The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov ... See more...

Aliases for PCLO Gene

Aliases for PCLO Gene

  • Piccolo Presynaptic Cytomatrix Protein 2 3 5
  • Aczonin 2 3 4
  • Protein Piccolo 3 4
  • ACZ 3 4
  • Piccolo (Presynaptic Cytomatrix Protein) 2
  • KIAA0559 4
  • PCH3 3

External Ids for PCLO Gene

Previous GeneCards Identifiers for PCLO Gene

  • GC07M080985
  • GC07M082048
  • GC07M082061
  • GC07M081999
  • GC07M082094
  • GC07M082266
  • GC07M082383
  • GC07M076984

Summaries for PCLO Gene

Entrez Gene Summary for PCLO Gene

  • The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for PCLO Gene

PCLO (Piccolo Presynaptic Cytomatrix Protein) is a Protein Coding gene. Diseases associated with PCLO include Pontocerebellar Hypoplasia, Type 3 and Pontocerebellar Hypoplasia. Among its related pathways are Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include calcium ion binding and transporter activity. An important paralog of this gene is BSN.

UniProtKB/Swiss-Prot Summary for PCLO Gene

  • Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity).

Gene Wiki entry for PCLO Gene

Additional gene information for PCLO Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PCLO Gene

Genomics for PCLO Gene

GeneHancer (GH) Regulatory Elements for PCLO Gene

Promoters and enhancers for PCLO Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J083162 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 507.1 +0.2 167 2.9 ZNF217 EP300 NRF1 POLR2G USF1 CTCF REST ZBTB10 CLOCK ZBTB26 PCLO lnc-SEMA3E-1
GH07J082894 Promoter 0.3 EPDnew 500.1 +268.4 268433 0.1 PCLO piR-55705-047 RF00001-307 RNA5SP235
GH07J083140 Enhancer 0.2 Ensembl 18.1 +21.9 21929 0.8 PCLO lnc-SEMA3E-1
GH07J083148 Enhancer 0.4 Ensembl 0.4 +13.7 13730 0.4 RBAK FOSL2 FOS JUND lnc-SEMA3E-1 PCLO
GH07J083117 Enhancer 0.4 Ensembl 0.3 +44.5 44529 2 RFX1 RFX5 SRF CEBPB FOXA1 piR-49423-249 lnc-SEMA3E-1 PCLO piR-33605-413
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PCLO on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PCLO

Top Transcription factor binding sites by QIAGEN in the PCLO gene promoter:
  • AREB6
  • C/EBPalpha
  • CHOP-10
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • PPAR-gamma2

Genomic Locations for PCLO Gene

Genomic Locations for PCLO Gene
chr7:82,754,005-83,162,930
(GRCh38/hg38)
Size:
408,926 bases
Orientation:
Minus strand
chr7:82,383,321-82,792,246
(GRCh37/hg19)
Size:
408,926 bases
Orientation:
Minus strand

Genomic View for PCLO Gene

Genes around PCLO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCLO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCLO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCLO Gene

Proteins for PCLO Gene

  • Protein details for PCLO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6V0-PCLO_HUMAN
    Recommended name:
    Protein piccolo
    Protein Accession:
    Q9Y6V0
    Secondary Accessions:
    • A4D1A7
    • A6NNX9
    • O43373
    • O60305
    • Q08E72
    • Q9BVC8
    • Q9UIV2
    • Q9Y6U9

    Protein attributes for PCLO Gene

    Size:
    5142 amino acids
    Molecular mass:
    560699 Da
    Quaternary structure:
    • Interacts with BSN, ERC2/CAST1, RIMS1 and UNC13A (By similarity). Interacts (via C-terminus) with TRIO (via N-terminus) (By similarity). Interacts with CTBP1 (By similarity). Interacts with SIAH1; this interaction negatively regulates SIAH1 E3 ligase activity (By similarity).
    SequenceCaution:
    • Sequence=AAB97937.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD21789.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAL24187.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PCLO Gene

    Alternative splice isoforms for PCLO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCLO Gene

Post-translational modifications for PCLO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PCLO Gene

Domains & Families for PCLO Gene

Gene Families for PCLO Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PCLO Gene

Blocks:
  • C2 domain
  • Synaptotagmin signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PCLO Gene

GenScript: Design optimal peptide antigens:
  • Aczonin (PCLO_HUMAN)
  • PCLO protein (Q32P40_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6V0

UniProtKB/Swiss-Prot:

PCLO_HUMAN :
  • C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change.
Domain:
  • C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change.
genes like me logo Genes that share domains with PCLO: view

Function for PCLO Gene

Molecular function for PCLO Gene

UniProtKB/Swiss-Prot Function:
Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity).

