The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the... See more...

Aliases for PCNA Gene

Aliases for PCNA Gene

  • Proliferating Cell Nuclear Antigen 2 3 4 5
  • Cyclin 3 4
  • DNA Polymerase Delta Auxiliary Protein 3
  • ATLD2 3

External Ids for PCNA Gene

Previous GeneCards Identifiers for PCNA Gene

  • GC20M005083
  • GC20M005090
  • GC20M005043
  • GC20M005095

Summaries for PCNA Gene

Entrez Gene Summary for PCNA Gene

  • The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCNA Gene

PCNA (Proliferating Cell Nuclear Antigen) is a Protein Coding gene. Diseases associated with PCNA include Ataxia-Telangiectasia-Like Disorder 2 and Bowen's Disease. Among its related pathways are Tight junction and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include identical protein binding and damaged DNA binding.

UniProtKB/Swiss-Prot Summary for PCNA Gene

  • Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (PubMed:24695737).

Gene Wiki entry for PCNA Gene

Additional gene information for PCNA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PCNA Gene

Genomics for PCNA Gene

GeneHancer (GH) Regulatory Elements for PCNA Gene

Promoters and enhancers for PCNA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J005125 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 770.9 -0.7 -719 3.6 ZNF785 SIN3A ZNF24 ZBTB40 SP1 CTCF SREBF1 ZBTB6 SMARCE1 RBPJ PCNA CDS2 TMEM230 MCM8 TRMT6 lnc-PRND-2
GH20J005116 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 783.6 +7.6 7635 4 E2F8 SIN3A SP1 ZBTB6 MLX RBPJ POLR2A USF2 CTBP1 HDAC2 PCNA PCNA-AS1 lnc-CDS2-13 CDS2 MCM8 TMEM230 TRMT6 ENSG00000252367
GH20J005111 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 28.6 +13.5 13512 3 SIN3A SP1 ZBTB40 CTCF SIX5 MLX RBPJ POLR2A ATF1 CREB1 TMEM230 ENSG00000252367 piR-41652-004 MCM8 PCNA TRMT6
GH20J005911 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 15.2 -785.2 -785152 1.6 CTCF ZBTB6 MLX RBPJ ATF1 CREB1 MIXL1 MYC NFYC HLF CHGB MCM8 PCNA TRMT6 lnc-TRMT6-1
GH20J005607 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -483.9 -483927 6.7 ZNF24 ZBTB40 SP1 CTCF MLX RBPJ SMARCE1 POLR2A USF2 NR2F1 GPCPD1 PCNA ENSG00000230563 CDS2 LINC00654 TRMT6 SHLD1 HE856208
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PCNA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PCNA gene promoter:
  • AML1a
  • Lhx3a
  • LHX3b
  • PPAR-gamma1
  • PPAR-gamma2
  • SEF-1 (1)

Genomic Locations for PCNA Gene

Genomic Locations for PCNA Gene
chr20:5,114,953-5,126,626
(GRCh38/hg38)
Size:
11,674 bases
Orientation:
Minus strand
chr20:5,095,599-5,107,272
(GRCh37/hg19)
Size:
11,674 bases
Orientation:
Minus strand

Genomic View for PCNA Gene

Genes around PCNA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCNA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCNA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNA Gene

Proteins for PCNA Gene

  • Protein details for PCNA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12004-PCNA_HUMAN
    Recommended name:
    Proliferating cell nuclear antigen
    Protein Accession:
    P12004
    Secondary Accessions:
    • B2R897
    • D3DW02

