and requires non-canonical polyubiquitination on Lys-164 through Lys-63 linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases, HLTF, RNF8 and SHPRH. This error-free pathway, also known as template switching, employs recombination mechanisms to synthesize across the lesion, using as a template the undamaged, newly synthesized strand of the sister chromatid. Monoubiquitination at Lys-164 also takes place in undamaged proliferating cells, and is mediated by the DCX(DTL) complex, leading to enhance PCNA-dependent translesion DNA synthesis. Sumoylated during S phase.
- Ubiquitination at Lys13, isoforms=77, isoforms=110, Lys117, Lys138, Lys164, Lys181, Lys248, and Lys254
- Modification sites at PhosphoSitePlus
Other Protein References for PCNA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PCNA
- AM03183PU-N
- AM03183PU-S
- AM10035FC-N
- AM10035PU-N
- AM10035PU-S
- AM20660PU-N
- AM50151PU-N
- AM50151PU-S
- AM50151PU-T
- AP06281PU-N
- AP08374PU-N
- AP09007PU-N
- AP12489PU-N
- AP32026PU-N
- CF804965
- TA804965
- CF804936
- TA804936
- CF804935
- TA804935
- CF800985
- TA800985
- CF800983
- TA800983
- CF800976
- TA800976
- CF800975
- TA800975
- CF800970
- TA800970
- CF800921
- TA800921
- CF800915
- TA800915
- CF800899
- TA800899
- CF800897
- TA800897
- CF800894
- TA800894
- CF800883
- TA800883
- CF800881
- TA800881
- CF800880
- TA800880
- CF800879
- TA800879
- CF800876
- TA800876
- CF800875
- TA800875
- TA700541
- TA700540
- TA700539
- TA700538
- TA600540
- TA600539
- TA600538
- TA590137
- TA354016
- TA353373
- TA348967
- TA347457
- TA332379
- TA328131
- TA324743
- TA321511
- TA320434
- TA319163
- TA319162
- TA312025
- TA309795
- Novus Biologicals Antibodies for PCNA
-
Abcam antibodies for PCNA
- Invitrogen Antibodies for PCNA
- antibodies-online: Search results for 727 available PCNA Antibodies ranked by validation data
- Compare Top PCNA Antibodies
-
Recommended
- 516 WB Antibodies (anti-human)
- 60 IF (p) Antibodies (anti-human)
- 25 FACS Antibodies (anti-human)
- 16 IHC (p) Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 7 LMNX Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 2 ICS Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 215 WB Antibodies (anti-mouse)
- 60 IF (p) Antibodies (anti-mouse)
- 16 FACS Antibodies (anti-mouse)
- 7 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 207 WB Antibodies (anti-rat)
- 60 IF (p) Antibodies (anti-rat)
- 14 FACS Antibodies (anti-rat)
- 9 IHC (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 3 IP Antibodies (anti-rat)
- 516 WB Antibodies (anti-human)
- 60 IF (p) Antibodies (anti-human)
- 25 FACS Antibodies (anti-human)
- 16 IHC (p) Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 7 LMNX Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 2 ICS Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 215 WB Antibodies (anti-mouse)
- 60 IF (p) Antibodies (anti-mouse)
- 16 FACS Antibodies (anti-mouse)
- 7 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 207 WB Antibodies (anti-rat)
- 60 IF (p) Antibodies (anti-rat)
- 14 FACS Antibodies (anti-rat)
- 9 IHC (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 3 IP Antibodies (anti-rat)
- GeneTex PCNA antibody for PCNA
-
Santa Cruz Biotechnology (SCBT) Antibodies for PCNA
- Sino Biological Antibodies for PCNA
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PCNA
- Origene Custom Protein Services for PCNA
- Sino Biological Cell Lysates for PCNA
- Sino Biological Recombinant Proteins for PCNA
- ProSpec Recombinant Proteins for PCNA
- Search GeneTex for Proteins for PCNA
-
Abcam proteins for PCNA
Assay Products
- antibodies-online: Search results for 53 available PCNA Elisa Kits ranked by validation data
- Compare Top PCNA Elisa Kits
-
Recommended
- 3 Chicken ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 1 Dog (Canine) ELISA Kit
- 2 Guinea Pig ELISA Kits
- 15 Human ELISA Kits
- 1 Mammalian ELISA Kit
- 2 Monkey ELISA Kits
- 13 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 11 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 3 Chicken ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 1 Dog (Canine) ELISA Kit
- 2 Guinea Pig ELISA Kits
- 15 Human ELISA Kits
- 1 Mammalian ELISA Kit
- 2 Monkey ELISA Kits
- 13 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 11 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
-
Abcam assays for PCNA
No data available for DME Specific Peptides for PCNA Gene
Domains & Families for PCNA Gene
Gene Families for PCNA Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PCNA Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PCNA Gene
Graphical View of Domain Structure for InterPro Entry
P12004- Family:
-
- Belongs to the PCNA family.