Phenotypes From GWAS Catalog for PCLO Gene

Gene Ontology (GO) - Molecular Function for PCLO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding ISS --
GO:0005515 protein binding IEA --
GO:0005522 profilin binding ISS --
GO:0005544 calcium-dependent phospholipid binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PCLO: view
genes like me logo Genes that share phenotypes with PCLO: view

Human Phenotype Ontology for PCLO Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PCLO Gene

MGI Knock Outs for PCLO:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PCLO Gene

Localization for PCLO Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCLO Gene

Cell junction, synapse, presynaptic active zone. Note=Colocalizes with BSN in developing axons. {ECO:0000250 UniProtKB:Q9JKS6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCLO gene
Compartment Confidence
cytoskeleton 5
plasma membrane 3
nucleus 3
cytosol 3
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PCLO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton NAS 10508862
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with PCLO: view

Pathways & Interactions for PCLO Gene

PathCards logo

SuperPathways for PCLO Gene

SuperPathway Contained pathways
1 Aldosterone synthesis and secretion
genes like me logo Genes that share pathways with PCLO: view

Pathways by source for PCLO Gene

1 KEGG pathway for PCLO Gene

Gene Ontology (GO) - Biological Process for PCLO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization ISS --
GO:0007416 synapse assembly IEA --
GO:0016079 synaptic vesicle exocytosis NAS 10508862
GO:0017157 regulation of exocytosis IEA --
GO:0019933 cAMP-mediated signaling IEA --
genes like me logo Genes that share ontologies with PCLO: view

No data available for SIGNOR curated interactions for PCLO Gene

Drugs & Compounds for PCLO Gene

(1) Drugs for PCLO Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
genes like me logo Genes that share compounds with PCLO: view

Transcripts for PCLO Gene

mRNA/cDNA for PCLO Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCLO Gene

No ASD Table

Relevant External Links for PCLO Gene

GeneLoc Exon Structure for
PCLO

Expression for PCLO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PCLO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCLO Gene

This gene is overexpressed in Brain - Cerebellum (x6.6), Brain - Cerebellar Hemisphere (x6.3), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for PCLO Gene

This gene is overexpressed in Frontal cortex (25.1), Fetal gut (12.3), and Spinal cord (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PCLO Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PCLO

SOURCE GeneReport for Unigene cluster for PCLO Gene:

Hs.12376

mRNA Expression by UniProt/SwissProt for PCLO Gene:

Q9Y6V0-PCLO_HUMAN
Tissue specificity: Moderately expressed in the developing cerebral cortex.

Evidence on tissue expression from TISSUES for PCLO Gene

  • Nervous system(4.8)
  • Blood(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PCLO Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • lip
  • mouth
  • neck
  • nose
  • outer ear
  • skull
Thorax:
  • chest wall
Abdomen:
  • abdominal wall
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with PCLO: view

No data available for Protein tissue co-expression partners for PCLO Gene

Orthologs for PCLO Gene

This gene was present in the common ancestor of animals.

Orthologs for PCLO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCLO 31 30
  • 99.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PCLO 31 30
  • 88.47 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pclo 17 31 30
  • 84.46 (n)
rat
(Rattus norvegicus)
Mammalia Pclo 30
  • 84.19 (n)
dog
(Canis familiaris)
Mammalia PCLO 31 30
  • 82.74 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PCLO 31
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCLO 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCLO 31 30
  • 71.34 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCLO 31
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pclo 30
  • 66.36 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-108d22.4 30
  • 60.73 (n)
pcloa 31
  • 49 (a)
OneToMany
pclob 31
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F45E4.3 31
  • 26 (a)
OneToMany
Species where no ortholog for PCLO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCLO Gene

ENSEMBL:
Gene Tree for PCLO (if available)
TreeFam:
Gene Tree for PCLO (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PCLO: view image