    Protein attributes for PCNA Gene

    Size:
    261 amino acids
    Molecular mass:
    28769 Da
    Quaternary structure:
    • Homotrimer (PubMed:24939902). Interacts with p300/EP300; the interaction occurs on chromatin in UV-irradiated damaged cells (PubMed:24939902). Interacts with CREBBP (via transactivation domain and C-terminus); the interaction occurs on chromatin in UV-irradiated damaged cells (PubMed:24939902). Directly interacts with POLD1, POLD3 and POLD4 subunits of the DNA polymerase delta complex, POLD3 being the major interacting partner; the interaction with POLD3 is inhibited by CDKN1A/p21(CIP1) (PubMed:11595739, PubMed:16510448, PubMed:22148433, PubMed:24939902). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with EXO1, POLH, POLK, DNMT1, ERCC5, FEN1, CDC6 and POLDIP2 (PubMed:9305916, PubMed:9302295, PubMed:9566895, PubMed:11784855, PubMed:12522211, PubMed:15225546, PubMed:15149598, PubMed:24911150, PubMed:15616578). Interacts with APEX2; this interaction is triggered by reactive oxygen species and increased by misincorporation of uracil in nuclear DNA (PubMed:11376153, PubMed:19443450). Forms a ternary complex with DNTTIP2 and core histone (PubMed:12786946). Interacts with KCTD10 and PPP1R15A (By similarity). Directly interacts with BAZ1B (PubMed:15543136). Interacts with HLTF and SHPRH (PubMed:17130289, PubMed:18316726, PubMed:18719106). Interacts with NUDT15; this interaction is disrupted in response to UV irradiation and acetylation (PubMed:19419956). Interacts with CDKN1A/p21(CIP1) and CDT1; interacts via their PIP-box which also recruits the DCX(DTL) complex. The interaction with CDKN1A inhibits POLD3 binding (PubMed:11595739, PubMed:16949367, PubMed:18794347, PubMed:18703516). Interacts with DDX11 (PubMed:18499658). Interacts with EGFR; positively regulates PCNA (PubMed:17115032). Interacts with PARPBP (PubMed:22153967). Interacts (when ubiquitinated) with SPRTN; leading to enhance RAD18-mediated PCNA ubiquitination (PubMed:22681887). Interacts (when polyubiquitinated) with ZRANB3 (PubMed:22704558, PubMed:22705370, PubMed:22759634). Interacts with SMARCAD1 (PubMed:21549307). Interacts with CDKN1C (PubMed:22634751). Interacts with PCLAF (via PIP-box) (PubMed:21628590, PubMed:23000965). Interacts with RTEL1 (via PIP-box); the interaction is direct and essential for the suppression of telomere fragility (PubMed:24115439). Interacts with FAM111A (via PIP-box); the interaction is direct and required for PCNA loading on chromatin binding (PubMed:24561620). Interacts with LIG1 (PubMed:24911150). Interacts with SETMAR (PubMed:20457750). Interacts with ANKRD17 (PubMed:23711367). Interacts with FBXO18/FBH1 (via PIP-box); the interaction recruits the DCX(DTL) complex and promotes ubiquitination and degradation of FBXO18/FBH1 (PubMed:23677613). Interacts with POLN (PubMed:19995904). Interacts with SDE2 (via PIP-box); the interaction is direct and prevents ultraviolet light induced monoubiquitination (PubMed:27906959). Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR; interaction at least with PCNA occurs during DNA replication (PubMed:28191891). Interacts with MAPK15; the interaction is chromatin binding dependent and prevents MDM2-mediated PCNA destruction by inhibiting the association of PCNA with MDM2 (PubMed:20733054). Interacts with PARP10 (via PIP-box) (PubMed:24695737). Interacts with DDI2 (PubMed:29290612). Interacts with HMCES (via PIP-box) (PubMed:30554877).
    • (Microbial infection) Interacts with herpes virus 8 protein LANA1.
    Miscellaneous:
    • Antibodies against PCNA are present in sera from patients with systemic lupus erythematosus.

    Three dimensional structures from OCA and Proteopedia for PCNA Gene

neXtProt entry for PCNA Gene

Post-translational modifications for PCNA Gene

  • Phosphorylated. Phosphorylation at Tyr-211 by EGFR stabilizes chromatin-associated PCNA.
  • Acetylated by CREBBP and p300/EP300; preferentially acetylated by CREBBP on Lys-80, Lys-13 and Lys-14 and on Lys-77 by p300/EP300 upon loading on chromatin in response to UV irradiation (PubMed:24939902, PubMed:19419956). Lysine acetylation disrupts association with chromatin, hence promoting PCNA ubiquitination and proteasomal degradation in response to UV damage in a CREBBP- and EP300-dependent manner (PubMed:24939902). Acetylation disrupts interaction with NUDT15 and promotes degradation (PubMed:19419956).
  • Ubiquitinated (PubMed:24939902, PubMed:20227374). Following DNA damage, can be either monoubiquitinated to stimulate direct bypass of DNA lesions by specialized DNA polymerases or polyubiquitinated to promote recombination-dependent DNA synthesis across DNA lesions by template switching mechanisms. Following induction of replication stress, monoubiquitinated by the UBE2B-RAD18 complex on Lys-164, leading to recruit translesion (TLS) polymerases, which are able to synthesize across DNA lesions in a potentially error-prone manner. An error-free pathway also exists and requires non-canonical polyubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases, HLTF, RNF8 and SHPRH. This error-free pathway, also known as template switching, employs recombination mechanisms to synthesize across the lesion, using as a template the undamaged, newly synthesized strand of the sister chromatid. Monoubiquitination at Lys-164 also takes place in undamaged proliferating cells, and is mediated by the DCX(DTL) complex, leading to enhance PCNA-dependent translesion DNA synthesis. Sumoylated during S phase.
  • Methylated on glutamate residues by ARMT1/C6orf211.
  • Ubiquitination at Lys13, Lys77, Lys80, Lys110, Lys117, Lys138, Lys181, Lys248, and Lys254
  • Modification sites at PhosphoSitePlus