Function for PCNA Gene
Molecular function for PCNA Gene
- GENATLAS Biochemistry:
- cell-cycle regulated nuclear protein,proliferating cell nuclear antigen,complexing with RFCs to form a processivity factor (sliding clamp),for DNA polymerases delta and epsilon,also complexing with RFC,FEN1,GADD45,MSH2,MLH1,CDKN1A,LIG1,also involved in nucleotide mismatch repair (MM) and nucleotide excision repair (NER)
- UniProtKB/Swiss-Prot Function:
- Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerases processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3-5 exonuclease and 3-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while Lys-63-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000701 | purine-specific mismatch base pair DNA N-glycosylase activity | IDA | 11005803 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IDA | 24939902 |
| GO:0003684 | damaged DNA binding | IDA | 24939902 |
| GO:0005515 | protein binding | IPI | 9305916 |
Phenotypes for PCNA Gene
- MGI mutant phenotypes for PCNA:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for PCNA:
-
- Mitotic spindle defects
- Increased viability
- Decreased hepcidin::fluc mRNA expression
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Increased G1 DNA content
- G0/1 arrest
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased cell death HMECs cells
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased viability with MLN4924 (a NAE inhibitor)
- Increased Nanog expression
- Increased telomere dysfunction-induced foci (TIF) formation
Animal Models for PCNA Gene
- MGI Knock Outs for PCNA:
-
- Pcna tm1.1Mdsc
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PCNA
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PCNA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PCNA gene
- Search ViGene Biosciences for PCNA
CRISPR Products
-
OriGene CRISPR knockouts for PCNA
- genomics-online: gRNA clones - Search results for 149 available PCNA gene related products
- Overview of 149 available PCNA gene related products
- Applied Biological Materials CRISPR for PCNA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PCNA
- GenScript: Design CRISPR guide RNA sequences for PCNA
miRNA for PCNA Gene
- miRTarBase miRNAs that target PCNA
-
- hsa-mir-193b-3p (MIRT016528)
- hsa-mir-124-3p (MIRT023210)
- hsa-mir-26b-5p (MIRT030351)
- hsa-mir-24-3p (MIRT030631)
- hsa-mir-615-3p (MIRT039725)
- hsa-mir-30a-5p (MIRT049960)
- hsa-mir-18a-5p (MIRT050722)
- hsa-mir-5580-3p (MIRT350330)
- hsa-mir-7855-5p (MIRT454870)
- hsa-mir-6866-5p (MIRT454871)
- hsa-mir-877-5p (MIRT454872)
- hsa-mir-542-3p (MIRT454873)
- hsa-mir-5002-5p (MIRT454874)
- hsa-mir-374c-3p (MIRT454875)
- hsa-mir-8087 (MIRT454876)
- hsa-mir-7161-5p (MIRT454877)
- hsa-mir-548u (MIRT454878)
- hsa-mir-4642 (MIRT560220)
- hsa-mir-222-5p (MIRT560221)
- hsa-mir-5580-5p (MIRT560222)
- hsa-mir-5588-5p (MIRT560223)
- hsa-mir-4799-3p (MIRT560224)
- hsa-mir-4720-5p (MIRT560225)
- hsa-mir-16-1-3p (MIRT560226)
- hsa-mir-4728-3p (MIRT560227)
miRNA Products
- Search ViGene Biosciences for PCNA
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PCNA
- Browse OriGene Inhibitory RNA Products For PCNA
- genomics-online: shRNA clones - Search results for 149 available PCNA gene related products
- Overview of 149 available PCNA gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PCNA gene
Clone Products
- Sino Biological Human cDNA Clone for PCNA
- VectorBuilder custom plasmid, inducible vectors for PCNA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PCNA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PCNA
- Applied Biological Materials Clones for PCNA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PCNA
-
ViGene Biosciences adenoviral particle packaged cDNA for PCNA gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PCNA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PCNA gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for PCNA Gene
Localization for PCNA Gene
Subcellular locations from UniProtKB/Swiss-Prot for PCNA Gene
- Nucleus. Note=Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. {ECO:0000269 PubMed:24939902}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 3 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000784 | nuclear chromosome, telomeric region | HDA,IDA | 19135898 |
| GO:0005634 | nucleus | IEA,IDA | 15494374 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005657 | replication fork | IDA | 9774970 |
| GO:0005663 | DNA replication factor C complex | TAS | 2565339 |
Pathways & Interactions for PCNA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Telomere C-strand (Lagging Strand) Synthesis |
.67
|
|
| 2 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | ||
| 3 | Mismatch repair |
.54
.01
|
.01
|
| 4 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 5 | DNA Double-Strand Break Repair |
.53
|
|
Pathways by source for PCNA Gene
1 GeneTex pathway for PCNA Gene
10 BioSystems pathways for PCNA Gene
60 Reactome pathways for PCNA Gene
8 KEGG pathways for PCNA Gene
5 GeneGo (Thomson Reuters) pathways for PCNA Gene
5 Qiagen pathways for PCNA Gene
1 Cell Signaling Technology pathway for PCNA Gene