Paralogs for PCLO Gene

Paralogs for PCLO Gene

(11) SIMAP similar genes for PCLO Gene using alignment to 6 proteins:

  • PCLO_HUMAN
  • E9PE96_HUMAN
  • H7C114_HUMAN
  • H7C261_HUMAN
  • L8E9M5_HUMAN
  • Q32P40_HUMAN
genes like me logo Genes that share paralogs with PCLO: view

Variants for PCLO Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PCLO Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
708091 Likely Benign: not provided 82,902,684(-) T/C MISSENSE_VARIANT
708670 Likely Benign: not provided 83,134,242(-) T/TATATATATATATA INTRON_VARIANT
709579 Likely Benign: not provided 83,134,544(-) G/A SYNONYMOUS_VARIANT
709805 Benign: not provided 82,824,226(-) T/C INTRON_VARIANT
709806 Likely Benign: not provided 82,950,997(-) A/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for PCLO Gene

Structural Variations from Database of Genomic Variants (DGV) for PCLO Gene

Variant ID Type Subtype PubMed ID
dgv6516n100 CNV gain 25217958
esv1000997 CNV deletion 20482838
esv1579695 CNV insertion 17803354
esv2641869 CNV deletion 19546169
esv2675648 CNV deletion 23128226
esv2677988 CNV deletion 23128226
esv2752186 CNV gain 17911159
esv3305049 CNV mobile element insertion 20981092
esv3305139 CNV mobile element insertion 20981092
esv3341429 CNV insertion 20981092
esv3344369 CNV insertion 20981092
esv3411020 CNV insertion 20981092
esv3613915 CNV loss 21293372
esv3613918 CNV loss 21293372
esv3613920 CNV loss 21293372
esv3613921 CNV loss 21293372
esv3613922 CNV loss 21293372
esv3613923 CNV loss 21293372
nsv1023612 CNV loss 25217958
nsv1137264 CNV deletion 24896259
nsv1139902 CNV duplication 24896259
nsv1161574 CNV deletion 26073780
nsv442054 CNV loss 18776908
nsv464614 CNV loss 19166990
nsv519920 CNV loss 19592680
nsv524315 CNV gain 19592680
nsv528771 CNV loss 19592680
nsv5817 CNV deletion 18451855
nsv607700 CNV gain 21841781
nsv607701 CNV loss 21841781
nsv607702 CNV loss 21841781
nsv818530 CNV loss 17921354
nsv819983 CNV gain 19587683
nsv824188 CNV loss 20364138
nsv831046 CNV gain 17160897

Variation tolerance for PCLO Gene

Residual Variation Intolerance Score: 1.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.90; 99.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCLO Gene

Human Gene Mutation Database (HGMD)
PCLO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCLO

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCLO Gene

Disorders for PCLO Gene

MalaCards: The human disease database

(16) MalaCards diseases for PCLO Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pontocerebellar hypoplasia, type 3
  • pch3
pontocerebellar hypoplasia
  • pch
major depressive disorder
  • mdd
vertebral artery insufficiency
  • vertebral artery syndrome
bipolar disorder
  • major affective disorder 1
- elite association - COSMIC cancer census association via MalaCards
Search PCLO in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PCLO_HUMAN
  • Pontocerebellar hypoplasia 3 (PCH3) [MIM:608027]: A form of pontocerebellar hypoplasia, a disorder characterized by structural defects of the pons and cerebellum. Brain MRI shows an abnormally small cerebellum and brainstem, decreased cerebral white matter, and a thin corpus callosum. PCH3 features include seizures, short stature, optic atrophy, progressive microcephaly, severe developmental delay. {ECO:0000269 PubMed:25832664}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PCLO

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PCLO: view

No data available for Genatlas for PCLO Gene

Publications for PCLO Gene

  1. Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. (PMID: 19065144) Sullivan PF … Penninx BW (Molecular psychiatry 2009) 3 23 41 54
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 54
  3. Loss of PCLO function underlies pontocerebellar hypoplasia type III. (PMID: 25832664) Ahmed MY … Mochida GH (Neurology 2015) 3 4 54
  4. Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. (PMID: 21621269) Aragam N … Pan Y (Journal of affective disorders 2011) 3 41 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for PCLO Gene

Sources for PCLO Gene