Other Protein References for PCNA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PCNA

No data available for DME Specific Peptides for PCNA Gene

Domains & Families for PCNA Gene

Gene Families for PCNA Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PCNA Gene

GenScript: Design optimal peptide antigens:
  • Cyclin (PCNA_HUMAN)
  • Proliferating cell nuclear antigen (Q6FHF5_HUMAN)
  • Proliferating cell nuclear antigen (Q6FI35_HUMAN)
  • Truncated proliferating cell nuclear antigen (Q7Z6A0_HUMAN)
  • Proliferating cell nuclear antigen (Q7Z6A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P12004

UniProtKB/Swiss-Prot:

PCNA_HUMAN :
  • Belongs to the PCNA family.
Family:
  • Belongs to the PCNA family.
genes like me logo Genes that share domains with PCNA: view

Function for PCNA Gene

Molecular function for PCNA Gene

UniProtKB/Swiss-Prot Function:
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (PubMed:24695737).
GENATLAS Biochemistry:
cell-cycle regulated nuclear protein,proliferating cell nuclear antigen,complexing with RFCs to form a processivity factor (sliding clamp),for DNA polymerases delta and epsilon,also complexing with RFC,FEN1,GADD45,MSH2,MLH1,CDKN1A,LIG1,also involved in nucleotide mismatch repair (MM) and nucleotide excision repair (NER)

Phenotypes From GWAS Catalog for PCNA Gene

Gene Ontology (GO) - Molecular Function for PCNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000701 purine-specific mismatch base pair DNA N-glycosylase activity IDA 11005803
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA 23277426
GO:0003684 damaged DNA binding IDA 24939902
GO:0005515 protein binding IPI 9305916
genes like me logo Genes that share ontologies with PCNA: view
genes like me logo Genes that share phenotypes with PCNA: view

Human Phenotype Ontology for PCNA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PCNA Gene

MGI Knock Outs for PCNA:
  • Pcna Pcna<tm1.1Mdsc>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for PCNA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PCNA Gene

Localization for PCNA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNA Gene

Nucleus. Note=Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. {ECO:0000269 PubMed:24939902}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCNA gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
extracellular 0
mitochondrion 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PCNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA --
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0000785 chromatin IDA 23277426
GO:0005634 nucleus IBA,IDA 15494374
GO:0005652 nuclear lamina IEA --
genes like me logo Genes that share ontologies with PCNA: view

Pathways & Interactions for PCNA Gene

PathCards logo

SuperPathways for PCNA Gene

SuperPathway Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
2 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
3 Mismatch repair
.54
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
5 DNA Double-Strand Break Repair
genes like me logo Genes that share pathways with PCNA: view

Pathways by source for PCNA Gene

5 Qiagen pathways for PCNA Gene
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • GADD45 Pathway
  • Mismatch Repair in Eukaryotes
  • Nucleotide Excision Repair Pathway
1 Cell Signaling Technology pathway for PCNA Gene
1 GeneTex pathway for PCNA Gene

SIGNOR curated interactions for PCNA Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PCNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0000723 telomere maintenance TAS --
GO:0006260 DNA replication IEA --
GO:0006272 leading strand elongation IBA 21873635
genes like me logo Genes that share ontologies with PCNA: view

Drugs & Compounds for PCNA Gene

(91) Drugs for PCNA Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Channel blocker, Target, downregulator 1403
Liothyronine Approved, Vet_approved Pharma Target, antagonist 0
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1551
Nelarabine Approved, Investigational Pharma Prodrug of ara-G for T-LBL/T-ALL 0
Oxaliplatin Approved, Investigational Pharma Antitumor agent, Platinum 1803