Interacting Proteins for PCNA Gene
Selected Interacting proteins:
ENSP00000368438
P12004-PCNA_HUMAN
for PCNA Gene via
STRING
MINT
UniProtKB
IID
SIGNOR curated interactions for PCNA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0000723 | telomere maintenance | TAS | -- |
| GO:0006260 | DNA replication | IEA | -- |
| GO:0006266 | DNA ligation | TAS | -- |
| GO:0006272 | leading strand elongation | IBA | -- |
Drugs & Compounds for PCNA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Liothyronine | Approved, Vet_approved | Pharma | Target | 0 | ||
| Capecitabine | Approved, Investigational | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines | 1402 | ||
| Nelarabine | Approved, Investigational | Pharma | Prodrug of ara-G for T-LBL/T-ALL | 0 | ||
| Oxaliplatin | Approved, Investigational | Pharma | Antitumor agent, Platinum | 1560 | ||
| Uridine | Experimental, Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(10) ApexBio Compounds for PCNA Gene
| Compound | Action | Cas Number |
|---|---|---|
| Adenine sulfate | Sulfate salt form of adenine | 321-30-2 |
| Blasticidin S HCl | 3513-03-9 | |
| Capecitabine | 154361-50-9 | |
| Carmofur | Cytostatic derivative of fluorouracilm,antineoplatic agent | 61422-45-5 |
| Gemcitabine HCl | Inhibits DNA synthesis,deoxycytidine analog | 122111-03-9 |
| Mercaptopurine (6-MP) | Purine synthesis inhibitor | 50-44-2 |
| Nelarabine | Prodrug of ara-G for T-LBL/T-ALL | 121032-29-9 |
| Oxaliplatin | Antitumor agent | 61825-94-3 |
| Rifaximin (Xifaxan) | RNA synthesis inhibitor, PXR activator | 80621-81-4 |
| Uridine | 58-96-8 |
Transcripts for PCNA Gene
mRNA/cDNA for PCNA Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (733) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PCNA Gene
CRISPR Products
-
OriGene CRISPR knockouts for PCNA
- genomics-online: gRNA clones - Search results for 149 available PCNA gene related products
- Overview of 149 available PCNA gene related products
- Applied Biological Materials CRISPR for PCNA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PCNA
- GenScript: Design CRISPR guide RNA sequences for PCNA
miRNA Products
- Search ViGene Biosciences for PCNA
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PCNA
- Browse OriGene Inhibitory RNA Products For PCNA
- genomics-online: shRNA clones - Search results for 149 available PCNA gene related products
- Overview of 149 available PCNA gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PCNA gene
Clone Products
- Sino Biological Human cDNA Clone for PCNA
- VectorBuilder custom plasmid, inducible vectors for PCNA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PCNA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PCNA
- Applied Biological Materials Clones for PCNA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: | - |
Expression for PCNA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
- Bone (Muscoskeletal System)
- NULL (Uncategorized)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
- Blood (Hematopoietic System)
- Spinal Cord (Nervous System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Kidney (Urinary System)
-
Esophagus (Gastrointestinal Tract)
This gene is overexpressed in Bone (13.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PCNA Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PCNA Gene:
PCNASOURCE GeneReport for Unigene cluster for PCNA Gene:
Hs.147433Evidence on tissue expression from TISSUES for PCNA Gene
- Liver(4.6)
- Lung(4.6)
- Bone marrow(4.4)
- Muscle(4.2)
- Kidney(4)
- Nervous system(4)
- Skin(3)
- Intestine(2.9)
- Stomach(2.3)
- Lymph node(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PCNA Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- eye
- eyelid
- face
- head
- mouth
- pharynx
Thorax:
- esophagus
Abdomen:
- stomach
Limb:
- foot
- lower limb
General:
- blood vessel
- peripheral nerve
- peripheral nervous system
- skin
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for PCNA
-
OriGene qPCR primer pairs and template standards for PCNA
- genomics-online: primer clones - Search results for 149 available PCNA gene related products
- Overview of 149 available PCNA gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCNA Gene
Orthologs for PCNA Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PCNA 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PCNA 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Pcna-ps2 34 |
|
OneToMany | |
| Pcna 33 16 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | PCNA 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PCNA 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pcna 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PCNA 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PCNA 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PCNA 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pcna 33 |
|
||
| Str.6228 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | pcna-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pcna 33 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10814 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | mus209 35 33 34 |
|
||