(54) Additional Compounds for PCNA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(10) ApexBio Compounds for PCNA Gene

Compound Action Cas Number
Adenine sulfate Sulfate salt form of adenine 321-30-2
Blasticidin S HCl 3513-03-9
Capecitabine 154361-50-9
Carmofur Cytostatic derivative of fluorouracilm,antineoplatic agent 61422-45-5
Gemcitabine HCl Inhibits DNA synthesis,deoxycytidine analog 122111-03-9
Mercaptopurine (6-MP) Purine synthesis inhibitor 50-44-2
Nelarabine Prodrug of ara-G for T-LBL/T-ALL 121032-29-9
Oxaliplatin Antitumor agent 61825-94-3
Rifaximin (Xifaxan) RNA synthesis inhibitor, PXR activator 80621-81-4
Uridine 58-96-8
genes like me logo Genes that share compounds with PCNA: view

Transcripts for PCNA Gene

mRNA/cDNA for PCNA Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(733) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for PCNA

Alternative Splicing Database (ASD) splice patterns (SP) for PCNA Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: - - - -
SP3: -
SP4:
SP5: -

Relevant External Links for PCNA Gene

GeneLoc Exon Structure for
PCNA
ECgene alternative splicing isoforms for
PCNA

Expression for PCNA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCNA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PCNA Gene

This gene is overexpressed in Bone (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PCNA Gene



Protein tissue co-expression partners for PCNA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PCNA Gene:

PCNA

SOURCE GeneReport for Unigene cluster for PCNA Gene:

Hs.147433

Evidence on tissue expression from TISSUES for PCNA Gene

  • Liver(4.6)
  • Lung(4.6)
  • Bone marrow(4.4)
  • Muscle(4.2)
  • Kidney(4)
  • Nervous system(4)
  • Skin(3)
  • Intestine(2.9)
  • Stomach(2.3)
  • Lymph node(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PCNA Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • eye
  • eyelid
  • face
  • head
  • mouth
  • pharynx
Thorax:
  • esophagus
Abdomen:
  • stomach
Limb:
  • foot
  • lower limb
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with PCNA: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCNA Gene

Orthologs for PCNA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PCNA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCNA 33 32
  • 99.11 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PCNA 33
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcna-ps2 33
  • 96 (a)
OneToMany
Pcna 17 33 32
  • 88.38 (n)
cow
(Bos Taurus)
Mammalia PCNA 33 32
  • 92.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PCNA 33 32
  • 92.21 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcna 32
  • 89.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PCNA 33
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCNA 33 32
  • 83.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCNA 33
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcna 32
  • 79.69 (n)
Str.6228 32
African clawed frog
(Xenopus laevis)
Amphibia pcna-A 32
zebrafish
(Danio rerio)
Actinopterygii pcna 33 32 32
  • 77.13 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10814 32
fruit fly
(Drosophila melanogaster)
Insecta mus209 33 34 32
  • 65.89 (n)
OneToMany
CG10262 33 34
  • 49 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010220 32
  • 63.85 (n)
worm
(Caenorhabditis elegans)
Secernentea pcn-1 33 34 32
  • 54.62 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL309W 32
  • 50.06 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POL30 35 33 32
  • 47.29 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12078g 32
  • 46.25 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PCNA2 32
  • 64.86 (n)
soybean
(Glycine max)
eudicotyledons Gma.431 32
rice
(Oryza sativa)
Liliopsida Os02g0805200 32
  • 64.09 (n)
Os.3376 32
wheat
(Triticum aestivum)
Liliopsida Ta.2876 32
corn
(Zea mays)
Liliopsida Zm.531 32
barley
(Hordeum vulgare)
Liliopsida Hv.6407 32
bread mold
(Neurospora crassa)
Ascomycetes NCU09239 32
  • 56.11 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pcn1 32
  • 53.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.3511 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3511 32
Species where no ortholog for PCNA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PCNA Gene

ENSEMBL:
Gene Tree for PCNA (if available)
TreeFam:
Gene Tree for PCNA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PCNA: view image

Paralogs for PCNA Gene

Pseudogenes.org Pseudogenes for PCNA Gene

genes like me logo Genes that share paralogs with PCNA: view

No data available for Paralogs for PCNA Gene

Variants for PCNA Gene

Sequence variations from dbSNP and Humsavar for PCNA Gene