| CG10262 35 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010220 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | pcn-1 35 33 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADL309W 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | POL30 33 34 36 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B12078g 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | PCNA2 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.431 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0805200 33 |
|
||
| Os.3376 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.6407 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.2876 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.531 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU09239 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pcn1 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3511 33 |
|
- Species where no ortholog for PCNA was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for PCNA Gene
Pseudogenes.org Pseudogenes for PCNA Gene
No data available for Paralogs for PCNA Gene
Variants for PCNA Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs369958038 | pathogenic, Ataxia-telangiectasia-like disorder 2, Ataxia-telangiectasia-like disorder 2 (ATLD2) [MIM:615919] | 5,115,472(-) | C/A | coding_sequence_variant, missense_variant | |
| rs1000006799 | -- | 5,126,851(-) | C/G | upstream_transcript_variant | |
| rs1000464762 | -- | 5,127,071(-) | A/G | upstream_transcript_variant | |
| rs1000473176 | -- | 5,114,959(-) | T/C | 3_prime_UTR_variant | |
| rs1000498780 | -- | 5,126,435(-) | T/C | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.22;
4.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PCNA Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCNA Gene
Disorders for PCNA Gene
(43) MalaCards diseases for PCNA Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ataxia-telangiectasia-like disorder 2 |
|
|
| bowen's disease |
|
|
| actinic keratosis |
|
|
| ataxia-telangiectasia |
|
|
| oral leukoplakia |
|
Search PCNA in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PCNA_HUMAN- Ataxia-telangiectasia-like disorder 2 (ATLD2) [MIM:615919]: A neurodegenerative disorder due to defects in DNA excision repair. ATLD2 is characterized by developmental delay, ataxia, sensorineural hearing loss, short stature, cutaneous and ocular telangiectasia, and photosensitivity. {ECO:0000269 PubMed:24911150}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for PCNA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PCNA Gene
Publications for PCNA Gene
- Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage. (PMID: 19443450) Burkovics P … Haracska L (Nucleic acids research 2009) 3 4 22 58
- Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. (PMID: 19419956) Yu Y … Zhu WG (The Journal of biological chemistry 2009) 3 4 22 58
- The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21. (PMID: 9305916) Gary R … Park MS (The Journal of biological chemistry 1997) 3 4 22 58
- Structure of the human gene for the proliferating cell nuclear antigen. (PMID: 2565339) Travali S … Calabretta B (The Journal of biological chemistry 1989) 2 3 4 58
- Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism. (PMID: 28191891) Reynolds JJ … Stewart GS (Nature genetics 2017) 3 4 58
Products for PCNA Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for PCNA
- AM03183PU-N
- AM03183PU-S
- AM10035FC-N
- AM10035PU-N
- AM10035PU-S
- AM20660PU-N
- AM50151PU-N
- AM50151PU-S
- AM50151PU-T
- AP06281PU-N
- AP08374PU-N
- AP09007PU-N
- AP12489PU-N
- AP32026PU-N
- TA309795
- TA312025
- TA319162
- TA319163
- TA320434
- TA321511
- TA324743
- TA328131
- TA332379
- TA347457
- TA348967
- TA353373
- TA354016
- TA590137
- TA600538
- TA600539
- TA600540
- TA700538
- TA700539
- TA700540
- TA700541
- TA800875
- CF800875
- TA800876
- CF800876
- TA800879
- CF800879
- TA800880
- CF800880
- TA800881
- CF800881
- TA800883
- CF800883
- TA800894
- CF800894
- TA800897
- CF800897
- TA800899
- CF800899
- TA800915
- CF800915
- TA800921
- CF800921
- TA800970
- CF800970
- TA800975
- CF800975
- TA800976
- CF800976
- TA800983
- CF800983
- TA800985
- CF800985
- TA804935
- CF804935
- TA804936
- CF804936
- TA804965
- CF804965
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PCNA
- Origene Custom Protein Services for PCNA
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PCNA
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- OriGene qPCR primer pairs and template standards for PCNA
- OriGene qPCR primer pairs for PCNA
- OriGene CRISPR knockouts for PCNA
- OriGene ORF clones in human for PCNA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for PCNA in any vector
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- GenScript: Design CRISPR guide RNA sequences for PCNA
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for PCNA
- Sino Biological Cell Lysates for PCNA
- Sino Biological Recombinant Proteins for PCNA
- Sino Biological Antibodies for PCNA
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for PCNA
- Novus Biologicals lysates and proteins for PCNA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PCNA